Manuel Angeles-Castellanos

• phD
• National Autonomous University of Mexico

Diverticular colon disease is the most common cause of colovesical fistulas, a rare and complex entity in their diagnosis and treatment. This report details the case of a 56-year-old patient who had presented with pneumaturia and gas in the vagina for six years and exudate in the abdominal wall in a midline wound. Given the suspicion, the diagnosis...

2024, septiembre-octubre). Dormir bien o dormir con apnea obstructiva del sueño. Revista Digital Universitaria (rdu), 25(5). http://doi. Resumen Los seres humanos realizamos gran cantidad de actividades, que hacen necesario tanto la ingesta de alimentos como el descansar, para poder recuperar la energía y estar listos para un nuevo día. La mejor fo...

Non-coding RNAs (ncRNAs) and the innate immune system are closely related, acting as defense mechanisms and regulating gene expression and innate immunity. Both are modulators in the initiation, development and progression of cancer. We aimed to review the major types of ncRNAs, including small interfering RNAs (siRNAs), microRNAs (miRNAs), piwi-in...

Non-coding RNAs (ncRNAs) and the innate immune system are closely related, acting as defense mechanisms and regulating gene expression and innate immunity. Both are modulators in the ini-tiation, development and progression of cancer. We aimed to review the major types of ncRNAs, including small interfering RNAs (siRNAs), microRNAs (miRNAs), piwi-i...

Generalized tetanus, caused by the tetanospasmin toxin from Clostridium tetani, remains a health issue in rural areas with low vaccination coverage. This case describes a 38-year-old man from Oaxaca, Mexico, who developed this infection. Treatment included antitetanus immunoglobulin, broad-spectrum antibiotics, invasive mechanical ventilation, and...

Abstract Background: Myocardial bridge (MB) is described as an abnormal band of myocardium covering a variable portion of any coronary artery. Methods: The current study explores the presence of MB throughout the coronary arterial system and provides a morphometric description through instrumented dissection of a sample of 100 human hearts. The stu...

Introduction: During childhood these sutures close, forming the characteristic sutures of the skull, one of these is the frontal suture, which joins the two frontal bones perfectly, simulating a single frontal bone. However, this suture can persist into adulthood, giving an anatomical variant known as metopism. Case Report: A 19-year-old Mexican ma...

1. Abstract During the dissection practice, anatomical variants occur, pathological findings or alterations, and structural lesions may be found. This report deals with the discovery of a diaphragmatic hernia on the right side that was found during a dissection practice, in the corpse of a 71-year-old man, whose reported cause of death was severe r...

Circadian rhythm is essential for living beings. This rhythm regulates sleeping and waking patterns, hormone production, eating habits, digestion, and body temperature in humans and other animals. Prolonged use of Light at Night (LatN) has become a factor that can confuse biological clocks. In our research, we utilized ANOVA to perform feature sele...

Introduction: Total hip arthroplasty (THA) is one of the most frequently performed surgeries worldwide, with high satisfaction rates. However, the orientation of the acetabular component in THA has a direct impact on the risk of dislocation in 2 -3%, the safety zone of 15° anteversion / 45° inclination is described, and these radiographic measureme...

The circadian system is synchronized to the light-dark cycle generated by the rotation of the earth, ensuring that wake¬fulness is during the day and sleep occurs at night. However, the sleep-wake rhythm may be out of sync with the light-dark cycle or endogenously out of sync, resulting in insomnia, fatigue, and poor performance in activities of da...

The Continuous bright light conditions to which premature infants are subjected while hospitalized in Neonatal Intensive Care Units (NICU) can have deleterious effects in terms of growth and development. This study evaluates the benefits of a light/darkness cycle (LDC) in weight and early hospital discharge from the NICU. Subjects were recruited fr...

Throughout history, Mexico has been affected by major epidemics and pandemics, for this reason the health system of each era has had to develop, adopt and perpetuate multiple actions and health security measures, in which the following measures stand out: vaccination, adequate personal hygiene, a balanced diet, water chlorination, suspension of som...

Introduction: Midazolam is a benzodiazepine used for sedation, however, can cause respiratory depression and increases morbidity in patients. Melatonin is an effective alternative to manage anxiety in the perioperative period and could help to reduce the use of benzodiazepines during surgery. The aim of this clinical trial was to determine the eff...

