Manouchehr Safari

Manouchehr Safari
Semnan University of Medical Sciences | SUMS · Anatomy

professor

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55
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580
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February 2010 - present
Semnan University of Medical Sciences
Position
  • academic member

Publications

Publications (55)
Article
Introduction: Parkinson's disease (PD) is the result of the destruction of Dopaminergic neurons in the brain. The aim of this study was to investigate the protective effects of natural antioxidants such as caffeic acid phenethyl ester for the maintenance of these neurons. Methods: Caffeic acid phenethyl ester (CAPE) is one of the main ingredients o...
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Background Alumina-titanium (Al 2 O 3 -Ti) biocomposites have been recently developed with improved mechanical properties for use in heavily loaded orthopedic sites. Their biological performance, however, has not been investigated yet. Methods The aim of the present study was to evaluate the in vivo biological interaction of Al 2 O 3 -Ti. Spark pl...
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The numerous factors regulate the bone marrow mesenchymal stem cell (BMMSC) self-renewal and differentiation response. We aimed to analyze the influence of electromagnetic field (EMF) as an external inducing factor on rat BMMSC differentiation and proliferation to neuron and astrocyte cells. BMMSCs extracted from the rats femurs and tibias and incu...
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Brain stroke is one of the causes of human death and disability worldwide. Global ischemia results in the accumulation of free radicals in the neurons. It leads to histologically brain damage. The CA1 region of the hippocampus is a sensitive area for free radicals. This study investigated the combined therapy of the Granulocyte colony stimulating f...
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Aim: Orofacial chronic neuropathic pain commonly occurs following trigeminal nerve injuries. We investigated whether swimming exercise can reduce trigeminal neuropathic pain through improving antioxidant capacity. Materials and methods: Twenty-eight Wistar rats of either sex and 180-220 grams were divided into 4 groups as sham, neuropathy, neuro...
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Background: Recent studies have shown bone marrow mesenchymal stem cells (BMSCs) have a putative ability to promote neurogenesis and produce behavioral and functional improvement. We have previously demonstrated that co-treatment granulocyte colony-stimulating factor (G-CSF) and BMSCs have beneficial effects on Parkinson's models. The main purpose...
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Background: L-carnitine (Lc) as a type of flavonoid antioxidants and bone marrow stromal cells (BMSCs) as a type of mesenchymal stem cells may recover damaged ovaries. It seems that Lc has favorable effects on differentiation, increasing lifespan and decreasing apoptosis in BMSCs. The aim of this study was to investigate effects of co-administrati...
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Objectives: Exercise ameliorates the quality of life and reduces the risk of neurological derangements such as Alzheimer's (AD) and Parkinson's disease (PD). Irisin is a product of the physical activity and is a circulating hormone that regulates the energy metabolism in the body. In the nervous system, Irisin influences neurogenesis and neural di...
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Background: Bone marrow stromal cells (BMSCs), as a type of mesenchymal stem cells, and the granulocyte colony-stimulating factor (G-CSF), as a type of growth factor, may recover damaged ovaries. The aim of the present study was to investigate the effects of the coadministration of BMSCs and the G-CSF on damaged ovaries after creating a chemothera...
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Anthropometry is a scientific study of linear dimensions and angles of living subjects. Knowing the details and anthropometric properties of nasofacial for each specific ethnic group is important for cosmetic operation as well as identifying individuals. In this study, facial and nasal anthropometric factors were studied in students of Shiraz Unive...
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Oxidative stress is an imbalance between the amount produced nd the removal of oxidants produced. In other words, the increase in reactive oxygen species (ROS) or reactive nitrogen species (RNS) and/or the reduction of the antioxidant/intrinsic/extrinsic is the main cause of this problem [1]. This is one of the most important causes of acute and ch...
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Background: Parkinson’s disease is a common and progressive neuropathology disorder caused by the neuronal degradation of the dopaminergic system of the substantia nigra. We investigated the increase of levodopa in the brain to protect neurons. Methods:Twenty eight male Wistar rats(weighing200-250grams)were randomly divided into four groups(n=7each...
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Introduction: hypoxia result in harmful changes in brain structure and function. Reduction of inflammation, inhibition of apoptosis, repair of damaged axons and angiogenesis are factors that can helps repair nerve tissue in damaged areas and reduce complications.Cryotherapy reduces cellular damage by decreasing edema and complications caused by rep...
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Introduction: Thyroid hormones play a key role in the evolution of various body systems. Relatively, maternal hypothyroidism results in structural and functional changes in the testis by decreasing thyroid hormones. Exercise can potentially improve these changes by increasing thyroid hormones. The purpose of this study was to investigate the effect...
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Background: Apigenin is a plant-derived compound belonging to the flavonoids category and bears protective effects on different cells. The aim of this study was to evaluate the effect of apigenin on the number of viable and apoptotic blastomeres, the zona pellucida (ZP) thickness and hatching rate of pre-implantation mouse embryos exposed to H2O2...
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Background: Quercetin is a flavonoid with the ability to improve the growth of embryos in vitro, and actinomycin D is an inducer of apoptosis in embryonic cells. Objective: The aim was to evaluate the effect of quercetin on the number of viable and apoptotic cells, the zona pellucida (ZP) thickness and the hatching rate of preimplantation embryo...
