Márcia I. Goettert

Márcia I. Goettert
Universidade do Vale do Taquari - UNIVATES · Department of Biotechnology

Doctor of Pharmacy

About

94
Publications
26,918
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
1,237
Citations
Citations since 2017
49 Research Items
950 Citations
2017201820192020202120222023050100150200250
2017201820192020202120222023050100150200250
2017201820192020202120222023050100150200250
2017201820192020202120222023050100150200250

Publications

Publications (94)
Chapter
Affecting more than 50 million people worldwide and with high global costs annually, neurological disorders such as Alzheimer's disease (AD) and Parkinson’s disease (PD) are a growing challenge worldwide. Globally, only in 2018, AD costs reached astonishing $ 1 trillion, and since the annual costs of AD are rapidly increasing, the projections estim...
Book
Full-text available
o Programa de Pós-Graduação em Biotecnologia (PPGBiotec) da Universidade do Vale do Taquari (Univates) alicerça suas pesquisas nas áreas Agroalimentar e da Saúde, sendo que já foram obtidos resultados importantes para a produção sustentável de alimentos e nos cuidados com a saúde humana. Com intuito de divulgar suas pesquisas e promover a conscient...
Article
Full-text available
There is a trend toward the use of natural substances present in plants and vegetables. In general, foods rich in antioxidants are complex matrices; therefore, understanding its absorption effects is extremely relevant to know its bioactive potential. Thus, this systematic review focused on clinical trials involving plants (or compounds) registered...
Article
Full-text available
Due to the high rate of transmissibility, Brazil became the new COVID-19 outbreak epicenter and, since then, is being monitored to understand how SARS-CoV-2 mutates and spreads. We combined genomic and structural analysis to evaluate genomes isolated from different regions of Brazil and show that the most prevalent mutations were located in the S,...
Article
Full-text available
Objective One-third of patients with severe rheumatoid arthritis (RA) do not achieve remission or low disease activity, or they have side effects from cDMARD and bDMARD. They will need a new treatment option such as the small molecule JAK inhibitors. In this systematic review, we evaluate the efficacy and safety data of the current jakinibs: tofaci...
Article
Full-text available
The p38δ mitogen-activated protein kinase is an important signal transduction enzyme. p38δ has recently emerged as a drug target due to its tissue-specific expression patterns and its critical roles in regulation of cellular processes related to cancer and inflammatory diseases, such as cell proliferation, cell migration, apoptosis, and inflammator...
Article
Full-text available
Introduction: The chronic metabolic disorder diabetes mellitus is a fast-growing global problem with huge social, health, and economic consequences, having one of the highest morbidities and mortality rates. Prolonged use of many available medications can produce undesirable side effects. Thus, plants appear as an important source of bioactive reso...
Article
Full-text available
Current treatments for neurodegenerative diseases (ND) are symptomatic and do not affect disease progression. Slowing this progression remains a crucial unmet need for patients and their families. c-Jun N-terminal kinase 3 (JNK3) are related to several ND hallmarks including apoptosis, oxidative stress, excitotoxicity, mitochondrial dysfunction, an...
Article
Full-text available
Introduction The COVID-19 global pandemic is a public health emergency due to its high virulence and mortality. Many vaccine development studies at clinical trials are currently conducted to combat SARS-CoV-2. Plants are a rich source of phytochemicals with different biological activities, including antiviral activities, which are the focus of many...
Article
The treatment of Parkinson´s disease (PD) has benefited from significant advances resulting from the increasing research efforts focused on new therapeutics. However, the current treatments for PD are mostly symptomatic, alleviating disease symptoms without reversing or retarding disease progression. Thus, it is critical to find new molecules that...
Article
Full-text available
The ever-increasing interest in keeping a young appearance and healthy skin has leveraged the skincare industry. This, coupled together with the increased concern regarding the safety of synthetic products, has boosted the demand for new and safer natural ingredients. Accordingly, the aim of this study was to evaluate the dermatological potential o...
Article
Full-text available
Marine natural products have exhibited uncommon chemical structures with relevant antitumor properties highlighting their potential to inspire the development of new anticancer agents. The goal of this work was to study the antitumor activities of the brominated diterpene sphaerodactylomelol, a rare example of the dactylomelane family. Cytotoxicity...
Preprint
Due to the high rate of transmissibility, Brazil became the new COVID-19 outbreak epicenter, being a reference region to monitor how SARS-CoV-2 is mutating and spreading. Here, we combined genomic and structural biology analysis evaluate genomes isolated from different regions of Brazil. We showed that the most prevalent mutations were located in t...