Resumen El procedimiento anestésico-quirúrgico provoca ansiedad en el paciente, sobre todo en la etapa pre-quirúrgica inmediata. La sedación preoperatoria da como resultado una mejor cooperación del paciente. Los benzodiacepinas son los medicamentos de uso preoperatorio más utilizados, aunque sus efectos adversos a menudo limitan el uso diario, ya...

Resumen El término síndrome metabólico se refiere a una serie de factores de riesgo que resultan de un desbalance metabólico. Se han señalado varias causas para su desarrollo, entre las que destacan la ingesta excesiva de calorías y el sedentarismo. Este desbalance entre la ingesta y el gasto energético resulta en un incremento de peso en la forma...

El término síndrome metabólico se refiere a una serie de factores de riesgo que resultan de un desbalance metabólico. Se han señalado varias causas para su desarrollo, entre las que destacan la ingesta excesiva de calorías y el sedentarismo. Este desbalance entre la ingesta y el gasto energético resulta en un incremento de peso en la forma de tejid...

The respiratory symptoms of Chronic Obstructive Pulmonary Disease (COPD), these are most acute during the night, altering the sleep-wake cycle, which is synchronized by melatonin, this hormone is inhibited by light exposition during the night, generating daytime sleepiness, decreased alertness, sleep problems and poor quality of sleep quality. In t...

Background Cholesteatomas are benign tumors mainly composed of cholesterol crystals that rarely arise within the orbit. However, orbital cholesteatomas require a complete surgical resection due to their recidivating potential. Transcranial approaches offering a broad surgical exposure of the orbital cavity have been scarcely used for the management...

Circadian rhythms are generated endogenously with a period of approximately 24h. Studies carried out during the last decade indicate that the circadian system develops before birth, and that the suprachiasmatic nucleus, a structure that is considered the mammalian circadian clock, is present in primates from the middle of pregnancy. Recent evidence...

This article illustrates the application of the Chronometric Constructive Cognitive Learning Evaluation Model to measure the structural, organizational, and temporal properties of the anatomical knowledge schemata acquired by 52 first-year medical students enrolled for a second time in an anatomy course. The participants took part in a mental repre...

Sporadic Creutzfeldt‑Jakob disease (sCJD) is a fatal and rapidly progressive form of dementia caused by the spread of a prion protein within the brain. Its real incidence is unknown since its definitive diagnosis requires histopathological analysis of brain specimens. However, novel tests that detect prion proteins in cerebrospinal fluid samples, s...

The current landscape represents an unprecedented challenge in managing surgical patients, decision-making and the use of resources such as protective equipment in the context of the COVID-19 pandemic. Therefore, the objective of this article is to provide guidelines for good conduct in the operating room, the use of personal protective equipment,...

Chronic obstructive pulmonary disease (COPD) is a chronic degenerative disease. It is a frequent, preventable and treatable disease characterized by persistent respiratory symptoms and airflow limitation. The National Institute of Respiratory Diseases (INER), ranked COPD in 2016 in fourth place in the table of annual morbidity and mortality in Mexi...

Chronic obstructive pulmonary disease (COPD) is a chronic degenerative disease. It is a frequent, preventable and treatable disease characterized by persistent respiratory symptoms and airflow limitation. The National Institute of Respiratory Diseases (INER), ranked COPD in 2016 in fourth place in the table of annual morbidity and mortality in Mexi...

Night-workers, transcontinental travelers and individuals that regularly shift their sleep timing, suffer from circadian desynchrony and are at risk to develop metabolic disease, cancer, and mood disorders, among others. Experimental and clinical studies provide evidence that food intake restricted to the normal activity phase is a potent synchroni...

ABSTRACT Introduction: The temporal bone is a valuable structure in the approach of intracranial pathologies to the middle and posterior fossa. Sometimes requiring the performance of petrosectomies or combined approaches for the resection of tumors in these regions. The purpose of this study is to perform morphometric analysis in adult skulls with...

Our planet and the life that develops in it are in constant movement, therefore, the geophysical rhythms influence the activity of organisms, in such a way that living beings have developed adaptative mechanims in order to respond to the daily variations of the environment. The circadian system is responsible for responding to these cyclical enviro...

El proyecto ANATOPROC surge de la colaboración entre el Departamento de Anatomía y el equipo del Modelo Educativo para Desarrollar Actividades Profesionales Confiables (MEDAPROC), de la Facultad de Medicina de la Universidad Nacional Autónoma de México, ante el alto porcentaje de reprobación y la necesidad de articular de forma vertical y horizonta...

