Marcelo Nacif

Marcelo Nacif
Universidade Federal Fluminense | UFF · Departamento de Radiologia (MRD)

MD, MSc, PhD, FSCCT

About

155
Publications
46,602
Reads
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2,624
Citations
Citations since 2017
24 Research Items
1484 Citations
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2017201820192020202120222023050100150200250
2017201820192020202120222023050100150200250
Introduction
Dr. Nacif holds a Master of Medicine and a PhD from "Rio de Janeiro Federal University". Dr Nacif did his post-doctoral research training at National Institutes of Health (NIH) and Johns Hopkins School of Medicine (USA) and he is currently at the Radiology Department, Federal Fluminense University, Niterói-RJ, Brazil.
Additional affiliations
May 2014 - June 2016
Universidade Federal Fluminense
Position
  • Vice Chair - Department of Radiology (MRD)
January 2012 - December 2012
Johns Hopkins University
January 2011 - present
Education
March 2010 - August 2012
Johns Hopkins Medicine
Field of study
  • Advanced Cardiovascular Imaging
March 2010 - August 2012
National Institutes of Health
Field of study
  • Advanced Cardiovascular Imaging
January 2007 - December 2009
Federal University of Rio de Janeiro
Field of study
  • Cardiac MR

Publications

Publications (155)
Article
Alterations in myocardial structure, function, tissue composition (e.g., fibrosis) may be associated with metabolic syndrome (MetS). This study aimed to determine the relation of MetS and its individual components to markers of cardiovascular disease in patients with type 1 Diabetes Mellitus (T1DM). A total of 978 subjects of the Diabetes Control a...
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Almost two decades ago, it became possible to use coronary computed tomography for the noninvasive assessment of the coronary arteries. That is an extremely accurate method for detecting or excluding coronary artery disease, even the subclinical forms. This pictorial essay aims to show the main imaging findings in 47 coronary computed tomography sc...
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We report the case of a fetus presenting aortic arch anomalies associated with a ven-tricular septal defect (VSD). This fetus, which was referred at 25 weeks of gestation, was suspected to have coarctation of aorta (CoA) evidenced by enlarged right chambers at the four-chamber view during a routine obstetric ultrasonographic scan. The prenatal diag...
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Background Cardiovascular disease is the leading cause of mortality in the world. Parietal calcifications of the arteries may be visualized and quantified at initial and subclinical states by computed tomography (CT), and expressed as calcium score (CS). It is possible to estimate the prognosis of future cardiovascular events using this score. Obj...
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Coronary computed tomography angiography (CCTA) has gained a prominent role in the evaluation of coronary artery disease. However, its anatomical nature does not allow the evaluation of the functional repercussion of coronary obstructions. It has been made possible to evaluate Myocardial computed tomography perfusion (Myocardial CTP) recently, base...
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Background: Functional assessment to rule out myocardial ischemia using coronary computed tomography angiography (CCTA) is extremely important and data on the Brazilian population are still limited. Objective: To assess the diagnostic performance of myocardial perfusion by CCTA in the detection of severe obstructive coronary artery disease (CAD)...
Article
Cardiac fibrosis, characterized by net accumulation of extracellular matrix in the myocardium, is a common final pathway of heart failure. This myocardial fibrosis (MF) is not necessarily the primary cause of dysfunction; it often results from a reparative process activated in response to cardiomyocyte injury. In light of currently available treatm...
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Amyloidosis is a disease caused by extracellular deposition of insoluble protein fibrils, that results in changes in tissue architecture and consequently modification of the organ structure. Cardiac involvement is common in amyloidosis. Two major types of systemic amyloidosis affect the myocardium - immunoglobulin light chain and transthyretin amyl...
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Objective To analyze the prevalence of cystic lesions of the pancreas on imaging exams and their association with signs of malignancy risk. Materials and methods This was an observational cross-sectional study, in which we evaluated 924 sequential computed tomography and magnetic resonance imaging scans of the abdomen. For all of the patients incl...
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Many non-invasive methods, such as imaging tests, have been developed aiming to add a contribution to existing studies in estimating patients’ prognosis after myocardial injury. This prognosis is proportional to myocardial viability, which is evaluated in coronary artery disease and left ventricular dysfunction patients only. While myocardial viabi...
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Objective To evaluate the accuracy of visual analysis and of the coronary artery calcium (CAC) score in nontriggered computed tomography (CT), in comparison with that of the CAC score in electrocardiogram-triggered CT, in identifying coronary calcification. Materials and Methods A total of 174 patients for whom CT was indicated for CAC scoring und...
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Objective: To compare an albumin-bound gadolinium chelate (gadofosveset trisodium) and an extracellular contrast agent (gadobenate dimeglumine), in terms of their effects on myocardial longitudinal (T1) relaxation time and partition coefficient. Materials and Methods: Study subjects underwent two imaging sessions for T1 mapping at 3 tesla with a m...