Article
Full-text available
Parkinsons Disease (PD) is the second most common neurodegenerative disease worldwide, and is characterized by a progressive degeneration of dopaminergic neurons. Without an effective treatment, it is crucial to find new therapeutic options to fight the neurodegenerative process, which may arise from marine resources. Accordingly, the goal of the p...
Article
Full-text available
Therapeutic clinical and preclinical studies using cultured cells are on the rise, especially now that the World Health Organization (WHO) declared coronavirus disease 2019 (COVID-19) a “public health emergency of international concern”, in January, 2020. Thus, this study aims to review the outcomes of ongoing clinical studies on stem cells in Seve...
Chapter
Neurodegenerative diseases (NDs) represent one of the most important public health problems, and worldwide, hundreds of millions of people are affected by NDs, displaying strong evidence to these diseases is one of the most significant challenges to public health. Neurological disorders include several common diseases of the central and peripheral...
Article
Full-text available
Alzheimer’s Disease (AD) is becoming more prevalent as the population lives longer. For individuals over 60 years of age, the prevalence of AD is estimated at 40.19% across the world. Regarding the cognitive decline caused by the disease, mitogen-activated protein kinases (MAPK) pathways such as the c-Jun N-terminal kinase (JNK) pathway are involve...
Article
Full-text available
Glycogen synthase kinase-3β (GSK-3β) is a potential target in the field of Alzheimer’s disease drug discovery. We recently reported a new class of 9H-pyrimido[4,5-b]indole-based GSK-3β inhibitors, of which 3-(3-((7-chloro-9H-pyrimido[4,5-b]indol-4-yl)(methyl)amino)piperidin-1-yl)propanenitrile (1) demonstrated promising inhibitory potency. However,...
Article
Cancer is a significant cause of morbidity and mortality. Scientific advances, coupled with potential flaws in current treatments, are driving research into the discovery of new bioactive molecules. This systematic review focused on scientific studies with clinical trials and patents registered on the National Relation of Medicinal Plants of Intere...
Article
Full-text available
Neurodegenerative diseases are multifactorial debilitating disorders of the nervous system affecting approximately 30 million individuals worldwide. Mitochondrial dysfunction and oxidative stress have also been implicated in causing neurodegeneration. As life expectancy is increasing, neurodegenerative disorders are becoming a major social issue. N...
Article
The aim of this study was to evaluate and compare the efficiency of bovine (CW) and buffalo cheese whey (BCW) as encapsulating agents for the spray-drying (SD) of endogenous Lactobacillus pentosus ML 82 and the reference strain Lactobacillus plantarum ATCC 8014. Their protective features were also tested for resistance to storage (90 days, 25 °C),...
Article
Grape polyphenols are studied for their bioactive activities and health benefits. Grape juice clarification produces a colored non-pomace solid residue that is rich in polyphenols and may have potential for nutraceutical applications. This study therefore firstly investigated antiproliferative and anti-inflammatory properties of the non-pomace sedi...
Article
Natural products are still a promising source of bioactive molecules. Food and Drug Administration data showed that approximately 49% of the approved molecules originate naturally or chemically-resemble these substances, of which more than 70% are being used in anticancer therapy. It is noteworthy that at present there are no scientific studies to...
Article
Improper nutrition provokes many types of chronic diseases and health problems, which consequently are associated with particularly high costs of treatments. Nowadays, consumer's interest in healthy eating is shifting towards specific foods or food ingredients. As a consequence, bioactive peptides as a promising source of health promoting food addi...
Chapter
Nitric oxide (NO) has an essential role in endothelial function and, besides its well-established vasodilating propriety, it is involved in several biological processes, including neurotransmission and cellular immunity. NO is endogenously produced by four different isoforms of nitric oxide synthase (NOS): the neuronal (nNOS), the endothelial (eNOS...
Article
Prostate cancer is one of the most prevalent cancer in men worldwide. With the progression of the disease to an independent condition of stimulation by androgen hormones, it becomes more difficult to control its progress. In addition, several studies have shown that chronic inflammation is directly related to the onset and progression of this cance...
Article
Background: Hematological malignancies are a heterogeneous group of tumors with increased proliferative and auto-replicative capacity. Despite treatment advances, post-treatment quality of life remains highly affected. Studies addressing the molecular mechanisms of these diseases are critical for the development of effective, rapid and selective t...
