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Introduction
Marc Henry currently works at the Laboratoire de Synthèse et Fonctions des Architectures Moléculaires, University of Strasbourg. Marc does research in Chemical Thermodynamics, Inorganic Chemistry, Materials Chemistry, homeopathy and consciousness.
Additional affiliations
September 2020 - present
University of Strasbourg
Position
- Professor Emeritus
October 1993 - September 2020
October 1981 - October 1993
Publications
Publications (193)
M. Henry (2020) Conscious- ness, Information, Electromagnetism and Water. Substantia 4(1): 23-36.
Abstract: From a thought experiment on the observation of a human intellect by itself, we will attempt to demonstrate that, unlike what many neuroscientists postulate, assemblies of neurons do not generate consciousness: Consciousness pre-exists any material system.
Keywords: Consciousness, meaning, information, activity, neurons.
A Ti( iv )-complex with thermotropic liquid crystal properties is reported.
Age-related macular degeneration (AMD) is both a poorly understood and devastating disease. Here, we analyze the physico-chemical forces at stake, including osmolarity, redox shift, and pressure due to inflammation. Hyperosmolarity plays a key role in diseases of the anterior segment of the eye such as glaucoma, cataracts or dry eyes, and corneal u...
Cancer cells are very diverse but mostly share a common metabolic property : they are strongly glycolytic even though oxygen is available. Herein, the metabolic abnormalities of cancer cells are interpreted as modifications of the electric currents in redox reactions. A lower current in the electron transport chain, an increase of the concentration...
We previously demonstrated that most diseases display a form of anabolism due to mitochondrial impairment: in cancer, a daughter cell is formed; in Alzheimer's disease, amyloid plaques; in inflammation cytokines and lymphokines. The infection by Covid-19 follows a similar pattern. Long-term effects include redox shift and cellular anabolism as a re...
Specialization characterizes pharmacology, with the consequence of classifying the various treatments into unrelated categories. Treating a specific disease usually requires the design of a specific drug. The second law of thermodynamics is the driving force both for chemical reactions and for life. It applies to diseases and treatment. In most com...
The formation of a tetranuclear self‐assembled species constructed around a TiO4N2 motif is reported. This aggregate is generated from Ti(OⁱPr)4, 2,2’‐bipyrimidine (bpym) and a bis‐biphenol strand (L²H4) where two 2,2’‐biphenol units are connected with a biphenyl spacer. The solid‐state structure of the [Ti4(L²)4(bpym)4] architecture reveals the fo...
Singlet dioxygen 1O2 is one excited state among the three other possible spectroscopic states of molecular oxygen. Here, we first describe the use of published spectroscopic data and thermodynamic modeling based on irreversible entropy production. Such concepts are further applied to the synthesis of singlet dioxygen and its reactions with crucial...
The synthesis and characterisation of novel chelate nitrogen ligands with phasmidic tails (pyridine-triazole ligand 1b; 2,2'-bipyrimidine ligands 2b and 3b) as well as their titanium(IV) coordination complexes are reported. The analogous ligands 1a, 2a and 3a with methoxy substituents instead of the tails were also synthesized, together with titani...
A hyper-specialization characterizes modern medicine with the consequence of classifying the various diseases of the body into unrelated categories. Such a broad diversification of medicine goes in the opposite direction of physics, which eagerly looks for unification. We argue that unification should also apply to medicine. In accordance with the...
Biology is currently plagued by several fossil concepts that may be responsible for the current stagnation in medicine. Through a careful screening of the origins of thermodynamics, such fossils concepts have been identified: assumption that heat is a form of energy, assimilation of entropy to disorder, assimilation of death to states of maximum en...
In nature, every physical process involving matter is ruled by the second law of thermodynamics (the total entropy of an isolated system can never decrease over time, and is constant if and only if all processes are reversible). The living cell being a material system should comply by releasing entropy either into the body or into the outside envir...
