Manuel Revilla

Manuel Revilla
Hendrix Genetics | HENDRIXGEN

PhD in Animal Breeding

About

65
Publications
6,421
Reads
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766
Citations
Additional affiliations
June 2020 - present
Hendrix Genetics
Position
  • Geneticist
September 2017 - May 2020
French National Institute for Agriculture, Food, and Environment (INRAE)
Position
  • PostDoc Position
September 2016 - December 2016
French National Institute for Agriculture, Food, and Environment (INRAE)
Position
  • PhD Student
Description
  • Fellowship Award: Erasmus+ Internship Program
Education
March 2014 - June 2017
October 2011 - July 2013
Polytechnic University of Valencia
Field of study
  • Animal breeding and Reproduction Biotechnology
October 2011 - July 2013
Autonomous University of Barcelona
Field of study
  • Animal breeding and Reproduction Biotechnology

Publications

Publications (65)
Article
Full-text available
Copy number variations (CNVs) are important genetic variants complementary to SNPs, and can be considered as biomarkers for some economically important traits in domestic animals. In the present study, a genomic analysis of porcine CNVs based on next-generation sequencing data was carried out to identify CNVs segregating in an Iberian x Landrace ba...
Article
Full-text available
Fat content and fatty acid composition in swine are becoming increasingly studied because of their effect on sensory and nutritional quality of meat. A QTL (quantitative trait locus) for fatty acid composition in backfat was previously detected on porcine chromosome 8 (SSC8) in an Iberian x Landrace F2 intercross. More recently, a genome-wide assoc...
Article
Full-text available
In the present study, liver co-expression networks and expression Genome Wide Association Study (eGWAS) were performed to identify DNA variants and molecular pathways implicated in the functional regulatory mechanisms of meat quality traits in pigs. With this purpose, the liver mRNA expression of 44 candidates genes related with lipid metabolism wa...
Article
Full-text available
The aim of this work is to better understand the genetic mechanisms determining two complex traits affecting porcine meat quality: intramuscular fat (IMF) content and its fatty acid (FA) composition. With this purpose, expression Genome-Wide Association Study (eGWAS) of 45 lipid-related genes associated with meat quality traits in swine muscle (Lon...
Article
APOA2 is a protein implicated in triglyceride, fatty acid and glucose metabolism. In pigs, the APOA2 gene is located on pig chromosome 4 (SSC4) in a QTL region affecting fatty acid composition, fatness and growth traits. In this study, we evaluated APOA2 as a candidate gene for meat quality traits in an Iberian × Landrace backcross population. The...
Article
Full-text available
Background: Resilience can be defined as the capacity of animals to cope with short-term perturbations in their environment and return rapidly to their pre-challenge status. In a perspective of precision livestock farming, it is key to create informative indicators for general resilience and therefore incorporate this concept in breeding goals. In...
Article
Full-text available
A dataset of 100 pigs, from the Piétrain NN Français line raised at the AXIOM boar testing station in 2020, was used. The farm was equipped with an automatic feeding system, recording individual weight and feed intake at each visit.We used a dynamic linear regressionmodel to characterise the evolution of the energetic allocation factor (at) which r...
Article
Full-text available
Background The impact of individual genetic and genomic variations on immune responses is an emerging lever investigated in vaccination strategies. In our study, we used genetic and pre-vaccination blood transcriptomic data to study vaccine effectiveness in pigs. Results A cohort of 182 Large White pigs was vaccinated against Mycoplasma hyopneumon...
Preprint
Full-text available
Background Resilience can be defined as the capacity of animals to cope with short-term perturbations in their environment and return rapidly to their pre-challenge status. In a perspective of precision livestock farming, it is key to create informative indicators for general resilience and therefore incorporate this concept in breeding goals. In t...
Article
Full-text available
Meat quality has an important genetic component and can be modified by the fatty acid (FA) composition and the amount of fat contained in adipose tissue and muscle. The present study aimed to find genomic regions associated with the FA composition in backfat and muscle (longissimus dorsi) in 439 pigs with three different genetic backgrounds but hav...
Article
Full-text available
The selection in commercial swine breeds for meat-production efficiency has been increasing among the past decades, reducing the intramuscular fat content, which has changed the sensorial and technological properties of pork. Through processes of natural adaptation and selective breeding, the accumulation of mutations has driven the genetic diverge...
Article
Full-text available
