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Manuel Ramos-Kuri

Manuel Ramos-Kuri
Centro de Investigación en Bioética y Genética, Querétaro, México

PhD in Molecular Genetics

About

32
Publications
2,664
Reads
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726
Citations
Citations since 2016
3 Research Items
204 Citations
2016201720182019202020212022010203040
2016201720182019202020212022010203040
2016201720182019202020212022010203040
2016201720182019202020212022010203040
Additional affiliations
September 2010 - November 2015
Centro de Investigación Social Avanzada, Querétaro, México
Position
  • Researcher
June 2008 - September 2010
Mount Sinai Hospital
Position
  • PostDoc Position
June 2008 - August 2010
Icahn School of Medicine at Mount Sinai
Position
  • PostDoc Position
Education
January 1976 - December 1981
Universidad Nacional Autónoma de México
Field of study
  • Medical School

Publications

Publications (32)
Article
Full-text available
Highlights -. The Ras (Rat Sarcoma) gene family is a group of small G proteins -. Ras is regulated by growth factors and neurohormones affecting cardiomyocyte growth and hypertrophy -. Ras directly affects cardiomyocyte physiological and pathological hypertrophy -. Genetic alterations of Ras and its pathways result in various cardiac phenotypes? -...
Article
Un tema muy significativo en relación con la infertilidad son las altas expectativas de éxito que se crean las parejas cuando acuden a las clínicas de fertilidad para realizar procedimientos como la fertilización in vitro (FIVET), la inyección intracitoplásmica de esperma (ICSI) o la inseminación artificial. Los índices de éxito anunciados por las...
Article
Full-text available
The importance of the oncogene Ras in cardiac hypertrophy is well appreciated. The hypertrophic effects of the con-stitutively active mutant Ras-Val12 are revealed by clinical syndromes due to the Ras mutations and experimental studies. We examined the possible anti-hypertrophic effect of Ras inhibition in vitro using rat neonatal cardiomyocytes (N...
Article
Full-text available
The importance of the oncogene Ras in cardiac hypertrophy is well appreciated. The hypertrophic effects of the constitutively active mutant Ras-Val12 are revealed by clinical syndromes due to the Ras mutations and experimental studies. We examined the possible anti-hypertrophic effect of Ras inhibition in vitro using rat neonatal cardiomyocytes (NR...
Article
Se revisan los avances recientes en el síndrome de Down (SD), haciendo énfasis en su terapia molecular y potencial terapéutico en enfermedades como Alzheimer (EA) y otros trastornos de déficit cognoscitivo. El SD es la principal causa de retraso mental a nivel mundial, causado por la trisomía completa o parcial del cromosoma 21, y es bien conocida...
Article
Se revisan los avances recientes en el síndrome de Down (SD), haciendo énfasis en su terapia molecular y potencial terapéutico en enfermedades como Alzheimer (EA) y otros trastornos de déficit cognoscitivo. El SD es la principal causa de retraso mental a nivel mundial, causado por la trisomía completa o parcial del cromosoma 21, y es bien conocida...
Article
Full-text available
This review examines recent advances in knowledge about Down's Syndrome (DS), with emphasis on molecular therapy and its potential in the treatment of other disorders related with DS such as Alzheimer's Disease (AD) and cognitive impairment. The close relationship between DS and early onset AD is well-known. DS, for which there is no specific treat...
Article
Background and Aims Fabry's disease (FD) is an X-linked lysosomal disorder caused by a deficiency of the enzyme α-galactosidase A that produces accumulation of glycosphingolipids with clinical abnormalities of skin, eye, kidney, heart, brain, and peripheral nervous system. We undertook this study to describe the molecular characteristics of the fir...
Article
The objective of this study was to evaluate the genetic structure of Mexican Criollo cattle populations using microsatellite genetic markers. DNA samples were collected from 168 animals from four Mexican Criollo cattle populations, geographically isolated in remote areas of Sierra Madre Occidental (West Highlands). Also were included samples from t...
Article
