
Manuel Prado-VelascoUniversity of Seville | US · Departamento de Ingeniería Gráfica
Manuel Prado-Velasco
Ph.D Industrial - Biomedical Engineering
Two major lines: In-silico M&S tool for Cyborgs (CybSim); Computer extended Descriptive Geometry for 3D systems (CeDG)
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80
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Introduction
Experience in research and development in biomedical engineering, energy generation and monitoring, computer processing and electronical design, both on private companies and University. Currently I am professor at the Department of Graphic Engineering of the University of Seville and research group leader at the Multiscale Modeling in bioengineering group.
Publications
Publications (80)
Boosted by health consequences and the cost of falls in the elderly, this work develops and tests a novel algorithm and methodology to detect human impacts that will act as triggers of a two-layer fall monitor. The two main requirements demanded by socio-healthcare providers-unobtrusiveness and reliability-defined the objectives of the research. We...
Persistent Developmental Stuttering affects 1-2% of the world adult population. Its etiology is still unkknown, although modern neuroimaging techniques have shown a new and exciting perspective of earlier ideas and hypotheses. However, it is now clear that a new approach to understand the true nature of the disorder is needed. We present a new etio...
The development of predictive engines based on pharmacokinetic-physiological mathematical models for personalised dosage recommendations is an immature field. Nevertheless, these models are extensively applied during the design of new drugs. This study presents new advances in this subject, through a stable population of patients who underwent kidn...
La geometría descriptiva y el modelado computacional de sistemas 3D han definido líneas separadas hasta hoy en día. La geometría descriptiva constituye un área científica importante que ha servido como base al dibujo técnico desde finales del siglo XIX hasta la actualidad. El modelado computacional de sistemas 3D está asociado a las herramientas de...
Introduction. CybSim is an open-source modelling and simulation software based on the experience and knowledge acquired through the design and development of PhysPK©. The latter emerged as a proprietary solution for modelling and simulation in the field of pharmaceutical industry that applies concepts of virtual prototyping based on the non - causa...
The Computer extended Descriptive Geometry (CeDG) is as a novel approach based on Descriptive Geometry to build 3D models within the framework provided by Dynamic Geometry Software tools. Parametric CeDG models can be interactively explored when continuous parameters change, but this is not the case for discrete
parameters. This study demonstrates...
Computer extended Descriptive Geometry (CeDG) technique has demonstrated its ability to build parametric computational models of 3D systems supported by Descriptive Geometry procedures in previous studies. When a parameter causes a non-continuous and qualitative change in the 3D model, it requires an additional logic. The treatment of visibility is...
Computer-extended Descriptive Geometry (CeDG) is a new approach to solving and building computer models of three-dimensional (3D) geometrical systems through descriptive geometry procedures (thus inheriting invariant-symmetry properties from projective geometry) that have demonstrated reliability and accuracy. CeDG may calculate a parametric implic...
Computer extended Descriptive Geometry (CeDG) is a new approach to solve and build computer models of three dimensional (3D) geometrical systems through descriptive geometry procedures that have demonstrated reliability and accuracy. CeDG may calculate a parametric algebraic exact form for the spatial curves generated in the intersection of two sur...
Computer Extended Descriptive Geometry (CeDG) is a new approach to computer modelling of 3D geometric systems that tries to overcome several limitations of current CAD systems. A preliminary version of CeDG for GeoGebra has demonstrated advantages in sheet metal and mechanisms field. This paper develops the theoretical basis of the Locus-based Surf...
Each year, infections caused around the 25% of neonatal deaths. Early empirical treatments help to reduce this mortality, although optimized dosing regimens are still lacking. The aims were to develop and validate a gentamicin physiologically-based pharmacokinetic (PBPK) model and then potentially explore dosing regimens in neonates using pharmacok...
There is a lack of Modeling and Simulation software systems in the bioscience arena that give both solutions compliant with current methodologies in drug discovery (pharmaceutic) and precision medicine (healthcare) fields, besides to support the addition of new biological mechanisms under a multilevel and multiformalism perspective, without penalize...
The emergence of computer-aided design (CAD) has propelled the evolution of the sheet metal engineering field. Sheet metal design software tools include parameters associated to the part’s forming process during the pattern drawing calculation. Current methods avoid the calculation of a first pattern drawing of the flattened part’s neutral surface,...
We present a Computer Extended Descriptive Geometry (CeDG) approach for modelling spatial geometric systems that surpasses several CAD limitations. A first concept proof has shown that the CeDG can be implemented on the dynamic geometry software (DGS) paradigm to generate parametric models based on descriptive geometric techniques. The reliability...
