Maoqing Wang

Maoqing Wang
Harbin Medical University | HMU · Department of Nutrition and Food Hygiene

Ph.D

About

69
Publications
16,240
Reads
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Introduction
Maoqing Wang, Professor, Ph.D. currently works at the Department of Nutrition and Food Hygiene, Harbin Medical University. I was awarded the 2013 BioMed Centrals Best Paper Award by the first author for my paper on calcium deficiency metabolomics published in the BMC Med.From April 2015 in the Genetics Department of the Stanford University School of Medicine in the United States, engaged in individualized integrated multiomics research (iPOP).
Additional affiliations
September 2013 - present
Harbin Medical University
Position
  • Professor (Associate)
July 2010 - September 2013
Harbin Medical University
Position
  • Instructor
July 2008 - September 2010
Harbin Medical University
Position
  • Research Assistant
Education
September 2010 - June 2013
Harbin Medical University
Field of study
  • Nutrion and Food Hygiene
September 2005 - June 2008
Harbin Medical University
Field of study
  • Nutrion and Food Hygiene

Publications

Publications (69)
Article
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To explore the effect of the refining process on the compounds of soybean oil, three different refined grade soybean oils were detected by ultra performance liquid chromatography‐high‐definition mass spectrometry and chemometrics for finding the differential compounds. The results of PCA and PLS‐DA showed that three different refined grade soybean...
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Background To identify biomarkers of papillary thyroid carcinoma (PTC) and explore the possible pathogenic mechanism. Methods This study included five patients with PTC. Protein expression of cancer tissues and adjacent normal thyroid tissues from each patient were analyzed by TMT proteomics technology. Differentially expressed proteins were ident...
Preprint
Objective To identify the biomarkers of papillary thyroid carcinoma and explore the possible pathogenic mechanism. Methods The cancer tissues of 5 patients with papillary thyroid carcinoma and adjacent normal thyroid tissues were analyzed for protein expression by TMT proteomics technology. Differentially expressed proteins were screened and identi...
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Background: Non-communicable diseases have become a major threat to public health, with cardiovascular diseases (CVDs) and cancer being the top two causes of death each year. Objective: Our objective is to evaluate the balanced association between the effect of red and processed meat intake on the risk of death and the effect of physical activit...
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The associations between social isolation, loneliness and the risk of mortality from all causes, cardiovascular disease (CVD) and cancer are controversial. We systematically reviewed prospective studies on the association between social isolation, loneliness and mortality outcomes in adults aged 18 years or older, as well as studies on these relati...
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In this study, monoamine oxidase B (MAOB) was activated under pathological conditions, and was the novel source of cardiovascular reactive oxygen species (ROS). ROS-induced endothelial dysfunction results in sustained and chronic vascular inflammation, which is central to atherosclerotic diseases. However, whether MAOB regulates endothelial oxidati...
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Correction for 'Marginal zinc deficiency alters the heart proteome of rats' by Yongzhi Sun et al., Food Funct., 2023, https://doi.org/10.1039/d2fo03815c.
Article
Zinc deficiency is closely related to cardiovascular diseases (CVDs), but the effects of marginal zinc deficiency (MZD) after birth on the heart are unknown. In this study, 4-week-old male rats were fed a low zinc diet (10 mg kg-1, 1/3 recommended nutrient intake, RNI) for 8 weeks. Echocardiography and histopathology were performed to assess the fu...
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Objective To estimate the global burden of type 2 diabetes in adolescents and young adults (aged 15-39 years) from 1990 to 2019. Design Systematic analysis. Data source Global Burden of Disease Study 2019. Participants aged 15-39 years from 204 countries and territories, 1990-2019. Main outcomes measures Age standardised incidence rate, age stan...
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During the coronavirus disease 2019 (COVID-19) pandemic and continuing emergence of viral mutants, there has been a lack of effective treatment methods. Zinc maintains immune function, with direct and indirect antiviral activities. Zinc nutritional status is a critical factor in antiviral immune responses. Importantly, COVID-19 and zinc deficiency...