The signaling pathways that control the life-death switch of a cell are of primary interest in modern biology. In this respect, NF-kappaB has emerged as a decisive transcription factor in the cell's response to apoptotic challenge and its effects on apoptosis have far-reaching consequences for normal development and/or homeostasis in many cells and...
Article
The signaling pathways that control the life-death switch of a cell are of primary interest in modern biology. In this respect, NF-κB has emerged as a decisive transcription factor in the cell's response to apoptotic challenge and its effects on apoptosis have far-reaching consequences for normal development and/or homeostasis in many cells and tis...
Article
Full-text available
Autonomic dysfunction is frequent in patients with fibromyalgia (FM). Heart rate variability analyses have demonstrated signs of ongoing sympathetic hyperactivity. Catecholamines are sympathetic neurotransmitters. Catechol-O-methyltransferase (COMT), an enzyme, is the major catecholamine-clearing pathway. There are several single-nucleotide polymor...
Article
Full-text available
The (CGG)n repeat size distribution in the FMR1 gene was studied in healthy individuals: 80 X chromosomes of Mexican Mestizos from Mexico City and 33 X chromosomes of Mexican Amerindians from three indigenous communities (Purepechas, Nahuas, and Tzeltales), along with alleles and haplotypes defined by two microsatellite polymorphic markers (DXS548...
Article
Full-text available
Background: Long QT syndromes (LQTS) are inherited cardiac disorders caused by mutations in the genes that encode sodium or potassium transmembrane ion channel proteins. More than 200 mutations, in at least six genes, have been found in these patients. The Jervell and Lange-Nielsen (JLN) syndrome is the recessive form of the disease and is associat...
Article
Full-text available
Nuclear factor kappaB (NF-kappaB) is a pleiotropic transcription factor implicated in the regulation of diverse morphologic cardiac alterations, for which the p50 and p65 subunits form the most prevalent dimeric form in the heart. NF-kappaB is inactivated by proteins of the IkappaB family, which trap it in the cytoplasm. It is not known whether NF-...
Article
Full-text available
Long QT syndromes (LQTS) are inherited cardiac disorders caused by mutations in the genes that encode sodium or potassium transmembrane ion channel proteins. More than 200 mutations, in at least six genes, have been found in these patients. The Jervell and Lange-Nielsen (JLN) syndrome is the recessive form of the disease and is associated with deaf...
Article
The sarcoglycan-sarcospan complex (alpha-, beta-, gamma-, delta-, epsilon-, and zeta-SG-SSPN), a component of the dystrophin-associated glycoprotein complex (DAGC), is located at the sarcolemma of muscle fibers where it contributes to maintain cell integrity during contraction-relaxation cycles; gamma- and delta-SG are also expressed in the sarcopl...
Article
Full-text available
Adeno-associated viruses (AAV) have unique properties, such as lack of parental agent pathogenicity and vector related cytotoxicity, minimal immunogenecity, and the capacity for stable long-term transgene expression which make them ideal vectors for gene transfer to the myocardium. Numerous serotypes of AAV have been identified with variable tropis...
Article
Full-text available
We describe the finding of two Mexican patients with a specific 27-bp deletion in the solute carrier family 4 gene (SLC4A1delta27) (also known as the band 3 gene found on chromosome 17q21-q22), characteristic of Southeast Asian ovalocytosis (SAO). The patients were asymptomatic, and the initial diagnosis was made by microscopic observation of the p...
Article
A Mexican population sample was obtained from the central region of the country, including five states. Two hundred and eleven individuals were PCR-typed for 15 STR loci with the AmpFiota STR Identifiler PCR amplification kit (Applied Biosystems). The following autosomal markers were analyzed: D8S1179, D21S11, D7S820, CSF1PO, D19S433, vWA, TPOX, D1...
Article
Full-text available
We describe the finding of two Mexican patients with a specific 27-bp deletion in the solute carrier family 4 gene (SLC4A1Δ27) (also known as the band 3 gene found on chromosome 17q21–q22), characteristic of Southeast Asian ovalocytosis (SAO). The patients were asymptomatic, and the initial diagnosis was made by microscopic observation of the prese...
Article
Full-text available
