Marcelino T Suzuki

Marcelino T Suzuki
Sorbonne Université | UPMC · Biodiversité et Biotechnologies Microbiennes (LBBM)

Prof Dr

About

98
Publications
15,243
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Introduction
At the Observatoire Océanologique de Banyuls since May 2009, Dr Suzuki is Professor of Sorbonne Université and the director of the Microbial Biodiversity and Laboratory (LBBM), and Scientific Advisor for the Marine Biodiversity and Biotechnology (bio2mar) platform of the OOB. He has le research on the biology of photoheterotrophs in the Ocean though the project ANR-RHOMEO, and the quest for new anticancer molecules from bacteria associated with marine lichens in the project ANR-MALICA .
Additional affiliations
January 2014 - December 2018
Sorbonne Université
Position
  • Unit Director
May 2009 - present
Sorbonne Université
Position
  • Université Pierre et Marie Curie
Description
  • Microbial Biodiversity and Biotechnology
September 2002 - March 2009
University of Maryland Center for Environmental Science
Description
  • Assistant Professorship

Publications

Publications (98)
Article
Full-text available
Multi-omic approaches have recently made big strides toward the effective exploration of microorganisms, accelerating the discovery of new bioactive compounds. We combined metabolomic, molecular networking, and genomic-based approaches to investigate the metabolic potential of the Streptomyces sp. RO-S4 strain isolated from the polluted waters of B...
Article
Aims The current study aimed to evaluate the occurrence of actinomycetes in the Coast of Bejaia City using selective isolation, as well as their bioactivity and phylogenitic diversity. Methods and Results Different selective media and methods were used, leading to the isolation of 103 actinomycete strains. The number of strains was influenced by i...
Preprint
Full-text available
Multi-omic approaches have recently made big strides towards the effective exploration of microorganisms and accelerating the discovery of new bioactive compounds. We combined metabolomic, molecular networking, and genomic-based approaches to investigate the metabolic potential of the Streptomyces sp. RO-S4 strain isolated from the polluted waters...
Article
All types of building materials are rapidly colonized by microorganisms, initially through an invisible and then later a visible biofilm that leads to their biodeterioration. Over centuries, this natural phenomenon has been managed using mechanical procedures, oils, or even wax. In modern history, many treatments such as high-pressure cleaners, bio...
Article
Full-text available
Objectives To analyse the diagnostic performance of eosinopenia, alone or combined with polymorphonuclear neutrophils (PMN) and/or lymphocytes, as a marker of active COVID-19 in patients hospitalized for suspicion of SARS-CoV-2 infection. Methods A prospective observational study including patients hospitalized for suspicion of COVID-19 in a COVID...
Article
Full-text available
Background: Avène Thermal Spring Water (TSW) exhibits therapeutic properties in the treatment of skin pathologies. Arising from a dolomitic aquifer system, its physico-chemical properties are well-established and its bacteriological quality regularly monitored. The microbiota of this aquifer have been characterized. Objectives: We aimed to descr...
Article
Full-text available
Microorganisms are an important component in shaping the evolution of hosts and as such, the study of bacterial communities with molecular techniques is shedding light on the complexity of symbioses between bacteria and vertebrates. Teleost fish are a heterogeneous group that live in a wide variety of habitats, and thus a good model group to invest...
Article
Full-text available
Metabolomic profiling of the hexacoral Pocillopora damicornis exposed to solar filters revealed a metabolomic signature of stress in this coral. It was demonstrated that the concentration of the known steroid (3β, 5α, 8α) -5, 8-epidioxy- ergosta- 6, 24(28) - dien- 3- ol (14) increased in response to octocrylene (OC) and ethylhexyl salicylate (ES) a...
Article
Full-text available
Understanding natural defense mechanisms against parasites can be a valuable tool for the development of innovative therapies. We have previously identified a butterflyfish species (Chaetodon lunulatus) that avoids gill monogenean parasites while living amongst closely related parasitized species. The metabolome and microbiome of several sympatric...
