Marcello Cherchi

Marcello Cherchi
Northwestern University | NU · The Ken and Ruth Davee Department of Neurology

MD, PhD, FAAN, FANA, FEAN

About

42
Publications
8,857
Reads
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271
Citations
Introduction
I am a board certified practicing neurologist specializing in otoneurology - the diagnosis and management of disorders of balance and hearing arising from diseases of the nervous system and ear. My research aims to bring those insights gleaned from a deepened understanding of vestibular and auditory neurophysiology to bear on practical implementation of new techniques and technology in this field. I am interested in software and hardware aspects of technology as they apply to diagnosis, particularly in the areas of biological signal processing.
Additional affiliations
May 2017 - present
Northwestern University
Position
  • Professor (Associate)
July 2009 - May 2017
Northwestern University
Position
  • Professor (Assistant)
Education
July 2007 - May 2009
Northwestern University
Field of study
  • Otoneurology
July 2004 - May 2007
Northwestern University
Field of study
  • Neurology
May 2003 - June 2004
Northwestern University
Field of study
  • Internal Medicine

Publications

Publications (42)
Article
Full-text available
The rapidly developing literature regarding COVID-19 and its treatments has documented an impressive breadth of pathology across multiple organ systems. In this entry, researchers highlight the audiologic and vestibular manifestations that have been reported in association with COVID-19, its vaccines, and some of its treatments.
Article
Full-text available
Introduction Vestibular disorders (VDs) are highly prevalent in primary care. Although in general they comprise conditions that are not life-threatening, they are associated with significant functional and physical disability. However, the current coronavirus disease 2019 (COVID-19) pandemic has imposed limitations on the standard treatment of beni...
Article
Full-text available
The idea of cervicogenic vertigo (CV) was proposed nearly a century ago, yet despite considerable scrutiny and research, little progress has been made in clarifying the underlying mechanism of the disease, developing a confirmatory diagnostic test, or devising an appropriately targeted treatment. Given the history of this idea, we offer a review ge...
Article
Objective: Explore how the terminology of some vestibulocochlear diseases leads to a misleading nosology that probably misrepresents the underlying neuroanatomy and pathology. Methods: Review what is known and unknown about neuroanatomical localization of some common vestibulocochlear diseases. Results: Literature on this topic often conveys, or st...
Article
Full-text available
Caloric testing during the COVID 19 pandemic: Is irrigation playing with fire? Studies suggest that SARSCoV2 can be present in secretions in the external auditory canal. These secretions can be aerosolized by various otologic procedures. Extra caution practiced in such circumstances should extend vestibular evaluations, particular when caloric test...
Article
Full-text available
Introduction: Posterior canal benign paroxysmal positional vertigo (PC-BPPV) is considered the most common cause of peripheral vertigo in the emergency department (ED). Although the canalith repositioning maneuver (CRM) is the standard of care, the most effective method to deliver it in the ED has been poorly studied. Objective: To compare two pr...
Article
Full-text available
Human temporal bone studies have described the distribution of afferent fibers from each of the five organelles in the labyrinth. Data from vestibular tests in patients with vestibular neuritis can be abnormal in almost any pattern. We propose a unified explanation for these patterns, based on histological and neuroanatomical factors.
Article
Full-text available
Acute vestibular neuropathy (AVN), often referred to as vestibular neuritis, is a cranial neuropathy responsible for a significant proportion of cases of acute vertigo. This study describes the spectrum of lesion patterns in AVN as identified by video head impulse testing (vHIT) which assesses the high frequency vestibulo-ocular reflex function of...
Article
PURPOSE OF REVIEW Vestibular testing, both at the bedside and in the laboratory, is often critical in diagnosing patients with symptoms of vertigo, dizziness, unsteadiness, and oscillopsia. This article introduces readers to core concepts, as well as recent advances, in bedside and instrumented vestibular assessments. RECENT FINDINGS Vestibular...
Article
Full-text available
Vestibular neuritis (VN) can affect utricular afferents. Utricular function can be assessed by ocular vestibular evoked myogenic potentials (oVEMPs) whose abnormalities include weak or absent responses, and ocular cycloposition whose abnormalities include ocular torsion (OT). When studied independently in vestibular neuritis, oVEMPs are abnormal in...
Chapter
This chapter is a brief overview of migraine associated vertigo (MAV), focusing on the points most relevant to the practicing clinician. We review the definition of MAV, theories regarding its underlying pathophysiology, clinical presentation, epidemiology, findings on physical examination and oto vestibular testing, differential diagnosis, managem...
Article
Full-text available
Patients with inner ear damage associated with bilateral vestibular impairment often ask “how much damage do I have.” Although there are presently three clinical methods of measuring semicircular canal vestibular function; electronystagmography (ENG or VENG), rotatory chair and video head-impulse (VHIT) testing; none of these methods provides a met...
Article
Full-text available
Bilateral vestibular weakness (BVW) is a rare cause of imbalance. Patients with BVW complain of oscillopsia. In approximately half of the patients with BVW the cause remains undetermined; in the remainder, the most common etiology by far is gentamicin ototoxicity, followed by much rarer entities such as autoimmune inner ear disease, meningitis, bil...
Chapter
This chapter focuses on several uncommon causes of disequilibrium in the adult. The diseases have been divided into the two broad categories of those causing chronic symptoms, and those causing episodic symptoms. The unusual causes of chronic disequilibrium in the adult include bilateral vestibular loss, progressive supranuclear palsy, spinocerebel...
Chapter
This chapter is a brief overview of migraine associated vertigo (MAV), focusing on the points most relevant to the practicing clinician. We review the definition of MAV, theories regarding its underlying pathophysiology, clinical presentation, epidemiology, findings on physical examination and otovestibular testing, differential diagnosis, manageme...
