Marc Ziegenbein

Klinikum Wahrendorff

Background Dementia ‐ one of the most common diseases in old age ‐ is often only diagnosed at a late stage. Therefore patients with dementia have often a 1.4 to 3.6 times greater risk of treatment as an inpatient. Consequently it is highly relevant within the caring system to identify and treat the onset of dementia at the earliest possible opportu...

Introduction Dementia - one of the most common diseases in old age - is often only diagnosed at a late stage. Therefore patients with dementia have often a 1.4 to 3.6 times greater risk of treatment as an inpatient. Consequently it is highly relevant within the caring system to identify and treat the onset of dementia at the earliest possible oppor...

Introduction Frontotemporal dementia (FTD) is common in presenile population. The overlapping symptoms with other psychiatric disorders can lead to wrong/late diagnosis which cause delays/difficulties regarding case-management. Especially, long-standing and/or late-onset depression can descriptively envelop bvFTD (behavioral-variant) and leads to u...

Introduction Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized with ritualized behavior, difficulties in communication/ social interaction, restricted interests, and sensitivity to external stimuli. The ASD has gained attention in recent years, however it’s still difficult in geropsychiatric setting to identify high-func...

Introduction Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized with difficulties in social interaction/communication, restricted interests, and repetitive behaviors. Sexual issues such as paraphilic behaviors in ASD have gained attention in recent years, however there is still a great paucity of research regarding this i...

Zusammenfassung Eine Vielzahl von Forschungsvorhaben weist auf die positive Wirkung von Sport und Bewegung bei der Behandlung von Menschen mit psychischen Erkrankungen hin. In der teil- und vollstationären psychiatrischen Versorgung werden in sporttherapeutischen Maßnahmen funktionelle, psychosoziale und pädagogische Ziele verfolgt. Die Studienlage...

Im Jahr 2015 nahmen in Deutschland rund 70.000 Menschen mit einer seelischen Behinderung Leistungen der stationären Wiedereingliederungshilfe nach SGB-XII in Anspruch. Ziel der Eingliederungshilfe ist, den Menschen wieder zu einem weitgehend selbstständigen Leben zu befähigen und in die Gesellschaft zu integrieren. Vor dem Hintergrund der Forderun...

Changes in sleep-EEG after endocrine stimulation tests in patients with schizophrenia include reduced sleep efficiency, prolonged sleep latency and increased awaking after sleep onset Findings on sleep associated growth hormone (GH) secretion were ambiguous. The aim of this study was to elucidate the sleep-endocrine activity especially in the GH sy...

Psychiatrie-Verlag Sozialpsychiatrische Information Ein Erfahrungsbericht Die Tagesklinik für Männer (TK) ist eine in dieser Form bislang einmalige teilstationäre Einrichtung für männliche Patienten, die unter Depression, Burnout, Ängsten oder psychosomatischen Erkrankungen leiden. Die Symptomatik von Depression kann sich bei Männern anders äußern...

The purpose of the study was to determine the therapeutic effect of physical exercise for patients with unipolar depression. Participants took part in an 8-week walking/running aerobic exercise program at a local sports club. Forty-six outpatients aged 18-65 years diagnosed with mild to severe depression (ICD-10 criteria) were randomly assigned to...

Ziele der Studie: In dieser Untersuchung wird das Depressivitätsrisiko von Frauen und Männern mit Migrationshintergrund im Vergleich zu der einheimischen Bevölkerung anhand einer Querschnittsstudie an Beschäftigten einer deutschen Universitätsklinik analysiert. Darüber hinaus werden geschlechtsspezifische Unterschiede bezüglich der Risikofaktoren f...

Aims: This study analysed the risk of depression in men and women with a background of immigration by means of a cross-sectional study amongst employees of a German university hospital. In addition we identified gender-specific differences related to risk factors for depressiveness in the subgroups. Methods: 7062 employees with or without a 1st...

Introduction Information about the relationship between personality disorder and ethnicity or migration is sparse. The few studies regarding the prevalence of borderline personality disorder (BPD) in immigrants compared to an indigenous population are inconsistent. Aims The aim of the present study was to compare the frequency of a BPD diagnosis i...