Article
Glycogen synthase kinase-3β (GSK3β) is involved in many pathological conditions and represents an attractive drug target. We previously reported dual GSK3β/p38α mitogen-activated protein kinase inhibitors and identified N-(4-(4-(4-fluorophenyl)-2-methyl-1H-imidazol-5-yl)pyridin-2-yl)cyclopropanecarboxamide (1) as a potent dual inhibitor of both tar...
Article
Full-text available
Inferior members ulcers are complications of Diabetes mellitus that demands a high coast to health’s services. The sap of Croton lechleri Müll. Arg. has demonstrated a huge potential for the treatment of wounds. The objective of this study was go along with chronic ulcers’ evolution in the inferior members in people with diabetes submitted to a thr...
Article
Full-text available
While the inactivation mutations that eliminate JAK3 function lead to the immunological disorders such as severe combined immunodeficiency, activation mutations, causing constitutive JAK3 signaling, are known to trigger various types of cancer or are responsible for autoimmune diseases, such as rheumatoid arthritis, psoriasis, or inflammatory bowel...
Article
Cancer is one of the largest causes of morbimortality in the world and due to its prevalence the discovery of novel anticancer drugs in of great importance. The past century brought great advances in the field of plant and microbiology research, with the development of several compounds used in cancer treatment protocols. Many successful anticancer...
Article
The composition of microbiota may influence the development of colorectal cancer (CRC). In addition, probiotics can decrease the chance of developing cancer or its progress. For that reason, it is encouraging to assess the influence of plant extracts as adjuvants of the health-promoting effects of probiotics. Thus, this study aimed to investigate t...
Article
Full-text available
Whey protein (WP) is a highly nutritious, commercially available alternative food source that is used primarily as a food supplement by athletes and physically active individuals to provide them with essential amino acids and bioactive peptides, and additional benefits have been attributed to WP consumption. In this context, the objective of this r...
Article
Full-text available
About 80% of the antineoplastic drugs produced in the last 30 years are of natural origin or their derivatives, evidencing the great contribution of natural products in the development of new drugs (1). Phytochemical constituents of various plants are a source of biomolecules candidates (2), including polyphenols as flavonoids, showing expressive a...
Article
Full-text available
Objective: The aim of this study was to conduct a systematic review of the healing potential of medicinal plants belonging to the Brazilian National List of Medicinal Plants of Interest to the Unified Health System (RENISUS). Method: PubMed and ScienceDirect databases were searched for relevant articles, regardless of the language, from 2010 to Ju...
Article
Despite the development of efficient boar semen extenders, there is still room for improvement of new formulas using new molecules that could increase fertilization outcomes and substitute toxic cryoprotectants and antibiotics. The goal of this work was to evaluate if the essential oils from the leaves of Myrrhinium atropurpureum and Cymbopogon cit...
Article
Several species of the genus Ceiba (Malvaceae) are ethnopharmacologically used. Thus, this study aimed to investigate the in vitro beneficial properties of the aqueous stem bark extract of Ceiba speciosa. The extract presented a great amount of phenolic compounds (117.4 ± 6.2 mg GAE/g). The antioxidant activity was assessed by DPPH (IC50 = 42.87 μg...
Article
Despite the development of efficient boar semen extenders, there is still room for improvement of new formulas using new molecules that could increase fertilisation outcomes and substitute cryoprotectants and antibiotics. The goal of this work was to evaluate if the essential oils from the leaves of Myrrhinium atropurpureum and Cymbopogon citratus...
Article
Full-text available
Current pharmacological therapies to treat neurological diseases are at best palliative and manage only the symptoms. Unfortunately, few therapies can affect diseases outcomes and alternative strategies such as stem cell therapy, neurotransplantation and deep brain stimulation are still in progress. Diseases such as Alzheimer’s and Parkinson’s dise...
Article
Full-text available
Leaves and roots of Acanthospermum australe (Asteraceae) have been used in Brazilian folk medicine for the treatment of various ailments including diarrhea, skin diseases, blennorrhagia, dyspepsia, parasitic worms and malaria. The aim of study was to characterize the chemical profiles of the aqueous and hydroalcoholic extracts of leaves and roots o...
Article
Full-text available
Current pharmacological therapies to treat neurological diseases are at best palliative and manage only the symptoms. Unfortunately, few therapies can affect diseases outcomes and alternative strategies such as stem cell therapy, neurotransplantation and deep brain stimulation are still in progress. Diseases such as Alzheimer's and Parkinson's dise...