Dipyrrolyldiketone ligands (dpkH) are used with Ti(OiPr)4 to afford monomeric titanium(IV) complexes displaying the general formula C2-[Ti(dpk)2(OiPr)2]. The dpkH ligands employed consist of two dipyrrolyldiketone compounds (2H and 3H) and three diphenyl-substituted analogues (4H-6H). The behavior of these octahedral [Ti(dpk)2(OiPr)2] species in so...
A multicomponent self‐assembly reaction involving a bis‐biphenolato ligand (LH4), a 2,2'‐bipyrimidine chelate substituted by two (anthryl)vinyl moieties (bAnt) and Ti(OiPr)4 was investigated. An assembly {[Ti3(L)3(bAnt)3]}, composed of three homochiral TiO4N2 nodes, was characterized as being the thermodynamically‐end product. The crystal structure...
The synthesis of monomeric octahedral complexes constructed around a TiO4N2 core bearing neocuproine derivatives is detailed. These architectures follow the [Ti(1)2(N-N)] general formulas, where 1 is the 6,6'-diphenyl-2,2'-biphenolato ligand and N-N is a 1,10-phenanthroline derivative. Single-crystal analysis revealed that the neocuproine-based lig...
Background Nuclear magnetic resonance (NMR) proton relaxation is sensitive to the dynamics of the water molecule, H2O, through the interaction of the spin of the proton (1H) with external magnetic and electromagnetic fields. NMR relaxation times describe how quickly the spin of 1H, forced in a direction by an external electromagnetic field, returns...
We report the case of a cohort of 2500 French patients treated among others with methylene blue for cancer care. During the COVID-19 epidemics none of them developed influenza-like illness. Albeit this lack of infection might be by chance alone, it is possible that methylene blue might have a preventive effect for COVID-19 infection. This is in lin...
The enantiomerically pure ligands (1a, 1b) and the meso 1c based on the trans-1,2-cyclohexanediol and cis-1,2-cyclohexanediol respectively were used for the formation of zig-zag 1D coordination polymers, when combined with bent HgCl2. A racemic mixture or 1a/1b in 1/1 ratio has also been studied. Four 1D Coordination Polymers have been obtained and...
Unresolved Anomalies
Pierandrea Lo Nostro, reply by Marc Henry
In response to “The Fourth State of Water” (Vol. 4, No. 4).
URL = https://inference-review.com/letter/unresolved-anomalies
M. Henry (2019) Water and the periodic table. Substantia 3(2) Suppl. 3: 9-11. doi: 10.13128/Substan-tia-701
This article describes the formation of neutral TiO4N2-based coordination entities where the titanium centers are coordinated by oxygenated ligands incorporating one or two biphenolato units, i.e. L¹ and L² respectively. In these systems, the sixfold coordination spheres of each metallic center are completed by the enantiopure bidentate diphenyleth...
"A scientific rationale for consciousness", Substantia 3(2): 37-54.
M. Henry, "The fourth state of water"
Inference : Int Rev. Sci., 4, n°4, July 2019
https://inference-review.com/article/the-fourth-state-of-water
Abstract: From a thought experiment on the observation of a human intellect by itself, we will attempt to demonstrate that, unlike what many neuroscientists postulate, assemblies of neurons do not generate consciousness: Consciousness pre-exists any material system.
Keywords: Consciousness, meaning, information, activity, neurons.
Paper published in the Indian Journal "Homeopathy and You"
Vol. 5, n°2, March 2019 (Part-1)
Vol. 5, n°3, April 2019 (Part-2)
Based on a conference made at the VIIth National Congress of Homeopathy, San Sebastian, Spain, May, 6-8, 2016
M. Henry, "Water and its mysteries"
Inference : Int Rev. Sci., 4, n°3, March 2019
URL = https://inference-review.com/article/water-and-its-mysteries
In this work, we report the formation of a coloured inorganic-organic hybrid material generated from the [Ti10O12(cat)8(py)8] (catecholato (cat), pyridine (py)) oxo-cluster and poly(4-vinylpyridine). The titanium oxo-cluster is linked to the organic polymer through Ti-N coordination bonds. Vibrational spectroscopies (FT-IR and Raman scattering) and...
