Manouchka Baron

• Adelphi University

Background While intravesical injections of botulinum neurotoxin A (BoNT-A) are currently recommended for patients experiencing refractory neurogenic overactive bladder and/or detrusor overactivity (OAB/DO), it is unclear how much this therapy is effective and sustainable in the long-term in patients with multiple sclerosis (MS). Objectives To ass...

Purpose: To assess the efficacy, safety, and predictive factors for failure of synthetic mid-urethral slings for the treatment of urinary incontinence in a large cohort of women with neurogenic lower urinary tract dysfunction. Materials and methods: Women aged 18 years or older who received a synthetic mid-urethral sling for stress urinary incon...

Objectives: The aim of this study was to assess midterm functional outcomes and complications of robot-assisted laparoscopic cystectomy with non-continent urinary diversion in patients with neurogenic lower urinary tract dysfunction. Materials and methods: We performed a retrospective single center study including all patients who underwent robo...

Purpose: To report long-term results of artificial urinary sphincter implantation for urinary incontinence due to intrinsic sphincter deficiency in children. Materials and methods: This retrospective monocentric study included all patients who underwent artificial urinary sphincter (AMS 800) implantation before 18 years of age between 1986 and O...

BACKGROUND Irritable bowel syndrome and bladder pain syndrome often overlap and are both characterized by visceral hypersensitivity. Since pelvic organs share common sensory pathways, it is likely that those syndromes involve a cross-sensitization of the bladder and the colon. The precise pathophysiology remains poorly understood. AIM To develop a...

Objective To describe the outcomes of ileal conduit as a salvage therapy for refractory lower urinary tract dysfunctions (LUTDs) due to multiple sclerosis (MS) in a national neurourology referral center network. Methods A retrospective multicenter French study was carried out to identify MS patients who underwent non-continent urinary diversion fo...

Background Functional dyspepsia and bladder pain syndrome are well‐known to overlap with irritable bowel syndrome. Whether functional dyspepsia overlaps with bladder pain syndrome remains unknown. Our aim was to evaluate the presence of bladder pain syndrome in functional dyspepsia patients and its impact. Methods All consecutive patients with inv...

Purpose To evaluate the impact of COVID-19 pandemic on functional urology procedures in France. Methods A prospective study was conducted within 11 secondary and tertiary referral centers in France. Patients aged > 18 years who were diagnosed with a functional urology disease before the national lockdown (March 17th, 2020) and who required a surge...

Introduction and hypothesisThe aim of our study was to evaluate the efficiency and safety of synthetic mid-urethral slings (sMUS) for the treatment of stress urinary incontinence (SUI) in women with neurogenic lower urinary tract dysfunction (NLUTD).MethodsA systematic review was performed and reported according to the Preferred Reporting Items for...

Introduction and hypothesisThe objective was to report the management of post-operative urinary incontinence after midurethral sling (MUS) revision for chronic pelvic pain (CPP), and to report functional outcomes.Methods From November 2004 to February 2018, a total of 89 women who underwent removal or section of MUS for CPP, were enrolled. Patients...

Introduction: Management of idiopathic overactive bladder (iOAB) after the failure of sacral nerve modulation (SNM) is very challenging. To the best of our knowledge, no study has evaluated the use of botulinum toxin A (BoNT-A) after SNM failure for iOAB. The aim of this study is to evaluate the tolerance and efficacy of BoNT-A injection after the...

Purpose: Data are lacking on long-term outcomes of intradetrusor injections of botulinum toxin A for neurogenic detrusor overactivity. The aim of this study was to assess the outcomes of intradetrusor injections of botulinum toxin A for neurogenic detrusor overactivity after more than 10 years of followup. Materials and methods: We retrospective...

Aims To evaluate the impact of the pre‐operative maximum detrusor pressure (MDP) on efficacy outcomes after incontinentation by sphincterotomy or urethral stent placement in male patients with neurogenic detrusor‐sphincter dyssynergia (DSD). Methods A retrospective study was performed in 41 male patients treated between 2006 and 2013 in a tertiary...

Introduction: Irritable bowel syndrome (IBS) and bladder pain syndrome (BPS) often overlap, and are both characterized by visceral hypersensitivity reproduced by pelvic organ distension. Since pelvic organs share a common innervation, it is likely that those syndromes involve a cross-sensitization of the bladder and the colon in response to distens...

