Manuel F Landecho

Manuel F Landecho
Universidad de Navarra | UNAV

About

89
Publications
6,081
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1,065
Citations
Citations since 2017
60 Research Items
960 Citations
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2017201820192020202120222023050100150200250
2017201820192020202120222023050100150200250
2017201820192020202120222023050100150200250
Introduction

Publications

Publications (89)
Article
Full-text available
Severe lung damage in COVID-19 involves complex interactions between diverse populations of immune and stromal cells. In this study, we used a spatial transcriptomics approach to delineate the cells, pathways and genes present across the spectrum of histopathological damage in COVID-19 lung tissue. We applied correlation network-based approaches to...
Article
Full-text available
Background One of the most important challenges in medical education is the preparation of multiple-choice questions able to discriminate between students with different academic level. Average questions may be very easy for students with good performance, reducing their discriminant power in this group of students. The aim of this study was to ana...
Preprint
Full-text available
Background. One of the most important challenges in medical education is the preparation of multiple-choice questions able to discriminate between students with different academic level. Average questions may be very easy for students with good performance, reducing their discriminant power in this group of students. The aim of this study was to an...
Article
Full-text available
Background: To analyze the long-term outcomes for advanced cancer patients admitted to an intermediate care unit (ImCU), an analysis of a do not resuscitate orders (DNR) subgroup was made. Methods: A retrospective observational study was conducted from 2006 to January 2019 in a single academic medical center of cancer patients with stage IV dise...
Article
Full-text available
Background: Excessive inflammation is pathogenic in the pneumonitis associated with severe COVID-19. Neutrophils are among the most abundantly present leukocytes in the inflammatory infiltrates and may form neutrophil extracellular traps (NETs) under the local influence of cytokines. NETs constitute a defense mechanism against bacteria, but also h...
Preprint
Full-text available
Rationale: People with pre-existing lung diseases like chronic obstructive pulmonary disease (COPD) are more likely to get very sick from SARS-CoV-2 disease 2019 (COVID-19), but an interrogation of the immune response to COVID-19 infection, spatial throughout the lung structure is lacking in patients with COPD. Objectives: To profile the immune mi...
Article
Full-text available
The purpose of this study was to assess vascular and histological alterations in two COVID-19 and three control post-mortem retinas. The macular areas of flat-mounted samples were processed for immunofluorescence. Lectin and collagen IV positive vessels were captured under confocal microscopy, and endothelium loss and tortuosity were analyzed. Expr...
Article
Full-text available
The purpose of this study was to evaluate the long-term evolution of retinal changes in COVID-19 patients with bilateral pneumonia. A total of 17 COVID-19 patients underwent retinal imaging 6 months after hospital discharge with structural optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). The parafoveal retinal...
Article
Full-text available
Background Active learning strategies such as formative assessment through clinical cases may help to get a deeper learning. We have studied the effect of this kind of online formative assessment in pathophysiology teaching. Methods Seven brief clinical cases were used to give formative assessment in the first semester of a pathophysiology course....
Article
Full-text available
Information on the immunopathobiology of coronavirus disease 2019 (COVID-19) is rapidly increasing; however, there remains a need to identify immune features predictive of fatal outcome. This large-scale study characterized immune responses to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection using multidimensional flow cytomet...
Article
Full-text available
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV2) disease (COVID-19) is a novel threat that hampers life expectancy especially in obese individuals. Though this association is clinically relevant, the underlying mechanisms are not fully elucidated. SARS CoV2 enters host cells via the Angiotensin Converting Enzyme 2 receptor, that is also...
Article
Full-text available
The purpose of this study was to evaluate the presence of retinal and microvascular alterations in COVID-19 patients with bilateral pneumonia due to SARS-COV-2 that required hospital admission and compare this with a cohort of age- and sex-matched controls. COVID-19 bilateral pneumonia patients underwent retinal imaging 14 days after hospital disch...
Article
Full-text available
Intermediate care units (ImCUs) have been shown as appropriate units for the management of selected septic patients. Developing specific protocols for residents in training may be useful for their medical performance. The objective of this study was to analyze whether a simulation-based learning bundle is useful for residents while acquiring compet...
Chapter
Full-text available
Aging is a complex and heterogeneous process that results from the accumulation of a wide variety of damage over time that leads to a progressive loss of physiological abilities named, in sum, elderly. Deterioration of function is generally detectable first as a loss of physiological reserve expressed as the incapacity to restore homeostasis under...
Article
Background SARS‐CoV‐2, the COVID‐19 causative agent, has infected millions of people and killed over 1.6 million worldwide. A small percentage of cases persist with prolonged positive RT‐PCR on nasopharyngeal swabs. The aim of this study was to determine risk factors for prolonged viral shedding among patient’s basal clinical conditions. Methods W...
