Marcello Guarino

Private laboratory · Pathology

An interesting mortuary practice widespread in Naples until the second half of the nineteenth century was the one housed in the hypogea located under the floor of churches and convents. These funerary crypts were structured according to two organizational models based on the double burial system: the terresante and the scolatoi, both of which aimed...

Background A mortuary practice of great interest based on secondary burial and widespread in Naples until the nineteenth century was the one hosted in the Terresante, the graves of the lay brotherhoods located within ecclesiastical hypogea. Methodology The article is based on a review of published papers and books dealing with secondary burial in...

Src is a non-receptor cytoplasmic tyrosine kinase which becomes activated following the stimulation of plasma membrane receptors including receptor tyrosine kinases and integrins, and is an indispensable player of multiple physiological homeostatic pathways. Once activated, Src is the starting point for several biochemical cascades that thereby pro...

Fibrosis of epithelial parenchymal organs and end-stage organ failure represent the final common pathway of many chronic diseases and are a major determinant of morbidity and mortality worldwide. Fibrosis is a complex response initiated to protect the host from an injurious event; nevertheless, it leads to serious organ damage when it becomes indep...

Invasion, the hallmark of malignancy, consists in the translocation of tumour cells from the initial neoplastic focus into neighbouring host tissues, and also allows tumour cells to penetrate vessel endothelium and enter the circulation to form distant metastasis. A histological pattern found at the periphery of carcinomas is the presence of indivi...

Carcinoma invasion implies potentiality to metastasize distantly but, despite its clinical importance, it is still a poorly understood process. There is increasing evidence pointing to a role of epithelial-mesenchymal transition by which tumour cells would weaken E-cadherin-dependent intercellular adhesion and enhance motility, thus becoming able t...

Extraskeletal chordoma arising within soft tissue is a rare occurrence. We report a case of chordoma that is unusual both for its location within the subcutaneous soft tissue of the sacrococcygeal region without involvement of adjacent bones and for the presence of eosinophilic roundish inclusion bodies within the cytoplasm of tumor cells. These bo...

In embryonic morphogenesis, dramatic changes from one state of differentiation to another take place, and some epithelia transform into mesenchymal cells endowed with the ability to migrate and to form connective tissue. In vitro model systems have been developed which have provided new insights into crucial aspects of this differentiation change....

ln embryonic morphogenesis, dramatic changes from one state of differentiation to another take place, and some epithelia transform into mesenchymal cells endowed with the ability to migrate and to form connective tissue. In vitro model systems have been developed which have provided new insights into crucial aspects of this differentiation change....

To investigate the distribution of basement membrane components type IV collagen and laminin in synovial sarcomas. Paraffin sections from synovial sarcomas were studied by the peroxidase-antiperoxidase procedure using specific antibodies to type IV collagen and laminin. Type IV collagen and laminin immunoreactivity was confined around epithelial ar...

Liposarcoma is a soft tissue tumor usually observed in adults. Although occasional cases have been reported in childhood, it is virtually unknown in infants and small children. Our experience documents a case of liposarcoma in a 6-year-old girl, an extremely rare occurrence in this age-group. The patient underwent wide local excision followed by ch...

Three cases of infiltrating congenital lipomatosis of the face are presented. These lesions shared the following morphologic criteria: 1) nonencapsulated congenital fatty tumor; 2) infiltration of adjacent muscle and soft tissue; 3) absence of lipoblast and malignant characteristics; 4) presence of fibrous elements with numerous nerve bundles and v...

A case of benign lymphoepithelial cyst of parotid gland is described. In this report the lesion was associated to undifferentiated carcinoma of parotid gland. Histogenesis, biological significance and differential diagnosis of lymphoepithelial lesions of salivary gland are discussed.