Purpose: The aim of the present study was to report the outcomes of botulinum toxin A (BTX-A) intradetrusor injections in adult patients with spina bifida. Materials and methods: All patients with spinal dysraphism who had undergone intradetrusor injections of BTX-A from 2002 to 2016 in 14 centers were included retrospectively. The primary endpo...

Objective: To assess the effectiveness of Intradetrusor injections of botulinum toxin type A (IDBTX-A) in children with spina bifida. Patients and methods: All patients aged under 16 year-old who underwent IDBTX-A between 2002 and 2016 at six institutions were included in a retrospective study. Our primary endpoint was the success rate of IDBTX-...

Aim: The aim of this study was to assess the feasibility, efficacy and tolerance of Greenlight™ and Holmium sphincterotomy for treating detrusor-sphincter dyssynergia. Methods: All men treated with this two techniques between may 2012 and june 2015 were analyzed. Preoperative evaluation included kidney ultrasound scan, urodynamic, retrograde and...

Intradetrusor injections of botulinum toxin are the cornerstone of medical treatment of neurogenic detrusor overactivity. The primary aim of this treatment is to ensure a low pressure regimen in the urinary bladder, but the mechanisms leading to long-term protection of the urinary tract remain poorly understood. In this paper, we highlight the pote...

Purpose: To evaluate literature data about urinary sacral neuromodulation and its effects on bowel symptoms other than fecal incontinence. Method: A systematic review was conducted using PubMed/Medline with the following keywords: sacral neuromodulation, urinary incontinence, voiding symptoms, intestinal bowel syndrome, constipation, epidemiolog...

Objectifs La courbe d’apprentissage de l’énucléation prostatique par laser Holmium (HOLEP) est réputée difficile. Un tutorat pour les premiers cas est conseillé. Notre objectif était d’évaluer l’intérêt de la mise en place d’un tutorat séquentiel en 2 étapes dans le processus de formation à la procédure au sein d’un centre universitaire. Méthodes...

Genomewide scans of bipolar disorder (BP) have not produced consistent linkage findings. Follow-up studies using enlarged samples and enhanced marker density can bolster or refute claims of linkage and pave the way to gene discovery. We conducted linkage and association analyses, using a ~3-cM density map of 10 candidate regions, in a large BP pedi...

We report a case of 31-year-old woman presented with a chronic pelvic pain and a 3-cm left ovarian cyst on ultrasonography. At the time of laparoscopy, we observed two blue peritoneal lesions at the pelvic insertion of left round ligament. Histopathological examination of a biopsy showed a pigmentation due to a decorative tattoo of the left thigh.

We report a case of 31-year-old woman presented with a chronic pelvic pain and a 3-cm left ovarian cyst on ultrasonography. At the time of laparoscopy, we observed two blue peritoneal lesions at the pelvic insertion of left round ligament. Histopathological examination of a biopsy showed a pigmentation due to a decorative tattoo of the left thigh....

Common hereditary neurodevelopmental disorders such as autism, bipolar disorder, and schizophrenia are most likely both genetically multifactorial and heterogeneous. Because of these characteristics traditional methods for genetic analysis fail when applied to such diseases. To address the problem we propose a novel probabilistic framework that com...

We report a case of T1N0 left breast cancer in a 47-year-old woman. Histopathological examination of a non sentinel axillary lymph node showed a pigmentation due to a decorative tattoo of the arm. The authors discuss a new concept: Axillary Reverse Mapping.

La présence d’une grossesse dans une corne rudimentaire d’un utérus pseudo-unicorne est un événement rare, pouvant se révéler par une rupture utérine en cours de grossesse. Le traitement recommandé, après extraction fœtale, consiste en l’exérèse de cette corne. Si cette dernière n’est pas effectuée, elle expose théoriquement au risque de récidive d...

Metastatic involvement of the adrenal glands due to gynaecological neoplasms is a relatively rare condition. The aim of our study was to present four cases of metastases to the adrenal gland due to endometrial adenocarcinoma, ovarian and cervical cancer. These cases are correlated with a review of the literature. CT scan and MRI have been previousl...

We report a case of laparoscopic ovarian transposition and ovarian cryopreservation in a nulliparous 25-year-old woman with rectal cancer. The authors focus on the surgical technique and the importance of preserving ovarian function.

