Marcin Czech

Medical University of Warsaw · Zakład Farmakoekonomiki

Objectives: Human papillomavirus (HPV) is a prevalent sexually transmitted infection with significant implications for public health. In Poland, a nationwide vaccination program offers a choice between the 9-valent (9v) and 2-valent (2v) HPV vaccines. We aimed to assess the cost-effectiveness of the 9v vs 2v vaccine from the public payer perspecti...

Clinical trials, by contributing to the development of diagnostics and to the search for modern, more effective, and safer therapies, have become one of the most important elements of the healthcare system. They enable the introduction of innovative drugs and treatments that can significantly improve patients’ quality of life. Not only does this re...

Despite the availability of affordable pharmaceuticals treating cardiovascular diseases (CVDs), many of the risk factors remain poorly controlled. Fixed-dose combinations (FDCs), a form of incremental innovation, have already demonstrated improvements over combinations of single medicines in adherence and hard clinical endpoints. Nevertheless, ther...

Clinical trials, by contributing to the development of diagnostics and to the search for modern, more effective, and safer therapies, have become one of the most important elements of the healthcare system. The aim of this study was to assess Poles' knowledge and beliefs about clinical trials. Methods: The survey was conducted among Poles aged 18 a...

All tasks performed by hospital pharmacies concern the management of medicinal products. The aim of this work is to analyze the functioning and implemen-tation costs of unit-dose and multi-dose automatic drug distribution systems in comparison with the classical mode of so-called ward medicine cabinets. The study was conducted from January 2020 to...

Background: Clinical trials, by contributing to the development of diagnostics and to the search for modern, more effective, and safer therapies, have become one of the most important elements of the healthcare system. The aim of this study was to assess Poles' knowledge and beliefs about clinical trials. Methods: The survey was conducted among Pol...

Biotechnology is developing at an ever-increasing pace, and the progressive computerization of health care and research is making it increasingly easy to share data. One of the fastest growing areas is biobanking. However, even with the best equipment and the best trained staff, a biobank will be useless without donors. For this reason, we have dec...

Background: ; Biotechnology is developing at an ever-increasing pace, and the progressive computerisation of health care and research is making it increasingly easy to share data. One of the fastest growing areas is biobanking. However, even with the best equipment and the best trained staff, a biobank will be useless without donors. For this reaso...

Introduction Meaningful patient involvement in health technology assessment (HTA) is essential in ensuring that the interests of the affected patient population, their families, and the general public are accurately reflected in coverage and reimbursement decisions. Central and Eastern European (CEE) countries are generally at less advanced stages...

Background: Spinal muscular atrophy (SMA) is a debilitating neuromuscular disease resulting in children's mortality and disability. Nusinersen is available to all SMA patients in Poland since 2019. Aim: To compare mortality or disease progression to mechanical ventilation in two patient cohorts before and after the program's introduction. Additi...

Background Artificial intelligence (AI) has attracted much attention because of its enormous potential in healthcare, but uptake has been slow. There are substantial barriers that challenge health technology assessment (HTA) professionals to use AI-generated evidence for decision-making from large real-world databases (e.g., based on claims data)....

This paper presents the role, tasks, and place of a hospital pharmacy in the structure of the entire facility. The role of hospital drug management and pharmacy seems to be extremely important in providing patients with high-quality care. Particular emphasis was placed on the distribution systems of medicinal products and medical devices in the hos...

The outbreak of the COVID-19 pandemic presented the world with many new challenges such as rapid and accurate diagnosis of infected individuals. RT-PCR has become the gold standard in COVID-19 diagnostics, but its limitations are: long turnaround time and the need to be conducted by specialized staff. The need for rapid and easy-to-use diagnostic t...

Aim: The incidence of fractures correlates with many independent and interrelated factors. The aim of the study was to examine trends in fracture incidence and to find possible reasons for changes. Materials and methods: A complete dataset of Polish population aged above 50 from the National Heath Fund-which is a single, state-owned payer for th...

The COVID-19 pandemic caused a major upheaval to the lives of people and placed a strain on societal mental health. The aim of this research is to estimate the impact of the pandemic on the mental condition of the Polish population measured through the consumption of relevant medication and medical leave of absence from the workplace. Methods: We a...

Introduction: In-hospital mortality is an important outcome of hospital admission. Objectives: To identify predictors that are independently associated with non-surgical units' in-hospital mortality. Patients and methods: The National Health Fund database provided data from 2014 on 2,855,029 hospitalizations of adults, unrelated to surgical pr...

Introduction: The subject of this study was to collect patient opinions related to coordinated health care organization before pilot implementation phase of a coordinated care project Primary Health Care PLUS (PHC PLUS) in Poland, co-financed from the European Social Fund. The research was intended to verify hypotheses regarding patients’ satisfact...

Introduction: Coordinated care is planned to be implemented in Poland based on solutions developed in the project "Preparation, testing and implementation of coordinated care in the healthcare system, Stage II. Pilot phase – Primary Care PLUS model” co-financed from the European Social Fund under the Operational Program Knowledge Education Developm...

