Marcelo L Berthier

Marcelo L Berthier
University of Malaga | UMA · Department of Medicine and Dermatology

MD PhD

About

165
Publications
44,182
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6,989
Citations
Citations since 2017
8 Research Items
1592 Citations
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2017201820192020202120222023050100150200250300
2017201820192020202120222023050100150200250300

Publications

Publications (165)
Article
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Background To explore whether the combination of white matter hyperintensities (WMHs) and amyloid-beta (Aβ) deposition is associated with worse cognitive performance on cognitive composites (CCs) domain scores in individuals with subjective cognitive decline (SCD). Methods Two hundred participants from the FACEHBI cohort underwent structural magne...
Article
Full-text available
Background: We require high-quality information on the current burden, the types of therapy and resources available, methods of delivery, care pathways and long-term outcomes for people with aphasia. Aim: To document and inform international delivery of post-stroke aphasia treatment, to optimise recovery and reintegration of people with aphasia. Me...
Article
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To determine whether lower performance on executive function tests in subjective cognitive decline (SCD) individuals are associated with higher levels of brain amyloid beta (Aβ) deposition and regional volumetric reduction in areas of interest for Alzheimer’s disease (AD). 195 individuals with SCD from the FACEHBI study were assessed with a neurops...
Article
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Emotive speech is a non-invasive and cost-effective biomarker in a wide spectrum of neurological disorders with computational systems built to automate the diagnosis. In order to explore the possibilities for the automation of a routine speech analysis in the presence of hard to learn pathology patterns, we propose a framework to assess the level o...
Article
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Background: Verb fluency (VF) is the less commonly used fluency test, despite several studies suggesting its potential as a neuropsychological assessment tool. Objective: To investigate the presence of VF deficits in mild cognitive impairment (MCI) and mild Alzheimer's disease (AD) dementia; to assess the usefulness of VF in the detection of cog...
Article
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Background: Patients with brain lesions and resultant chronic aphasia frequently suffer from depression. However, no effective interventions are available to target neuropsychiatric symptoms in patients with aphasia who have severe language and communication deficits. Objective: The present study aimed to investigate the efficacy of 2 different...
Article
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Background: Mitigated echolalia (ME) is a symptom of aphasia which refers to a seemingly deliberate repetition of just-heard words and phrase fragments. ME has historically been viewed as a compensatory strategy aimed to strengthen auditory comprehension. Nevertheless, this hypothesis and other possible functional deficits underlying ME have not be...
Article
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Foreign accent syndrome (FAS) is a speech disorder that is defined by the emergence of a peculiar manner of articulation and intonation which is perceived as foreign. In most cases of acquired FAS (AFAS) the new accent is secondary to small focal lesions involving components of the bilaterally distributed neural network for speech production. In th...
Chapter
Background: Bromocriptine has been used in previous studies to treat people with non-fluent aphasia with varying levels of success. Aims: This single case study set out to describe the effect of a 30 mgdose of bromocriptine on the behaviour, cognition and linguistic skills of a person with aphasia post-cerebrovas- cular accident. Methods and Proced...
Chapter
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Background: In the past two decades, single-case studies evaluated the effect of massed repetition training to improve speech production and short-term memory deficits in conduction aphasia (CA). Improvements were reported in treated language and memory domains with modest generalisation of gains to spontaneous speech or auditory com- prehension. A...
Book
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This book provides clinicians and researchers with the current state-of-the-art on the pharmacological treatment of aphasia. The focus is on the role of different pharmacological agents to improve aphasia associated with stroke and to attenuate language dissolution in degenerative conditions like Alzheimer's disease and primary progressive aphasia....
Article
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Changes in ERP (P100 and N400) and root mean square (RMS) were obtained during a silent reading task in 28 patients with chronic post-stroke aphasia in a randomized, double-blind, placebo-controlled trial of both memantine and constraint-induced aphasia therapy (CIAT). Participants received memantine/placebo alone (weeks 0-16), followed by drug tre...
Article
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Background/objective: The aim was to assess the neuropsychological performance of a group of middle-aged patients with well-controlled type 2 diabetes mellitus (T2DM) and to examine whether the neuropsychological deficits correlate with structural and functional brain alterations. Methods: We compared 25 subjects with T2DM aged 45-65 years with...
Article
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Patients with semantic dementia (SD) may undergo successful relearning of object names, but these gains are usually restricted to the trained exemplars, demonstrating poor generalization. We hypothesized that generalization could be improved by restoring an item's semantic network through specific strategies that recruit the remaining personal sema...