Article
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Myctophids are among the most abundant mesopelagic teleost fishes worldwide. They are dominant in the Southern Ocean, an extreme environment where they are important both as consumers of zooplankton as well as food items for larger predators. Various studies have investigated myctophids diet, but no data is yet available regarding their associated...
Article
Full-text available
Next-generation sequencing methods are increasingly used to identify eukaryotic, unicellular and multicellular symbiont communities within hosts. In this study, we analyzed the non-specific reads obtained during a metabarcoding survey of the bacterial communities associated to three different tissues collected from 13 wild Mediterranean teleost fis...
Article
Full-text available
Vibrio fischeri possesses a complex AHL-mediated Quorum-sensing (QS) system including two pathways, LuxI/R (3-oxo-C6-HSL and C6-HSL) and AinS/R (C8-HSL), which are important for the regulation of physiological traits. Diverse QS-dependent functional phenotypes have been described in V. fischeri; however, AHL diversity is still underestimated. In th...
Article
N-Acyl homoserine lactone (AHL)-mediated Quorum sensing (QS) is one of the most studied social behavior among Proteobacteria. However, despite the current knowledge on QS-associated phenotypes such as bioluminescence, biofilm formation, or pathogenesis, the characterization of environmental factors driving QS in realistic ecological settings remain...
Article
Full-text available
The microbial diversity and function of terrestrial lichens have been well studied, but knowledge about the non-photosynthetic bacteria associated with marine lichens is still scarce. 16S rRNA gene Illumina sequencing was used to assess the culture-independent bacterial diversity in the strictly marine cyanolichen species Lichina pygmaea and Lichin...
Data
Sample location and environmental conditions List of lichens sampled with details of the different clusters, their geographical location and the temperature at the time of sampling.
Data
Closest relatives of lichen marker gene sequences as assessed by blastn Results of the blastn analyses of the sequenced marker genes used to check the morphological lichen identifications.
Data
Closest relatives assessed by blastn of the top marine and terrestrial OTUs associated with the lichen species List of the 30 most abundant OTUs for either the marine lichens or the maritime-inland terrestrial lichen group, presented together with their GreenGenes taxonomic identity and the closest relative obtained by blastn analysis.
Data
Supplementary figures and data analysis pipeline Supplementary information comprising supplementary figures and details of the data analysis pipeline. Figure S1. Relative abundance (%) of bacterial and cyanobacterial sequences recovered from each lichen species. Xanthoria sp. Atl; from Brittany, and Xanthoria sp. Med. from the Mediterranean coast....
Data
Bacterial isolates and lichen bacterial OTUs showing >97% 16S rRNA gene sequence identity List of lichen bacterial 16S rRNA OTUs and their taxonomy that showed >97% 16S rRNA gene sequence identity to bacterial isolates cultured from L. pygmaea, L. confinis and L. auriforme.
Data
Barcodes and primers for each sample List of sample IDs for each lichen sample and their corresponding barcode used to tag the forward primer 341F.
Preprint
Full-text available
The microbial diversity and function of terrestrial lichens has been well studied, but knowledge about the non-photosynthetic bacteria associated with marine lichens is still scarce. 16S rRNA gene Illumina sequencing was used to assess the culture-independent bacterial diversity in the strictly marine cyanolichen species Lichina pygmaea and Lichina...
Article
Full-text available
Microbial diversity studies using small subunit (SSU) rRNA gene sequences continue to advance our understanding of biological and ecological systems. Although a good predictor of overall diversity, use of this gene to infer the presence of a species in a sample is more controversial. Here, we present a detailed polyphasic analysis of 10 bacterial s...
Article
Full-text available
Oceanic ecosystems are dominated by minute microorgan-isms that play a major role in food webs and biogeochemical cycles1. Many microorganisms thrive in the dilute environment due to their capacity to locate, attach to, and use patches of nutrients and organic matter2,3. We propose that some free-living planktonic bacteria have traded their ability...
Article
Full-text available
In the version of this Letter originally published, the authors incorrectly stated that primers 28F-519R were reported in ref. 54 to underestimate the abundance of SAR11 in the ocean. This statement has now been amended in all versions of the Letter.
