Marc Vidal

Marc Vidal
Université de Montréal | UdeM · Department of Chemistry

PhD

About

6
Publications
15,433
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67
Citations

Publications

Publications (6)
Article
Over the past few years, we have undertaken a multidisciplinary research effort to show that it is possible not only to study imidazolium cations at the molecular level, but also to tune the macroscopic properties of the supramolecular systems they form. The study of functional imidazolium-based supramolecular architectures gives rise to emerging o...
Article
The physiological importance of proteins that can regulate ion balance and transmembrane transport is highlighted by different diseases where ion channel dysfunction is observed. During the past two decades, considerable effort has been devoted to develop synthetic ionophores that can insert or cross cell membranes and restore the dysfunction of hi...
Article
We describe the molecular parameters governing the transmembrane activity of imidazolium-functionalized anion transporters and present a detailed mechanistic study. These ionophores adopt a mobile-carrier mechanism for short methyl and butyl chains, a combined mobile-carrier/transmembrane-pore mechanism for octyl and dodecyl chains, and form transm...
Article
We report here the thermophysical properties of a new family of imidazolium-functionalized binaphthols. These properties are influenced by the position of the imidazolium moieties on the binaphthol skeleton, the counteranions, and the length of the carbon chain on the imidazolium moieties. The ionic character of these molecules was also exploited t...
Article
This work describes the antimicrobial activity and selectivity for Gram-positive bacteria of imidazolium-functionalized binols, as a result of their insertion into the lipid membrane and alteration of its permeability. The most potent compound displayed micromolar minimal inhibitory concentrations against Gram-positive Bacillus thuringiensis and Li...
Article
We describe the synthesis of a diphenylglycoluril/dibenzo-crown-6 molecular chalice, the self-assembly at the air/water interface and its complexation properties in solution and at the water/chloroform interface.

Questions

Question (1)
Question
The determination of the MICs for antimicrobial activity requires a 24h exposure time, but for the cytotoxicity study, in the literature, I only find 1h exposure time for the hemolysis assay. Why not 24h exposure time for the hemolysis assay? Is a 1h hemolysis assay relevant when you want to study the cytotoxicity of a compound whose MIC was determined on a 24h period ?

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