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Marc Nicola Gallay

Marc Nicola Gallay
SoniModul AG

MD, Neurosurgeon FMH

About

29
Publications
4,816
Reads
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575
Citations
Additional affiliations
May 2015 - present
SoniModul Center for Ultrasound Functional Neurosurgery
Position
  • Neurosurgeon FMH
November 2014 - April 2015
Swiss Paraplegic Centre
Position
  • Medical Doctor
January 2013 - October 2014
Hôpitaux Universitaires de Genève
Position
  • Medical Doctor

Publications

Publications (29)
Article
Full-text available
OBJECTIVE Since the first clinical application of the incisionless magnetic resonance–guided focused ultrasound (MRgFUS) technology only small series of patients have been reported, and thus only extrapolations of the procedure-related risks could be offered. In this study, the authors analyze side-effects and targeting accuracy in 180 consecutive...
Article
Full-text available
Background: There is a long history, beginning in the 1940s, of ablative neurosurgery on the pallidal efferent fibers to treat patients suffering from Parkinson's disease (PD). Since the early 1990s, we undertook a re-actualization of the approach to the subthalamic region, and proposed, on a histological basis, to target specifically the pallidoth...
Article
OBJECTIVE In addition to the well-recognized ventral intermediate nucleus (Vim) thalamotomy for the treatment of chronic therapy-resistant essential tremor (ET), an alternative approach targeting the posterior part of the subthalamus was proposed in the 1960s and early 1970s and then was reactualized as cerebellothalamic tractotomy (CTT) with the a...
Article
Full-text available
Background: Trigeminal neuralgia (TN) is a recognized pain condition the treatment of which can be very challenging. Various surgical interventions can be applied in cases of therapy-resistance to drug treatments. The central lateral thalamotomy (CLT) against neurogenic (or neuropathic) pain is based on multiarchitectonic histological as well as ph...
Article
Full-text available
Objective: Bilateral stereotactic neurosurgery for advanced Parkinson's disease (PD) has a long history beginning in the late 1940s. In view of improved lesioning accuracy and reduced bleeding risk and in spite of long-standing caveats about bilateral approaches, there is a need to investigate bilateral MR-guided focused ultrasound (MRgFUS) interve...
Article
Full-text available
Background: MR-guided focused ultrasound (MRgFUS) offers the possibility of safe and accurate lesioning inside the brain. Until now, most MRgFUS thermal applications have been based on temperature or energy protocols. Experimental studies support however an approach centered on thermal dose control. Objective: To show the technical feasibility and...
Article
Full-text available
Background: MR-guided focused ultrasound (MRgFUS) offers new perspectives for safe and efficient lesioning inside the brain. The issue of target coverage remains primordial and sub-optimally addressed or solved in the field of functional neurosurgery. Objective: To provide an optimized planning and operative strategy to perform a pallidothalamic tr...
Conference Paper
Background After 60 years of history in the field of functional neurosurgery, the issue of target coverage remains primordial and sub-optimally addressed and solved. The possibility of intraoperative visualization and monitoring of a selected target heated with MR-guided high intensity focused ultrasound (MRgFUS) offers new perspectives for safe an...
Article
Full-text available
Already in the late 1960s and early 1970s, targeting of the “posterior subthalamic area (PSA)” was explored by different functional neurosurgical groups applying the radiofrequency (RF) technique to treat patients suffering from essential tremor (ET). Recent advances in magnetic resonance (MR)-guided focused ultrasound (MRgFUS) technology offer the...
Article
Full-text available
Les récentes avancées de la technologie des ultrasons focalisés permettent depuis 2008 la réalisation de lésions cérébrales thérapeutiques sans incision avec une précision et une sécurité jamais atteintes par les techniques stéréotaxiques avec pénétration cérébrale. Elle permet actuellement de proposer aux patients atteints de tremblement essentiel...
Article
Full-text available
Die neuen Entwicklungen der intrakraniellen fokussierten Ultraschalltechnologie erlauben seit 2008 die Durchführung von therapeutischen, inzisionslosen Eingriffen am Gehirn mit einer Präzision und Sicherheit, die durch stereotaktische Methoden mit Penetration des Gehirns niemals erreicht werden konnten. Sie bietet Patienten, die unter chronischen u...
Chapter
Full-text available
La technologie des ultrasons focalisés guidés par IRM permet la réalisation de lésions cérébrales thérapeutiques sans incision avec une précision et une sécu-rité jamais atteintes par les techniques stéréotaxiques avec pénétration. Elle permet actuellement de proposer aux patients atteints de tremblement essen-tiel, de la maladie de Parkinson ou de...
Article
Full-text available
The human insula has been the focus of great attention in last decade due to substantial progress in neuroimaging methodology and applications. Anatomical support for functional localization and interpretations, however, is still fragmented. The aim of the present study was to re-examine the microanatomical organization of the insula and relate cyt...
Article
Full-text available
The insula of Reil represents a large cortical territory buried in the depth of the lateral sulcus and subdivided into 3 major cytoarchitectonic domains: agranular, dysgranular, and granular. The present study aimed at reinvestigating the architectonic organization of the monkey's insula using multiple immunohistochemical stainings (parvalbumin, PV...
Article
Subdural hematomas (SDH) are associated with an increased morbidity and mortality and generally occur as chronic SDH among older patients. The most frequent signs and symptoms - like headache, alteration of consciousness, gait impairment and hemiparesis - are also prevalent among other diseases, which has to be taken into account in the differentia...
Article
Full-text available
Anatomical knowledge of the structures to be targeted and of the circuitry involved is crucial in stereotactic functional neurosurgery. The present study was undertaken in the context of surgical treatment of motor disorders such as essential tremor (ET) and Parkinson's disease (PD) to precisely determine the course and three-dimensional stereotact...
Article
Full-text available
The over-inhibition of thalamic relay cells by hyperactivity of the internal part of the globus pallidus is a cornerstone of the parkinsonian pathophysiology that leads to a distortion of the thalamocortical dynamics called thalamocortical dysrhythmia (TCD). Here, we present the results of the stereotactic pallidothalamic tractotomy (PTT), which in...

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