Preprint
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Background We aimed to assess the associations between social isolation (SI) and the risk of mortality from all causes, cardiovascular disease, and cancer. Methods This was a systematic review and meta-analysis of prospective cohort studies.We searched electronic databases, including PubMed, Web of Science, and Embase, from inception until October...
Article
Zinc deficiency during pregnancy and severe zinc deficiency after birth both impaired learning and memory ability, but the effects of marginal zinc deficiency (MZD) after birth on learning and memory are unclear. In the first experiment, 4-week-old male rats were randomly divided into three groups: the marginal zinc-deficient group (MZG, 10 mg kg-1...
Preprint
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Background: DNA methylation, which has been demonstrated to be influenced by dietary factors, is associated with changes in breast cancer (BC) risk and clinicopathological features. Methods: A case-control study (271 newly diagnosed cases, 326 controls) was conducted to evaluate the effect of dietary factors and HS3ST2 methylation in peripheral blo...
Article
Evidence regarding the effect of isomaltulose on glycemic and insulinemic responses is still conflicting, which limits isomaltulose's application on glycemic management. The purpose of this study was to comprehensively evaluate its effectiveness and evidence quality. We systematically searched PubMed, Embase, and the Cochrane Library for randomized...
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Fatty acid amides (FAAs) are endogenous lipid molecules that exhibit various physiological activities. FAAs are usually present at nanomolar levels in biological samples. In this study, a method for the qualitative and quantitative determination of six FAAs (linoleamide, linoleoyl ethanolamide, oleoyl ethanolamide, palmitic amide, oleamide, and oct...
Preprint
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Background Zinc serves as a cofactor for over 10% of the human proteome, including transcription factors and enzymes, and maintains protein structure and function. This provides a strong evidence regarding the involvement of zinc in metabolic processes. Zinc deficiency is one of the most common nutrient deficiencies worldwide. Our objective was to...
Article
During osteoporosis, fat mass and obesity-associated protein (FTO) promotes the shift of bone marrow mesenchymal stem cells to adipocytes and represses osteoblast activity. However, the role and mechanisms of FTO on osteoclast formation and bone resorption remain unknown. In this study, we investigated the effect of FTO on RAW264.7 cells and bone m...
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采用超高效液相色谱-串联四级杆飞行时间质谱(UPLC/Q-TOF MS/MS)联用仪对花生油甲醇提取液分离检测,分析花生油成分,并通过二级质谱图和标准品确定物质。结果表明:正离子模式下检出86种化合物,鉴定30种物质,其中芥酸、棕榈酰胺、硬酯酰胺、油酸酰胺、11Z-二十二碳二烯酸为已知的花生油成分,亚油酰乙醇胺、亚油酰胺、鞘氨醇、N-油酰乙醇胺、十八碳四烯酸、顺-4-癸二酸等26种物质均为首次被检出;在负离子模式下,共检出27种化合物,鉴定15种物质,其中包括花生油中常见的7种脂肪酸,首次检出(Z)-13-氧-9-十八烯酸、蓖麻油酸、烯油酸、13-羟基十八酸和2(R)-羟基海藻酸5种脂肪酸和其他3种物质。
Article
Background Zinc deficiency is a worldwide public health problem. Currently, there are no established biomarkers available for the accurate diagnosis of zinc-deficiency in individuals. Additionally, a comprehensive view of the adverse effects of zinc deficiency is lacking. Our aim was to identify superior biomarkers of zinc deficiency and uncover th...
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Alzheimer’s disease (AD) is an aging-related neurodegenerative disease. We aimed to investigate the metabolic mechanisms of aging and AD and to identify potential biomarkers for the early screening of AD in a natural aging population. To analyze the plasma metabolites related to aging, we conducted an untargeted metabolomics analysis using ultra-hi...
Article
Background & Aims Although high-fat diet (HFD) could impact the composition of fecal microbiome and their metabolites, it is still largely unknown which fecal bacteria and metabolites are relatively important in responding to the HFD. This study aimed to identify the crucial fecal bacteria and metabolites in the HFD mice using a microbial-metabolit...