Unpublished and academic exercise - This is an unpublished academic exercise, without any type of peer review and any conclusion is merely speculative.
Abstract - In this exercise a very simplistic network based analysis is used for the estimation of an upper bound of the maximum total number of SARS-CoV2 infections in a country or location, cons...
Background and objective:
The aims of this study are (i) to assess the predictive reliability of the physiologically based software PhysPK versus the well-known population approach software NONMEM for the cited semi-mechanistic PK model, (ii) to determine whether these modelling approaches are interchangeable and (iii) to compare acausal with caus...
According to FDA and EMEA bioavailability means the rate and extent to which the active substance or active moiety is absorbed from a pharmaceutical form, and becomes available at the site of action [1]. Due to the difficulty of evaluation, the rate and amount of the active substance delivered to the systemic circulation are accepted as surrogate i...
Introduction and objectives
According EMEA bioavailability means the rate and extent to which the active substance or active moiety is absorbed from a pharmaceutical form, and becomes available at the site of action. This definition support different metrics of the bioavailability, according rate or amount of drug and absolute or relative values. B...
There are hardly customized posology programs that can be used in clinical scenarios to optimize and monitor doses and administration times of drugs for patients with special requirements. However, PK / PD models have shown success in monitoring and description of distribution and elimination of drugs in clinical trials during drug development, as...
A brief description of PhysPK software for modeling, simulation and optimization in pharmacokinetics and physiolology is presented. This is followed by a case study focused to the generation of an autonomous software application to compute the optimal and personalized posology of tacrolimus in clinical scenarios, using PhysPK. It is described the b...
Reusability and multilevel modelling have been successfully tested in PhysPK/EcosimPro through the development of a PBPK model for MTX and 6-MP. This software tool combines a non-algorithmic and object-oriented modelling methodology with a three-layer specialized biomedical modelling architecture to fill the gap between current open and specialized...
Se ha desarrollado un nuevo sistema de modelado fisiológico, PhysPK/EcosimPro, compatible con las principales metodologías PBPK/PK/PD, pero con un alcance funcional mayor, y con una gran flexibilidad y usabilidad para el usuario final. Su diseño facilita la incorporación de nuevos mecanismos fisiológicos, así como la conexión con sistemas externos...
The intrinsic characteristics of physiological systems demand two critical requirements at the time of mathematical modeling: multilevel description and reusability. These features are not properly satisfied by current methodologies. In this paper the design of a multilevel and reusable methodology for modeling pharmacokinetic-physiological systems...
Renal replacement therapies keep the same principles that guided the first dialysis session performed by Kolff in 1943 over a human patient. Despite the interest to build an artificial kidney that replicate better the complex dynamics of the human kidneys, this task is still very immature. However, therapies based on artificial kidneys could improv...
Hemodialysis quantification has been the focus of intensive research since the discovery that urea clearance is related to survival of patients with End Stage Renal Disease (ESRD) submitted to hemodialysis, at the beginning of 80's. Sadly, efforts do not seem to have thrown light to that relationship yet. In the road, clinicians have learned that K...
Falls and accidents associated with physical activities are a serious problem in the elderly and people with disabilities. They induce injuries, hospital inputs, and even dead. Their consequences include psychological effects and finally loss of personal autonomy and dependence. Wearable and ubiquitous devices with ability to detect such risk event...
In Physical risk events like falls are a serious problem in the elderly and population with chronic pathologies. However, no falling detector has achieved wide acceptance by socio-healthcare providers yet.
In this paper we advance preliminary results related to the methodology and design of communications in a new Accelerometric Smart Sensor (SAS),...
Falls are a serious and growing problem in the elderly and other population with chronic pathologies. However, none falling detector has been widely accepted by socio-healthcare providers yet. This work analyzes this issue and moves forward a new paradigm that hybridizes system biology with e-health domains. We present succinctly the technology and...
Diabetes mellitus (DM) has a growing incidence and prevalence in modern societies, pushed by the aging and change of life styles. Despite the huge resources dedicated to improve their quality of life, mortality and morbidity rates, these are still very poor. In this work, DM pathology is revised from clinical and metabolic points of view, as well a...
Diabetes Mellitus has a growing incidence and prevalence in modern societies, pushed by the aging and change of life styles.
Despite the huge resources dedicated to improve the quality of life, mortality and morbidity rates, these are still very poor.
This work presents a succinct description of metabolism mechanisms involved in DM under a multilev...
Sistema de adquisición y control de señales biomédicas basado en un núcleo con licencia GPL: aplicación al estudio de un sistema farmacocinético mediante conductimetría Resumen Los sistemas de control y adquisición de señales analógicas y digitales (SCADA) han evolucionado durante décadas de aplicación en los diferentes dominios de la ingeniería de...
