Marcel T G de Jeu

Marcel T G de Jeu
Erasmus MC | Erasmus MC · Department of Neuroscience

Ph.D.

About

44
Publications
4,549
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2,621
Citations
Citations since 2016
4 Research Items
941 Citations
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2016201720182019202020212022020406080100120140
2016201720182019202020212022020406080100120140
Introduction
Motor function and muscle control are critical for an animal’s ability to interact with its environment. This interaction is important for many different behaviours, from finding food to defending itself against enemies. In vertebrates the olivocerebellar system controls movements and monitors its efficiency by collecting sensory information. All this information is evaluated to control and correct intended movements. Our group investigates this motor control on a neuronal level
Additional affiliations
September 2006 - present
Erasmus MC
Position
  • University lecturer/Group leader/Staff member
September 2003 - September 2006
Erasmus MC
Position
  • Groupleader/Staff member
September 2001 - September 2003
Erasmus University Rotterdam
Position
  • PostDoc Position
Education
September 1991 - June 1994
Vrije Universiteit Amsterdam
Field of study
  • Biology

Publications

Publications (44)
Book
The inferior olive in the ventral medulla oblongata provides climbing fibers to Purkinje cells in the cerebellar cortex as well as collaterals to the cerebellar nuclei and thereby exerts a strong impact on cerebellar output. As a consequence, the intrinsic properties of olivary neurons and the synaptic inputs that modify their output are critical f...
Article
Full-text available
The inferior olive (IO) is a nucleus located in the brainstem and it is part of the olivo-cerebellar loop. This circuit plays a fundamental role in generation and acquisition of coherent motor patterns and it relies on synchronous activation of groups of Purkinje cells (PC) in the cerebellar cortex. IO neurons integrate their intrinsic oscillatory...
Article
Full-text available
The neurons in the inferior olive express subthreshold oscillations in their membrane potential. This oscillatory activity is known to drive synchronous activity in the cerebellar cortex and plays a role in motor learning and motor timing. In the past years, it was commonly thought that olivary neurons belonged to a unique population of oscillating...
Data
Full-text available
Synchronization properties of 3×3 and 5×5 networks. A. An example of somatic membrane potential traces during synchronization in a 3×3 simulated network of IO cells with different STO properties due to variable T-type calcium expression levels. The network was initialized with random phase differences. At the start, STO amplitudes are small and pha...
Data
Full-text available
This supplementary text contains a full description of the dendritic, somatic and axon hillock compartments of the computational model used. (PDF)
Article
Full-text available
The inferior olive (IO) forms one of the major gateways for information that travels to the cerebellar cortex. Olivary neurons process sensory and motor signals that are subsequently relayed to Purkinje cells. The intrinsic subthreshold membrane potential oscillations of the olivary neurons are thought to be important for gating this flow of inform...
Article
Full-text available
The inferior olivary nucleus (IO) forms the gateway to the cerebellar cortex and receives feedback information from the cerebellar nuclei (CN), thereby occupying a central position in the olivo-cerebellar loop. Here, we investigated the feedback input from the CN to the IO in vivo in mice using the whole-cell patch-clamp technique. This approach al...
Data
Double stimulation experiments. An LTO neuron responding with a short latency EPSP is stimulated twice at different time intervals (first trace single stimulation, then 25, 175, 250, 350 ms intervals respectively, stimulation artifacts are indicated by red arrow heads). A second EPSP is evoked when the time interval is at least 350 ms (indicated by...
Data
Experiment performed with 15mM DNDS. Wild type SSTO cell (top trace) responding to CN stimulation, then (middle trace) the response of the same cell to CN stimulation in reduced after 20 minutes of dialysis with DNDS 15 mM, bottom trace represents the averages at the beginning of the experiment (black) and after 20 minutes of DNDS 15 mM (red). Even...
Article
Full-text available
Eye movements are very important in order to track an object or to stabilize an image on the retina during movement. Animals without a fovea, such as the mouse, have a limited capacity to lock their eyes onto a target. In contrast to these target directed eye movements, compensatory ocular eye movements are easily elicited in afoveate animals1,2,3,...
Article
Full-text available
The inferior olivary nucleus provides one of the two main inputs to the cerebellum: the so-called climbing fibers. Activation of climbing fibers is generally believed to be related to timing of motor commands and/or motor learning. Climbing fiber spikes lead to large all-or-none action potentials in cerebellar Purkinje cells, overriding any other o...