Article
The health effect of dietary fat has been one of the most vexing issues in the field of nutrition. Few animal studies have examined the impact of high-fat diets on lifespan by controlling energy intake. In this study, we found that compared to a normal diet, an isocaloric moderately high-fat diet (IHF) significantly prolonged lifespan by decreasing...
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Alcohol is commonly consumed around mealtimes. This study hypothesized that the association between alcohol and hypertension was influenced by overall diet quality. This study aims to test the hypothesis that overall diet quality influenced associations between alcohol and risk of hypertension across different ethnicities. Using nationally represen...
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Background We previously identified the urinary biomarkers to diagnose calcium deficiency and nutritional rickets by ultra-performance liquid chromatography/quadrupole time-of-flight tandem mass spectrometry (UPLC/Q-TOF MS/MS). To find biomarkers of calcium deficiency and further confirm these biomarkers in serum, we performed serum metabolomics an...
Article
Fried foods have potential adverse effects on health. However, the compounds produced during the process of frying in different vegetable oils are unknown. In this work, ultra performance liquid chromatography (UPLC), quadrupole time-of-flight mass spectrometry (Q-TOF MSMS) and chemical pattern recognition analysis was first conducted to analyze th...
Article
Previous randomised controlled trials have shown the controversial effectiveness of oral vitamin D supplementation in preventing osteoporotic fractures. PubMed, EMBASE and Cochrane Library electronic databases were searched. Pairwise meta-analysis, Bayesian network meta-analysis and meta-regression were applied. A total of 33 studies containing 83,...
Preprint
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Background and Aims: Alzheimer’s disease (AD) is an aging-related neurodegenerative disease. The current diagnosis of AD may fail to identify a substantial number of asymptomatic individuals who will progress to AD. We aimed to investigate the metabolic mechanisms of aging and AD and to identify potential biomarkers for the early screening of AD in...
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Purpose Numerous metabolomics studies have been conducted to detect the metabolic mechanisms and biomarkers related to gastric cancer and colorectal cancer. Because of the common metabolic features between gastric cancer and colorectal cancer, a differential diagnosis is difficult. Here, we performed a systematic review and meta-analysis to identif...
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Background: Colorectal cancer (CRC) is the result of complex interactions between the tumor's molecular profile and metabolites produced by its microenvironment. Despite recent studies identifying CRC molecular subtypes, a metabolite classification system is still lacking. We aimed to explore the distinct phenotypes and subtypes of CRC at the metab...
Preprint
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(1) Background Zinc deficiency decreases bone mineral density (BMD), but it is not known whether decreased BMD is a result of altered calcium absorption, excretion, and/or tissue distribution. To identified the associations between zinc deficiency, calcium metabolism and decreased BMD. (2) Methods we performed two zinc deficiency experiments. In...
Preprint
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Background We previously identified the urinary biomarkers to diagnose calcium deficiency and nutritional rickets by ultra-performance liquid chromatography/quadrupole time-of-flight tandem mass spectrometry (UPLC/Q-TOF MS/MS).To further confirm these biomarkers in vivo, we performed serum metabolomics analysis of calcium deficiency. Methods A calc...
Article
Evidences for the personalized use of nonsteroidal anti-inflammatory drugs (NSAIDs) in colorectal cancer (CRC) prevention and treatment that include consideration of prostaglandin E2 levels are necessary. This study was designed as a case-control study including 60 CRC patients and 120 cancer-free controls. A sensitive empirical method, precolumn d...
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Background: Zinc deficiency can change the concentrations of minerals and trace elements in the body. However, previous studies still had many limitations. Objective: To reveal the effects of zinc deficiency on homeostasis of 16 minerals and trace elements. Methods: Forty-five rats were divided randomly into three groups: normal zinc diet (30...