There is an increasing need of solutions for the well-being of citizens within a current scenario featured by the aging of population, growth of chronic pathologies, higher demand of healthcare, and change of social models. Despite the proved reliability of ICT to provide efficient solutions to e-health, their diffusion is still very scarce.
This w...
Despite the intense research in the last decade with the aim of developing a reliable solution for fall detection in the elderly and other risk populations, it can be asserted that the diffusion of fall detectors in the geriatric practice is near null. This scenario is similar to the very scarce use of telemedicine in healthcare. The present work b...
In health systems, there has been an emergence of new types of data and new technologies that allow continuously monitoring the status of the patients and make easy the achievement of real time information. The storage of all the acquired information makes possible to identify trends in medical data by means of new Clinical Decision Support subsyst...
Emerging concepts in renal replacement therapies such as daily hemodialysis (HD) and wearable artificial kidney (WAK) meet the challenges derived from the aging of renal disease population. The successful results of blood recirculation to improve the dialysis clearance of medium-high uremic toxins suggest that this technique could be used both in d...
Despite first written references to permanent developmental stuttering occurred more than 2500 years ago, the mechanisms underlying this disorder are still unknown. This paper briefly reviews stuttering causal hypothesis and treatments, and presents the requirements that a new stuttering therapeutic device should verify. As a result of the analysis...
Despite first references to stuttering appear in ancient Egyptian and China civilizations, the mechanisms underlying Permanent Developmental Stuttering remains unknown. This paper reviews concisely the causal hypothesis and treatments of stuttering, and presents the specifications that a stuttering therapeutic device should verify in the light of t...
We have performed a cross-sectional clinical study with near 100 stable End Stage Renal Disease (ESRD) patients submitted to thrice-weekly hemodialysis with the aim of comparing 16 relevant blood-side methods for measuring the hemodialysis dose (Kt/V) from a double perspective: patient and dialyzer. The study pursues both providing better clinical...
Several important problems in the majority of countries are challenging the centralized and overburdened current model of healthcare. Telehealthcare is presented as a new paradigm that offers high expectations to solve this picture. In this paper we present the major outcomes of the viability study of a novel personalized telehealthcare system for...
A computer simulation model is an abstract entity that describes the dynamics behavior of a target system. It can be designed according to different modeling methodologies and implemented in a computer by means of a programming language. Many specific programming languages have been developed to facilitate this implementation. These are formally de...
This paper is focused on the discussion of different trade-offs that frequently arise when selecting the appropriate antenna technology for a wireless sensor for home-care applications, and the implications that every decision represents for the overall design. In order to devise an optimum design strategy, the main methodological concerns are illu...
Several studies point out the paradox that classic telemedicine by which doctor interacts remotely with patients in real-time is disappearing despite it has not been widely adopted yet. Many cues indicate that health information technologies will be finally adopted because of the growth in health expenditure and the emerging healthcare challenges....
Despite the fact that urea kinetic modelling has been successfully applied to quantify the hemodialysis since the beginning of the 1980s, there is not a consensus yet concerning which is the most proper dialysis dose index and the method for calculating it. In this work, we propose that a combined measurement of the dialysis dose from two complemen...
The theoretical basis of the nonregenerated recirculating dialysate system (RDS) was derived in Part I of this work [M. Prado, L. M. Roa, A. Palma, and J. A. Milán, Ann. Biomed. Eng. (2005)]. This system pursues the maximization of the clearance of hollow fiber dialyzers whose performance is controlled by diffusion, as occurred in standard hemodial...
This paper presents a wearable human movement monitor designed within the context of a telehealthcare system for the elderly. One major characteristic of this device is the capability for an on-line personalization to the user. This capability compels to a trade-off among processing capacity, portability, low cost and power consumption, which are n...
The mathematical theory that underlies a novel non-regenerated recirculating dialysate system (RDS) for improving diffusive clearance in hemodialyzers is presented. The theory states the conditions that hemodialyzers must meet to be suitable in RDS optimization. We have verified the applicability of the RDS for several Cuprophan and polysulfone (PS...
This paper presents an analysis of different methodologies for modelling pharmacokinetic systems under the context of a telemedicine system oriented to the on-line and personalized knowledge generation. We use a simplified 3-pool kinetic system for a better clarification of several relevant modelling formalisms. A more complete 3-pool urea kinetic...
Several important problems in the majority of industrialized countries have challenged the centralized and overburdened current model of healthcare. Telehealthcare systems are presented as a new paradigm, offering high expectations to provide effective solutions to this picture. With this paper we present a new methodological approach for telehealt...