Article
Alphaproteobacterium strain MOLA1416, related to Mycoplana ramosa DSM 7292 and Chelativorans intermedius CC-MHSW-5 (93.6% 16S rRNA sequence identity) was isolated from the marine lichen, Lichina pygmaea and its chemical composition was characterized by a metabolomic network analysis using LC-MS/MS data. Twenty-five putative different compounds were...
Article
In this study, we investigated a culture supernatant of a Pseudovibrio denitrificans strain isolated from sea water. Five indole alkaloids were isolated from this culture. These include four known compounds, arundine (1), vibrindole A (2), 1,1,1-tris(indol-3-yl)methane (3), 7,7-bis(indol-3-yl)-p-cresol (4) and the new tetra(indol-3-yl)ethanone (5)....
Article
Full-text available
Since the discovery of quorum sensing (QS) in the 1970s, many studies have demonstrated that Vibrio species coordinate activities such as biofilm formation, virulence, pathogenesis, and bioluminescence, through a large group of molecules called N-acyl homoserine lactones (AHLs). However, despite the extensive knowledge on the involved molecules and...
Article
Full-text available
While recent studies have suggested that fish mucus microbiota play an important role in homeostasis and prevention of infections, very few studies have investigated the bacterial communities of gill mucus. We characterised the gill mucus bacterial communities of four butterflyfish species and although the bacterial diversity of gill mucus varied s...
Article
Full-text available
Two new compounds, cyaneodimycin (I) and cyaneomycin bearing a rare methacrylate residue, are isolated from cultures of the title bacterium associated with the marine lichen L.
Article
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Ecological interactions in the marine environment are now recognized to be partly held by chemical cues produced by marine organisms. In particular, sponges are sessile animals thought to rely on the bioactive substances they synthesize to ensure their development and defense. However, the mechanisms leading the sponges to use their specialized met...
Article
Two new compounds, cyaneodimycin (1) and cyaneomycin (2) bearing a rare methacrylate residue, were isolated from cultures of the bacterium Streptomyces cyaneofuscatus associated with the marine lichen Lichina confinis. These astonishing structures may be derived from a pyruvate biosynthetic pathway. Cyaneodimycin (1) exhibited antiproliferative pro...
Article
Full-text available
This review presents the state of knowledge on the medicinal potential of bacteria associated with lichens. In fact, besides the classical symbiotic partners (photobiont and mycobiont) forming the lichen thallus, associated bacteria have been recently described as a third partner. Various studies demonstrated the diversity of these communities with...
Article
Full-text available
The search for microorganisms from novel sources and in particular microbial symbioses represents a promising approach in biotechnology. In this context, lichens have increasingly become a subject of research in microbial biotechnology, particularly after the recognition that a diverse community of bacteria other than cyanobacteria is an additional...
Article
Full-text available
Cultivable Actinobacteria are the largest source of microbially derived bioactive molecules. The high demand for novel antibiotics highlights the need for exploring novel sources of these bacteria. Microbial symbioses with sessile macro-organisms, known to contain bioactive compounds likely of bacterial origin, represent an interesting and underexp...
Article
Full-text available
A type of photoheterotrophic bacteria contain a transmembrane light-driven proton pump called proteorhodopsins (PRs). Due to the prevalence of these organisms in the upper water column of the World’s Ocean, and their potential for light-driven ATP generation, they have been suggested to significantly influence energy and matter flows in the biosphe...
Article
Isolation of minor compounds from natural extracts remains a complicated task and development of new protocols to facilitate the access to new structure is still needed. Application of a highly efficient 2D LC hyphenated to high resolution mass spectroscopy on the crude extract of the Mediterranean marine sponge Crambe crambe led to the identificat...
Article
Full-text available
Ruegeria halocynthiae MOLA R1/13b is an alphaproteobacterium isolated from the Mediterranean sea sponge Crambe crambe. We report here the genome sequence and its annotation, revealing the presence of quorum-sensing genes. This is the first report of the full genome of a Ruegeria halocynthiae strain.
