Manuel Aguilar-DiosdadoServicio Andaluz de Salud | SAS · Endocrinology & Metabolism
Manuel Aguilar-Diosdado
MD
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257
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2,418
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Citations since 2017
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January 1987 - present
Publications
Publications (257)
Citation: Sánchez-Toscano, E.; Domínguez-Riscart, J.; Larrán-Escandón, L.; Mateo-Gavira, I.; Aguilar-Diosdado, M. Cardiovascular Risk Factors in Transgender People after Gender-Affirming Hormone Therapy. J. Clin. Med. 2023, 12, 6141. https:// Abstract: Introduction: In the last decade, healthcare for the transgender population has increased conside...
The intricate etiology of type 1 diabetes mellitus (T1DM), marked by a detrimental cross-talk between the immune system and insulin-producing beta cells, has impeded effective disease-modifying therapies. The discovery that pharmacological activation of the nuclear receptor LRH-1/NR5A2 can reverse hyperglycemia in mouse models of T1DM by attenuatin...
Background:
The literature provides limited evidence of cord blood leptin levels in gestational diabetes mellitus (GDM), with contradictory and inconsistent results with respect to their possible implications for maternal, perinatal, and future complications.
Methods:
MEDLINE/PubMed, Embase, Scopus, and Web of Science databases were searched in...
Endothelial dysfunction has been considered as a key etiological factor contributed to the development of vascular disease in diabetes mellitus. Serum level of endothelial cell adhesion molecules (AMs) were reported to be increased in GDM and pregnant women with normal glucose tolerance when compared with nonpregnant women. The literature provides...
Background
The risk of hypertensive disorders of pregnancy (HDP) varies in women with gestational diabetes mellitus (GDM), depending on the degree of insulin resistance and is also influenced by obesity. The aim of this study was to evaluate clinical features, blood pressure (BP) profiles and inflammatory markers, to identify patients with an eleva...
Obesity increases the risk of insulin resistance and type 2 diabetes through increased inflammation at cellular and tissue levels. Therefore, study of the molecular elements involved in obesity-related inflammation may contribute to preventing and controlling it. Inorganic polyphosphate is a natural phosphate polymer that has recently been attracti...
Diabetes mellitus (DM) is a world health problem of global repercussion [...]
Inflammatory processes play a central role in the pathogenesis of diabetic nephropathy (DN) in the early stages of the disease. The authors demonstrate that the glycolipid mimetic (Ss)-DS-ONJ is able to abolish inflammation via the induction of autophagy flux and provokes the inhibition of inflammasome complex in ex vivo and in vitro models, using...
Administration of the LRH-1 agonist BL0refrains hyperglycemia in 3 mouse models of type 1 diabetes (T1DM) . This antidiabetes action correlated with beta cell mass preservation and the presence of anti, rather than pro, inflammatory immune cells, indicating tolerization. Herein, we sought to translate these data to human immune cells of T1DM patien...
Huntington’s disease (HD) is a neurodegenerative disorder caused by a toxic, aggregation-prone expansion of CAG repeats in the HTT gene with an age-dependent progression that leads to behavioral, cognitive and motor symptoms. Principally affecting the frontal cortex and the striatum, mHTT disrupts many cellular functions. In fact, increasing eviden...
Gestational diabetes mellitus (GDM) represents a stage of subclinical inflammation and a risk factor for subsequent future type 2 diabetes and cardiovascular disease development. Leptin has been related with vascular and metabolic changes in GDM with heterogeneous and contradictory results with respect to their possible involvement in maternal, per...
Inflammatory processes play a central role in the pathogenesis of diabetic nephropathy (DN) in the early stages of the disease. In vitro approach using cell lines help to understand the mechanisms involves and allow the molecular and biochemical processes. Adult kidney (AK) explants remain an essential instrument for advancing our understanding of...
Gestational diabetes mellitus (GDM) increases the risk of hypertensive disorders of pregnancy (HDP). We aimed to analyze the altered inflammatory markers and angiogenic factors among women with GDM to identify pregnant women at higher risk of developing HDP.