Objective: The measurement invariance of the German version of the Center of Epidemiological Studies Depression scale (CES-D 20) among men and women with and without migration background has not been studied yet. Methods: A total of 2786 employed persons without (female n = 1772, male n = 598) and with an immigrant background (female n = 301, ma...

Einleitung Suizidales Verhalten hat es in der Menschheitsgeschichte schon immer gegeben. Dieser Beitrag liefert einen Überblick zur Suizidalität im Kontext psychischer Erkrankungen.

The aim of this study was to resolve the relationship between physical capacity (PC) and quality of life (Qol) in schizophrenic patients and healthy controls. 31 patients (PG: 18 male, 13 female) and a control group (CG) of 50 healthy subjects (15 male, 35 female) were involved. PC was assessed as peak oxygen uptake [VO2peak, (ml (min kgKG)-1)] and...

Background: Migrants in Europe may suffer from depression more often than the native-born population of the particular host country. Reports about the prevalence of depression in migrants are, however, heterogeneous and the possible causes are the subject of controversial discussion. Aims: The aims of this study are to determine the incidence of...

To investigate the frequency of traumatisation, suicidality and given diagnoses in expert opinions on asylum seekers and to describe the sociodemographic characteristics of this population. The psychiatric expert opinions on asylum seekers, furnished in an 8-year-period at Hannover Medical School, were analysed retrospectively for qualitative and q...

Objetivos: El trastorno por déficit de atención con hiperactividad (TDAH) tiene una gran importancia clínica no sólo por su elevada prevalencia sino también por su frecuente comorbilidad con enfermedades que están relacionadas con este trastorno. Diversos estudios han sido capaces de demostrar que el TDAH constituye un importante factor de riesgo p...

Objectives: Previous studies have indicated a possible correlation of acculturation and physical inactivity with increased health risks among immigrants. This study on multiethnic employed individuals investigates whether immigration background, indicators of acculturation and the degree of physical activity are correlated. Methods: For this cross-...

Der Wandel der Gesellschaften offenbart Versorgungsprobleme in den Gesundheitssystemen für Migranten. Eine Studie an einer universitären Psychiatrischen Institutsambulanz wurde retrospektiv auf das Migrationskriterium hin ausgewertet. In der Studie wurden über einen Zehn-Jahres-Zeitraum alle chronisch psychisch Erkrankten (ohne primär Sucht- und hi...

The number of ethnic German immigrants from former East bloc countries (Aussiedler) has considerably increased during the past 20 years. However, studies on the frequency of psychiatric disorders or on psychosocial risk factors for psychiatric morbidity in this partially inhomogenous population group are remarkably rare. We undertook a comprehensiv...

Attention-deficit/hyperactivity disorder (ADHD) is of great clinical importance not only because of its high prevalence but also due to the frequent comorbid illnesses that are connected with this disorder. Several studies were able to demonstrate that ADHD constitutes a significant risk factor for the exacerbation of habit-forming illnesses, i.e....

OBJECTIVE The number of ethnic German immigrants from former East bloc countries (Aussiedler) has considerably increased during the past 20 years. However, studies on the frequency of psychiatric disorders or on psychosocial risk factors for psychiatric morbidity in this partially inhomogenous population group are remarkably rare. METHOD We underto...

Background: In psychiatry, polypharmacy is more the rule than the exception. The present study investigates the frequency and type of polypharmacy in various diagnostic groups amongst patients of a psychiatric outpatient care unit. Methods: Patients' medical records were used to collect data on the last psychopharmacological medication prescribed i...

The diagnosis of personality disorders is highly dependent on how a society views certain behavior. Self concept, adaptation and social context are important aspects of the cultural dimensions of personality disorders. However, the relevance and implications of the influence of sociocultural factors are seen differently. Accordingly, there are very...