The gut microbiota has been evolving with its host along the time creating a symbiotic relationship. In this study, we assess the role of the host genome in the modulation of the microbiota composition in pigs. Gut microbiota compositions were estimated through sequencing the V3-V4 region of the 16S rRNA gene from rectal contents of 285 pigs. A tot...
Article
Full-text available
Weaning is a critical transition phase in swine production in which piglets must cope with different stressors that may affect their health. During this period, the prophylactic use of antibiotics is still frequent to limit piglet morbidity, which raises both economic and public health concerns such as the appearance of antimicrobial-resistant micr...
Preprint
Weaning is a critical transition phase in swine production in which piglets must cope with different stressors that may affect their health. During this period, the prophylactic use of antibiotics is still frequent to limit piglet morbidity, which raises both economic and public health concerns such as the appearance of antimicrobial-resistant micr...
Article
Full-text available
In addition to its value in meat production, the pig is an interesting animal model for human digestive tract studies due to its physiological similarities. The aim of this study was to describe the microbiome composition, distribution and interaction along the Iberian pig intestinal tract and its role in whole-body energy homeostasis. The V3-V4 re...
Article
Full-text available
The aim of this work was to study the genetic basis of the backfat expression of lipid-related genes associated with meat quality traits in pigs. We performed a genome-wide association study with the backfat gene expression measured in 44 genes by qPCR and the PorcineSNP60 BeadChip genotypes in 115 Iberian x Landrace backcross animals. A total of 1...
Article
Full-text available
This study aims identifying candidate genes and pathways associated with feed efficiency (FE) in pigs. Liver and duodenum transcriptomes of 37 gilts showing high and low residual feed intake (RFI) were analysed by RNA-Seq. Gene expression data was explored through differential expression (DE) and weighted gene co-expression network analyses. DE ana...
Article
The FABP4 and FABP5 genes, coding for fatty acid transport proteins, have long been studied as positional candidate genes for SSC4 QTL affecting fat deposition and composition traits in pigs. Polymorphisms in these genes, FABP4:g.2634_2635insC and FABP5:g.3000T>G, have previously been associated with fatness traits in an Iberian by Landrace cross (...
Data
Analysis by qPCR of CNVR112 (GPAT2). The y-axis represents the RQ quantitative measurement by qPCR for each sample and the x-axis shows the different samples. The baseline represents the calibrator. (TIFF)
Data
Analysis by qPCR of CNVR157 (CLCA4). The y-axis represents the RQ quantitative measurement by qPCR for each sample and the x-axis shows the different samples. The baseline represents the calibrator. (TIFF)
Data
Analysis by qPCR of CNVR298 (MOGAT2). The y-axis represents the RQ quantitative measurement by qPCR for each sample and the x-axis shows the different samples. The baseline represents the calibrator. (TIFF)
Data
Primers used for qPCR assays. (XLSX)
Data
Pathway analysis of genes identified in CNVRs. (XLSX)
Data
Analysis by qPCR of CNVR447 (PRKG1). The y-axis represents the RQ quantitative measurement by qPCR for each sample and the x-axis shows the different samples. The baseline represents the calibrator. (TIFF)
Data
Information of 540 identified CNVRs and gene annotation within the CNVRs retrieved from the Ensembl Genes 84 Database using the Biomart data management system. (XLSX)
Data
Duplication and deletion calls predicted by Control-FREEC software from all seven pigs. (XLSX)
Data
Association analysis between CNVRs and different phenotypic records in BC1_LD animals. (XLSX)
Article
Copy number variations (CNVs) are important genetic variants complementary to SNPs, and can be considered as biomarkers for some economically important traits in domestic animals. In the present study, a genomic analysis of porcine CNVs based on next-generation sequencing data was carried out to identify CNVs segregating in an Iberian x Landrace ba...
Article
Full-text available
Background In previous studies on an Iberian x Landrace cross, we have provided evidence that supported the porcine ELOVL6 gene as the major causative gene of the QTL on pig chromosome 8 for palmitic and palmitoleic acid contents in muscle and backfat. The single nucleotide polymorphism (SNP) ELOVL6:c.-533C > T located in the promoter region of ELO...
Article
Full-text available
Several QTLs have been identified for major economically relevant traits in livestock, such as growth and meat quality, revealing the complex genetic architecture of these traits. The use of network approaches considering the interactions of multiple molecules and traits provides useful insights into the molecular underpinnings of complex traits. H...

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