Traveling across several time zones requires a fast adjustment of the circadian system and the differential adjustment speeds of organs and systems results in what is commonly referred as jet lag. During this transitory state of circadian disruption, individuals feel discomfort, appetite loss, fatigue, disturbed sleep and deficient performance of m...

Background/objectives: Modern lifestyle promotes shifted sleep onset and shifted wake up time between weekdays and weekends, producing a condition termed "social-jet lag." Disrupted sleep promotes increased appetite for carbohydrate and fat-rich food, which in long term leads to overweight, obesity and metabolic syndrome. In order to mimic the hum...

Delirium is associated with circadian rhythm disruption. In this study we have explored whether cir-cadian variation of melatonin is an indicator for delirium. Melatonin levels were determined from the first day of hospitalization and up to three days after the onset of delirium. Patients who did not developed delirium exhibited a daily melatonin r...

Delirium is associated with circadian rhythm disruption. In this study we have explored whether circadian variation of melatonin is an indicator for delirium. Melatonin levels were determined from the first day of hospitalization and up to three days after the onset of delirium. Patients who did not developed delirium exhibited a daily melatonin rh...

Resumen Los grandes avances científicos en diversas áreas biomédicas, así como sus demandas de conocimiento y dedicación, han alejado al investigador de la cama del paciente y, por su parte, el clínico poco a poco se trasforma en un técnico en atención médica, y deja de lado el conocimiento científico. Es así como nace la necesidad de unir la inves...

The present review aims to present evidence obtained in clinical surveys and experimental studies that point out the relevance of meal schedules on metabolism and body weight. Recent findings indicate that in spite of ingesting equivalent amounts, food ingestion during the day or during the night can have completely different effects on metabolism...

The major scientific advances in various biomedical areas as well as its demands for knowledge and dedication have moved away the researcher from of the patient’s bedside, and the clinician is gradually been transformed into a technician in medical care, leaving aside the scientific knowledge. Therefore the need to join the basic research and the c...

Resumen El mundo mesoamericano fue creado por dioses diferentes a los que crearon el viejo mundo. Nuestros antepa-sados como lo cita el Dr. Carlos Viesca Treviño, no tuvieron nada que ver con Adán y Eva, sino decían descender de otros seres míticos, Oxomoco y Cipactonal, y fueron creados por el dios creador de los antiguos mexicanos, Ometéotl. Con...

Objetivo: Regular el proceso neurodegenerativo a través de una adecuada modulación de los factores inflamatorios mediante el uso de metilprednisolona y la evaluación con estudios de resonancia magnética. Pacientes y métodos: Pacientes mujeres que se encuentran entre la 1ª y 5ª década de la vida, con diagnóstico de EM, que se incluyeron por cumplir...

Resumen La esclerosis múltiple (EM) es una enfermedad inmune-in-flamatoria y crónico-degenerativa, que afecta a personas jóvenes y tiene un alto impacto social por los costos directos e indirectos. Objetivo: Regular el proceso neurodegenerativo a través de una adecuada modulación de los factores inflamatorios mediante el uso de metilprednisolona y...

Resumen. La enfermedad de Fournier es extremadamente rara en pediatría; se define como una infección progresiva de la región genital y perianal, manifestada como una fascitis necrotizante polimicrobiana. En el 95% de los casos se encuentra asociado a cirugías previas, patologías locales o sistémicas. El diagnóstico es clínico con apoyo de estu-dios...

The aim of this revisión is to highlight recent evidence that links low quality and quantity of sleep with an increased propensity to develop overweight or obesity. In this text we present evidence obtained with controlled clinical studies as well as with experimental models, both indicating that decreased hours of sleep lead to metabolic and behav...

Cases of intravenous leiomyoma with intracardiac extension are rare. Patients with signs of right-sided overload who present symptoms of acute heart failure and whose symptoms do not improve with conventional management, we must consider this entity. It is important to comprehensively assess with imaging studies such as electrocardiogram, echocardi...

Circadian rhythms are endogenously generated with a period length of approximately 24 hours. Studies performed during the past decade indicate that the circadian timing system develops prenatally and the suprachias-matic nucleus, considered the site of the circadian clock, is present by midgestation in primates. Recent evidence also shows that the...