Preprint
Full-text available
Background. Active learning strategies such as formative assessment through clinical cases may help to get a deeper learning. We have studied the effect of this kind of online formative assessment in pathophysiology teaching. Methods. Seven brief clinical cases were used to give formative assessment in the first semester of a pathophysiology course...
Conference Paper
Background: The immune system reacts to viral infection with cellular and humoral responses. Thus, myelo- and lympho-suppression caused by cancer itself as well as cytotoxic treatment may pose a challenge to COVID-19 patients with solid and hematological tumors, but severe events from initial onset of COVID-19 appear to be more frequent in blood ma...
Article
Full-text available
Background Weight loss after bariatric surgery varies among patients. Patients who do not complete long-term follow-up are considered to loose less weight than those with regular follow-up visits.Objective To evaluate the influence of patients’ follow-up compliance on long-term excess weight loss (%EWL) and total weight loss (%TWL) after bariatric...
Article
As of October 2020, the Severe Acute Respiratory Syndrome coronavirus 2 (SARS‐CoV‐2), responsible for Coronavirus Disease 2019 (COVID‐19), has infected over 33million individuals and killed over one million people worldwide. (https://coronavirus.jhu.edu/map.html accessed October 1 2020) Obesity and its complications are linked to severe forms of CO...
Article
Full-text available
In December 2019, an outbreak of severe acute respiratory syndrome associated to SARS-CoV2 was reported in Wuhan, China. To date, little is known on histopathological findings in patients infected with the new SARS-CoV2. Lung histopathology shows features of acute and organising diffuse alveolar damage. Subtle cellular inflammatory infiltrate has b...
Article
Importance COVID‐19 is caused by SARS‐CoV‐2, a betacoronavirus that uses the angiotensin‐converting enzyme‐related carboxypeptidase (ACE2) receptor to gain entry into cells. ACE2 receptor is widely expressed in multiple organs, including the retina, an extension of the central nervous system. The ACE2 receptor is involved in the diabetic and hypert...
Article
Full-text available
Since the description of ghrelin in 1999, several studies have dug into the effects of this hormone and its relationship with bariatric surgery. While some aspects are still unresolved, a clear connection between ghrelin and the changes after metabolic surgery have been established. Besides weight loss, a significant amelioration in obesity-related...
Article
Background Obesity is a major public health problem, which continues to be diagnosed and classified by BMI, excluding the most elemental concepts of the precision medicine approach. Obesity does not equally affect males and females, even with the same BMI. Microalbuminuria is a risk marker of cardiovascular disease closely related to obesity. The a...
Article
Atherosclerosis - the pathophysiological mechanism shared by most cardiovascular diseases - can be directly or indirectly assessed by a variety of clinical tests including measurement of carotid intima-media thickness, carotid plaque, -ankle-brachial index, pulse wave velocity, and coronary -artery calcium. The Prospective Studies of Atherosclerosi...
Chapter
Obesity represents an important cause of noncommunicable diseases (NCDs) constituting a relevant cause of death worldwide. It is a pandemia that has proven to be frequently refractory to conventional treatment. Type 2 diabetes (T2D) is among the most deleterious travel partners of obesity since it plays a big role in the excess mortality associated...
Article
Background Latero-lateral duodenojejunostomy is the treatment of choice for superior mesenteric artery syndrome (SMAS). The present study analyzes the long-term outcomes in 13 patients undergoing laparoscopic surgery for SMAS. Materials and methods A retrospective study of 10 females and three males undergoing surgery between 2001 and 2013 was per...
Article
Full-text available
In hypertensive patients with heart failure (HF) a serum biomarker combination of high carboxy-terminal propeptide of procollagen type-I (PICP) and low carboxy-terminal telopeptide of collagen type-I to matrix metalloproteinase-1 (CITP:MMP-1) ratio identifies a histomolecular phenotype of malignant myocardial fibrosis (mMF) associated with severe d...
Article
Full-text available
Obesity, which is a worldwide epidemic, confers increased risk for multiple serious conditions including type 2 diabetes, nonalcoholic fatty liver disease, and cardiovascular diseases. Adipose tissue is considered one of the largest endocrine organs in the body as well as an active tissue for cellular reactions and metabolic homeostasis rather than...
Article
Aim: The aim of this study is to compare the utility of several supervised machine learning (ML) algorithms for predicting clinical events in terms of their internal validity and accuracy. The results, which were obtained using two statistical software platforms, were also compared. Materials and methods: The data used in this research come from...