We present a depressive patient who developed mild parkinsonian signs and camptocormia after the introduction of olanzapine. She had been treated before with other antipsychotic drugs. When camptocormia was diagnosed, olanzapine was withdrawn and levodopa was introduced. Depressive symptoms got worse and electroconvulsive therapy was tried. When th...

Paget's disease of the vulva is difficult to diagnose, as far as the extent of this lesion is concerned, since it is often coupled with invasive adenocarcinoma of the vulva. Thus, we present two cases of Paget's disease of the vulva, with use of sentinel lymph node analysis— a non-validated technique in this very context. Evaluation of sentinel lym...

Cancer arising in abdominal wall endometriosis is a rare event, hindering diagnosis and making management uncertain. A cesarean section scar is generally at the origin of the disease. We report the case of a 45-year-old woman, with a past medical history of cesarean deliveries, complaining of a repeat abdominal wall endometriosis which transformed...

La cancérisation d’une endométriose pariétale est une éventualité peu connue rendant son diagnostic hésitant, sa prise en charge incertaine. Le point de départ est généralement une cicatrice de césarienne.

We conducted a 9-cM genome scan in a large bipolar pedigree sample from the National Institute of Mental Health genetics initiative (1060 individuals from 154 multiplex families). We performed parametric and nonparametric analyses using both standard diagnostic models and comorbid conditions thought to identify phenotypic subtypes: psychosis, suici...

The clinical features of cluster headache (CH) disclose some vascular changes in the symptomatic region, but few instrumental studies have assessed orbital hemodynamics in patients with this disorder. Orbital blood flow reactivity elicited by Valsalva maneuver (VM) was studied with ophthalmic artery eco-Doppler in 16 patients (14 men and 2 women; m...

Linkage analysis of phenotypic subtypes can expedite detection of susceptibility genes and clarify the genetic relationship among disease subsets. There is growing interest in applying this strategy to bipolar disorder (BP), a complex psychiatric disease with a strong, yet poorly understood genetic component.

Paget's disease of the vulva is difficult to diagnose, as far as the extent of this lesion is concerned, since it is often coupled with invasive adenocarcinoma of the vulva. Thus, we present two cases of Paget's disease of the vulva, with use of sentinel lymph node analysis- a non-validated technique in this very context. Evaluation of sentinel lym...

Several independent studies and meta-analyses aimed at identifying genomic regions linked to bipolar disorder (BP) have failed to find clear and consistent evidence of linkage regions. Our hypothesis is that combining the original genotype data provides benefits of increased power and control over sources of heterogeneity that outweigh the difficul...

Objective measurements of duration of attacks have been performed in 8 (5 female and 3 male) patients suffering from primary first division (V-1) trigeminal neuralgia. The mean age of the patients was 67.5 +/- 11.4 years, and the mean age at onset 64.0 +/- 9.7 years. During the study the patients were off treatment. A total of 192 attacks were witn...

The low-to-moderate resolution of linkage analysis in complex traits has underscored the need to identify disease phenotypes with presumed genetic homogeneity. Bipolar disorder (BP) accompanied by psychosis (psychotic BP) may be one such phenotype. We previously reported a genome-wide screen in a large bipolar pedigree sample. In this follow-up stu...

To study the clinical features of nummular headache (NH) and get an approach to its epidemiology. NH has been recently described as a primary disorder characterized by head pain exclusively felt in a small rounded area typically 2-6 cm in diameter. Through a 1-year period we have studied all patients referred to our neurologic clinic because of hea...

Changes in intraocular pressure (IOP) elicited by a Valsalva manoeuvre were studied in 11 male patients (mean age 39.8 years) suffering from episodic cluster headache (CH), and 12 healthy male controls (mean age 39.9 years). The tests were performed at rest and while exhaling hard through a mouthpiece connected to a mercury manometer. In the CH gro...

Genome scans of bipolar disorder (BPD) have not produced consistent evidence for linkage. The rank-based genome scan meta-analysis (GSMA) method was applied to 18 BPD genome scan data sets in an effort to identify regions with significant support for linkage in the combined data. The two primary analyses considered available linkage data for "very...