A coordination chemistry involving trans-TiO4N2 motifs is described, where the oxygen ligands are 2,2′-biphenolato derivatives (L¹ or L²) and the nitrogen ligands are pyridine (Pyr), 2,3-dihydro-7-azaindole (DHA) or 2-(methylamino)pyridine (MePyr). Monomeric complexes and double-stranded helicates incorporating this set of ligands are characterized...
Background
NMR proton relaxation is sensitive to the dynamics of the water molecule H2O, through the interaction of the spin of the proton (¹H) with external magnetic and electromagnetic fields.
Methods
We measured dilution and potentization processes through measurements of ¹H spin-lattice T1 and spin–spin T2 relaxation times. In order to interpr...
The multicomponent coordination chemistry involving Ti(OPrⁱ)4, the ortho-phenylenediamine ligand (opda) and 2,2′-biphenol-based proligands (L²H4 and L³H6) is described. The proligands L²H4 and L³H6 incorporate two and three 2,2′-biphenol units linked with p-phenylene bridges (p-PLB) respectively. We demonstrate that this selected set of components...
Semi-empirical approach based on the partial charge formalism has been used to calculate 183W NMR chemical shifts in polyoxotungstates (POTs). Good consistency between calculations and experimental measurements allowed determining the main effective parameters for modeling the electronic state of the {WVIO6} centers. As the three 183W NMR chemical...
Resumen
Dentro del marco de la teoría cuántica, analizamos la sugerencia original de Samuel Hahnemann acerca de la existencia de una fuerza dinámica inmaterial para explicar la homeopatía. Basándonos en la teoría cuántica de campos y el concepto de los dominios de coherencia 2D, proponemos un modelo plausible de acción de los remedios homeopáticos...
As a chemist, and somebody who has tried to promote the philosophy of chemistry, I was delighted to see Marc Henry’s article.1 As numerous authors have emphasized, chemistry, the central science, seems to have been largely neglected by philosophers of science until about the mid 1990s.2 But even in the twenty or so subsequent years the field remain...
Chemistry Self-Crystallizing
Pierre Laszlo, reply by Marc Henry
In response to “Super-Saturated Chemistry” (Vol. 2, No. 4).
URL = https://inference-review.com/letter/chemistry-self-crystallizing
Journal: Inference : Int. Rev. Sci., 2[4] (2016)
URL: http://inference-review.com/article/super-saturated-chemistry.
This manuscript describes the synthesis of a series of neutral titanium(iv) monomeric complexes constructed around a TiO4N2 core. The two nitrogen atoms that compose the coordination sphere of the metallic center belong to 2,2'-bipyrimidine ligands homo-disubstituted in the 4 and 4' positions by methyl (2a), phenylvinyl (2b), naphthylvinyl (2c) or...
It is suggested that electromagnetic quantum vacuum fluctuations are at the very deep root of the so-called “specific ions effects” in concentrated solutions or in living cells. A many-body quantum-mechanical frame of thinking is proposed based on the concept of quantum coherence taking into account explicitly density and excitation frequencies of...
A series of deep-red colored nano-sized titanium oxo-clusters bearing catecholato ligands is reported. These architectures are produced via post-synthetic modification of the Ti10O12(cat)8(py)8 (cat = catecholato, py = pyridine) complex through quantitative substitution of labile pyridine ligands by three substituted pyridines (pico, 4-Phpy and pyr...
The structural identification in solution of the Zr(iv) complexes involving two 2,2-biphenol-based proligands is reported. The proligand L(1)H2 contains one 2,2-biphenol unit whereas L(2)H4 incorporates two 2,2-biphenol units linked by a para-phenylene bridge. Diffusion Ordered Spectroscopy (DOSY) combined with electrospray mass spectrometry analys...