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The myocardial bridge is one of the most prevalent congenital anomalies that involve the coronary circulation, and its incidence in the general population is high, affecting from 23 to 55% in necropsy studies.1The impairment of the anterior descending artery is more frequent, on its proximal 2/3.1In most patients, the myocardial bridges do not caus...
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Background Cardiac Magnetic Resonance is in need of a simple and robust method for diastolic function assessment that can be done with routine protocol sequences. Objective To develop and validate a three-dimensional (3D) model-based volumetric assessment of diastolic function using cardiac magnetic resonance (CMR) imaging and compare the results...
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The study of myocardial viability is of great importance in the orientation and management of patients requiring myocardial revascularization or angioplasty. The technique of delayed enhancement (DE) is accurate and has transformed the study of viability into an easy test, not only for the detection of fibrosis but also as a binary test detecting w...
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A 50 year old man went to the emergency service with an unspecific abdominal pain complaint. We performed a multidetector computed tomography (MDCT) of the abdomen, with and without iodinated intravenous contrast, that showed a hypodense nodule formation with regular and well delimited outlines, few heterogeneous foci and fat density (-35 HU), sizi...
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Background Amyloidosis is a disease caused by deposits of insoluble fibrils in extracellular spaces. The most common type of familial amyloidosis is mediated by mutation of transthyretin, especially Val30Met. Symptoms and ejection fraction decrease may occur in cardiac amyloidosis only in case of poor prognosis. Myocardial strain detected by two-di...
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Objective The objective of this study was to profile patients who undergo defecography, by age and gender, as well as to describe the main imaging and diagnostic findings in this population. Materials and Methods This was a retrospective, descriptive study of 39 patients, conducted between January 2012 and February 2014. The patients were evaluate...
Article
Objectives: The aim of this longitudinal study was to define the determinants of aging-related left ventricular (LV) remodeling and function in a large multiethnic population. Background: The influence of risk factor exposure on myocardial remodeling and function in humans across adult life remains incompletely understood. MESA (Multi-Ethnic Stu...
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Abstract Half the patients with coronary artery disease present with sudden death - or acute infarction as first symptom, making early diagnosis pivotal. Myocardial perfusion scintigraphy is frequently used in the assessment of these patients, but it does not detect the disease without flow restriction, exposes the patient to high levels of radiati...
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Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiovascular disease and represents the main cause of sudden death in young patients. Cardiac magnetic resonance (CMR) and cardiac computed tomography (CCT) are noninvasive imaging methods with high sensitivity and specificity, useful for the establishment of diagnosis and prognosis of...
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Ischemic cardiomyopathy is one of the major health problems worldwide, representing a significant part of mortality in the general population nowadays. Cardiac magnetic resonance imaging (CMRI) and cardiac computed tomography (CCT) are noninvasive imaging methods that serve as useful tools in the diagnosis of coronary artery disease and may also he...
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Importance Myocardial scarring leads to cardiac dysfunction and poor prognosis. The prevalence of and factors associated with unrecognized myocardial infarction and scar have not been previously defined using contemporary methods in a multiethnic US population.Objective To determine prevalence of and factors associated with myocardial scar in mid...
Article
Duplicated inferior vena cava is a rare anomaly, and thrombosis in one or both segments is even less frequent. We present a case of deep venous thrombosis of the left lower limb involving the popliteal, femoral, and iliac veins as well as the left segment of the duplicated vena cava and nutcracker syndrome. After catheter-directed thrombolysis comp...
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BACKGROUND: Cardiovascular diseases are the leading cause of death worldwide. Their main risk factor is old age. Aging is associated with morphostructural cardiovascular abnormalities which may be used as risk markers of cardiac events. OBJECTIVE: To describe biomarkers routinely used in cardiac magnetic resonance (MRI) that best correlate with agi...
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The Multi-Ethnic Study of Atherosclerosis (MESA), initiated in July 2000, is a six-center longitudinal population-based study that included 6,814 men and women at baseline study. Cardiac MRI was part of the study procedures, representing the first large-scale application of cardiac MRI in a multi-center and multi-ethnic population study in the USA....
Article
PurposeOptimization of sequence and sequence parameters to allow three-dimensional (3D) sodium imaging of the entire human heart in vivo in a clinically reasonable time.Theory and MethodsA stack of spirals pulse sequence was optimized for cardiac imaging by considering factors such as spoiling, nutation angles, repetition time, echo time, T1/T2 rel...
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-Tagged cardiac magnetic resonance (CMR) provides detailed information on regional myocardial function and mechanical behavior. T1 mapping by CMR allows non-invasive quantification of myocardial extracellular expansion (ECE) which has been related to interstitial fibrosis in previous clinical and sub-clinical studies. We assessed gender associated...
