Manuel Alejandro Martínez-Vázquez

Manuel Alejandro Martínez-Vázquez
Escuela de Medicina Tec de Monterrey · Department of Internal Medicine

MD

About

45
Publications
10,698
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588
Citations
Citations since 2016
15 Research Items
469 Citations
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2016201720182019202020212022020406080
2016201720182019202020212022020406080
Introduction
Manuel Alejandro Martínez-Vázquez currently works at the Medicina Interna, Escuela de Medicina Tec de Monterrey. Manuel does research in Gastroenterology and inflammatory bowel disease. Their current project is 'Biology of anti-TNF agents in immune-mediated inflammatory diseases: therapeutic implications.'
Additional affiliations
July 2017 - present
Escuela de Medicina Tec de Monterrey
Position
  • Professor
January 2012 - June 2017
Hospital Universitario Dr. Jose E. Gonzalez
Position
  • Universidad de Monterrey

Publications

Publications (45)
Article
Full-text available
Background Crohn’s disease is one of the two categories of inflammatory bowel diseases that affect the gastrointestinal tract. The heritability estimate has been reported to be 0.75. Several genes linked to Crohn’s disease risk have been identified using a plethora of strategies such as linkage-based studies, candidate gene association studies, and...
Article
Resumen La incidencia en enfermedad inflamatoria intestinal (EII) va en aumento. El microbioma es uno de los factores más importantes en su desarrollo y afecta los diferentes escenarios clínicos en pacientes con EII dependiendo su composición y diferentes alteraciones. Se realizó una revisión sistemática para discutir la asociación entre el microbi...
Article
Full-text available
Objectives: Our study aimed to identify the prevalence and severity of gastrointestinal (GI) symptoms and dysphagia in patients with amyotrophic lateral sclerosis (ALS) and to assess whether a correlation exists between these symptoms and the severity of ALS progression. Methods: The presence and severity of GI symptoms and dysphagia were identi...
Article
Full-text available
Introduction Inflammatory bowel disease (IBD) is a chronic and incurable entity. Therapy with anti-TNF-α agents was the first biologic therapy approved in Mexico for IBD. New biologic agents, such as vedolizumab and ustekinumab, have recently been added, as have small-molecule inhibitors. Aim To update the biologic therapeutic approach to IBD in M...
Article
Full-text available
Resumen Antecedentes La enfermedad inflamatoria intestinal (EII) es una entidad crónica e incurable. La terapia con agentes anti-TNF alfa fue la primera terapia biológica aprobada en México en EII. Recientemente han aparecido nuevos agentes biológicos, como el vedolizumab y el ustekinumab, así como inhibidores de moléculas pequeñas. Objetivo Actu...
Article
Full-text available
Despite the worldwide increasing incidence and prevalence of Inflammatory Bowel Disease (IBD), our knowledge about it in Mexico is still limited. The aim of this study is to describe the incidence and prevalence of IBD as well as its clinical and socio-demographical characteristics in Mexico from a nation-wide perspective.Multicenter nation-wide co...
Article
Full-text available
Background Despite the worldwide increasing incidence of inflammatory bowel disease (IBD), our knowledge about this disease is still limited in some regions, especially developing countries. Methods Multicentric nation-wide study. Clinical and socio-demographical characteristics of Mexican patients with histopathological diagnosis of IBD (ulcerati...
Article
Full-text available
Background Prior studies have shown poor compliance with quality measures for IBD at academic and private practices. We sought to provide focused interventions to improve compliance and documentation with the IBD measures. Methods Two centers, academic practice (AP) and private practice (PP), initially reviewed their compliance with eight establish...
Conference Paper
Full-text available
NOVEDADES EN ENFERMEDAD INFLAMATORIA INTESTINAL Y OTROS PROCESOS INFLAMATORIOS Colitis ulcerativa
Article
Full-text available
Biologics are increasingly being used to modify the course of immune-mediated inflammatory diseases. Some main agents are monoclonal antibodies and a fusion-protein that target TNF. This group includes adalimumab, infliximab, certolizumab pegol, golimumab and etanercept. Although the efficacy of anti-TNFs is supported by numerous randomized clinica...
Article
Background: Ustekinumab is a fully human monoclonal IgGk antibody that blocks the p40 subunit shared by IL-12/23, inhibiting its binding to the receptor in T, NK and CPA cells 1. Multiple clinical trials have proved its efficacy in the treatment of psoriasis and for the induction and maintenance of remission in anti-TNF resistant Crohn's disease.1,...
Article
Background & aims: Quality measures are used to standardize health care and monitor quality of care. In 2011, the American Gastroenterological Association established quality measures for inflammatory bowel disease (IBD), but there has been limited documentation of compliance from different practice settings. Methods: We reviewed charts from 367...
Article
Currently, the predictors of readmission after colectomy specifically for ulcerative colitis (UC) are poorly investigated. We sought to determine the rates and predictors of 30-day readmissions after colectomy for UC. Patients undergoing total proctocolectomy and end ileostomy, abdominal colectomy with end ileostomy, proctocolectomy with ileoanal p...
Article
Full-text available
