Manuel Glauco Carbone

Manuel Glauco Carbone
Università degli Studi dell'Insubria | UNINSUBRIA · Department of Clinical and Experimental Medicine

Doctor of Medicine

About

29
Publications
2,194
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151
Citations
Citations since 2016
29 Research Items
151 Citations
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201620172018201920202021202201020304050
201620172018201920202021202201020304050
201620172018201920202021202201020304050

Publications

Publications (29)
Article
Objectives: Vitamin B12, folic acid and homocysteine play a key role in "one-carbon metabolism", involved in different brain processes. Altered levels have been reported in mood disorders (MDs), particularly in major depression (MDD), while the information in bipolar disorders (BDs) is limited. The present study aimed at assessing vitamin B12, hom...
Article
Background Oxytocin is a nonapeptide synthesized in the paraventricular and supraoptic nuclei of the hypothalamus. Historically, this molecule has been involved as a key factor in the formation of infant attachment, maternal behavior and pair bonding and, more generally, in linking social signals with cognition, behaviors and reward. In the last de...
Article
Objective: Calcifications in basal ganglia could be an incidental finding up to 20% of asymptomatic patients undergoing computed tomography (CT) or magnetic resonance imaging (MRI) scan. The presence of neuropsychiatric symptomatology associated with basal ganglia calcifications identifies a clinical entity defined as Fahr's Disease. This term is...
Article
Full-text available
According to the latest estimates, there are around 24.6 million cocaine users worldwide, and it is estimated that around a quarter of the population worldwide has used cocaine at some point in their lifetime. It follows that such widespread consumption represents a major risk for pub‐ lic health. Long‐term use of cocaine, in addition to being rela...
Article
Objectives. The present paper compared vitamin D levels in adult patients with OCD, and explored correlations with patients' characteristics. Methods. Fifty outpatients with OCD, according to DSM-5 criteria, were included and assessed by the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and the Hamilton Rating Scale for Depression (HRSD). Results....
Article
Major depressive disorder (MDD) and bipolar disorders (BDs), the most severe types of mood disorders (MDs), are considered as among the most disabling illnesses worldwide. Several studies suggested that inflammatory neuroinflammation might be involved in the pathophysiology of MDs, while reporting increasing data on the relationships between these...
Article
Background Late-onset depression (LOD) is the most common neuropsychiatric disorder associated with Alzheimer's disease (AD), often associated with structural and functional brain changes, neuropsychological impairments and negative family history for affective disorders. LOD could be a risk factor or a prodromal phase of AD; this has led to the in...
Article
One of the central lesions in the brain of subjects with Alzheimer's disease (AD) is represented by aggregates of β-amyloid (Aβ), a peptide of 40-42 amino acids derived from the amyloid precursor protein (APP). The reasons why Aβ accumulates in the brain of individuals with sporadic forms of AD are unknown. Platelets are the primary source of circu...
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The processing of the amyloid precursor protein (APP) is a critical event in the formation of amyloid plaques. Platelets contain most of the enzymatic machinery required for APP processing and correlates of intracerebral abnormalities have been demonstrated in platelets of patients with AD. The goal of the present paper was to analyze studies explo...
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Full-text available
Hiccups are sudden, repeated, and involuntary contractions of the diaphragm muscle (myoclonic contraction). It involves a reflex arc that, once activated, causes a strong contraction of the diaphragm immediately followed by the closure of the glottis translating into the classic "hic" sound. Hiccups can be short, persistent, and intractable dependi...
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Full-text available
Endometriosis is a chronic inflammatory condition, which is distinguished by the presence of the endometrial-like glands and stroma outside the uterine cavity. Pain and infertility are the most commonly expressed symptoms, occurring in 60% and 40% of cases, respectively. Women with endometriosis, especially those with pelvic pain, also have a great...
Article
Objective: A moderate sport activity is considered beneficial for both physical and mental health. On the contrary, different studies have shown that professional players may be more vulnerable to suffer from psychological and/or psychiatric disorders. Given the limited information available, the present study aimed to investigate the possible pre...
Article