Methods:
This was a prospective study of 149 women without hypertension diagnosed in the...
During Type 1 Diabetes Mellitus (T1DM) progression, there is chronic and low-grade inflammation that could be related to the evolution of the disease. We carried out a systematic review and meta-analysis to evaluate whether peripheral levels of pro-inflammatory markers such as interleukin-1 beta (IL-1β) is significantly different among patients wit...
This document is an update to the clinical practice recommendations for the management of cardiovascular risk factors (CVRF) in diabetes mellitus. The consensus has been developed by a multidisciplinary team made up of members of the Cardiovascular Risk Group of the Spanish Diabetes Society (SED). The work is a necessary update as, since the last r...
Objectives
The association of OLP with other autoimmune processes points to the possibility that OLP-affected patients are actually developing an autoimmune status that predisposes them to autoaggression against different targets. This systematic review and meta-analysis aims to evaluate the current evidence on the prevalence of autoimmune disorder...
Background:
Retinopathy is the most common microvascular complication of diabetes mellitus. It is the leading cause of blindness among working-aged people in developed countries. The use of telemedicine in the screening system has enabled the application of large-scale population-based programs for early retinopathy detection in diabetic patients....
sp2-Iminosugar glycolipids (sp2-IGLs) represent a consolidated family of glycoconjugate mimetics encompassing a monosaccharide-like glycone moiety with a pseudoamide-type nitrogen replacing the endocyclic oxygen atom of carbohydrates and an axially-oriented lipid chain anchored at the pseudoanomeric position. The combination of these structural fea...
Cardiovascular disease (CVD) is the most common cause of morbidity and mortality in developed countries. The prevalence of CVD is much higher in patients with type 2 diabetes mellitus (T2DM), who may benefit from lifestyle changes, which include adapted diets. In this review, we provide the role of different groups of nutrients in patients with T2D...
Resumen
El presente documento es una actualización de las recomendaciones de práctica clínica para el manejo de los factores de riesgo cardiovascular (FRCV) en la diabetes mellitus. Este consenso ha sido elaborado por los miembros del Grupo de Riesgo Cardiovascular de la Sociedad Española de Diabetes (SED). El trabajo es una actualización necesaria...
Introduction
Diabetes mellitus (DM) is one of the most prevalent chronicdiseases and has a significant health and social impact. Strict control of blood glucose levels and other risk factors for vascular disease (VD) reduces complications and mortality and is related to the quality of care received. Although care should be interdisciplinary, based...
Diabetic retinopathy (DR) is one of the most common complications of Diabetes Mellitus (DM) and is directly associated with inflammatory processes. Currently, neuro-inflammation is considered an early event in DR and proceeds via microglia polarization. A hallmark of DR is the presence of retinal reactive gliosis. Here we report the beneficial effe...
Rationale: We recently demonstrated that the 'Metabesity' factor HMG20A regulates islet beta-cell functional maturity and adaptation to physiological stress such as pregnancy and pre-diabetes. HMG20A also dictates central nervous system (CNS) development via inhibition of the LSD1-CoREST complex but its expression pattern and function in adult brai...
Review Article
Therapeutic Approach with PCSK9 Inhibitors for Effective
Cardiovascular Risk Reduction in Diabetes
Introduction
Very little is known about the influence of socioeconomic status on type 1 diabetes mellitus (T1DM) complications. Our aim was to determine whether socioeconomic level is a risk factor for the development of diabetic retinopathy (DR) in patients with T1DM.
Research design and methods
A cohort of 150 patients with T1DM were studied pro...
Diabetic retinopathy (DR) is a preventable cause of vision loss and blindness worldwide. We aim at analyzing the impact of a population-based screening program of DR using retinal photography with remote reading in terms of population coverage, diagnosis of asymptomatic DR and impact on visual disability, in the region of Andalusia, Spain, in the p...