Chapter
Dizziness and vertigo are common symptoms. About 2.5% of all primary care visits are for dizziness and about 1% are for vertigo. Dizziness and vertigo have diverse etiologies, spanning multiple organ systems. Thus, a broadly based approach to the dizzy patient is necessary, at times requiring serious and life-threatening medical problems such as ca...
Chapter
Mal de débarquement syndrome (MdDS) is typified by a prolonged rocking sensation – for a month or longer – that begins immediately following a lengthy exposure to motion. The provoking motion is usually a sea voyage. About 80% of MdDS sufferers are women, and most of them are middle-aged. MdDS patients are troubled by more migraine headaches than c...
Chapter
This book chapter briefly reviews neurologic causes of dizziness for the practicing otolaryngologist.
Article
Full-text available
Objective (Background): Vestibular evoked myogenic potentials (VEMPs) are used to evaluate function of the vestibular system. Sound evoked triceps myogenic potentials (SETMPs) have not been studied extensively and differ anatomically from sternocleidomastoid (SCM) VEMPs because the efferent pathway for SETMPs traverses the spinal cord. The aim of t...
Article
Full-text available
We report a case of renal cell carcinoma manifesting with ataxia and up beat nystagmus.
Article
Full-text available
Objective: To determine whether the amplitude of the sound evoked triceps myogenic potential (SETMP) scales with the tonic force exerted by the muscle. Study design: A prospective study of myogenic potentials was conducted in 16 normal subjects. A monaural acoustic stimulus was presented to subjects while they while they exerted varying degrees of...
Article
Full-text available
We present a case of torsional saccadic oscillations and discuss the possible underlying neuroanatomical substrate.
Chapter
The basic anatomy and physiology of the vestibular peripheral end organ, the central processing of the vestibular system (including sensory integration), and its motor output are reviewed in this article.
Chapter
We review the clinical presentations of migraine associated vertigo, its diagnostic criteria, how it fits into the broader classification of migraine, relevant diagnostic testing, and management strategies.
Article
Full-text available
Bilateral vestibular loss is a rare cause of visual disturbance (oscillopsia) and imbalance. When severe, the most common cause is iatrogenic-gentamicin ototoxicity. Bilateral loss is easily diagnosed at the bedside with the dynamic illegible E test. If this test is omitted, it can easily be misdiagnosed as a cerebellar syndrome. Treatment is large...
Article
Full-text available
The epidemiology of dizziness is challenging due to the variety of descriptors, the variability of clinical presentation, differences in the setting of the clinical evaluation and diagnostic techniques, methods of reporting, and various biases in sampling and referral. We briefly review these challenges and then present an overview of the frequency...
Chapter
This neurology board review book chapter provides an overview of vestibular and auditory neuroanatomy and neurophysiology, pathologies illustrating representative disease states, and relevant audiovestibular testing.
Article
Full-text available
This article presents a brief overview of migraine-associated vertigo for the practicing otolaryngologist. Discussion includes the definition of migraine-associated vertigo and its pathophysiology, clinical features, demographics, findings on physical examination, use of otologic and vestibular testing, differential diagnosis, treatment, and progno...
Article
This content focuses on some of the less common causes of dizziness in the adult. The diseases have been divided into the 2 broad categories of those causing chronic symptoms and those causing episodic symptoms. Presented here are the unusual causes of chronic disequilibrium in the adult, including bilateral vestibular loss, progressive supranuclea...
Chapter
This chapter discussses maneuvers that are employed during physical examination to provoke nystagmus and, thereby diagnose compensated or episodic vestibular disorders. Maneuvers are divided into four broad categories: (1) those used primarily in diagnosing unilateral vestibular loss; (2) those used in diagnosing pressure sensitivity; (3) those use...
Article
To determine if a sound evoked myogenic potential could be obtained from the triceps with the recording and stimulus parameters routinely used to obtain a vestibular evoked myogenic potential (VEMP) from the sternocleidomastoid. Prospective study of myogenic potentials recorded from the triceps in healthy subjects. We used a monaural acoustic stimu...
Article
Torsional pendular nystagmus is most commonly reported to be caused by brainstem lesions resulting in dysfunction of central oscillators that produce eye movement without an external trigger. In contrast, our case demonstrates that superior semicircular canal dehiscence (SCD) is a mechanical, peripheral vestibular etiology that should be considered...
Article
Abrupt onset of hearing loss in chronic myelogenous leukemia has been reported. We report a patient in whom hearing loss and dizziness developed sub-acutely, and MRI revealed bilateral labyrinthine hemorrhage.
Article
Full-text available
It is arguable that no figure in Soviet lingui stics has had more influence on that and related disciplines than the Georgian linguist Nikolaj Jakovlevich Marr (in Georgian, Niko Iakobisdze Mari) ( 1864- 1934). This influence was so powerful and pervasive that its end was stipulated by no less a figure than Joseph Stalin, in no less a venue than a...
Book
This is a brief grammar of Modern Georgian
Book
Full-text available
This structuralist study begins by identifying criteria that delimit a specific class of verbs in modern Georgian based on morphological properties of the verbs themselves and the associated nouns they syntactically govern. I place this class in the context of other traditionally identified verb classes in the language exhibiting mixed nominative/e...
Chapter
Full-text available
This is a brief ethnographic review of the history, cultural relations, settlements, economy, kinship, family structure, sociopolitical organization and religion of the Yezidi people.

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Projects

Projects (7)
Project
To characterize the clinical presentation, diagnostic approaches, etiologies and treatments of bilateral vestibular weakness.
Project
Characterize specific otoneurological disease states, their pathophysiology, diagnosis and management