Background and aims: Quality metrics allows health care to be standardized and monitored. The American Gastroenterological Association (AGA) established quality metrics for inflammatory bowel disease (IBD) in 2011, but compliance is unknown. Methods: Patients with IBD seen in the gastroenterology clinics at a tertiary care medical center during...
Article
Background: Infliximab (IFX) is effective in the treatment of inflammatory bowel disease; however, the effect is often not durable. It is unknown if proactive therapeutic concentration monitoring (TCM) of IFX improves outcomes. Methods: This is a retrospective observational study examining the use of proactive TCM and titration of IFX to a targe...
Article
Full-text available
Background: Acute pancreatitis (AP) etiology and frequency vary in relation to geographic region. Aims: To determine the etiology, frequency, and mortality of AP in a Mexican population. Patients and methods: We carried out a prospective study of first episode AP patients over a period of 6 years. Results: A total of 605 patients with a mean...
Article
Full-text available
Irritable bowel syndrome (IBS) is characterized by recurrent abdominal pain, bloating, and changes in bowel habit. To determine the clinical effectiveness of the antispasmodic agents available in Mexico for the treatment of IBS. We carried out a systematic review and meta-analysis of randomized controlled clinical trials on antispasmodic agents for...
Article
Full-text available
Herein, we describe the isolation of Staphylococcus pasteuri, Staphylococcus pettenkoferi and Staphylococcus gallinarum and summarize the clinical characteristics of five patients. Cases were identified over a 2-year surveillance period that identified the respective strains using microbiologic and molecular methods. These data suggest that rare co...
Article
The revised score of the International Autoimmune Hepatitis Group (R-IAIHG) and the simplified criteria (SC) are used for diagnosis of autoimmune hepatitis (AIH). Our aim is to evaluate the performance of these classifications to differentiate AIH from other autoimmune liver diseases. The frequency of diagnosis of definite AIH was similar both by t...
Article
Full-text available
The incidence of coagulase-negative staphylococci reported as causative agents of nosocomial infections has risen in the last decade. The aim of this study was to characterize biofilm formation, antibiotic resistance, SCCmec type, and genetic relatedness in clinical isolates of Staphylococcus cohnii, Staphylococcus hominis, and Staphylococcus sciur...
Article
Full-text available
Mexicans have an increased rate of alcohol abuse and alcoholic liver disease. Factors influencing the severity of alcoholic hepatitis (AH) in Mexicans are unknown. The aims of the present study were to identify the prognostic factors of short-term mortality in Mexican patients with AH and to validate the existing prognostic models. One hundred seve...
Article
Background: Inflammatory Bowel Disease (IBD) compromises two entities: Ulcerative Colitis (UC) and Crohn Disease (CD). The incidence and prevalence vary widely in relation to ethnicity and demographic localization. Historically it has been considered a rare disease in Mexico. Objective: To determine the frequency of new UC cases and their clinic...
Article
We report the case of an Hispanic female diabetic patient admitted to our hospital complaining of progressive abdominal pain, weight loss, nausea and vomiting. Work-up included an abdominal computed tomography (CT) scan which reported a large liver mass consistent with atypical abscess. Serum alpha-fetoprotein value was normal, so a fine needle asp...
Article
Background: In Mexico, there are few reviews of life quality related to health. These reviews do not substitute symptom, analytic and morphologic evaluations by physicians. They only complement them, by introducing the patient;s vision about his perception of his own health. They also intent to reflect the impact of disease on the patient and on h...
Article
Full-text available
Aim. To compare the efficacy of pentoxifylline and prednisolone in the treatment of severe alcoholic hepatitis and to evaluate the role of different liver function scores in predicting prognosis. Methods. Sixty-eight patients with severe alcoholic hepatitis (Maddrey score 3 32) received pentoxifylline (n = 34, group I) or prednisolone (n = 34, grou...
Article
Full-text available
Type 1 hepatorenal syndrome (HRS) is a functional renal failure that complicates end-stage cirrhosis. The vasopressin analogue terlipressin has been associated with improved renal function in patients with type 1 HRS. To evaluate the effectiveness of an infusion of terlipressin plus albumin in reversing type 1 HRS, its tolerability, and its adverse...
Article
Full-text available
to assess the efficacy of rabeprazole (RPZ), amoxicillin (Am), and clarithromycin (Cla) (7 vs. 14 days) in the eradication of H. pylori, and to determine the effect of strain-specific antibiotic resistance and host CYP2C19 status. first, we determined the CYP2C19 status of 100 healthy subjects to establish a sample size for the clinical trial. Then...
Article
Full-text available
Objective: to assess the efficacy of rabeprazole (RPZ), amoxicillin (Am), and clarithromycin (Cla) (7 vs. 14 days) in the eradication of H. pylori, and to determine the effect of strain-specific antibiotic resistance and host CYP2C19 status. Material and methods: first, we determined the CYP2C19 status of 100 healthy subjects to establish a sample...
Article
Objective: to assess the efficacy of rabeprazole (RPZ), amoxicillin (Am), and clarithromycin (Cla) (7 vs. 14 days) in the eradication of H. pylori, and to determine the effect of strain-specific antibiotic resistance and host CYP2C1 9 status. Material and methods: first, we determined the CYP2C19 status of 100 healthy subjects to establish a sample...