The soil redox potential (Eh) can provide essential information to characterise soil conditions. In practice, however, numerous problems may arise regarding: (i) Eh determination in soils, especially aerobic soils, e.g. variations in the instrumentation and methodology for Eh measurement, high spatial and temporal Eh variability in soils, irreversi...
This study aims to elucidate the interactions between water, subjected to electromagnetic waves of very low frequency (VLF) (kHz) with low strength electromagnetic fields (3.5 mT inside the coils), and the development of microbial biofilms in this exposed water. Experimental results demonstrate that in water exposed to VLF electromagnetic waves, th...
M. Henry, « The hydrogen bond »,
Inference : Int. Rev. Sci., 1[2] (2015)
URL = http://inference-review.com/article/the-hydrogen-bond.
The synthesis of a bowl-shaped trinuclear circular titanium-based helicate is reported. The strategy allowing access to this neutral architecture is based on a multicomponent self-assembly approach in which the ligands involved in the process are a bis-biphenol strand and 2,2′- bipyrimidine. By reacting the bis-biphenol ligand and 2,2′-bipyrimidine...
Water is everywhere in nature, requiring new imaging techniques for visualization of information storage or transfer in liquids or hydrated solids. Corona discharges created by exciting matter in the UV spectrum is a mean to measure in a reproducible way « bio-compatibility » between a living body and any chemical substance. In medicine, a better m...
The spontaneous self-assembly of a neutral circular trinuclear Ti(IV) -based helicate is described through the reaction of titanium(IV) isopropoxide with a rationally designed tetraphenolic ligand. The trimeric ring helicate was obtained after diffusion of n-pentane into a solution with dichloromethane. The circular helicate has been characterized...
We describe the synthesis and characterisation of a robust S4-symmetry titanium-based architecture bearing catecholato and pyridine ligands. This neutral complex formulated as [Ti10O12(cat)8(py)8] displays a tetrahedral inorganic core decorated by catecholato ligands with unusual coordination modes. In solution, the pyridine ligands are labile as s...
We report the synthesis and structural characterisation of two titanium(IV) complexes. A new titanium(IV) complex bearing four picolinato ligands, denoted as Ti(pic)4, has been prepared under solvothermal conditions. This complex identified by single‐crystal diffraction is a new example of an octacoordinated environment for titanium(IV) and is clos...
P. Lo Nostro & B. W. Ninham Eds
In October 1611, Cosimo II De' Medici sponsored a debate in Florence starring Galileo on "Why ice floats on water." 400 years later 25 scientists commemorated the event, revisiting all things to do with water: modern views on Galileo, fresco restoration, cement. Water, its history, in jellyfish; solutions of salts an...
P. Lo Nostro & B. W. Ninham Eds
In October 1611, Cosimo II De' Medici sponsored a debate in Florence starring Galileo on "Why ice floats on water." 400 years later 25 scientists commemorated the event, revisiting all things to do with water: modern views on Galileo, fresco restoration, cement. Water, its history, in jellyfish; solutions of salts an...
The consumption of alkaline reduced water produced by domestic electrolysis devices was approved in Japan in 1965 by the Ministry of Health, Labour and Welfare for the cure of gastro-intestinal disorders. Today, these devices are freely available in several countries and can be easily purchased without reserve. The commercial information included w...
X-ray diffraction analysis of cyclometalated, chiral-at-metal rhodium and iridium complexes with the general formula [Cp*MCl{κ2(N,C)-(2-phenyl-2-imidazoline}] reveals that they undergo noncovalent self-assembly through intermolecular NH···Cl hydrogen bonding and, in some cases, CH/π interactions. Compound (±)-6b coordinated with an unsubstituted, a...
The work presented here concerns the evaluation of the reactivity of the [Ti8O8(OOCCH2But)(16)] cluster towards phenol, resorcinol and catechol using NMR techniques. Whereas the reactions conducted in the presence of phenol and resorcinol showed to be particularly slow, it appeared that catechol allowed the quantitative displacement of the carboxyl...