Chapter
Full-text available
The inferior olive provides all climbing fibers to the Purkinje cells in the cerebellar cortex and thereby has a strong impact on cerebellar output. As a consequence, the integration of inputs to olivary neurons as well as their intrinsic properties are critical for cerebellar function. In this chapter, all issues that are relevant for their ultima...
Article
Long-term depression at parallel fiber-Purkinje cell synapses (PF-PC LTD) has been proposed to be required for cerebellar motor learning. To date, tests of this hypothesis have sought to interfere with receptors (mGluR1) and enzymes (PKC, PKG, or αCamKII) necessary for induction of PF-PC LTD and thereby determine if cerebellar motor learning is imp...
Article
Full-text available
Traditionally studies aimed at elucidating the molecular mechanisms underlying cerebellar motor learning have been focused on plasticity at the parallel fiber to Purkinje cell synapse. In recent years, however, the concept is emerging that formation and storage of memories are both distributed over multiple types of synapses at different sites. Her...
Article
Full-text available
Mefloquine (a marketed anti-malaria drug) prophylaxis has a high risk of causing adverse events. Interestingly, animal studies have shown that mefloquine imposes a major deficit in motor learning skills by affecting the connexin 36 gap junctions of the inferior olive. We were therefore interested in assessing whether mefloquine might induce similar...
Article
Full-text available
Synaptic gain control and information storage in neural networks are mediated by alterations in synaptic transmission, such as in long-term potentiation (LTP). Here, we show using both in vitro and in vivo recordings from the rat cerebellum that tetanization protocols for the induction of LTP at parallel fiber (PF)-to-Purkinje cell synapses can als...
Article
The level of electrotonic coupling in the inferior olive is extremely high, but its functional role in cerebellar motor control remains elusive. Here, we subjected mice that lack olivary coupling to paradigms that require learning-dependent timing. Cx36-deficient mice showed impaired timing of both locomotion and eye-blink responses that were condi...
Article
Full-text available
Learning motor skills is critical for motor abilities such as driving a car or playing piano. The speed at which we learn those skills is subject to many factors. Yet, it is not known to what extent gonadal hormones can affect the achievement of accurate movements in time and space. Here we demonstrate via different lines of evidence that estradiol...
Article
Full-text available
In vitro whole-cell recordings of the inferior olive have demonstrated that its neurons are electrotonically coupled and have a tendency to oscillate. However, it remains to be shown to what extent subthreshold oscillations do indeed occur in the inferior olive in vivo and whether its spatiotemporal firing pattern may be dynamically generated by in...
Article
Activation of postsynaptic alpha-calcium/calmodulin-dependent protein kinase II (alphaCaMKII) by calcium influx is a prerequisite for the induction of long-term potentiation (LTP) at most excitatory synapses in the hippocampus and cortex. Here we show that postsynaptic LTP is unaffected at parallel fiber-Purkinje cell synapses in the cerebellum of...
Article
The mouse mutant Ozzy, originating from an ENU-mutagenesis programme, displays a head bobbing phenotype. We report here that Ozzy mice show a clear deficit in vestibulo-ocular reflex (VOR). Micro-CT scanning of the inner ears showed narrowing and truncations of at least one of the semicircular canals and loss of the ampullae. Frequency-specific aud...
Article
The zones of the flocculus have been mapped in many species with a noticeable exception, the mouse. Here, the functional map of the mouse was constructed via extracellular recordings followed by tracer injections of biotinylated-dextran-amine and immunohistochemistry for heat-shock protein-25. Zones were identified based on the Purkinje cell comple...
Article
Full-text available
According to the multisensory integration theory vestibular, optokinetic and proprioceptive inputs act in concert to maintain a stable retinal image of the visual world. Yet, it remains elusive to what extent the otolith organs contribute to this process and whether a specific loss of otolith input is compensated for. Here we investigated the compe...
Article
Full-text available
Compensatory mechanisms after genetic manipulations have been documented extensively for the nervous system. In many cases, these mechanisms involve genetic regulation at the transcription or expression level of existing isoforms. We report a novel mechanism by which single neurons compensate for changes in network connectivity by retuning their in...
Article