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Projects (2)
Project
Primary Outcome Measures : Percentage of Participants with Active CD at Day 1 [ Time Frame: Day 1 ] Percentage of participants with active CD observed, where active CD will be defined as Harvey Bradshaw index (HBI) greater than or equal to (>=) 8 or Crohn's disease active index (CDAI) >=220. CDAI assesses CD based on clinical signs and symptoms such as number of liquid stools, intensity of abdominal pain, general wellbeing, presence of comorbid conditions, use of antidiarrheal, physical examination and laboratory findings. Total score ranges from 0 to 600 points. Higher score indicates more severe disease. HBI score is used to measure disease activity of CD and consists of 5 clinical parameters: general well-being, abdominal pain, number of liquid stools per day, abdominal mass, and complications. Total score is sum of individual parameters. Score ranges from a minimum score of 0 to no pre-specified maximum score as it depends on number of liquid stools, where higher scores indicates more severe disease. Percentage of Participants with Active UC at Day 1 [ Time Frame: Day 1 ] Percentage of participants with active disease UC disease will be observed, where UC is defined as 9-point Partial Mayo Score (pMayo score) >=5. The Mayo score is composed of four categories (bleeding, stool frequency, physician assessment, and endoscopic appearance) rated from 0-3 that are summed into a total score ranging from 0-12. pMayo score consists of 3 sub scores: stool frequency, rectal bleeding, and physician global assessment of disease severity, each graded from 0 to 3. These scores are summed to give a total score range of 0 to 9; where higher scores indicating more severe disease. The pMayo score when compared with the full Mayo score and categorizes UC patients as being in remission (score of 0 to 2), having mild activity (pMayo of 3 or 4) or moderate to severe activity (pMayo of >=5).