Article
Full-text available
Type 2 diabetes mellitus (T2DM) is an emerging risk factor for cognitive impairment. Whether this impairment is a direct effect of this metabolic disorder on brain function, a consequence of vascular disease, or both, remains unknown. Structural and functional neuroimaging studies in patients with T2DM could help to elucidate this question. We desi...
Chapter
Aphasia is a generic term used to describe a range of impairments in language function following acquired brain damage typically involving the left hemisphere [1–3]. Aphasia may affect all modes of expressive and receptive communication including speaking, understanding, writing, reading, and gesturing [1–3]. This definition seems superficial becau...
Article
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Assessment of brain-damaged subjects presenting with dissociated repetition deficits after selective injury to either the left dorsal or ventral auditory pathways can provide further insight on their respective roles in verbal repetition. We evaluated repetition performance and its neural correlates using multimodal imaging (anatomical MRI, DTI, fM...
Article
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Knowledge on the patterns of repetition amongst individuals who develop language deficits in association with right hemisphere lesions (crossed aphasia) is very limited. Available data indicate that repetition in some crossed aphasics experiencing phonological processing deficits is not heavily influenced by lexical-semantic variables (lexicality,...
Article
Full-text available
Background: Bromocriptine has been used in previous studies to treat people with non-fluent aphasia with varying levels of success.Aims: This single case study set out to describe the effect of a 30mg dose of bromocriptine on the behaviour, cognition and linguistic skills of a person with aphasia post-cerebrovascular accident.Methods & Procedures:...
Article
Full-text available
Background: In the past two decades, single-case studies evaluated the effect of massed repetition training to improve speech production and short-term memory deficits in conduction aphasia (CA). Improvements were reported in treated language and memory domains with modest generalisation of gains to spontaneous speech or auditory comprehension. Alt...
Article
Full-text available
a b s t r a c t Foreign accent syndrome (FAS) is a rare condition which is placed in the mildest end of the spectrum of speech disorders. The impairment, not severe enough to elicit phonological errors, is associated with various alterations in the fine execution of speech sounds which cause the impression of foreignness. There is a growing interes...
Article
Full-text available
Aphasia, a condition defined as the partial or complete loss of language function after brain damage, is one of the most devastating cognitive deficits produced by stroke lesions. Over the past decades, there have been great advances in the diagnosis and treatment of post-stroke language and communication deficits. In particular, the advent of func...
Article
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This review considers the role of drug therapy in the treatment of post-stroke aphasia, the evidence for efficacy of different agents, and the theory-based explanations of drug-related benefits for aphasia rehabilitation. Pharmacological interventions modulating stroke-induced disruption of diverse neurotransmitters may improve language and communi...
Article
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Previous research on semantic dementia (SD) has demonstrated a link between conceptual representations and ability on a range of ‘non-semantic’ tasks, both verbal and nonverbal. In all cases, SD patients perform well on items that conform to the underlying statistical ‘surface’ structure of the domain in question but poor performance on items that...
Article
Repetition ability is a major criterion for classifying aphasic syndromes and its status is helpful in the determination of the involved neural structures. It is widely assumed that repetition deficits correlate with injury to the left perisylvian core including the arcuate fasciculus (AF). However, descriptions of normal repetition despite damage...
Article
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Introduction The study of the neural networks involved in music processing has received less attention than work researching the brain's language networks. For the last two decades there has been a growing interest in discovering the functional mechanisms of the musical brain and understanding those disorders in which brain regions linked with perc...
Article
The authors performed a cross-sectional study to examine the relationship between specific cognitive domains and behavioral and psychological symptoms in dementia (BPSD) in 125 patients with probable AD. Cognitive deficits were evaluated with the mini mental state examination (MMSE), trail-making test (TMT), Rey auditory verbal learning test (RAVLT...
Article
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We report the rare case of a patient, JNR, with history of mixed handedness, developmental dyslexia, dysgraphia, and attentional deficits associated with a Klippel-Trenaunay syndrome and a small subcortical frontal lesion involving the left arcuate fasciculus. In adulthood, he suffered a large right perisylvian stroke and developed atypical conduct...
Article
The treatment of aphasias-acquired language disorders-caused by stroke and other neurological conditions has benefitted from insights from neuroscience and neuropsychology. Hebbian mechanisms suggest that massed practice and exploitation of residual neurological capacities can aid neurorehabilitation of patients with poststroke aphasia, and progres...
Article
Single photon emission computerized tomography (SPECT) with 99mTc-HMPAO was used to examine the functional status of the left perisylvian language cortex (PLC) in eight patients with transcortical aphasias (TAs) due to cerebrovascular accidents. According to the lesion location within the left hemisphere, the aphasic patients were divided into two...