Recibido: 22-octubre-12. Aprobado: 07-enero-13. Resumen Son raros los casos de leiomiomas intravenosos con exten-sión intracardiaca. En pacientes con manifestaciones de sobrecarga de cavidades derechas o quienes debutan con síntomas de insuficiencia cardiaca aguda y cuyos síntomas no mejoran con el manejo convencional, se debe considerar esta entid...

Temporomandibular disorders (TMDs) are a set of clinical problems that involve different anatomical structures such as masticatory muscles, the temporomandibular joint and related anatomical structures. They are considered a subclass of musculoskeletal disorders and have been identified as a major cause of non-dental facial pain. TMDs are character...

The oblique facial clefts are extremely rare facial anomalies, although the exact incidence of these facial clefts is unknown, is reported an incidence de 1.5 to 5 per 100,000 births. Tessier in 1976 proposed an anatomic classification of the facial, craniofacial, and laterofacial clefts. Number 3 clefts o oral-nasal-ocular cleft was described by M...

Circadian desynchrony occurs when individuals are exposed to abrupt phase shifts of the light-dark cycle, as in jet lag. For reducing symptoms and for speeding up resynchronization, several strategies have been suggested, including scheduled exercise, exposure to bright light, drugs, and especially exogenous melatonin administration. Restricted fee...

Vieja madera para arder, viejo vino para beber, viejos amigos en quien confiar, y viejos autores para leer. Sir Francis Bacon (1561-1626) resumen El envejecimiento es el conjunto de modificaciones morfo-lógicas y fisiológicas generadas como consecuencia de la acción del tiempo sobre los seres vivos. Entre estas modifi-caciones se debe de incluir la...

Aging is the set of morphological and physiological changes generated by the action of time on living beings. These changes include the inability to adapt and respond to environmental challenges, by organs, apparatus and systems. Aging of organisms and particularly of man, has become a concern in recent years, because our life expectancy has increa...

Food anticipatory behavior (FAA) is induced by limiting access to food for a few hours daily. Animals anticipate this scheduled meal event even without the suprachiasmatic nucleus (SCN), the biological clock. Consequently, a food-entrained oscillator has been proposed to be responsible for meal time estimation. Recent studies suggested the dorsomed...

The relevance of a synchronized temporal order for adaptation and homeostasis is discussed in this review. We present evidence suggesting that an altered temporal order between the biological clock and external temporal signals leads to disease. Evidence mainly based on a rodent model of "night work" using forced activity during the sleep phase sug...

Resumen Las suras oblicuas faciales son anormalidades poco frecuen-tes, aunque la incidencia exacta es desconocida, se reporta una incidencia de 1.5 a 5 por 100,000 nacimientos. Tessier en 1976 propuso una clasicación de las suras faciales, craneofa-ciales y laterofaciales. Morian describió la sura oral nasoor-bitaria ((sura número 3), que represen...

Internal synchrony among external cycles and internal oscillators allows adaptation of physiology to cyclic demands for homeostasis. Night work and shift work lead to a disrupted phase relationship between external time cues and internal rhythms, also losing internal coherence among oscillations. This process results in internal desynchrony (ID) in...

The present study explored the effects of malnutrition and nutritional rehabilitation on the response to glucose in hypothalamic nuclei involved in metabolic homeostasis. Male Wistar rats were malnourished during gestation-lactation (MGL) or at weaning to 55 days (MPW). Two groups of rats were rehabilitated with a balanced diet until 90 days (MGL-R...

Shift work or night work is associated with hypertension, metabolic syndrome, cancer, and other diseases. The cause for these pathologies is proposed to be the dissociation between the temporal signals from the biological clock and the sleep/activity schedule of the night worker. We investigated the mechanisms promoting metabolic desynchrony in a m...

Background and objective: To explore the role of the suprachiasmatic nucleus (SCN) for masking by light in rats bearing bilateral complete or partial lesions of the suprachiasmatic nucleus. Methods: Rats were submitted to electrolytic SCN lesions, and their spontaneous activity was monitored to verify arrhythmia in different lighting conditions, un...

Daily feeding schedules entrain temporal patterns of behavior, metabolism, neuronal activity and clock gene expression in several brain areas and periphery while the suprachiasmatic nucleus (SCN), the biological clock, remains coupled to the light/dark cycle. Because bilateral lesions of the SCN do not abolish food entrained behavioral and hormonal...

Food-anticipatory activity (FAA) and especially the food-entrained oscillator (FEO) have driven many scientists to seek their mechanisms and locations. Starting our research on FAA we, possibly like many other scientists, were convinced that clock genes held the key to the location and the underlying mechanisms for FAA. In this review, which is aim...