We described the development of a set of highly symmetric multitopic oligophenylene molecules decorated with hydroxyl functions that are all derived from the resorcinol moiety. All these resorcinol-based oligophenylene self-assembled structures and the corresponding methoxy protected precursors were found to be highly crystalline materials, with tw...
We examine in some detail the interaction of water molecules with the radiative electromagnetic field and find the existence of phase transitions from the vapor phase to a condensed phase where all molecules oscillate in unison, in tune with a self-trapped electromagnetic field within extended mesoscopic space regions (Coherence Domains). The prope...
a] Keywords: Titanium / N ligands / Bond energy / Thermodynamics A rational approach leading to a novel family of monomeric heteroleptic titanium complexes formed with two biphenol-ate derivatives and six different bidentate nitrogenated che-lates is proposed. Only one case of loss of structural predict-ability was observed in the case of a N,O-coo...
Well-defined biphenol/binaphtolate group 4 alkoxide salt species [(Ph-Biphen-O)(2)M(O(i)Pr)]Li(THF) (2a, M = Ti; 4a, M = Zr) and [(Ph-binapht-O)(2)M(O(i)Pr)]Li(THF) (2b, M = Ti; 4b, M = Zr) were found to be readily accessible in good yields via alcohol elimination routes and/or substitution reactions from the corresponding pro-ligands Ph-Biphen-OH...
The asthma therapeutic theophylline exists in at least three anhydrous polymorphs and a monohydrate. The single-crystal X-ray structure of the high-temperature polymorph form I is presented for the first time, and the energetic relationship between forms I and II is investigated using the partial charges and chemical hardness analysis (PACHA) algor...
A new class of organic crystalline 2,2'-biphenol-based H-bonded material displaying 1D-channels encapsulating solvent molecules is described. A reversible guest-induced crystal-to-crystal conversion between the solvated H-bonded phase and a compact H-bonded non-solvated phase was observed. The energy competition between intramolecular H-bonds forma...
The force of water like the Captain Cook Memorial Fountain in Canberra (Australia), has been investigated in three polymorphs of highly hydrated p-sulfonatocalix[4]arene tetrasodium salt. Single-crystal neutron structures reveal a “compressed” water molecule with short OH bonds, and PACHA calculations give an OH⋅⋅⋅π interaction energy of 6.9–7.5 kJ...
Tetrasodium p-sulfonatocalix[4]arene exists as a hydrate with approximately 14 water molecules and has three polymorphic modifications, all of which contain a water molecule in the molecular cavity that is engaged in OH···π interactions. Single-crystal neutron structures are reported for two of these three forms and reveal a "compressed" water mole...
Here we describe the fabrication and characterization of selective nanocomposite membranes based on ethylene–vinyl alcohol copolymers and polyoxomolybdate clusters. Larger “buckyball”-type polyoxomolybdates have been shown to display hydrophilic pores which allow the transport of water molecules but prevent the passage of larger, hydrophobic molecu...
Two nanosized zigzag-shaped oligophenylene strands incorporating 2,2'-biphenol units were prepared by Suzuki-Miyaura coupling methodology. The two strands are made up of ten and seven phenyl rings, respectively. Two synthetic pathways were evaluated. The first involved the preparation of the target oligophenylene molecules by a sequential approach,...
We report the hydrothermal synthesis, X-ray crystal structures, and thermal, optical, and magnetic properties of two isostructural layered coordination polymers, [M(II)(5)(OH)(2)(chtc)(2)(H(2)O)(10)]·2H(2)O where M = Co (1Co) or Ni (2Ni) and chtc = cis,cis,cis-1,2,4,5-cyclohexanetetracarboxylate. The structures consist of segregated layers where ea...
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A binuclear Ti(IV)-based helicate synthesized from a symmetric tetrahydroxyheptaphenylene strand was self-assembled in solution and shown to undergo a spontaneous head-to-tail differentiation according to single-crystal X-ray diffraction.