Introduction: Disease management programs are a component of the coordinated care project Primary Health Care PLUS (PHC PLUS) in Poland, co-financed from the European Social Fund under the Operational Program Knowledge Education Development, financed under the European Commission Priority Axis 4 and 5. Together with health check-ups, coordinators o...

Background: Medical assistants/care coordinators play a crucial role in the coordinated care system. The tasks of nurses and some qualified supporting staff have been extended to include this role along with the implementation of the pilot program POZ Plus in Polish primary healthcare. A personalized approach to the patient is especially important...

Background This study aimed to undertake an analysis of ten years of real-world evidence (RWE) on overall survival (OS) following treatment of advanced gastrointestinal stromal tumor (GIST) with imatinib, sunitinib, and sorafenib using data from the Polish National Health Fund. Material/Methods Data from the Polish National Health Fund, the sole P...

Introduction The aim of the study was to estimate the overall survival of patients with EGFR mutation-positive non-small-cell lung cancer treated with erlotinib, gefitinib or afatinib. Material and methods Real-world patients who received afatinib, erlotinib or gefitinib between 1 July 2012 and 30 October 2017 were analysed in five subgroups. Res...

Background: Organizational and educational activities in primary care in Poland have been introduced to improve the chronic heart failure (CHF) management. Objectives: To assess the use of diagnostic procedures, pharmacotherapy and referrals of CHF in primary care in Poland. Methods: The cross-sectional survey was conducted in 2013, involving 390 p...

Background and aims: Optimal management of heart failure (HF) patients is crucial to reduce both mortality and a number of hospital admissions, at the same time improving patients' quality of life. The aim of the study was to assess a quality of care of hospitalized patients with HF in Poland in 2013 and compare it with the results of similar surv...

Aims: The purpose of this study was to investigate differences of insulin therapy regimens in five European countries. Methods: Proportions of basal bolus therapy (intensified insulin therapy (ICT), basal insulin supported oral therapy (BOT), conventional therapy (CT), and short-acting prandial insulin (SIT) among insulin-treated diabetes patien...

Aims: To compare short-term basal insulin therapy persistence and its predictors in Poland and Germany. Methods: Persistence was defined as proportions of patients remaining on the initial basal insulin (analogs: Poland: n = 6,889, Germany: n = 454,067; neutral protamine Hagedorn (NPH) insulins: Poland: n = 50,761, Germany: n = 226,064) over 2 y...

Purpose: Radiofrequency ablation (RFA) is considered the treatment of choice in cases of atrioventricular nodal reciprocating tachycardia (AVNRT) and atrioventricular reciprocating tachycardia (AVRT). Published studies suggest a considerable time gap between the onset of the arrhythmia, correct diagnosis, and RFA which may reach 10-15 years. The c...

Objective: Complications contribute largely to the economic gravity of diabetes mellitus (DM). How they arise and are treated differ substantially between countries. In this paper we assess the total annual, direct and indirect, cost of severe hypoglycaemia events (SHEs) in nine European countries: Bulgaria, Croatia, the Czech Republic, Greece, Hu...

Background: Surgery-related mortality depends on a number of factors including the type of surgical procedure, quality of healthcare, co-morbidities, and age of patient. The objective of the study was to assess the in-hospital mortality in the elderly undergoing surgical treatment. Methods: This was a national data-based retrospective cohort stu...

Process of demographic ageing, especially in recent decades, is steadily growing in dynamics and importance due to increasing health-related needs and expectations with regard to a guarantee of social services. Elaboration of the most effective model of care, tailored to Polish conditions, requires an estimation of actual costs of this care, includ...

Background Diabetes mellitus (DM) leads to multiple complications, including severe hypoglycaemia events (SHEs). SHEs can impact a patient’s quality of life and compliance and may directly result in additional costs to the health care system. The aim of this review was to evaluate the risk of severe hypoglycaemia in patients with type 1 (T1) and 2...

Diabetes mellitus (DM) is associated with severe hypoglycemia events (SHEs) that vary in severity and resource consumption. Here we perform a systematic review in Medline of studies evaluating SHE-related health resource use. Eligible studies investigated patients with DM and included ≥10 SHEs. We also assessed studies identified in another systema...

The objective of this study was to evaluate the cost of hospitalizations due to micro- and macrovascular complications in an observed cohort of 433 patients with diabetes. A six-month combined retrospective and prospective observational study was performed. The patients were separated into two groups depending on the type of diabetes and further in...

Background: The regional analyses play an important role in understanding a state of diabetes mellitus management and to support informed policy options. They need to be explored in more details in order to ensure an equal patients' access to health care services of the same value and quality. Aim: The aim of this study is to analyze regional di...

A259 respectively, which shows that usage of drugs associated with higher SHE risks varies between countries. E.g. in type 1 DM 42.65% patients in Hungary use basal-bolus with human basal (related to 1.1 events/person-year), while only 8% in Croatia. In type 2 DM 9.37% patients in Hungary use basal-bolus regimen with basal human insulin (0.6 events...

Background: Lack of established Polish terminology is a serious limitation of the development of health-related quality of life (HRQoL) studies in Poland. Our goal is to suggest the best translations in order to create the Polish dictionary of QoL terms. Methods: In February 2012, QoL Special Interest Group of ISPOR Poland Chapter took on the task...