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Objective To evaluate and describe indications, mainly diagnoses and cardiac magnetic resonance imaging findings observed in clinical practice. Materials and Methods Retrospective and descriptive study of cardiac magnetic resonance performed at a private hospital and clinic in the city of Niterói, RJ, Brazil, in the period from May 2007 to April 2...
Conference Paper
PURPOSE To determine accuracy and sensitivity of post-contrast myocardial T1, partition coefficient (λ) and ECV in discriminating healthy tissue from diffuse fibrotic tissue in hear failure (HF) subjects. METHOD AND MATERIALS Nine healthy and seventeen subjects (age and sex matched) with heart failure (HF) underwent cardiac MRI on 3T scanners aft...
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ContextGastrointestinal stromal tumors are uncommon abdominal neoplasms and can affect any portion of the gastrointestinal tract.Objectives Describe the tomographic findings of the gastrointestinal stromal tumor of gastric origin, correlating it with the mitotic index.Methods Twenty-one patients were selected within the period of January 2000 and 2...
Article
Purpose: Myocardial extracellular volume fraction (ECVF) is a surrogate imaging biomarker of diffuse myocardial fibrosis, a hallmark of pathologic ventricular remodeling. Low dose cardiac CT is emerging as a promising modality to detect diffuse interstitial myocardial fibrosis due to its fast acquisition and low radiation; however, the insufficien...
Article
Left ventricular mass (LVM) and hypertrophy (LVH) are important parameters, but their use is surrounded by controversies. We compare LVM by echocardiography and cardiac magnetic resonance (CMR), investigating reproducibility aspects and the effect of echocardiography image quality. We also compare indexing methods within and between imaging modalit...
Article
The purpose of this study was to determine the relationship of cardiovascular magnetic resonance (CMR) measures of tissue composition to age in the Multi-Ethnic Study of Atherosclerosis (MESA). Animal and human studies have demonstrated increased collagen deposition in senescent hearts. New CMR indices of tissue composition using T1 mapping are sen...
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In Volume 98, Issue 6, June 2012, we read with great interest the article written by Azevedo et al(1), in which the role of calcium scoring and coronary CT angiography in cardiovascular risk stratification was extensively discussed. The issue deserves thorough scientific discussion and the transition to everyday clinical practice should be rethough...
Conference Paper
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4D (3D + time) model is valuable in comprehensive assessment of cardiac functions. Usually, the generation of the 4D myocardial models involves myocardium segmentation, mesh generation and non-rigid registration (to build mesh node correspondence). In this paper, we present a method to simultaneously perform the above tasks. This method begins from...
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Gadolinium enhanced coronary magnetic resonance angiography (MRA) at 3 T appears to be superior to non-contrast methods. Gadofosveset is an intravascular contrast agent that may be well suited to this application. The purpose of this study was to perform an intra-individual comparison of gadofosveset and gadobenate for coronary MRA at 3 T. In this...
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Background: Coronary multidetector CT angiography (CTA) has shown good accuracy for detection of coronary stenosis. Although this is a promising technique for the evaluation of CAD, its correlation with the functional expression of the disease is not yet well established. Objective: To evaluate whether the presence of CAD and the degree of coron...
Article
Modified Look-Locker imaging is frequently used for T(1) mapping of the myocardium. However, the specific effect of various MRI parameters (e.g., encoding scheme, modifications of flip angle, heart rate, T(2) , and inversion times) on the accuracy of T(1) measurement has not been studied through Bloch simulations. In this work, modified Look-Locker...
Conference Paper
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MRI-derived T1 times are associated with diffuse interstitial myocardial fibrosis. LV diastolic dysfunction and fibrosis are important components of cardiac disease, but their relationship has not been firmly established. Early diastolic strain rate (Epeak) has been validated as an indicator of diastolic function by tagged MRI. We derive a novel st...
Conference Paper
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A novel strain relaxation index (SRI) is introduced to assess diastolic function by CMR, using myocardial deformation during LV relaxation. We investigate how SRI relates to standard diastolic parameters by echocardiography (echo). We also relate SRI to mass to volume ratio (MVR) by CMR, which is seen to increase in diastolic dysfunction. SRI accou...
Conference Paper
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Late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) is the non-invasive reference standard for myocardial scar assessment and has prognostic value for ischemic and non-ischemic cardiomyopathies. However, actual standard methods for determining scar quantification compromise its reproducibility. This study evaluates reliability of seven...
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Cardiovascular disease represents the main cause of mor-tality in the world. The capability of identifying, among asymp-tomatic individuals, the subgroup at higher risk for developing cardiovascular events, is a fundamental step in any strategy in-tended to reduce the rates of cardiovascular events (1) . The present issue of Radiologia Brasileira i...
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MS. Which is your diagnosis? Radiol Bras. 2013 Jan/Fev;46(1):XV–XVI. A 47-year-old female patient was admitted to the emergency department presenting abdominal discomfort for ten days, with stitch pain in the epigastric region. The patient reported worsen-ing with fever over the last three days. No history of previous disease was reported. Laborato...