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195 · 人类消化道中存在大量的微生物, 被统称为肠道微生 物组, 通常称为肠道菌群。营养是机体摄取食物, 经过消 化、 吸收、 代谢和排泄, 利用食物中的营养素和其他对身体 有益的成分满足自身生理需要的过程。从营养的概念可 知, 肠道是机体获得营养的主要场所, 因此, 肠道菌群与人 体营养之间必定存在密不可分的关系。 肠道菌群的组成和活动, 从宿主出生开始主要受宿主 基因、 营养和生活方式的影响, 并与宿主共同存在和发展 的。肠道菌群不仅参与一些营养素的消化、 吸收和合成, 例 如利用蛋白质残渣合成必需氨基酸、 苯丙氨酸和苏氨酸等; 也参与宿主多个代谢通路, 进而影响宿主的身体健康。因 此, 详细了解肠道菌群与人体营养和健康相互关系和作用, 是将来合理调整肠道菌群, 并针对性地提出膳食干...
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Background: The aims of the current study were to assess the nutritional status of 25OHD3 and retinol in a northern Chinese population using our established reliable method for the simultaneous determination of serum 25OHD3 and retinol. Method: We established a reliable method for the simultaneous determination of 25OHD3 and retinol using SPE an...
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Background: In children with Henoch-Schonlein purpura (HSP), the severity of Henoch-Schonlein purpura nephritis (HSPN) is considered responsible for the prognosis of HSP. The pathological process from HSP to HSPN is not clear yet and current diagnostic tools have shortcomings in accurate diagnosis of HSPN. This study aims to assess clinical charac...
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Background: Early detection and diagnosis are very important for autism. Current diagnosis of autism relies mainly on some observational questionnaires and interview tools that may involve a great variability. We performed a metabolomics analysis of serum to identify potential biomarkers for the early diagnosis and clinical evaluation of autism....
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The study was to assess the long-term toxic effects of acetochlor on rats. Two different doses (42.96 and 107.4. mg/kg. body. weight/day) of acetochlor were administered to Wistar rats through their food for over 24. weeks. Rat urine samples were collected at two time-points for the measurements of the metabonomics profiles with ultra-performance l...
Article
This paper was designed to study metabolomic characters of the high-fat diet (HFD)-induced hyperlipemia and the intervention effects of Mangiferin (MG). In this study, we aimed to investigate the intervention of MG on rats with hyperlipemia induced by HFD and explore the possible mechanisms of hyperlipemia. Urine metabolic profiles were analyzed us...
Article
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Alzheimer disease (AD) can be diagnosed by clinical and neuropsychologic tests and at autopsy, but there are no simple effective diagnostic methods for detecting biomarkers in patients at early stages of cognitive impairment. Early metabolic alterations that may facilitate AD diagnosis have not been thoroughly explored. We applied a nontargeted met...
Article
Full-text available
Nutritional rickets is a worldwide public health problem; however, the current diagnostic methods retain shortcomings for accurate diagnosis of nutritional rickets. To identify urinary biomarkers associated with nutritional rickets and establish a noninvasive diagnosis method, urinary metabonomics analysis by ultra performance liquid chromatography...
Article
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Background: Isolated postchallenge diabetes (IPD), a subtype of type 2 diabetes mellitus (T2DM) defined as 2-h postprandial plasma glucose ≥ 200 mg/dL (≥ 11.1 mmol/L) and fasting plasma glucose (FPG) <108 mg/dL (<6.0 mmol/L), is often overlooked during screening for diabetes on the basis of FPG concentrations. A key challenge is early identificati...
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Background Calcium deficiency is a global public-health problem. Although the initial stage of calcium deficiency can lead to metabolic alterations or potential pathological changes, calcium deficiency is difficult to diagnose accurately. Moreover, the details of the molecular mechanism of calcium deficiency remain somewhat elusive. To accurately a...
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To study the toxic effect of chronic exposure to 3-chloro-1,2-propanediol (3-MCPD) at low doses, a metabonomics approach based on ultrahigh-performance liquid chromatography and quadruple time-of-flight mass spectrometry (UPLC-Q-TOF-MS) was performed. Two different doses of 3-MCPD (1.1 and 5.5mg/kg bw/d) were administered to Wistar rats for 120 day...
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Background Lipoprotein lipase (LPL) and serum 25-hydroxyvitamin D [25(OH)D] play important roles in the regulation of lipid metabolism. Although dyslipidemia is associated with insulin resistance (IR) and type 2 diabetes (T2D), there are limited data available regarding the relationship of LPL and 25(OH)D to IR and T2D at a population level. The ob...
