Marc Hébert

Marc Hébert
Laval University | ULAVAL · Department of Ophtalmology and Head and Neck Surgery

PhD Neurobiology

About

122
Publications
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2,500
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Publications

Publications (122)
Article
Full-text available
This paper describes eight imagery datasets including around 12000 images grouped in 1220 sets. The images were captured inside an architectural model aimed at exploring the impact of shading panels on photobiological lighting parameters. The architectural model represents a generic space at 1:10 scale with a single side fully glazing façade used t...
Article
Introduction: The COVID-19 pandemic and associated restrictive measures have caused important disruptions in economies and labour markets, changed the way we work and socialise, forced schools to close and healthcare and social services to reorganise. This unprecedented crisis forces individuals to make considerable efforts to adapt and will have...
Article
Full-text available
We previously proposed the electroretinogram (ERG) as a promising biomarker of major psychiatric disorders such as schizophrenia (SZ) and bipolar disorder (BP), given that we found anomalies in the ERG parameters of patients with these diagnoses as well as in their children who are at high risk (HR) of developing such disorders. The aim of the pres...
Article
Full-text available
Inherited retinal dystrophy (IRD) is a subset of degenerative diseases of the retina which have marked clinical, molecular, and genetic heterogeneity. Clinical presentation can be variable and include night or color blindness, tunnel vision, visual field defects, and subsequent progression to complete blindness. Pathogenic variants in more than 250...
Article
Full-text available
This paper presents a computational method for spatial visualization and probability evaluations of window view access in architecture based on human eyes' vision fields and biophilic recommendations. Window view access establishes occupants' visual connections to outdoors. Window view access has not, yet, been discussed in terms of the typical vis...
Poster
Full-text available
This research analyzes the impact of biophilic ambiance transition by means of coloured surfaces to respond to lighting needs of individuals who inhabit northern regions. Biophilic design aims to reduce the distance between humans and nature through architecture, a condition which is enhanced in northern latitudes due to their extreme climate condi...
Poster
Full-text available
The present research aims to promote colour combination in interior architecture to develop light-responsive ambiances for northern regions. Humans are highly sensitive to light and colour, thus their application should be properly applied in extreme latitudes where light varies over a year. Latest discoveries have proved that colour application in...
Article
Full-text available
Major depressive disorder (MDD) is one of the most common consequences of chronic stress. Still, there is currently no reliable biomarker to detect individuals at risk to develop the disease. Recently, the retina emerged as an effective way to investigate psychiatric disorders using the electroretinogram (ERG). In this study, cone and rod ERGs were...
Article
Full-text available
Northern building envelopes must provide efficient indoor-outdoor connections based on photobiological-psychological needs of occupants for positive relationships with the sub-Arctic nature, particularly daylighting and day/night cycles. Envelope configurations of Northern Canada’s buildings have not yet considered such requirements. Potentials of...
Poster
Les architectes ont pratiqué le confort et le bien-être des occupants dans des conditions climatiques variées. Sous les hautes latitudes, la satisfaction du confort des occupants est une tâche complexe pour les concepteurs en raison des conditions climatiques extrêmes. Cette recherche porte sur l'évaluation du confort et du bien-être afin de souten...
Article
Circadian adaptation to night work usually does not occur in naturalistic conditions, largely due to exposure to low levels of light during the night and light in the morning on the way home. This leads to circadian misalignment, which has documented deleterious effects on sleep and functioning during waking hours. Chronic circadian misalignment is...
Chapter
This article will focus on age-related changes in the circadian timing system. It will present age-related changes in circadian regulation of the sleep–wake cycle and circadian entrainment in humans. It will then address non-visual effects of light, eye's characteristics, as well as plasticity and adaptative mechanisms in aging. Lastly, it will rep...
Presentation
Daylight availability and solar radiation play an important role in the well-being of building occupants. In the Arctic regions of northern Canada, multiple factors such as extreme cold climate, specific photoperiod, and solar geometry constitute challenges when dealing with design problems. This research addresses decision-making problems in the d...
Presentation
This research focuses on developing adaptive high-performance envelopes to enable biophilic healthy buildings in Arctic climates responding to occupants’ wellbeing needs for relationships with the outdoor nature and to energy efficiency requirements. Building envelopes are the main element connecting indoors to the extreme cold weather and drastic...
Preprint
Full-text available
Background The COVID-19 pandemic and the isolation measures taken to control it has caused important disruptions in economies and labour markets, changed the way we work and socialize, forced schools to close and healthcare and social services to reorganize in order to redirect resources on the pandemic response. This unprecedented crisis forces in...