A437 cular complications-41%. In the type 1 diabetes group the cost was equal to 15 364 EUR with the following split: 63% due to (general) diabetes, 19% due to microvascular complications, and 18% due to macrovascular complications. CONCLUSIONS: Type 2 diabetes is more costly than type 1 when hospitalizations occur. People with type 2 diabetes pay...

Objectives The burden of acute gastrointestinal infections (AGIs) on the society has not been well studied in Central European countries, which prevents the implementation of effective, targeted public health interventions. Methods We investigated patients of 11 randomly selected general practices and 8 hospital units. Each patient meeting the int...

OBJECTIVES: Hypoglycaemia, a common side effect of insulin therapy, can act as a barrier to optimal diabetes management and has a negative impact on patients' quality of life. However, there are few data on the frequency of hypoglycaemic events outside clinical trials. METHODS: Type-1 (T1) and insulin-treated type-2 (T2: basal only, T2BOT; basal-bo...

The goal of this study was to calculate and compare the direct medical cost of diabetes and its complications for insulin treated patients from the perspective of the health insurance fund. In a combined prospective and retrospective observational study with duration of 6 months, 433 patients were randomly selected and were divided into 3 subgroups...

Heart failure (HF) is a chronic disease of great clinical and economic significance for both the healthcare system and patients themselves. To determine the consumption of medical resources for treatment and care of HF patients and to estimate the related costs. The study involved 400 primary care practices and 396 specialist outpatient clinics, as...

HbA1c are likely to lead to substantial clinical and economic benefits, driven by reduced complication rates. The cost-effectiveness of interventions designed to improve glycemic control in Saudi Arabia is worthy of investigation. OBJECTIVES: A1chieve is a prospective, international, observational study of basal, bolus and biphasic insulin analogue...

S. healthcare system – its structure and background for modifications in the light of the economic crisis Streszczenie. Amerykañski system ochrony zdrowia w odró¿nieniu do systemów europejskich nie realizuje idei solidaryzmu spo³ecznego. G³ówn¹ rolê odgrywaj¹ tu ubezpieczyciele komercyjni, choae wybranym grupom osób przys³uguje ubezpieczenie w rama...

SUMMARYA prospective survey was conducted in patients admitted to 11 randomly selected general practices and eight hospitals located in six provinces of Poland. For each patient meeting the international acute gastrointestinal infection (AGI) case definition criteria, information was collected on healthcare resources used. Antibacterial drug consum...

The aim of this study was to assess the long-term cost-effectiveness of biphasic insulin aspart 30 versus human premix insulin in patients with type 2 diabetes from a third-party payer perspective in a Bulgarian setting. The extensively published and validated CORE Diabetes Model was populated with the clinical data from the IMPROVETM observational...

Health Technology Assessment (HTA) is a multidisciplinary process that summarizes information about medical, social, economic and ethical issues related to the use of a health technology in a systematic, transparent, unbiased, robust manner. HTA constitutes an integral part of a decision making process covering, among others, pricing and reimbursem...

The objective of this study was to conduct an economic evaluation of liraglutide combined with metformin (MET) and/or sulfonylurea therapy (SU) in comparison with exenatide in combination with MET and/or SU therapy in type 2 diabetes not adequately controlled with MET and/or SU. The study was conducted with respect to conditions of the Bulgarian he...

Goal of this study is to model the long-term health care and economic consequences of the new antidiabetic medicine (liraglutide) for the health care system in Bulgaria using the CORE diabetes model. The CORE diabetes model is a disease computer simulation model developed to project long-term health and social outcomes of interventions in type 1 an...

The aim of the survey was to collect data on practice and preferences of decision-makers and experts in health economics concerning the role of indirect costs in Poland. The questionnaire contained 18 questions covering the need for indirect costs calculation in economic evaluations and measures used to calculate indirect cost. Fifty four responden...

The aim of the survey was to collect data on practice and preferences of decision-makers and experts in health economics concerning the role of indirect costs in Poland. The questionnaire contained 18 questions covering the need for indirect costs calculation in economic evaluations and measures used to calculate indirect cost. Fifty four responden...

Polish heart failure surveys from 1999 and 2005 indicated that non-invasive and invasive diagnostic procedures in heart failure patients are underused, mostly due to limited availability. To assess the access to procedures used for the diagnosis and treatment of heart failure in randomly selected outpatient clinics and hospital wards in Poland. The...

The objective of creating Educational Standards of the Polish Pharmacoeconomic Society (Polish Chapter of the International Society for Pharmacoeconomics and Outcomes Research) was to define and establish a scope of knowledge and skills needed for people conducting and interpreting pharmacoeconomic analyses as well as health technology assessments....

OBJECTIVES: The aim of the review was to evaluate the efficacy and safety of imiquimod 5% cream compared with vehicle for treating superficial basal cell carci-noma. METHODS: The analysis was performed in accordance with the rules of systematic review, based on the Cochrane Collaboration (Cochrane Reviewer's Handbook) guidelines and the Health Tech...