Article
Full-text available
Plants are being researched as to their neuroprotective potential. The objective of this review was to quantify the research that refer therapeutic potential of kidney disease from the study of plants RENISUS, published between 2010 and February 2013 in three scientific databases (SciELO, Science Direct and Springer). The initial search resulted in...
Article
The search for new bioactive substances derived from natural products is daily growing. Among biologically active products used in therapeutic approaches, essential oils are described with wide range of therapeutic and pharmacological potential. Plants from Myrtaceae family have the presence of essential oils in its composition. Calyptranthes grand...
Article
Full-text available
Anti-tumor therapies based on anti-inflammatory effects have been considered in cancer treatment. Survival, proliferation and, resultantly, invasion and metastasis of tumor cells are regulated by local inflammatory mediators. Primary inflammatory cytokines, such as tumor necrosis factor (TNF), are targets for anticancer therapy. Several anti‑inflam...
Article
Medicinal plants are a plentiful source of bioactive molecules with much structural diversity. In cancer treatment, molecules obtained from plants represent an attractive alternative to other treatments because several plant-derived compounds have exhibited lower toxicity and higher selectivity against cancer cells. In this review, we focus on the...
Article
Full-text available
Calyptranthes tricona is a species (Myrtaceae) native to South Brazil. Plants belonging to this family are folkloric used for analgesia, inflammation, and infectious diseases. However, little is known about the toxic potential of C. tricona. The present study aimed to evaluate the antioxidant activity of C. tricona ethanol and hexane leaf extracts,...
Article
Full-text available
Theory and practice about biotechnology-related issues have been topics of workshops for students and teachers of the Post Graduate in Biotechnology UNIVATES to secondary education students. We held ten different workshops aimed at the food production and health, among which stands out in this study, the workshop entitled "Antioxidants: the fountai...
Article
Full-text available
Among the neoplasias, colorectal cancer is one of the leading causes of cancer death in men and women. The increasing incidence of this type of cancer is due to the increase in the population’s life expectancy, by the increase in chronic inflammatory bowel diseases, primarily ulcerative colitis and Crohn’s disease, and the change in eating habits....
Conference Paper
Full-text available
Introduction: Considering that most anticancer drugs produced are derived from naturally occurring compounds or their derivatives, there is a constant search for new metabolites from natural origin, particularly from plants, which have potential for efficacious drugs. Myrtaceae is one of the largest plant families present in tropical areas and is o...
Article
Full-text available
Introdução: A lesão ou disfunção hepática é considerada um grave problema de saúde. Os medicamentos sintéticos disponíveis para tratar doenças hepáticas são caros e podem causar efeitos adversos com uso prolongado. Assim, os efeitos hepatoprotetores de plantas têm sido investigados. Objetivos: Quantificar as pesquisas que referem potencial terapêut...
Article
Full-text available
Pain is an unpleasant sensory and emotional experience associated with real or potential tissue damage. The incidence of pain may result in the risk of developing some limitations in daily activities, overload in the use of health services, abuse of controlling medication, among other factors. This systematic review aimed to quantify the preclinica...
Article
Full-text available
Helicobacter pylori infects similar to 50% of the world population, causing chronic gastritis and other forms of cellular damage. The present study assessed the influence of H. pylori on the mRNA expression levels of nuclear factor-kappa B1 (NFKB1), p38 alpha and tumor necrosis factor-alpha (TNF-alpha) in human gastric mucosa in a southern Brazilia...
Article
Full-text available
As doenças transmitidas por alimentos ocorrem principalmente devido à ingestão de alimentos contaminados por microrganismos patogênicos, dentre eles a Escherichia coli e Listeria monocytogenes. Uma das alternativas estudadas para minimizar a contaminação de alimentos é o emprego de plantas, ou seus extratos, como agentes antimicrobianos de origem n...
Article
Full-text available
The purpose of this systematic review was to quantify the publications generated from 2010 to February 2013 in three scientific databases, SciELO, Science Direct and Springer describing therapeutic potential for a plant listed in the National List of Medicinal Plants of Interest to Brazilian Unified Health System (Relação Nacional de Plantas Medici...
Article
Full-text available
Introdução: doenças cardiovasculares constituem uma das principais causas de mortalidade, pois muitos são os fatores de risco associados ao seu desenvolvimento. Estudos vêm demonstrando que moléculas extraídas de plantas medicinais podem reduzir o risco de doenças crônicas. Assim, o Ministério da Saúde, publicou em fevereiro de 2009, a Relação Naci...