Article
Objective: Assess the change in sleep and vigilance of underground miners during long periods of extended shifts. Methods: Seventy miners worked 14 consecutive 12-hour day and/or night shifts. Also, they wore an actigraph and completed a visual analog scale for vigilance 4 times per shift. Linear regression models with mixed effects were used....
Preprint
Full-text available
Major depressive disorder (MDD) is one of the most common consequences of chronic stress. Still, there is currently no reliable biomarker to detect individuals at risk to develop MDD. Recently, the retina emerged as an effective way to approach the brain and investigate psychiatric disorders with the use of the electroretinogram (ERG). In this stud...
Conference Paper
This research aims at studying the potentials of single-skin and multi-skin envelopes with different window sizes to promote biophilic, healthy lighting and thermal performance of buildings in extreme sub-Arctic climatic conditions. Single-skin envelopes with low window-to-wall ratios (WWR) are most often recommended for sub-Arctic climates to redu...
Conference Paper
The aim of this research is to develop climate-based lighting adaptation scenarios for proper photobiological responses in high-performance biophilic buildings throughout the year. Photobiological responses refer to image forming (IF) and non-image forming (NIF) effects of light after reaching human eyes. IF effects enable vision. NIF effects regul...
Article
Modes of representation are key elements in communicating the properties of natural and built environments. This research proposes a capture and representation method for daylighting dynamics in interior and exterior spaces for the photopic (daytime vision) and melanopic (biological clock) portions of the electromagnetic spectrum. The proposed repr...
Article
Introduction : Almost a third of the offspring of parents diagnosed with schizophrenia or bipolar disorder could develop a mental disorder or related symptoms. The objectives of this study were to test the existence of two distinct subgroups of youth at-risk, according to their retinal response to luminance measured with electroretinography (ERG),...
Article
Introduction Adverse effects of night shift work are well known but there is scarce data on how vigilance and sleep vary across a large number of consecutive night shifts. Methods In summer, 38 underground miners (mean age (SD): 36.8 (13.9) years) wore an actigraph, filled out the Morningness-Eveningness questionnaire, and completed a Visual Analo...
Article
Full-text available
This study investigates shading panels' (SPs) impacts on daylighting features in a lab scale model in terms of parameters representing potential human eyes' biological responses identified as image forming (IF) and non-image forming (NIF). IF responses enable vision and NIF responses regulate internal body clocks known as circadian clocks. Human-ce...
Article
Objectif Analyser la vigilance subjective de travailleurs de mines souterraines pendant 14 quarts de nuit consécutifs et son interaction avec l’âge et le chronotype. Méthodes Pendant 14 quarts de nuit consécutifs, 38 mineurs (âge moyen [É.T] : 36,8 [13,9] ans) ont indiqué leur niveau de vigilance en plaçant une barre verticale sur une ligne de 100...
Article
Full-text available
This paper develops an integrated design framework of adaptive building façades (ABFs) to respond to photobiological and thermal needs of occupants, biophilic factors, energy requirements and climatic features in Northern Canada, i.e. near and above 50°N. The paper discusses the importance of biophilic and photobiological factors and ABFs to improv...
Presentation
Full-text available
This research develops climate-responsive adaptation scenarios through which the indoor lighting ambiance could be adjusted to photobiological needs of occupants for different activities. Photobiological needs refer to image-forming (IF) and non-image forming (NIF) requirements of individuals to perform a particular activity. Recent photobiological...
Presentation
Full-text available
This research explores health and well-being responses of occupants to the daylighting design of northern latitude buildings. Photobiological and biophilic studies have shown the significant impacts of daylighting and natural cycles on occupants’ health and well-being. Northern people have forced to spend most of their time in buildings due to stro...
Poster
Full-text available
A smart portable device is proposed to monitor and analyze photobiological parameters of light, i.e. image forming and non-image forming, in the space and control artificial lighting and building façades systems with respect to occupants’ behavior and local photoperiods. The proposed device could operate in a real-time spatial basis to monitor inte...
Poster
Full-text available
This study discusses the potential of climate-responsive building envelopes (CRBEs) to address biophilic and human-centric lighting factors inside buildings and satisfy occupants’ needs. Biophilic and human-centric lighting guidelines emphasize on image forming (IF) and non-image-forming (NIF) responses of building occupants to light and natural cy...
Poster
Full-text available
This research aims at developing shading panels of building envelopes to fulfill occupants’ health and well-being in terms of image forming (IF) and non-image forming (NIF) responses to light and natural cycles. In the last few years, photobiological studies have brought attention to the health and well-being of occupants in terms of IF and NIF res...