Background Blood platelets, due to shared biochemical and functional properties with presynaptic serotonergic neurons, constituted, over the years, an attractive peripheral biomarker of neuronal activity. Therefore, the literature strongly focused on the investigation of eventual structural and functional platelet abnormalities in neuropsychiatric...
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Full-text available
Background: Pregabalin is an antiepileptic drug belonging to the gabapentinoid family used for antinociceptive, anticon- vulsant and anxiolytic purposes. In recent years, a growing body of observational studies and surveys has been highlight- ing the increasingly common recourse to a non-medical use of pregabalin. Young subjects with a past or curr...
Article
Full-text available
Background: The Mountain Activities Neuro-behavioural Research Programme is a research project born in the 2 nd Unit of Psychiatry, Department of Clinical and Experimental Medicine at the University of Pisa to investigate the effects of altitude on the mental and neuro-behavioural aspects of people performing activities in mountainous areas. Meth...
Article
Background For some time now, there has been a strong consensus that the migration process can influence the onset, course, development, outcome, and clinical aspects of psychiatric pathologies. Methods In this study, we have analyzed the influence of the migration process on the clinical expression of heroin use disorder (HUD). In a naturalistic...
Article
Background: In previous research projects of ours, we have succeeded in defining a psychopathology that appears to be specific to the substance use disorder, while remaining stable and independent of many factors and variables. The primary symptom dimensions considered were: W/BT, SS, S/P, PA, and V/S. Methods: Continuing this line of investigation...
Article
Summary The use of dietary supplements and herbal medicines is spreading across many developed countries. Although patients without specific problems can administer most, relevant toxic- ities might occur with a reckless use of dietary supplements, especially when psychiatric or medical comorbidities are present. Limited research is available on th...
Article
Objective: Selective serotonin (5-HT) reuptake inhibitors (SSRIs) are amongst the most prescribed drugs worldwide not only for psychiatric conditions, but also for medical purposes. Converging data gathered throughout the decades following their development would indicate that SSRIs have a broader side effect profile than previously assumed. There...
Article
Gambling disorder is a pathologic condition, resulting from the interaction of multiple risk factors. Among these, dopamine neurotransmission is known for playing a significant role, as seen, for example, in patients using dopamine replacement therapy prescribed for Parkinson disease, in which gambling is considered to be iatrogenic. Considering th...
Article
Background. Using the SCL90 checklist, we previously showed that a cluster of five psychopathological symptoms could be found in Heroin Use Disorder patients. This aggregation demonstrated a high degree of stability, as it proved to be independent of addiction-related conditions such as treatment chosen, intoxication status, and presence of psychia...
Article
Objectives: Fibromyalgia (FM) is defined as a severe, chronic, non-articular rheumatic condition characterised by widespread musculoskeletal pain, hyperalgesia and generalised tender points, in the absence of inflammatory or structural musculoskeletal abnormalities. Pain is the predominant symptom, allodynia and hyperalgesia are common signs. Extr...
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Full-text available
Autism Spectrum Disorder (ASD) has been recently highlighted as potentially related to a higher risk for suicide. ASD features are often under-recognized, especially in subjects with high level of functioning. We present the case of a 21-year-old man who attempted suicide jumping from the third floor of his home. The patient had been treated during...
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Full-text available
This case report draws attention to the potential relevance of undetected autism spectrum symptoms in a bipolar patient with high work functioning showing a peculiar addictive profile with impulsive and antisocial behaviors. A 23-year-old man with a diagnosis of Bipolar Disorder (BD) and Substance Use Disorder (SUD) was hospitalized at the Psychiat...
Article
Full-text available
Delirious mania is a severe but often underrecognized syndrome characterized by rapid onset of delirium, mania, and psychosis, not associated with a prior toxicity, physical illness, or mental disorder. We discuss the case of a delirious mania potentially triggered and maintained by a systemic hypotension induced by antihypertensive drugs. Symptoms...
Article
Introduction: The severity of emotional responses to life events (PTSD spectrum) as part of Post Traumatic Stress Disorder (PTSD) in Substance Use Disorder (SUD) patients has often been considered from a unitary perspective. Light has also been shed on the possible definition of a specific psychopathology of SUD patients. This psychopathology has...

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