The main Creole pig population in Mexico, the hairless Mexican pig, remains as an unimproved and endangered genetic resource. In order to learn more about the genetic characteristics of this pig population, we assessed the allele frequency of 10 microsatellite loci in 177 unrelated hairless pigs from seven regions at Mexico and in 111 pigs of four...
Article
Full-text available
Apolipoprotein E (APOE) genotypes were determined in 75 Mazatecan Indians and 83 Mexican mestizos. APOE allele and genotype frequencies in Mazatecans and mestizos were similar, with high frequencies of the APOE*3 allele (0.900 and 0.915, respectively) and the E3/3 genotype (0.813 and 0.831, respectively) and an absence in both samples of the APOE*2...
Article
Using PCR-SSOP and sequencing, we examined DRB1*04 nucleotide polymorphism in 137 DR4-positive Mexican healthy individuals (46 Mexican Mestizos, 64 Mazatecans, and 27 Nahuas), carrying a total of 147 DR4 haplotypes. Eleven different DRB1*04 alleles were detected in Mexican Mestizo population, whereas, in the two Indian groups a restricted polymorph...
Article
Full-text available
To examine the genetic features of the long terminal repeat (LTR) derived from six HIV-1-infected individuals enrolled in the Mexico City Cohort, we cloned and sequenced a 505-bp fragment of the proviral LTR from their peripheral blood mononuclear cells (PBMCs). All patients harbored HIV-1 LTR quasispecies corresponding to the B subtype. Three pati...
Article
The first step of the herpes virus infection is the attachment to heparan sulfate molecules on the cellular membrane. In order to improve the characterization of this phenomenon, we compared the inhibitory effect of six sulfated polyelectrolytes (PE): heparin, heparan, low molecular weight heparin, chondroitin, dextran and protamine on plaque forma...
Article
To ascertain the reliability of serological diagnosis of neurocysticercosis in the everyday a priori situation of neurological consultation, the enzyme-linked immunosorbent assay test was used to predict the eventual diagnosis of neurocysticercosis in an unselected sample of 1064 consecutive neurological cases. Results showed 69% sensitivity and 71...
Article
• To ascertain the reliability of serological diagnosis of neurocysticercosis in the everyday a priori situation of neurological consultation, the enzyme-linked immunosorbent assay test was used to predict the eventual diagnosis of neurocysticercosis in an unselected sample of 1064 consecutive neurological cases. Results showed 69% sensitivity and...
Article
A bibliographic update on the herpes simplex virus (HSV) envelope is made with special emphasis on the membrane glycoproteins and their role in adsorption, spreading and escape of the immune response. The HSV has at least seven glycoproteins on its envelope; three out of them are essential for in vitro replication, they are designated as gB, gD and...
Article
Full-text available
The possible antiherpetic effect of three polyanions (heparin, chondroitin sulfate and dextran sulfate), as well as one polycation (protamine sulfate) was tested in vitro and in vivo against pseudorabies virus (Suid herpesvirus 1). The in vitro experiments revealed that heparin, dextran sulfate and protamine sulfate significantly reduced the number...

Questions

Questions (3)
Question
- The EndNote is making miss-abbreviations.
- Instead of write the full second name of all the authors,
suddenly it abbreviates some last name.
- For example, instead of say Hajjar RJ It appears HRJ....
- In the Library all last names and abbreviations are well written, but in most of the references appears one or two wrong abbreviations.
- I have corrected one by one, but it changes again to the wrong abbreviation.
- (Note: first I used the Mendeley program and it makes the same mistake)
Question
I need two H-Ras variants (Ras-Wild type and a Dominant Negative Ras) in Adeno Associated Virus.
Are there some commercial? Should I send construct them?Thanks a lot in advance.
Question
I received a few samples of isolated DNA from patients, but it is in FTA card.
HOW CAN I ISOLATE THE DNA FROM THE FTA PAPER for making DNA sequencing?
Should I follow the full protocol of Quiagen, Quiamp DNA mini kit? or the DNA IQ Kit of Promega?
I think that maybe with just washing with some buffer, because it is not a sample of blood, or saliva, etc. The first lab made a good extraction of DNA and send the DNA in the FTA card.
Thanks a lot!

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