Article
The aim of this study is to know the prevalence of anxiety and depression in caregivers of patients with Alzheimer's disease (AD) and assess the association of caregiver burden (CB) with characteristics of both patients and caregivers. Sociodemographic and clinical variables have been obtained (patients: age, gender, marital status, years of educat...
Article
Patients with Alzheimer's disease (AD) show high incidence of behavioral and psychological symptoms (BPS).The occurrence of BPS has a great impact on the patients and caregiver's quality of life, increases caregiver's burden, and in many cases precipitates admission of the patients to a geriatric center. On the other hand, the importance of the BPS...
Article
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Although midbrain nuclei (substantia nigra, ventral tegmental area, and periaqueductal grey) are considered candidate loci of pathology in Tourette's syndrome (TS), few imaging studies have examined midbrain structure. The objective of this study was to evaluate the presence of subtle structural abnormalities in the midbrain of patients with TS. Hi...
Article
We assessed the cognitive and functional outcomes of donepezil treatment in mild versus moderate Alzheimer's disease (AD) patients. We performed a 6-month prospective, observational, multicenter study of the progression of cognitive and functionality abilities in a large sample patients with AD who initiated treatment with donepezil in monotherapy....
Article
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The authors describe the reactivation of obsessive-compulsive disorder (OCD) in three patients with lesions in the prefronto-subcortical circuits after decades of being asymptomatic. The patients also reported the emergence of new OCD symptoms and motor/phonic tics as well as mental rituals thematically related to the negative experience of sufferi...
Article
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We conducted a randomized, double-blind, placebo-controlled, parallel-group study of both memantine and constraint-induced aphasia therapy (CIAT) on chronic poststroke aphasia followed by an open-label extension phase. Patients were randomized to memantine (20 mg/day) or placebo alone during 16 weeks, followed by combined drug treatment with CIAT (...
Article
Background: Previous studies looking at relearning and retention of word labels in people with semantic dementia have shown some improvement in naming immediately after the period of learning but this has not usually been maintained. Studies have also shown rigid learning of names, in the order of presentation and to the picture exemplars only, wit...
Article
The objective of this study is to describe the frequency and severity of behavioral and psychological symptoms (BPS) in a group of 125 patients diagnosed of Alzheimer's disease (AD) (DSM-IV-TR and NINCDSADRDA criteria). The evaluation of the BPS was carried out using the Neuropsychiatric Inventory (NPI; Cummings et al., 1994). The sociodemographic...
Article
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Background Brain research has documented that the cortical mechanisms for language and action are tightly interwoven and, concurrently, new approaches to language therapy in neurological patients are being developed that implement language training in the context of relevant linguistic and non-linguistic actions, therefore taking advantage of the m...
Article
Objective: The objective of this study is to describe the socio-demographic data, cognitive profile, functional status and behavioral and psychological symptoms (BPS) in a group of 125 patients diagnosed with Alzheimer's disease (AD), as also the burden and distress of their caregivers. Material and methods: We collected socio-demographic and clini...
Article
Full-text available
Electrophysiological and neuroimaging studies suggest that regular and irregular verbs are differently represented in the brain. Findings from studies of patients seem to agree with this view, but there are discordant data. To test if there is a dissociation in regular and irregular verb processing between patients with anterior lesions, characteri...
Article
We studied 26 patients in a randomized, placebo-controlled, double-blind parallel trial to evaluate the efficacy and safety of donepezil in chronic poststroke aphasia. Donepezil (10 mg/day) improved aphasia severity at endpoint (week 16) relative to placebo (p = 0.037).
Article
Background: Echographia, an extremely rare syndrome first described by Pick (1900, 1924), is characterised by automatic translation of visual and sometimes also auditory stimuli into writing. Little information is available about surface symptoms, pathological correlates, and functional mechanisms of this syndrome. Aims: We here review Pick's origi...
Article
Full-text available
Aphasia, the loss or impairment of language caused by brain damage, is one of the most devastating cognitive impairments of stroke. Aphasia is present in 21-38% of acute stroke patients and is associated with high short- and long-term morbidity, mortality and expenditure. Recovery from aphasia is possible even in severe cases. While speech-language...
Article
The loss of neurotransmitters coupled with the degeneration of cortico-subcortical neural networks may underlie the full array of cognitive, behavioural, and functional deficits in dementia. Recent advances in the neurochemical and functional neuroimaging correlates of cognition and behavioural and psychological signs and symptoms of dementia have...
Article
Pharmacotherapy of poststroke sensorimotor deficits is currently used alone or combined with physiotherapy to promote recovery of mobility problems. This case study examined the effectiveness of donepezil hydrochloride (HCl) administered to a stroke patient with chronic, dense, left sensorimotor deficit. The patient received donepezil HCl (5 mg dai...