Article
Recent studies have shown that glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme for the pentose phosphate pathway, was involved in insulin resistance via reduced nicotinamide adenine dinucleotide phosphate, while the roles of pentose were not examined. In the present study, the association of G6PD, pentose, and pentosidine with in...
Article
Single-walled carbon nanotubes (SWCNTs)/poly (Evans blue)(poly-EB) film-modified glassy carbon (GC) electrodes were fabricated for the voltammetric determination of rutin and puerarin in teas and pharmaceutical preparations. The SWCNTs/poly-EB film-modified electrode showed excellent electrocatalytic activity towards the oxidation of rutin and puer...
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Mangiferin, an active component of traditional Chinese herbal medicine, although it is reported to have various pharmacological effects, the limited number of pharmacokinetic studies limit its wide application. To evaluate the pharmacokinetics of mangiferin in human, a sensitive high performance liquid chromatography–mass spectrometry (HPLC–MS) met...
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The purpose of the current study was to assess the effects of long-term exposure to low levels of DDVP on the biochemical parameters and metabolic profiles of rats. Three different doses (2.4, 7.2, and 21.6 mg/kg body weight/day) of DDVP were administered to rats through their drinking water over 24 weeks. Significant changes in blood cholinesteras...
Article
A novel electrochemical DNA biosensor for the detection of adenovirus specific DNA sequence is presented in this paper. Dimercapto succinic acid was self-assembled on gold electrode surface and amino group ended single-strand DNA (NH2-ssDNA) probe was immobilized covalently to carboxylic group of dimercapto succinic acid monolayer in the presence o...
Article
Polyluminol/single-walled carbon nanotube (SWCNT) composite film-modified glassy carbon (GC) electrodes were successfully used for simultaneous determination of propyl gallate (PG) and ascorbic acid (Vc). The polyluminol/SWCNT composite films were characterized by scanning electron microscopy and cyclic voltammetry. The composite film-modified elec...
Article
The interaction of probenecid and aniline blue was characterized by resonance light-scattering (RLS) measurement. Thereby, a new method for the determination of probenecid with high sensitivity and electivity by using resonance light-scattering technique was developed. At pH 0.6-1.2, probenecid reacted with aniline blue to form an ionassociation co...
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DNA biosensors were prepared by electrodepositing platinum nanoparticles (Pt-nano) on the surface of a glassy carbon electrode (GCE). A 19-mer ssDNA of promoter 35S, which was specific to most inserted sequences in genetically modified food, was immobilized on the Pt nanoparticle-deposited GC electrode. The morphology of the surface of Pt nanoparti...
Article
A layer-by-layer (LbL) thin film composed of poly(ethyleneimine) (PEI) and carboxymethyl cellulose (CMC) was prepared on the surface of a gold (Au) disk electrode and the LbL layer was impregnated with hemin to fabricate amperometric hydrogen peroxide (H2O2) sensors. Hemin can be easily immobilized in the LbL layer by immersing the LbL film-coated...
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DNA biosensors were prepared using platinum (Pt) nanoparticles that are electrochemically deposited on the surface of a glassy carbon (GC) electrode. The morphology of the surface of Pt nanoparticle-deposited GC electrodes was investigated with a scanning electron microscope (SEM). A cyclic voltammetry (CV) was also used for evaluating electrochemi...
Article
Hemin-confined thin films composed of poly(ethyleneimine) (PEI) and carboxymethylcellulose (CMC) were fabricated by layer-by-layer (LbL) deposition on the surface of a glassy carbon (GC) electrode for the detection of hydrogen peroxide (H2O2). Hemin could be easily immobilized in LbL films by immersing an LbL-film-modified electrode in hemin soluti...
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Bismuth film-modified gold (Au) electrodes were prepared by an ex-situ and in-situ plating for the simultaneous determination of a trace level of lead (Pb2+) and cadmium (Cd2+) ions by anodic stripping voltammetry. The effects of several key operational parameters in the electrochemical deposition of Bi3+ ion on a Au substrate, such as the concentr...

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