Restricted feeding schedules (RFS) entrain digestive, hormonal, and metabolic functions as well as oscillations of clock genes, such as Per1 and Per2, in peripheral organs. In the brain, in particular the hypothalamus, RFS induce and shift daily rhythms of Per1 and Per2 expression. To determine whether RFS affect clock genes in extra-SCN oscillator...

The clock gene protein Per 1 (PER1) is expressed in several brain structures and oscillates associated with the suprachiasmatic nucleus (SCN). Restricted feeding schedules (RFS) induce anticipatory activity and impose daily oscillations of c-Fos and clock proteins in brain structures. Daily access to a palatable treat (chocolate) also elicits antic...

Individuals engaged in shift- or night-work show disturbed diurnal rhythms, out of phase with temporal signals associated to the light/dark (LD) cycle, resulting in internal desynchronization. The mechanisms underlying internal desynchrony have been mainly investigated in experimental animals with protocols that induce phase shifts of the LD cycle...

Restricted feeding schedules (RFS) are a potent Zeitgeber that uncouples daily metabolic and clock gene oscillations in peripheral tissues from the suprachiasmatic nucleus (SCN), which remains entrained to the light-dark cycle. Under RFS, animals develop food anticipatory activity (FAA), characterized by arousal and increased locomotion. Food avail...

Entrainment by daily restricted feeding schedules (RFS) produces food anticipatory activity (FAA) which involves motivational processes which may be regulated by corticolimbic structures and the nucleus accumbens. The present study aimed first to determine whether corticolimbic structures participate in the expression of FAA, therefore c-Fos immuno...

Food is considered a potent Zeitgeber for peripheral oscillators but not for the suprachiasmatic nucleus (SCN), which is entrained principally by the light-dark cycle. However, when food attains relevant properties in quantity and quality, it can be a potent Zeitgeber even for the SCN. Here we evaluated the entrainment influence of a daily palatabl...

Restricted feeding schedules (RFS) entrain behavioral and physiological rhythms even in suprachiasmatic nucleus ablated animals, suggesting the existence of a food-entrained oscillator. The nucleus accumbens is an important structure for the expression of motivational behaviors and because its anatomical subterritories, Shell (Acc-Sh) and Core (Acc...

When food is restricted to a few hours daily, animals increase their locomotor activity 2-3 h before food access, which has been termed food anticipatory activity. Food entrainment has been linked to the expression of a circadian food-entrained oscillator (FEO) and the anatomic substrate of this oscillator seems to depend on diverse neural systems...

Food anticipatory activity (FAA) is the expression of a food entrained oscillator, which manifests under restricted feeding schedules (RFS). Food restriction to 2 h daily represents a metabolic challenge and requires behavioral and physiological adaptations in order to allow animals to ingest sufficient food for a 24 h cycle in a short 2 h interval...

Food entrainment of clock genes in peripheral tissues and anticipatory response in the liver of rats maintained under a restricted feeding schedule have suggested that the liver may be a relevant element for a food entrained oscillator (FEO). Recent data suggest that mechanisms underlying food-entrainment for metabolic and behavioral or locomotor f...

Rats maintained under restricted feeding schedules (RFS) develop food-anticipatory activity and entrainment of physiological parameters. Food entrainment is independent of the suprachiasmatic nucleus and depends on food-entrainable oscillators (FEO). Restricted feeding schedules lead animals toward a catabolic state and to increase their food drive...

Digestive and metabolic processes are entrained by restricted feeding (RFS) schedules and are thought to be potential elements of a food-entrained oscillator (FEO). Due to the close relationship of leptin with metabolic regulation and because leptin is a relevant communication signal of the individual's peripheral metabolic condition with the centr...

The present study aimed to identify the hypothalamic nuclei involved with food entrainment by using c-Fos-like immunoreactivity (c-Fos-IR) as a marker of functional activation. We studied rats entrained 3 wk to restricted feeding schedules (RF), their ad libitum (AL) controls, and the persistence of c-Fos-IR temporal patterns in entrained-fasted ra...

Introducción El concepto de homeostasis, es decir, la constancia del medio interno, que ha dominado la enseñanza, la investiga-ción y la práctica de la medicina durante el siglo XX, está siendo desafiado por nuevos conceptos del campo de la cro-nobiología, que es la ciencia de los ritmos biológicos. En la última década la aplicación de la cronobiol...