Background: In psychiatry, polypharmacy is more the rule than the exception. The present study investigates the fre- quency and type of polypharmacy in various diagnostic groups amongst patients of a psychiatric outpatient care unit. Methods: Patients' medical records were used to collect data on the last psychopharmacological medication prescribed...

Although the idea of an increased tendency for somatization and vulnerability to offences in immigrants is widespread among clinicians, there are only few studies in this field and the respective data do not yet convey a clear message. In this study, the treatment courses of n = 55 first generation immigrants were compared to those of a parallel sa...

Zusammenfassung Im klinischen Alltag wird bei Migranten häufig eine vermehrte Neigung zu Somatisierung und eine erhöhte Kränkbarkeit wahrgenommen. Diesbezüglich existieren jedoch kaum Studien, und die bestehende Datenlage ist uneinheitlich. Die Therapieverläufe von n = 55 Migranten der 1. Generation und einer Parallelstichprobe aus n = 55 einheimis...

Due to increasing immigration in Germany the German Mental Health Care System today has to deal in a growing number with the assessment of the level of psychic functioning and the capability of self control in patients of different ethnic origin. For clinicians this is a challenge, since suicidal behaviour in terms of its frequency, meaning, motive...

The psychiatric evaluation of immigrants presents a particular challenge in the medical assessment process. Knowledge of cultural aspects of the aetiology, epidemiology and manifestation as well as the treatment of mental disorders is not only an important facet in daily psychiatric work with immigrants, it is also important for the assessment proc...

Due to the effects of globalization there has to be dealt with an increased number of immigrants in the German health care system. However, esp. the mental health care system in Germany is not sufficiently prepared for this challenge. It will be given an overview on the current situation of mental health care of immigrants with mental disorders. Th...

To assess the effect of cultural identification in Turkish immigrants living in Germany on attitudes towards psychotherapy. The approach to psychotherapy of 139 Turkish immigrants and 164 Germans was examined. Overall the Turkish population reported a less positive attitude towards psychotherapy in comparison to the German population. The Turkish i...

Objective: To assess the effect of cultural identification in Turkish immigrants living in Germany on attitudes towards psychotherapy. Methods: The approach to psychotherapy of 139 Turkish immigrants and 164 Germans was examined. Results: Overall the Turkish population reported a less positive attitude towards psychotherapy in comparison to th...

Objective: Due to the effects of globalization there has to be dealt with an increased number of immigrants in the German health care system. However, esp. the mental health care system in Germany is not sufficiently prepared for this challenge. Methods: It will be given an overview on the current situation of mental health care of immigrants wi...

Attention deficit/hyperactivity disorder (ADHD) is a widely examined disease in childhood. There is evidence that the disease responds well to medication with methylphenidate (MPH). The effect of MPH in adults with ADHD is a question that is often raised, because many adults request such therapy today. As yet, there is a lack of studies on event-re...

Prolactin has been discussed to be useful for differential diagnosis in epilepsia. Aim of the present study was to investigate the association between prolactin serum levels and previous alcohol withdrawal seizures. We assessed 118 male patients admitted for detoxification treatment. Previous withdrawal seizures were recorded and prolactin serum le...

Several studies have shown that attention-deficit/hyperactivity disorder (ADHD) represents a significant risk factor for the onset and development of an addiction. Thirty-five per cent of adult ADHD patients are known to be addicted to alcohol. Many ADHD patients also have an increased nicotine consumption, which typically, leads to an improvement...

Angesichts der Öffnung unserer Gesellschaft und des zunehmenden Einzugs von Migranten in psychiatrisch-psychotherapeutische Versorgungssysteme gewinnt die Beurteilung des Funktionsniveaus und der Steuerungsfähigkeit von Menschen aus anderen Kulturkreisen Bedeutung und Brisanz. Kulturelle und ethnische Faktoren haben einen erheblichen Einfluss auf S...

To obtain data and results concerning the acute treatment of psychiatric patients within a general ED. Retrospective examination of psychiatric cases treated in the ED of the Hannover Medical School in the year 2002. Patient characteristics were evaluated concerning diagnosis, technical examinations, therapeutic steps and data relating to the lengt...