Bipolar disorder (BP) is a severe and common psychiatric disorder characterized by extreme mood swings. Family, twin and adoption studies strongly support a genetic component. The mode of inheritance is complex and likely involves multiple, as yet unidentified genes. To identify susceptibility loci, we conducted a genome-wide scan with 343 microsat...

The case of a 16-year-old woman with typical clinical features of acute vulval ulcer, Lipschutz's disease, is reported. The main differential diagnoses are discussed. Isolated vulval ulcer can reveal a recurrent aphthous ulcer, Behçet's disease or Crohn's disease. In contrast, acute vulval ulcer spontaneously heals with no recurrence, that must be...

Background: Intracystic papillary carcinoma of the breast is a rare tumor with distinctive pathological features that can appear in a pure form (intracystic papillary carcinoma alone) or associated with ductal carcinoma in situ or invasive carcinoma. Pure intracystic papillary carcinoma is associated with an excellent prognosis. There is no consens...

Numular headache is a chronic, mild to moderate, pressurelike pain in a circumscribed cranial area of approximately 2 to 6 cm in diameter. Pain usually is limited to the parietal region, although it may appear in any cranial site. It is a benign process of usually unknown origin.

A total of 26 episodes of V-1 trigeminal neuralgia attacks have been recorded in two female patients. Autonomic phenomena were assessed according to a semiquantitative scale. Attacks lasted 17 +/- 5 s. Mild lacrimation without conjunctival hyperaemia, rhinorrhea or ptosis was observed, even in relatively long lasting episodes. This is in clear cont...

A 27-year-old woman underwent surgery for an abdominal wall mass later confirmed to be a relapse of Stage I ovarian mucinous adenocarcinoma. The authors stress that caution should be observed during laparotomy to remove a malignant neoplasm in order to avoid parietal dissemination.

Manic-depressive illness is a common psychiatric disorder with complex etiology that likely involves multiple genes and non-genetic influences. The uncertain path to gene discovery has spurred considerable debate over genetic findings and gene-finding strategies. In this article, I review the main findings, with a focus on: (1) putative linked loci...

Crossed apraxia is an unusual alteration in praxic function due to a cerebral lesion which is contralateral to that which would be expected. We report a case of crossed apraxia due to a right parietal lesion in a left handed patient who had been obliged to be right handed. We discuss the peculiar neuropsychological profile and possible relation of...

With the human DNA sequence nearing completion, the search for complex disease genes is gaining momentum, as is the debate over gene-finding strategies. This overview contrasts two pivotal methods: linkage analysis and association mapping. Linkage analysis has been used successfully to identify the genes underlying rare mendelian disorders. It has...

Evidence for linkage between bipolar affective disorder (BP) and 21q22 was first reported by our group in a single large pedigree with a lod score of 3.41 with the PFKL locus. In a subsequent study, with denser marker coverage in 40 multiplex BP pedigrees, we reported supporting evidence with a two-point lod score of 2.76 at the D21S1260 locus, abo...

Schizophrenia (MIM 181500) is a severe and common psychiatric disorder afflicting 1% of the world population. The disease is characterized by psychotic symptoms and by cognitive, affective, and psychosocial impairment. As a leading cause of psychiatric admissions, schizophrenia accounts for a considerable portion of health-care expenditures and is...

Twin Reversed Arterial Perfusion (TRAP) sequence, or the acardiac anomaly, is a rare complication of monozygotic twins, that occurs in approximately 1 in 35,000 births. In the first trimester, once the diagnosis of monochorionic twins is made, particularly if one embryo shows abnormal development or generalized edema, the TRAP sequence must be cons...

Evidence for linkage between bipolar affective disorder (BP) and 21q22 was first reported by our group in a single large pedigree with a LOD score of 3.41 at the PFKL locus (1). Subsequently, several other groups obtained linkage evidence in this region. In a follow-up study with dense marker coverage in 40 multiplex BP pedigrees, we reported suppo...

The X-chromosome breakpoint in a female patient with a balanced translocation t(X;12)(q24;q15), bipolar affective disorder and mental retardation was mapped within the glutamate receptor 3 (GRIA3) gene by fluorescence in situ hybridization. The GRIA3 cDNA of 5894 bp was cloned, and the gene structure and pattern of expression were determined. The m...