A novel normalized single pool urea kinetic model (nspUKM) for the quantification of the urea removal, dialyzer urea clearance and urea generation rate during a dialysis session, is presented. Its major goal is the computation of an accurate estimate of the fractional dialyzer urea clearance (dKt/V), which is denoted nKt/V, in contrast to the equil...
The article presents the early outcomes of the evaluation of an intelligent accelerometer unit (IAU) utilized for detecting the falling events of elderly people . The overall design of the monitor where the IAU is integrated is briefly exposed. The outcomes of a laboratory study carried out over 8 volunteers show that the device is able to distingu...
The adequacy of dialysis based on urea kinetic modeling has more than 20 years of history. Its methodological approach has demonstrated a strong capacity to improve the outcomes of the dialysis therapy. However, recent results of clinical interventional studies and necessary advances in new models of dialysis schemes, particularly daily and nocturn...
La insuficiencia renal crónica terminal (RCT) en España presenta una prevalencia de aproximadamente 900 personas por cada millón de habitantes (pmp). Este valor está creciendo a un ritmo superior al 4% anual. Las cifras son similares, o incluso peores, en otros países industrializados como EEUU, donde la tasa de prevalencia, de acuerdo con una tend...
Performance and methodology issues associated to Kt/V indices for hemodialysis adequacy are analyzed by means of concepts obtained from dynamics similarity theory, together with urea kinetic modeling. This theoretical analysis suggests the acceptance of Kt/V against other indices like Kt. Afterwards, the study justifies, presents, and validates by...
This paper presents a communications infrastructure to provide a home telecare service to cover the territory of Andalusia (Spain) with the requirements of a high quality of service and cost efficiency. After analyzing several alternatives based on different access technologies, it is shown that X.25-based packet-switched networks provide the best...
The virtual center for renal support (VCRS) is a novel telehealthcare system based on a hybrid approach for signal processing and knowledge discovering. It is featured by the addition of a new signal processing layer to the more classical telehealthcare computational architectures. This layer is a realtime simulator composed by customized dynamics...
It is widely accepted that a minimum Kt/V of nearly 1.2 is necessary as an adequate hemodialysis dose for end stage renal disease patients. Nevertheless, delivered HD dose in large patients is often below that value, what increases morbidity and mortality risks. Increasing the area of dialyzer is not always a good solution, because large dialyzers...
This paper presents a novel renal telemedicine system, Virtual Center for Renal Support (VCRS), focused on the end-stage renal disease (ESRD) population. The VCRS design modifies the telemedicine paradigm, currently centered on communication technologies and monitoring devices, by emphasizing the way that biosignals are used to extract on-line know...
The patient physiological image (PPI) is a novel concept which manages the knowledge of the virtual center for renal support (VCRS), currently being developed by the Biomedical Engineering Group of the University of Seville. PPI is a virtual "replica" of the patient, built by means of a mathematical model, which represents several physiological sub...
A novel approach for the detection of falls, the analysis of body postures, mobility and metabolic energy expenditure of elderly people has been developed. It is based on a distributed intelligence architecture, supported by it wireless personal area network (WPAN) which allows a full 24-hour supervision of the user, both indoor and outdoor home. A...
The Patient Physiological Image (PPI) is a novel concept that manages the knowledge of Virtual Center for Renal Support (VCRS), currently being developed by the Biomedical Engineering Group of the University of Seville (GIB). PPI is a "virtual" replica of a patient, built by means of a mathematical model. From a technical point of view, PPI is a co...
The Biomedical Engineering Group of the University of Seville (GIB) is developing new strategies to apply the home health care paradigm within end stage renal disease (ESRD) patients. In this paper, we first review the current status of ESRD patients in Spain, Europe and USA. In the second part, a formal definition of the novel virtual center for r...
We try to develop a pilot experience in home care teleservices to the elderly through the investigation of solutions based on the application of information technologies and communications. To that end, an individualized attendance to each elderly person will be supplied, which will comprise from the monitoring of certain biological variables, diag...
The National Cooperative Dialysis Study (NCDS) showed the
viability of the single-pool urea kinetic model (spUKM) to maintain the
blood urea nitrogen (BUN) level of the renal patient in an adequate
target interval, defining the single-pool normalized clearance of urea
spKt/V as an index of the hemodialysis dose. However, the urea
distribution is a...
Urea Kinetic Modeling (UKM) is recognized as the most efficient method for quantitating hemodialysis treatments, and the dimensionless parameter Kt/V is widely used to monitor dialysis prescription. Although many shortcut methods have been developed to directly calculate it, there is no agreement on which is the best method to be applied. The autho...
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