Article
Full-text available
A seven-year oceanographic time series in NW Mediterranean surface waters was combined with pyrosequencing of ribosomal RNA (16S rRNA) and ribosomal RNA gene copies (16S rDNA) to examine the environmental controls on SAR11 ecotype dynamics and potential activity. SAR11 diversity exhibited pronounced seasonal cycles remarkably similar to total bacte...
Article
Full-text available
Strain MOLA455 is a marine gammaproteobacterium isolated from the bay of Banyuls-sur-Mer, France. Here, we present its genome sequence and annotation. Genome analysis revealed the presence of genes associated with a possibly photoheterotrophic lifestyle that uses a proteorhodopsin protein.
Article
Strain MOLA455 is a marine gammaproteobacterium isolated from the bay of Banyuls-sur-Mer, France. Here, we present its genome sequence and annotation. Genome analysis revealed the presence of genes associated with a possibly photoheterotrophic lifestyle that uses a proteorhodopsin protein.
Article
Full-text available
Strain MOLA814 is a marine betaproteobacterium that was isolated from seawater in the Beaufort Sea. Here, we present its genome sequence and annotation. Genome analysis revealed the presence of a proteorhodopsin-encoding sequence together with its retinal-producing pathway, indicating that this strain might generate energy by using light.
Article
Full-text available
Crambe crambe is a marine sponge that produces high concentrations of the pharmacologically significant pentacyclic guanidine alkaloids (PGAs), Crambescines and Crambescidines. Although bio-mimetic chemical synthesis of PGAs suggests involvement of microorganisms in their biosynthesis, there are conflicting reports on whether bacteria are associate...
Article
Full-text available
A Gram-negative, aerobic, cream pigmented, non-motile, non-spore forming straight rod, strain MOLA115T, was isolated from a coastal water sample from the Mediterranean Sea. On the basis of phylogenetic analysis of the 16S rRNA gene sequences, strain MOLA115T was shown to belong to the Gammaproteobacteria, adjacent to members of the genera Marinicel...
Article
The Dead Sea is a unique hypersaline ecosystem with near toxic magnesium levels (∼2 M), dominance of divalent cations and a slightly acidic pH. Previously, we reported a haloarchaeon related to Halobacterium salinarum to dominate in a microbial bloom that developed in 1992 in the upper water layers of the lake following massive freshwater runoff. W...
Article
Determining in situ growth rates for specific bacterioplankton is of critical importance to understanding their contributions to energy and matter flow in the Ocean. Quantifying expression of genes central to cell division is a plausible approach for obtaining these measurements. In order to test this approach's assumptions, a quantitative PCR assa...
Article
Full-text available
Anaerobic anoxygenic phototrophic bacteria can be found in the suboxic waters of shallow stratified coastal systems, and may play important roles in the total primary production of subtropical stratified coastal lagoons. We investigated the spatiotemporal variability of light CO(2) fixation and net oxygen production in the stratified Conceição Lago...
Article
Full-text available
A novel high-light (HL)-adapted Prochlorococcus clade was discovered in high nutrient and low chlorophyll (HNLC) waters in the South Pacific Ocean by phylogenetic analyses of 16S ribosomal RNA (rRNA) and 16S-23S internal transcribed spacer (ITS) sequences. This clade, named HNLC fell within the HL-adapted Prochlorococcus clade with sequences above...
Article
Full-text available
Owing to the extreme salinity ( approximately 10 times saltier than the oceans), near toxic magnesium levels (approximately 2.0 M Mg(2+)), the dominance of divalent cations, acidic pH (6.0) and high-absorbed radiation flux rates, the Dead Sea represents a unique and harsh ecosystem. Measures of microbial presence (microscopy, pigments and lipids) i...
Article
Full-text available
Specific SYBR green-based quantitative-PCR assays targeting conserved regions in the 16S-23S rRNA internal transcribed spacer regions were developed for five subgroups of the environmentally abundant and biogeochemically active Roseobacter clade of marine bacteria. The assays were applied to field samples demonstrating their utility in investigatio...