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Previously, we demonstrated evidence of linkage to bipolar affective disorder (BP) in a single large, multigenerational family with a LOD score of 3.41 at the PFKL locus on chromosome 21q22.3. Additional families showed little support for linkage to PFKL under homogeneity or heterogeneity, in that study. We have expanded on that analysis, with 31 m...

A55-year-old man complained of dyspnea on exertion. On examination, he had a loud parasternal diastolic murmur indicative of aortic valve regurgitation and an apical middiastolic and presystolic rumble (Austin Flint murmur). The patient was referred for a cardiac MRI examination to quantify aortic regurgitation and determine ventricular volumes. A...

In 1994, we detected a potential linkage to bipolar affective disorder (BP) in one large, multigenerational family with a lod score of 3.41 at the PFKL locus on chromosome 21q22.3 [Straub et al., 1994]. An additional 46 families demonstrated little support for linkage to PFKL under homogeneity or heterogeneity in that initial study. We have followe...

Bipolar affective disorder (BP) is a severe psychiatric disorder characterized by mania (BPI) or hypomania (BPII) alternating with periods of depression. BP is a major public health concern owing to a lifetime prevalence of 0.5% to 1.5% and substantial morbidity and mortality. Twin, family, and adoption studies strongly support the role of genetic...

Cutaneous vasculitis is a known complication of hepatitis B vaccination with recombinant vaccine. A renal transplant recipient with the HLD-DR4 susceptibility antigen developed histologically proven cutaneous vasculitis with serum antibodies after vaccination with anti-hepatitis B recombinant vaccine. The skin manifestation, evolved favorably after...

Bipolar affective disorder (BP) is a major neuropsychiatric disorder with high heritability and complex inheritance. Previously reported linkage between BP and DNA markers in the pericentromeric region of chromosome 18, with a parent-of-origin effect (linkage was present in pedigrees with paternal transmission and absent in pedigrees with exclusive...

Cystic dystrophy of the excreto-urinary mucosa is a disease for which frequency rises with age. The disease is rarely identified due to the usual absence of clear symptoms and the fact that the symptoms frequently become banal in patients of advanced age. Diagnosis is mainly based on intravenous urography. Differential diagnosis then addresses the...

1. Major family studies of bipolar disorder report the frequency of affective disorder among probands' relatives, but do not usually report the frequency of a positive family history among probands. A single previous study was not population based. 2. The Division of Psychiatry of Ben Gurion University provides virtually all psychiatric services fo...

A series of 57 extended pedigrees with high density of bipolar affective disorder is described. Ascertainment and diagnostic procedures are documented and simulation studies to assess statistical power are carried out. The pedigrees, obtained in the US and Israel, are comprised of 1508 adult individuals with best estimate consensus diagnoses (12-71...

The hypothesis that chromosomal region Xq27-28 harbours a gene for manic-depression has been a focus of interest in human genetics. X-linked inheritance of manic depressive illness has been re-examined in 3 multigeneration Israeli kindreds. Extension and re-evaluation of pedigree data, including new individuals, diagnostic follow-up, and analysis w...

Recent advances in molecular genetics have radically altered the prospects for determining the role of heredity in the transmission of major psychiatric disorders. Identification of the actual gene(s) involved, elucidation of their structure, and determination of their products are the steps which theoretically follow successful demonstration of li...

The concept of visual interaction is introduced as the process which links perception and problem solving such that problem solving is affected by what is seen, and conversely, what is seen and perceived is affected by the current state of the problem-solving process. The development of a cognitively based model of the visual interaction process in...

The concept of Visual Interaction is introduced as the process which links perception and problem-solving such that problem-solving is affected by what is seen, and conversely, what is seen and perceived is affected by the current state of the problem-solving process. This paper describes the development of a cognitively-based model of the visual i...

Advances in genetic linkage strategies, including techniques of molecular genetics, augur well for the discovery of disease-related genes in mental disorders. Recent studies showing linkage of chromosomal loci to bipolar affective illness and schizophrenia attest to the potential in the 'new genetics'. However, the failure to replicate some of the...

Genetic linkage studies have opened new vistas for behavioral and psychiatric genetics. However, phenotypic diversity and diagnostic uncertainties can lead to spurious linkage findings. A method of analysis is proposed that takes these factors into account. When applied to manic-depressive disease, the results indicate that previous evidence for a...