Article
3,4 We studied donepezil HCl in chronic poststroke aphasia. Methods. Subjects and study design. This was a 20-week open-label pilot study evaluating the effects of donepezil HCl in chronic poststroke aphasia. The patients were recruited from a language therapy center, where they received two weekly sessions of conventional speech–language therapy....
Article
We describe the coexistence of Asperger and Tourette syndromes (AS and TS) caused by discrete hypoxic-ischaemic necrosis of the midbrain, infrathalamic and thalamic nuclei, and striatum in an adolescent male with positive family history for tics and obsessive-compulsive disorder. Behavioural ratings, cognitive tests, and volumetric measurements of...
Article
We describe the coexistence of Asperger and Tourette syndromes (AS and TS) caused by discrete hypoxic–ischaemic necrosis of the midbrain, infrathalamic and thalamic nuclei, and striatum in an adolescent male with positive family history for tics and obsessive–compulsive disorder. Behavioural ratings, cognitive tests, and volumetric measurements of...
Article
Repetitive transcranial magnetic stimulation (rTMS) of human cortex may disrupt or facilitate cortical activity. The aim of the present study was to investigate the consequences of rTMS applied over different cortical areas during various memory tasks, measuring immediate, working and episodic verbal memory. The study was performed in 16 right-hand...
Article
Three patients with PD developed manic behavior after bilateral implantation of electrodes for deep-brain stimulation (DBS). Common to all three patients were manic symptoms unremitting after levodopa reduction or stimulation "off," lower electrodes positioning caudal to the subthalamic nucleus area, postoperative DBS with the lower contacts (0) of...
Article
The role of the basal ganglia in conditions with co-occurring movement disorders and neuropsychiatric symptoms is not well known. It has been hypothesized that hyperkinesia -disinhibited behaviors and hypokinesia-inhibited behaviors result from an imbalance between the direct and indirect striatal output pathways, and that differential involvement...
Article
Full-text available
The goal of this study was to evaluate behavior and cognition in a consecutive series of patients who developed obsessive-compulsive disorder (OCD) after suffering a traumatic brain injury (TBI). Because OCD is a rare sequelae of TBI, the phenomenology of obsessions and compulsions, the comorbid psychiatric disorders, the performance on cognitive t...
Article
A Vietnam veteran with a combat-related posttraumatic stress disorder developed recurrent dissociative flashbacks (related to the atrocities of a specific war incident) several months after suffering a traumatic brain injury. CT disclosed a small lesion in the right dorsolateral prefrontal cortex. SPECT demonstrated more extensive functional change...
Article
The syndrome of transcortical sensory aphasia (TCSA) is usually associated with extraperisylvian lesions of the left hemisphere that involve either posterior cortical regions (temporal-occipital cortex and inferior parietal cortex) or subcortical structures (thalamus). In exceptional cases, TCSA occurs in association with anterior perisylvian lesio...
Article
Full-text available
Objective: The goal of this study was to evaluate behavior and cognition in a consecutive series of patients who developed obsessive-compulsive disorder (OCD) after suffering a traumatic brain injury (TBI). Background: Because OCD is a rare sequelae of TBI, the phenomenology of obsessions and compulsions, the comorbid psychiatric disorders, the per...
Article
To study the startle reflex and the effect of the startle reflex stimulus over reaction time (start-react effect) in Gilles de la Tourette syndrome (GTS). Ten GTS patients and ten matched healthy volunteers underwent a simple RT paradigm (4 blocks of 50 trials). Forty acoustic startle reflex stimuli (110 dB) were randomly delivered with a 20% occur...
Article
The cognitive effects of dopaminergic treatment in Parkinson's disease (PD) are still controversial. To evaluate, in previously untreated patients with PD, whether chronic dopaminergic stimulation produces significant cognitive changes; whether they are sustained beyond the period of a few months; and whether the cognitive status of two motor-compa...
Article
BACKGROUND: The cognitive effects of dopaminergic treatment in Parkinson's disease (PD) are still controversial. OBJECTIVE: To evaluate, in previously untreated patients with PD, whether chronic dopaminergic stimulation produces significant cognitive changes; whether they are sustained beyond the period of a few months; and whether the cognitive st...
Article
Although obsessive-compulsive symptoms are uncommon among patients with neurological diseases, structural neuroimaging (CAT or MRI) disclose focal brain lesions in some patients. However, little is know about the clinical phenomenology of obsessive-compulsive symptoms and the cognitive deficits that occur in neurological conditions. To review the c...