Resumen
Introducción
La diabetes mellitus (DM) es una de las patologías crónicas más prevalentes en nuestro medio, con un importante impacto sanitario y social. El control estricto de la glucemia y de otros factores de riesgo de enfermedad vascular reduce las complicaciones y mortalidad y se relaciona con la calidad de la atención recibida. Aunque...
Objectives:
To evaluate current evidence on the prevalence and risk of oral cancer and potentially malignant oral disorders among patients with diabetes mellitus.
Material and methods:
We searched PubMed, Embase, Web of Science, and Scopus for observational studies published before November-2019. We evaluated the studies quality using GRADE, QUI...
Objective:
To assess the impact of a telemedicine visit using the platform Diabetic compared with a face-to-face visit, on clinical outcomes, patients' health-related quality of life (HRQoL), and physicians' satisfaction in patients with type 1 diabetes.
Research design and methods:
PLATEDIAN (Telemedicine on Metabolic Control in Type 1 Diabetes...
To evaluate the effectiveness of the different insulin therapies on obstetrics-fetal outcomes in women with pregestational diabetes mellitus. We enrolled 147 pregnant women with pre-existing type 1 or 2 diabetes mellitus. Clinical and biochemical parameters were analysed in relation to obstetric and fetal outcomes. 14.2% received treatment with Neu...
RESUMEN La obesidad supone un importante impacto sociosanitario por su elevada prevalencia, las comorbilidades asociadas y su elevada mortalidad. La cirugía bariátrica, aunque no exenta de riesgos, se postula como un tratamiento eficaz en la consecución de una importante pérdida ponderal y mejoría de las patologías asociadas a la obesidad. Los dato...
RESUMEN Introducción: la obesidad mórbida es hoy en día unos de los principales problemas de salud a nivel mundial y la gastrectomía vertical es la técnica quirúrgica bariátrica más utilizada para su tratamiento. En el presente artículo analizamos sus indicaciones, detalles técnicos, resultados y principales complicaciones, para intentar comprender...
Resumen
En las últimas décadas se ha producido un notable incremento en la prevalencia e incidencia del sobrepeso y de la obesidad tanto a nivel mundial como en nuestro país, dentro del cual, nuestra comunidad se encuentra entre las regiones con datos más desfavorables. La obesidad eleva el riesgo de complicaciones crónicas que afectan a la salud y...
Resumen
La obesidad supone un importante impacto sociosanitario por su elevada prevalencia, las comorbilidades asociadas y su elevada mortalidad. La cirugía bariátrica, aunque no exenta de riesgos, se postula como un tratamiento eficaz en la consecución de una importante pérdida ponderal y mejoría de las patologías asociadas a la obesidad. Los dato...
Resumen
La investigación en medicina es la única herramienta útil utilizada por el médico para avanzar en su actividad. La cirugía bariátrica no es ajena a esta dinámica natural instaurada. Desde sus comienzos y hasta la época actual las indicaciones y directrices han ido variando. Las sociedades científicas, cada vez más estructuradas y organizada...
Resumen
Introducción: la obesidad mórbida es hoy en día unos de los principales problemas de salud a nivel mundial y la gastrectomía vertical es la técnica quirúrgica bariátrica más utilizada para su tratamiento. En el presente artículo analizamos sus indicaciones, detalles técnicos, resultados y principales complicaciones, para intentar comprender...
RESUMEN La investigación en medicina es la única herramienta útil utilizada por el médico para avanzar en su actividad. La cirugía bariátrica no es ajena a esta dinámica natural instaurada. Desde sus comienzos y hasta la época actual las indicaciones y directrices han ido variando. Las sociedades científicas, cada vez más estructuradas y organizada...
Background:
Continuous glucose monitoring could detect certain patterns of hyperglycemia at different times of the day that may help predict the development of maternal-fetal complications and the probability of needing pharmacological treatment.
Methods:
This study prospectively examined 77 women with gestational diabetes mellitus who were plac...
Immunomodulatory glycolipids, among which α-galactosylceramide (KRN7000) is an iconic example, have shown strong therapeutic potential in a variety of conditions ranging from cancer and infection to autoimmune or neurodegenerative diseases. A main difficulty for those channels is that they often provoke a cytokine storm comprising both pro- and ant...