Article
Full-text available
This systematic review aimed to quantify the studies related to therapeutic action of plants listed in the Brazilian National List of Medicinal Plants of Interest to the Unified Health System (RENISUS), published between 2010 and 2013 in three scientific databases (SciELO, Science Direct and Springer). Initially, the searching of the papers was per...
Article
Full-text available
Introduction: cardiovascular diseases are a major cause of mortality, because there are many risk factors associated with its development. Studies have shown that molecules extracted from medicinal plants can reduce the risk of chronic diseases. Thus, the Ministry of Health, published in February 2009, the National List of Medicinal Plants of Inter...
Article
Full-text available
O objetivo desta análise sistemática foi quantificar as publicações que descrevem potencial terapêutico para planta listada na Relação Nacional de Plantas Medicinais de Interesse ao SUS (RENISUS), Curcuma longa L., geradas entre 2010 e fevereiro de 2013 em três bases de dados científicas: SciELO, Science Direct e Springer. A análise dos 1.139 artig...
Article
Full-text available
RESUMO Introdução: A lesão ou disfunção hepática é considerada um grave problema de saúde. Os medicamentos sintéticos disponíveis para tratar doenças hepáticas são caros e podem causar efeitos adversos com uso prolongado. Assim, os efeitos hepatoprotetores de plantas têm sido investigados. Objetivos: Quantificar as pesquisas que referem potencial t...
Article
Full-text available
This systematic review aimed to quantify the studies related to therapeutic action of plants listed in the Brazilian National List of Medicinal Plants of Interest to the Unified Health System (RENISUS), published between 2010 and 2013 in three scientific databases (SciELO, Science Direct and Springer). Initially, the searching of the papers was per...
Article
Full-text available
Parasitas são seres vivos que extraem de outros organismos os recursos necessários para a sua sobrevivência. Esta ligação acarreta em danos para o hospedeiro resultando em diversas doenças. Esta revisão sistemática objetivou quantificar os estudos clínicos que referem potencial antiparasitário a partir do estudo de plantas constantes na Relação Nac...
Article
Full-text available
Introdução: O gengibre (Zingiber officinale Roscoe) é uma planta originária da Ásia, que tem sido usada como tempero e composto medicinal há milhares de anos, sendo que vários de seus compostos já foram isolados, identificados e estudados por seus efeitos farmacológicos. Objetivos: Quantificar os estudos clínicos que referem alguma forma de ação te...
Article
Full-text available
Apoptosis and NETosis of neutrophils are two major mechanisms of programmed cell death that differ in their morphological characteristics and effects on the immune system. Apoptosis can be delayed by the presence of pathogens or chemicals components such as lipopolysaccharide (LPS). Neutrophils have other antimicrobial strategy, called neutrophil e...
Article
Full-text available
Introdução: Fungos podem causar doenças graves em plantas, animais e seres humanos. Plantas apresentam uma vasta gama de metabólitos secundários, os quais são cada vez mais estudados para suas aplicações terapêuticas, inclusive em relação ao seu potencial antifúngico. Objetivo: Esta revisão sistemática objetivou quantificar os estudos clínicos que...
Article
Full-text available
Resumo: A presente revisão sistemática quantifica os estudos clínicos que referem ação terapêutica sobre Diabetes mellitus (DM), publicados, entre 2010 e 2013, em três bases de dados científicas (SciELO, Science Direct e Springer), sobre as plantas medicinais indicadas na RENISUS. Dos 21.357 artigos encontrados nas bases de dados pesquisadas, a aná...
Article
Full-text available
Espécies de bactérias podem apresentar a capacidade genética de adquirir e transmitir resistência contra agentes antibacterianos, tornando-se multi-resistentes aos medicamentos disponíveis. Esta revisão sistemática objetivou quantificar os estudos clínicos que referem potencial terapêutico sobre doenças antibacterianas a partir do estudo de plantas...
Article
Full-text available
Resumo A inflamação é uma resposta aguda à lesão do tecido responsável por produzir sintomas característicos que levam a alterações na homeostase do tecido e no fluxo sanguíneo, sendo um mecanismo de defesa do sistema imune. No entanto, a inflamação crônica é a causa de inúmeras doenças como câncer, arteriosclerose, diabetes e doenças neurodegenera...