The orange-colored and hydrolytically stable compound {[Ti2O(Hbhmpc)(H(2)bhmpc)(H(2)bhmpc)] C4H8O2 HX}(2) (with H(3)bhmpc = 2,6-bis(hydroxymethyl)-p-cresol and X = OEt or CCl3) has been studied by a combination of single crystal Xray diffraction data, U V-vis. spectroscopy, IR and Raman spectroscopes, H-1, C-13 and O-17 solution NMR spectroscopes,...
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The 3,3'-diphenyl-2,2'-biphenol (dpbpolH(2)) ligand is shown to react with Ti(OPr(i))(4) in a 2:1 ratio to yield a novel C(2)-symmetric mononuclear octahedral Ti(IV) bis-biphenolate complex, cis-Ti(dpbpol)(2)(HOPr(i))(2).
Among all the chemical substances available in the universe, water, with its deceptively simple formula H2O, is the most discussed subject either in science or in philosophy [1]. If you are not convinced by this affirmation, a little experiment at no cost may help you change your mind. Just open your favorite web browser and type the word “water” i...
Using a combination of charge-assisted H- and coordination-bonds, a tetra component system composed of a dicationic and a dianionic organic tecton, Ag(+) cation and XF(6)(-) (X= P, As, Sb) anion behaves as planned and leads to the formation of 2-D isostructural networks for which the energetic contributions of the two recognition events dominate th...
The Stokes-Einstein expression of the diffusion coefficient as a function of the hydrodynamic radius of the diffusing object does not explicitly carry the mass dependency of the object. It is possible to correlate the translational self-diffusion coefficients D with the molecular weight M for an ensemble of cyclic or hollow clusters ranging from ab...
The surface energy of some clays belonging to the smectite group has been calculated starting from crystal structures and combining a partial charge model with the computation of the lattice energy. The dioctahedral smectites studied here include montmorillonite; beidellites; and nontronite. One of the differences between these clays is the locatio...
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The ionic recognition properties of neutral oxothiomolybdenum wheels can be changed from anionic to cationic through ionization of the internal aquo ligands. In the solid state, [Mo8O8S8(OH)10(H2O)]2- (1) interacts with two Cs+ cations to give a close supramolecular host-guest arrangement. Such interactions appear to be maintained in solution as a...
Stuck in the middle with you: The spherical cluster {(Mo)Mo 5}12Cr30 (1) fills, with its spin, a gap in the series of the analogous Fe (S = 5/2) and V (S = 1/2) clusters. This allows a deeper understanding of the magnetic properties of the series members, particularly with reference to geometric frustration, also found in the famous Kagomé lattices...
The enthalpy produced during immersion in water of a smectite, identified as a montmorillonite, substituted by Ca or Na is analyzed using three different approaches. The heat of immersion is measured using the classical calorimetric method. It is compared to an estimate using adsorption techniques. And it is calculated from a theoretical estimate o...
The surface energy of exchanged forms of montmorillonite has been computed using a partial charge model introduced in the calculation of the lattice energy. The results are in correct agreement with data on heats of adsorption. However, the difference between theoretical and experimental data increases from light cations to heavy cations associated...
The surface energies of talc and chlorite is computed using a simple model, which uses the calculation of the electrostatic energy of the crystal. It is necessary to calculate the atomic charges. We have chosen to follow Henry's model of determination of partial charges using scales of electronegativity and hardness. The results are in correct agre...
Clays play an important role in a wide variety of industrial processes. Indeed, they present interesting surface properties. For these reasons, we study the surface energy of models of clays by solid state calculations using electronegativities equalization. In this article, we focus on kaolinite and serpentine, two clays characterized by a simple...
The sol-gel synthesis of metal oxides can be performed via the hydrolysis and condensation of metal cations in aqueous solutions. This inorganic route provides a cheap and reliable way for industrial uses. However, many hydrolyzed precursors can be present simultaneously in the precursor solution and very few data are available on the formation of...