Article
Purpose: to assess the long-term benefits of bariatric surgery in super-obese (body mass index [BMI] ≥ 50) and in elderly obese (age > 60 years) populations. Methods: one hundred and twenty one patients who underwent laparoscopic Roux-en-Y gastric bypass or laparoscopic sleeve gastrectomy in a university hospital were retrospectively subdivided...
Article
In the published version of this paper the author Neus Baena's name was incorrectly given as Neus Baena Diez. This has now been corrected in both the HTML and PDF versions of the paper.
Article
Full-text available
Aims Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular risk. Methods and results From 31 cohorts with two CIMT scans (total n = 89070) on average 3.6 years apart and clinical fo...
Data
Data sharing restrictions, availability and contacts by study. (PDF)
Data
List of collaborators within the PROG-IMT study group, current from 10th June 2016. (PDF)
Data
Forest plots of the HR of MI in group A (asymptomatic individuals with three or more CVD risk factors) with 95% Cls. Left panel: HR for MI per one SD of annual mean CCA-IMT change, adjusted for age, sex and average mean CCA-IMT (model 1). Right panel: HR for MI per one SD of average mean CCA-IMT, adjusted for age, sex and annual mean CCA-IMT change...
Data
Forest plots of the HR of stroke in group A (asymptomatic individuals with three or more CVD risk factors) with 95% Cls. Left panel: HR for stroke per one SD of annual mean CCA-IMT change, adjusted for age, sex and average mean CCA-IMT (model 1). Right panel: HR for stroke per one SD of average mean CCA-IMT, adjusted for age, sex and annual mean CC...
Data
Meta-regression plots for the HR (combined endpoint) per SD of annual mean CCA-IMT change, by the year of the study start for group A cohorts. The size of each circle represents the precision of the log HR. Left panel: Model 1 (HR adjusted for age, sex, and average mean CCA-IMT): weighted regression line y = 7.07+0.004*x (p = 0.34). Right panel: Mo...
Data
Distribution of average mean CCA-IMT, annual change of mean CCA-IMT, and crude event rates by cohort and subgroup. *mean CCA-IMT not available, maximal CCA-IMT used instead. &combined endpoint not available, total mortality used instead. (DOCX)
Data
Forest plots of the HR of total mortality in group A (asymptomatic individuals with three or more CVD risk factors) with 95% Cls. Left panel: HR for total mortality per one SD of annual mean CCA-IMT change, adjusted for age, sex and average mean CCA-IMT (model 1). Right panel: HR for total mortality per one SD of average mean CCA-IMT, adjusted for...
Data
Forest plots of the HR of the combined endpoint in group A (asymptomatic individuals with three or more CVD risk factors) for maximal CCA-IMT with 95% Cls. Left panel: HR for the combined endpoint per one SD of annual maximal CCA-IMT change, adjusted for age, sex and average maximal CCA-IMT (model 1). Right panel: HR for the combined endpoint per o...
Data
Study-specific details of the ultrasound protocols. +plaques purposely included. #internal landmarks in computer aided navigation aid. ++2D images extracted from 3D dataset. n.s. = not specified. (DOCX)
Data
Flowchart on available studies. (DOCX)
Data
Forest plots of the HR of the combined endpoint per one SD of annual mean CCA-IMT change, grouped by IMT measurement protocol, with 95% Cls. Group B (asymptomatic individuals with carotid plaques), HR adjusted for age, sex and average mean CCA-IMT (model 1). (DOCX)
Article
Purpose We delineate the clinical spectrum and describe the histology in arterial tortuosity syndrome (ATS), a rare connective tissue disorder characterized by tortuosity of the large and medium-sized arteries, caused by mutations in SLC2A10. Methods We retrospectively characterized 40 novel ATS families (50 patients) and reviewed the 52 previousl...
Article
Full-text available
Aims: Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular risk. Methods and Results: From cohorts with two CIMT scans on average 3.6 years apart and clinical follow-up, subcohorts...
Article
Full-text available
Summary Obstructive sleep apnea-hypopnea syndrome is very prevalent among developed societies, associated with a series of risk factors like obesity, male gender, age, endocrine illnesses, cranio-facial abnormalities and family history. Although there is still controversy about the clinical consequences of sleep apnea, they appear to be related to...
Chapter
Obesity is a worldwide main health concern, with a high treatment failure. This chapter focuses on the definition of obesity, based on excessive fat accumulation and thus underscores the importance of body composition, and the clinical tools currently used to diagnose it, mainly body mass index that is only a proxy measure of body composition. It a...