RESUMEN En las últimas décadas se ha producido un notable incremento en la prevalencia e incidencia del sobrepeso y de la obesidad tanto a nivel mundial como en nuestro país, dentro del cual, nuestra comunidad se encuentra entre las regiones con datos más desfavorables. La obesidad eleva el riesgo de complicaciones crónicas que afectan a la salud y...
Background and objective
Gestational diabetes mellitus (GDM) is associated to an increased risk of pregnancy-induced hypertension (PIH). Ambulatory blood pressure monitoring (ABPM) has been used to detect PIH and preeclampsia, but few data are currently available on its use in women with GDM. The aim of this study was to achieve early identificatio...
Retinal degenerative diseases are a group of heterogeneous diseases that include age-related macular degeneration (AMD), retinitis pigmentosa (RP), and diabetic retinopathy (DR). The progressive degeneration of the retinal neurons results in a severe deterioration of the visual function. Neuroinflammation is an early hallmark of many neurodegenerat...
This document is an update to the clinical practice recommendations for the management of cardiovascular risk factors in diabetes mellitus. The consensus is made by members of the Cardiovascular Risk Group of the Spanish Diabetes Society. We have proposed and updated interventions on lifestyle, pharmacological treatment indicated to achieve therape...
This document is an update to the clinical practice recommendations for the management of cardiovascular risk factors in diabetes mellitus. The consensus is made by members of the Cardiovascular Risk Group of the Spanish Diabetes Society. We have proposed and updated interventions on lifestyle, pharmacological treatment indicated to achieve therape...
Background
The impact of subclinical hypothyroidism (SH) and thyroid autoimmunity on obstetric and perinatal complications continues to be a matter of interest and highly controversial.
Aim
To assess the impact of SH and autoimmunity in early pregnancy on the obstetric and perinatal complications in our population.
Material and method
A retrospec...
Background and objective:
Gestational diabetes mellitus (GDM) is associated to an increased risk of pregnancy-induced hypertension (PIH). Ambulatory blood pressure monitoring (ABPM) has been used to detect PIH and preeclampsia, but few data are currently available on its use in women with GDM. The aim of this study was to achieve early identificat...
Supplementary material for "The type 2 diabetes-associated HMG20A gene is mandatory for islet beta cell functional maturity" published in Cell Death & Disease (2018)
Objective:
To assess the modifying effect of marital status on social and gender inequalities in mortality from diabetes mellitus (DM) in Andalusia.
(PI FIS: Exp. 15/01106)
Material and methods:
A cross-sectional study was conducted using the Andalusian Longitudinal Population Database. DM deaths between 2002 and 2013 were analyzed by educational...
Objective
To assess the modifying effect of marital status on social and gender inequalities in mortality from diabetes mellitus (DM) in Andalusia.
Material and methods
A cross-sectional study was conducted using the Andalusian Longitudinal Population Database. DM deaths between 2002 and 2013 were analyzed by educational level and marital status....
HMG20A (also known as iBRAF) is a chromatin factor involved in neuronal differentiation and maturation. Recently small nucleotide polymorphisms (SNPs) in the HMG20A gene have been linked to type 2 diabetes mellitus (T2DM) yet neither expression nor function of this T2DM candidate gene in islets is known. Herein we demonstrate that HMG20A is express...
Background:
The impact of subclinical hypothyroidism (SH) and thyroid autoimmunity on obstetric and perinatal complications continues to be a matter of interest and highly controversial.
Aim:
To assess the impact of SH and autoimmunity in early pregnancy on the obstetric and perinatal complications in our population.
Material and method:
A ret...
Increased adhesion molecules and oxidative stress markers may be the result of early vascular abnormalities and metabolic changes in gestational diabetes mellitus, and may be responsible for maternal and fetal complications. There are no conclusive results in the literature regarding the role of adipokines, oxidative stress, and adhesion molecules...