Poster
Full-text available
This research aims at developing biophilic adaptive façades as a promising solution to promote occupants’ health and building energy efficiency in the extreme-cold climate of Quebec's northern territories. Adaptive façades point to the (self-) adjustment of façade components (such as shading panels, windows and blinds) to occupants’ needs and envir...
Presentation
Full-text available
This research aims at developing biophilic adaptive façades as a promising solution to promote occupants’ health and building energy efficiency in the extreme-cold climate of Quebec's northern territories. Adaptive façades point to the (self-) adjustment of façade components (such as shading panels, windows and blinds) to occupants’ needs and envir...
Article
Full-text available
Background: The retina is recognized as an approachable part of the brain owing to their common embryonic origin. The electroretinogram (ERG) has proved to be a valuable tool to investigate psychiatric disorders. We therefore investigated its accuracy as a tool to differentiate schizophrenia (SZ) from bipolar disorder (BP) even after balancing pat...
Presentation
Full-text available
Le concours Ma thèse en 180 secondes est l'occasion pour les doctorants de présenter leur sujet de recherche en termes simples à un auditoire diversifié.
Article
Background The retinal response to light assessed by electroretinography (ERG) has been recognized as a promising site of investigation for psychiatric disorders. Indeed, ERG anomalies were reported in major depression, schizophrenia and offspring of patients (1,2,3). Traditionally, it is performed with bulky equipment using a corneal electrode whi...
Article
Objectif L’objectif de cette étude était de comparer les effets de l’exposition nocturne à de la lumière enrichie en bleu sur la vigilance nocturne et le sommeil diurne de travailleurs affectés à des quarts de nuit de 12 heures pendant 12 jours successifs. Méthodes Treize travailleurs attitrés à la surveillance de procédés miniers sur écrans d’ord...
Article
Full-text available
This paper proposes the biophilic design approach as a plausible hypothesis for the challenging conditions related to living and working in extreme cold climates. Biophilic design has recently been developed to overcome the adverse effects of the built environment and to improve human well-being by redefining the human-nature relationship. Yet, bio...
Poster
Full-text available
The biophilic design approach has recently been developed to confront adverse effects of the built environment development and improve human well-being by redefining the human-nature relationship. However, suggested biophilic design recommendations are rarely discussed in extreme climatic conditions such as very cold climates in which harsh nature,...
Presentation
Full-text available
The biophilic design approach has recently been developed to confront adverse effects of the built environment development and improve human well-being by redefining the human-nature relationship. However, suggested biophilic design recommendations are rarely discussed in extreme climatic conditions such as very cold climates in which harsh nature,...
Article
Full-text available
Background Adult patients having schizophrenia, bipolar disorder or major depression display indicators of brain dysfunctions that may be detectable in healthy children-adolescents at genetic risk, such as those born to an affected parent (Maziade, New Eng J Med 2017; Schizophr Res 2013). For instance, cognitive deficits are displayed by both adult...
Article
Retinal development occurs through the sequential but overlapping generation of six neuronal and one glial cell types. Of these, rod and cone photoreceptors represent the functional unit of light detection and phototransduction and are frequently affected in retinal degenerative diseases. During mouse development, the Polycomb group protein Bmi1 is...
Article
Eveningness has been suggested as a facilitating factor in adaptation to shift work, with several studies reporting evening chronotypes (E-types) as better sleepers when on night shifts. Conversely, eveningness has been associated with more sleep complaints during day shifts. However, sleep during day shifts has received limited attention in previo...
Article
This review highlights morphological and functional anomalies found along the entire visual pathway in schizophrenia, from the retina to the cortex. Based on the evidence of widespread anatomical and functional visual abnormalities, we posited that a neurodevelopmental anomaly occurring early in life was likely to explain those. Incidentally, suppo...
Article
Full-text available
Light exposure, particularly blue light, is being recognized as a potent mean to stimulate alertness and cognition in young individuals. Aging is associated with changes in alertness regulation and cognition. Whether the effect of light on cognitive brain function changes with aging is unknown, however. Cross-sectional study. Functional Neuroimagin...
Chapter
Abstract Aging is associated with important modifications in the sleep–wake cycle even among healthy individuals. These changes may be related to many factors including changes in the circadian regulation of the sleep–wake cycle (e.g., phase advance, reduced amplitude, vulnerability of the sleep–wake cycle to circadian challenges), in circadian ent...
Article
Electroretinogram (ERG) anomalies occur in patients with psychiatric disorders and represent potential biomarkers for diagnosis. For instance, decreased rod ERG (b-wave amplitude at Vmax) is a biological endophenotype in young offspring at high genetic risk (HR) for schizophrenia (SZ) and bipolar disorder (BD). Also, a decrease in cone a-wave and r...