With a prevalence of 2 to 4 %, ADHD is one of the most frequently seen disorders in adulthood. Due to the putative addiction potential the treatment of this disorder with the amphetamine derivate methylphenidate is discussed controversially, particularly by the treatment of ADHD and comorbid addiction. Atomoxetine, a selective norepinephrine reupta...

With a prevalence of 2 to 4 %, ADHD is one of the most frequently seen disorders in adulthood. Due to the putative addiction potential the treatment of this disorder with the amphetamine derivate methylphenidate is discussed controversially, particularly by the treatment of ADHD and comorbid addiction. Atomoxetine, a selective norepinephrine reupta...

Psychosis due to dopamimetic treatment is a difficult problem in patients with Parkinson's disease (PD). The aim of this structured review with meta-analysis was to evaluate which neuroleptic drugs can efficiently be used to treat drug-induced psychosis (DIP) in Parkinson's disease. Electronic databases were screened for the key words Parkinson's d...

OBJECTIVE: To obtain data and results concerning the acute treatment of psychiatric patients within a general ED. METHODS: Retrospective examination of psychiatric cases treated in the ED of the Hannover Medical School in the year 2002. Patient characteristics were evaluated concerning diagnosis, technical examinations, therapeutic steps and data r...

Quality management is an important management tool in modern health care systems. This applies also to the mental health care system, where in the past decade many concepts have been developed on how to implement quality management appropriately and successfully. However, for the German speaking countries there are only very few studies on the eval...

Long-stay hospitalization is often a consequence of insufficient care structures. This article examines the characteristics and care conditions of long-stay hospitalization (LSH) in an urban area in Germany. Extensive data of patients in the urban catchment area of the Medical School of Hannover, capital of Lower Saxony, were evaluated during a 10...

The assessment of the level of psychic functioning and the capability of self-control in patients of different ethnic origin is a challenge. Suicidal behaviour in terms of its frequency, meaning, and manner is very much dependent on the cultural context in which it occurs. There is a (not undisputed) relation between the degree of difference betwee...

Zusammenfassung Die Beurteilung des Funktionsniveaus der Persönlichkeit und der Steuerungsfähigkeit bei Migranten ist für kulturfremde Kliniker eine Herausforderung. Suizidales Verhalten ist im Hinblick auf Form, Bedeutung und Häufigkeit sehr stark von der jeweiligen Kultur beeinflusst, in deren Kontext es steht. Zwischen dem Grad des Kulturwandels...

To investigate a possible association of nicotine dependence and alcohol craving. A prospective cross-sectional study on patients diagnosed with alcohol dependence. Detoxification unit of a regional psychiatric hospital. A total of 127 smoking male patients were included in the study at admission for detoxification from alcohol. The Fagerström Test...

Microdeletion 22q11.2 (22q11DS) is the most frequent chromosomal deletion known in man. Velocardiofacial syndrome is one of numerous clinical syndromes that can be attributed to this micro deletion. There is an increasing recognition of associations with neuropsychiatric disorders. Particularly, schizophrenic psychosis, attention-deficit/hyperactiv...

Microdeletion 22q11.2 (22qllDS) is the most frequent chromosomal deletion known in man. Velocardiofacial syndrome is one of numerous clinical syndromes that can be attributed to this micro deletion. There is an increasing recognition of associations with neuropsychiatric disorders. Particularly, schizophrenic psychosis, attention-deficit/hyperactiv...

Elevated plasma homocysteine concentrations can influence genomic and gene-specific DNA methylation in peripheral blood cells. The aim of this study was to investigate in patients with alcohol dependence, who show chronically elevated homocysteine levels, whether DNA methylation pattern within the HERP (homocysteine-induced endoplasmic reticulum pr...

Weight gain is an important side effect of some antipsychotics. With the development of extrapyramidal symptoms (EPS) being reduced by the second generation of antipsychotics, weight gain is becoming a critical factor in the pharmacotherapy of patients with schizophrenia. The clinical characteristics suggest that the underlying pathophysiology of d...