Article
Full-text available
What is known and objective: Chylous ascites is a rare condition. The most frequent causes are lymphomas, solid malignancies, abdominal trauma and cirrhosis. Isolated case reports describe the relationship between calcium channel blockers (CCB) and chyloperitoneum. Lercanidipine is a third-generation dihydropyridine with low rate of adverse events...
Article
Vascular calcification is a common feature in atherosclerosis and associates with cardiovascular events. Oxidative stress may be involved in the pathogenesis of vascular calcification. Previous studies have shown that the phagocytic NADPH oxidase is associated with atherosclerosis. The objective of the present study was to investigate the associati...
Article
Interleukin (IL)-32 is a recently described cytokine involved in the regulation of inflammation. We aimed to explore whether IL-32 could function as an inflammatory and angiogenic factor in human obesity and obesity-associated type 2 diabetes. Samples obtained from 90 subjects were used in the study. We show, for the first time that increased circu...
Article
Background: The World Health Organization has emphasized that an increased body mass index (BMI) is a major risk factor for non-communicable diseases (NCDs) such as cardiovascular disease (CVD) together with diabetes, musculoskeletal disorders and some cancers. The American Heart Association had already identified obesity as an independent risk fa...
Article
A Joint Statement endorsed by 45 international organizations, clinicians, and researchers indicating when to recommend or consider metabolic surgery in type 2 diabetes mellitus (T2DM) treatment has been recently published. These new guidelines, resulting from the Second Diabetes Surgery Summit (DSS-II), represent the most radical change in T2DM man...
Article
Background: To develop a prediction rule to describe the risk of death as a result of enterococcal bloodstream infection. Methods: A prediction rule was developed by analysing data collected from 122 patients diagnosed with enterococcal BSI admitted to the Clínica Universidad de Navarra (Pamplona, Spain); and validated by confirming its accuracy...
Article
Full-text available
Background Intermediate Care Units (ImCU) have become an alternative scenario to perform Non-Invasive Ventilation (NIV). The limited number of prognostic studies in this population support the need of mortality prediction evaluation in this context. Objective The objective of this study is to analyze the performance of Simplified Acute Physiology...
Article
Full-text available
Application of illness-severity scores in Intermediate Care Units (ImCU) shows conflicting results. The aim of the study is to design a severity-of-illness score for patients admitted to an ImCU. We performed a retrospective observational study in a single academic medical centre in Pamplona, Spain. Demographics, past medical history, reasons for a...
Article
Current evidence suggests that local anesthetic wound infiltration should be employed as part of multimodal postoperative pain management. There is scarce data concerning the benefits of this anesthetic modality in laparoscopic weight loss surgery. Therefore, we analyzed the influence of trocar site infiltration with bupivacaine on the management o...
Article
Full-text available
Background: To analyze predictors of mortality and poor outcome in cancer patients diagnosed with E. faecium bloodstream infection. Methods: Demographic, clinical and microbiological data were collected (January 1998-June 2011). Results: After multivariate analysis, presence of a urinary catheter was associated with a worse 7-day prognosis, an...
Article
Full-text available
Germline GATA2 mutations have been identified as the cause of familial syndromes with immunodeficiency and predisposition to myeloid malignancies. GATA2 mutations appear to cause loss of function of the mutated allele leading to haploinsufficiency; however, this postulate has not been experimentally validated as the basis of these syndromes. We hyp...
Article
Left ventricular hypertrophy (LVH) is an independent marker of mortality in hypertension. Although the mechanisms contributing to LVH are complex, inflammation and oxidative stress may favor its development. We analyzed the association of the phagocytic NADPH oxidase-mediated superoxide anion release and LVH in patients with essential hypertension...
Article
Full-text available
The efficacy and reliability of prognostic scores has been described extensively for intensive care, but their role for predicting mortality in intermediate care patients is uncertain. To provide more information in this field, we have analyzed the performance of the Simplified Acute Physiology Score (SAPS) II and SAPS 3 in a single center intermed...
Article
In the last 20 years, endovascular procedures have radically altered the treatment of diseases of the aorta. The objective of endovascular treatment of dissections is to close the entry point to redirect blood flow toward the true lumen, thereby achieving thrombosis of the false lumen. In extensive chronic dissections that have evolved with the for...
Article
Hospitalized patients are complex and institutions have to face the high cost of critical care and the limited resources of the ward. Intermediate care appears as an attractive strategy to provide rational care according to patient needs. It is an interesting scenario to expand co-management and teaching. Retrospective observational study. Intermed...
Article
Advanced kidney disease is a major health problem due to its association with high cardiovascular morbidity and mortality. Early recognition of advanced kidney disease is the mainstay to avoid its progression. Since metabolic syndrome and insulin resistance are risk factors for both cardiovascular and advanced kidney disease, we investigated the re...