Article
Investigating the living brain remains one of the major obstacles in psychiatry research in order to better understand the biological underpinning of brain disorders. Novel approaches are needed to study brain functions indirectly. Since it is part of the central nervous system, retinal functions as measured with the flash electroretinogram (ERG) m...
Article
Melatonin follows a circadian rhythm entrained by the light/dark cycle and plays a role in promoting light sensitivity at night. It has been suggested that melatonin and dopamine reciprocal inhibition may contribute to the switch between day and night vision. The purpose of this study was to investigate the impact of a high dose of melatonin admini...
Article
To compare multifocal electroretinography (mfERG) retinal function and the anatomical and visual outcomes of macular hole surgery performed with indocyanine green (ICG) or trypan blue (TB). Prospective, randomized study. Twenty-five eyes of 24 patients. Patients underwent a pars plana vitrectomy with removal of the internal limiting membrane. In 14...
Article
Background: Dysfunctions in brain dopamine and serotonin neurotransmission are believed to be involved in the etiology of psychiatric disorders, and electroretinogram (ERG) anomalies have been reported in psychiatric patients. The goal of this study was to evaluate whether ERG anomalies could result from central dopamine or serotonin dysfunctions...
Article
A study is presented about the effects of three glazing colour types (blue, neutral, bronze) on daylight quality, arousal and switch-on patterns for electric lights. This study was carried out using a scale model (1:4) of an office room, where subjective evaluations of the luminous conditions were performed by 36 participants (mean age 23.8 years)...
Article
Many nonvisual functions are regulated by light through a photoreceptive system involving melanopsin-expressing retinal ganglion cells that are maximally sensitive to blue light. Several studies have suggested that the ability of light to modulate circadian entrainment and to induce acute effects on melatonin secretion, subjective alertness, and ge...
Article
Students who work during the school year face the potential of sleep deprivation and its effects, since they have to juggle between school and work responsibilities along with social life. This may leave them with less time left for sleep than their nonworking counterparts. Chronotype is a factor that may exert an influence on the sleep of student...
Article
To compare the efficacy of intravitreal bevacizumab and ranibizumab for the treatment of neovascular age-related macular degeneration using an as-needed treatment regimen. Retrospective chart review. One hundred and ninety two eyes of 184 patients. Patients received an initial treatment of 3 monthly intravitreal injections of ranibizumab or bevaciz...
Article
Vulnerability to the reduction in natural light associated with fall/winter is generally accepted as the main trigger of seasonal affective disorder (SAD), whereas light therapy is a treatment of choice of the disorder. However, the relationship between exposure to light and mood regulation remains unclear. As compared with green light, blue light...
Article
Our goal was to challenge both normal controls and patients with seasonal affective disorders (SAD) to various light histories and then measure their retinal response modulation using the electroretinogram (ERG) in both winter and summer. In winter and summer, 11 normal controls and 12 SAD patients were exposed to three different light conditions f...
Article
Full-text available
This study investigates the possibility of an endogenous circadian rhythm in retinal cone function in humans. A full-field cone electroretinogram (ERG) was performed every 2 h for 24 h under continuous rod-saturating ambient white light (53 ± 30 lux; pupils dilated) in nine healthy subjects. Distinct circadian variations were superimposed upon a gr...
Article
Seasonal affective disorder (SAD) is characterized by a mood lowering in autumn and/or winter followed by spontaneous remission in spring or summer. Bright light (BL) is recognized as the treatment of choice for individuals affected with this disease. It was speculated that BL acts on photosensitive retinal ganglion cells, particularly sensitive to...
Article
Full-text available
We investigated the possibility of performing electroretinography (ERG) in non-pharmacologically dilated eyes using brighter flash (time-integrated) luminance. Photopic (N = 26; background 25.5 cd·m−2, white LED flashes) and scotopic ERG (N = 23, green LED flashes) luminance response functions were obtained simultaneously in a dilated (DE) and non-...
Article
Bright light at night paired with darkness during the day seem to facilitate adaptation to night work. Considering the biological clock sensitive to short wavelengths, we investigated the possibility of adaptation in shift workers exposed to blue-green light at night, combined with using blue-blockers during the day. Four sawmill shift workers were...
Article
Full-text available
Best disease is a slowly progressive macular dystrophy that typically has an onset in early childhood. Multiple lines of evidence suggest that dietary docosahexaenoic acid (DHA) protects against the development of macular degeneration. Our trial tested the effect of an oral supplement of DHA on visual function in patients with Best disease. Double-...