Electrotonic coupling by gap junctions between neurons in the inferior olive has been claimed to underly complex spike (CS) synchrony of Purkinje cells in the cerebellar cortex and thereby to play a role in the coordination of movements. Here, we investigated the motor performance of mice that lack connexin36 (Cx36), which appears necessary for fun...
Article
Full-text available
A Ba2+-sensitive K+ current was studied in neurons of the suprachiasmatic nucleus (SCN) using the whole cell patch-clamp technique in acutely, prepared brain slices. This Ba2+-sensitive K+ current was found in approximately 90% of the SCN neurons and was uniformly distributed across the SCN. Current-clamp studies revealed that Ba2+ (500 μM) reversi...
Article
A Ba ²⁺ -sensitive K ⁺ current was studied in neurons of the suprachiasmatic nucleus (SCN) using the whole cell patch-clamp technique in acutely prepared brain slices. This Ba ²⁺ -sensitive K ⁺ current was found in approximately 90% of the SCN neurons and was uniformly distributed across the SCN. Current-clamp studies revealed that Ba ²⁺ (500 μM) r...
Article
Full-text available
The central biological clock of the mammalian brain is located in the suprachiasmatic nucleus. This hypothalamic region contains neurons that generate a circadian rhythm on a single-cell basis. Clock cells transmit their circadian timing signals to other brain areas by diurnal modulation of their spontaneous firing rate. The intracellular mechanism...
Article
Full-text available
Gramicidin-perforated patch-clamp recordings were made from slices of the suprachiasmatic nucleus (SCN) of adult rats to characterize the role of gamma-amino butyric acid (GABA) in the circadian timing system. During the day, activation of GABA(A) receptors hyperpolarized the membrane of SCN neurons. During the night, however, activation of GABA(A)...
Article
Full-text available
Three independent electrophysiological approaches in hypothalamic slices were used to test the hypothesis that gamma-amino butyric acid (GABA)A receptor activation excites suprachiasmatic nucleus (SCN) neurons during the subjective day, consistent with a recent report. First, multiple-unit recordings during either the subjective day or night showed...
Article
The suprachiasmatic nucleus is commonly considered to contain the main pacemaker of behavioral and hormonal circadian rhythms. Using whole-cell patch-clamp recordings, the membrane properties of suprachiasmatic nucleus neurons were investigated in order to get more insight in membrane physiological mechanisms underlying the circadian rhythm in firi...
Article
The suprachiasmatic nucleus is commonly considered to contain the main pacemaker of behavioral and hormonal circadian rhythms. Using whole-cell patch-clamp recordings, the membrane properties of suprachiasmatic nucleus neurons were investigated in order to get more insight in membrane physiological mechanisms underlying the circadian rhythm in firi...
Article
Perforated patch clamp recordings of neurons in slices of the suprachiasmatic nucleus (SCN) were made in their subjective day and night phases. The spontaneous firing rate and input resistance were significantly higher during the subjective day as compared to the subjective night. In parallel, the membrane potential of neurons recorded at daytime w...
Article
Full-text available
Vasopressin (VP) neurons in the suprachiasmatic nucleus (SCN) are thought to be closely linked to neural mechanisms for circadian timekeeping. To gain insight into the cellular-physiological principles that govern spike-driven VP release and to examine whether VP cells can be electrophysiologically and morphologically identified by a unique combina...
Article
1. Whole cell patch clamp recordings of neurons in slices of the suprachiasmatic nucleus (SCN) were made in order to assess their electrophysiological and morphological heterogeneity. This assessment was accomplished by (i) quantification of intrinsic membrane properties recorded in current clamp mode, (ii) studying frequency distributions of these...
Article
Neurons of the rat suprachiasmatic nucleus (SCN) exhibit a circadian rhythm in spontaneous firing rate. In this whole-cell patch-clamp study in slices, we examined the possibility that H-current (IH) contributes to the spontaneous firing rate of SCN neurons. Most of our experiments were performed during the subjective day, because this is the time...
Article
Neurons of the rat suprachiasmatic nucleus (SCN) exhibit a circadian rhythm in spontaneous firing rate. In this whole-cell patch-clamp study in slices, we examined the possibility that H-current (IH) contributes to the spontaneous firing rate of SCN neurons. Most of our experiments were performed during the subjective day, because this is the time...
Article
In the pond snail Lymnaea stagnalis egg laying is induced by multiple peptides, which are released by the neuroendocrine caudo-dorsal cells (CDCs). Egg laying in Lymnaea starts at about 50 days and increases initially with age to decreases again at an age of about 250 days. From that age on, the total number of animals that stop egg laying increase...

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