Therapeutic options for patients with treatment-resistant schizophrenia are limited, and combination treatment with atypical antipsychotic drugs is an often used strategy. We tested the hypothesis that the combination of aripiprazole and clozapine would lead to an improvement in this patient group. Eleven patients with treatment-resistant schizophr...

Patients with psychiatric problems often seek help and assistance in hospital emergency departments. An important task of emergency room staff is to decide whether such patients need to be admitted or whether they can be treated on an outpatient basis. Psychiatric treatments given in the Central Interdisciplinary Emergency Department (CED) at the M...

The problem of long-stay hospitalization is still a pressing issue. In this study we examined the possibility of detecting and characterising the group at risk of long-stay hospitalization in advance. This study examines the data of patients in the urban catchment area of the Medical University of Hannover, capital of Lower Saxony, Germany, during...

Changes in the activity of the renin-angiontensin-aldosterone system (RAAS) in depression have recently been reported. Renin and aldosterone secretion are coupled to sleep in healthy subjects. As total sleep deprivation (TSD) leads to a rapid mood improvement in patients with depression, it is of interest to investigate its effect on the response o...

Background: Therapeutic options for patients with treatment-resistant schizophrenia are limited. In such cases, a combination of atypical antipsychotic drugs is an often used strategy. We tested the hypothesis that the combination of amisulpride and clozapine would lead to long-term improvement in this patient group. Objective: 15 patients with tre...

Background: Patients with psychiatric diagnoses have a higher prevalence for smoking cigarettes compared to the general population by almost 35-50%. Patients with schizophrenia are very affected. The reasons for the higher prevalence for smoking cigarettes are still unclear. Different studies discussed the interactions of nicotine and diverse psych...

It has been shown that beer consumption is associated with alcohol craving, in contrast to wine or spirits consumption. The present study was undertaken to evaluate whether the daily volume intake of alcoholic beverages is associated with craving in patients undergoing alcohol withdrawal. A total of 158 male patients were assessed using the obsessi...

Aim of this prospective study was to investigate a possible association between the apolipoprotein E4 (ApoE4) genotype and clinically well-known cognition deficits during alcohol withdrawal. We examined 172 patients with alcohol dependence (137 men, 35 women) during withdrawal treatment. The ApoE genotype was determined in all patients using polyme...

Therapeutic options for patients with treatment-resistant schizophrenia are limited. In such patients, combined application of atypical antipsychotic drugs is an often-used strategy. The authors tested the hypothesis that the combination of ziprasidone and clozapine would lead to an improvement in this patient group. Nine patients with treatment-re...

To analyze the turnaround times of psychiatric patients within the Emergency Department (ED) from registration to discharge or hospitalization in a University Hospital in 2002. Data from a one-year period of psychiatric admissions to the emergency service at a University Hospital were monitored and analyzed focused on turnaround times within the ED...

The introduction of newer antidepressants and neuroleptics has made the treatment of many psychiatric diseases more comfortable, easier and safer. With new compounds the possible adverse drug related effects have changed to other types, and new events have occurred concerning antidepressants and neuroleptics. The purpose of this paper is a review o...

Reboxetine is a novel selective noradrenaline reuptake inhibitor. The antidepressive properties of the substance are established. The influence of reboxetine on the sleep-EEG of eight patients with depression HAMD (mean +/- SD) 19.7 +/- 1.5 (5 women, 3 men; age range 31 to 75 years) was investigated. Sleep EEG was examined twice. The first examinat...

Recently, we demonstrated that the intravenous administration of the neuropeptide galanin acts on the sleep EEG of healthy young subjects similar to sleep deprivation. As this effect could imply an antidepressive potency we studied the effect of intravenous galanin administration on psychopathology and sleep EEG in patients with depression. Galanin...

Recently we demonstrated that the intravenous administration of the neuropeptide galanin acts on the sleep EEG of healthy young subjects similar to sleep deprivation. As galanin gene expression is upregulated in sleep deprivation in animal models this effect could imply a role of galanin in the physiological effects to sleep deprivation as well as...