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This study examined whether post-stroke bone marrow stromal cells (BMSCs) therapy combined with exercise (EX) and/or thyroid hormone (TH) could reduce brain damage in an experimental ischemic stroke in mice. Focal cerebral ischemia was induced under Laser Doppler Flowmetry (LDF) guide by 45 min of middle cerebral artery occlusion (MCAO), followed b...
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Objective(s): Granulocyte-colony stimulating factor (G-CSF) is used in clinical practice for the treatment of neutropenia and to stimulate generation of hematopoietic stem cells in bone marrow donors. In the present study, the ability of G-CSF in mobilizing exogenous bone marrow stem cells (BMSCs) from peripheral blood into the brain was tested. We...
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L-carnitine (LC) is an antioxidant with the ability to promote the growth in vitro embryo. Objective The goal was to evaluate the effect of LC on some indicators of embryo development and blastocyst quality including zona pellucid (ZP) thickness, the hatching of blastocysts and their cell numbers. Materials and Methods Mouse embryos were randomly...
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Aims/introduction: Oxidative stress has a key role in the pathogenesis of diabetes. Propolis and its constituents have a wide range of medicinal properties against oxidative stress. In this study we evaluated antioxidant effects of ethanolic extracts of propolis (EEP) on kidney in diabetes mellitus rats. Materials and methods: Forty male Wistar...
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Objective(s): The main characteristic of mesenchymal stem cells (MSCs) is their ability to produce other cell types. Electromagnetic field (EMF) stimulates differentiation of MSCs into other cells. In this study, we investigated whether EMF can effect on the differentiation of MSCs into dopaminergic (DA) neurons. Materials and Methods: An EMF with...
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Objective: Bone marrow and umbilical cord stromal cells are multipotential stem cells that have the ability to produce growth factors that play an important role in survival and generation of axons. The goal of this study was to evaluate the effects of the two different mesenchymal stem cells on peripheral nerve regeneration. Materials and method...
Article
The interaction between environment electromagnetic field (EMF) and cells can effect on various physiological processes. EMF as an external inducing factor, could effect on proliferation or differentiation of cells. The purpose of this study was to evaluate the influence of the electromagnetic field on the viability, proliferation and differentiati...
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Objective(s): The effect of maternal voluntary exercise on hippocampal BDNF level in rat offspring was studied. In addition, the possible role of hippocampal BDNF receptors in maternal exercise induced enhancement of learning in the rat pups was investigated. Materials and Methods: Pregnant rats have been randomly assigned to sedentary control or v...
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Introduction: Stem cells are found in different portions of the body, including the bone marrow, these cells are capable of differentiated into bone, ligament, muscle, nerve, pancreatic beta cells and etc. Thus, these cells can treat degenerative diseases such as brain injuries, spinal cord injuries, and other disease. Given the lack of research on...
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Regenerative medicine using bone marrow cells is noteworthy therapy for the improvement of patients with severe liver disease. Bone marrow stem cells can participate to liver ‎regeneration. However, conflicting results have been reported. Twenty five, 12 week old albino-wistar male rats were randomly assigned into five groups. In treatment groups ‎...
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Propolis is a resinous natural live product derived from plant exudates collected by honey bees. It has been extensively used in folk medicine. In the present study, the ‎neuroprotective effects of propolis was investigated in the rat model of Parkinson’s disease. The PD rats which was induced by 6-OHDA were compared with control (C) and ‎treatment...
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Background: Exposure to morphine decreases neurogenesis in the hippocampus. Recent studies have shown that voluntary running decreases the severity of anxiety behaviors and cognitive deficits, and increased synaptic plasticity in morphine-dependent rats.
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Introduction: The use of stem cells is one of the ideal methods in treatment of Parkinson's disease (PD). Recently, low-frequency magnetic fields have been used for differentiation and reproduction of stem cells. In this study, we used electromagnetic fields (EMF) impact on bone marrow stem cells and evaluated its effect on the serum levels of brai...
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Background: Stroke is the third leading cause of death. Hypothermia has been recognized as an effective method in reducing brain injury. In this study, we assessed the effects of granulocyte colony-stimulating factor (G-CSF) as a neuroprotective agent and mild hypothermia on mortality, behavioral function, infarct volume, and brain edema in Wistar...
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Background: Neuropathy is one of the most complications of diabetes that may be associated with changes in the structure and function of the basement membranes in nerves. Laminin is one of the most important components of basement membranes in sciatic nerve.
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Introduction: Training in experimental science, with all the complexity and diversity of education is a major concern of experts. There are several difficulty between traditional and new teaching methods in different groups .This study was performed to compare the effects of two teaching approaches, lecture and work in small groups in education of...
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Some growth factors, such as Epidermal Growth Factor (EGF), Growth Hormone (GH) and Platelet Derived Growth Factor (PDGF) have beneficial effects on keratinocyte ‎proliferation and wound healing. Although the mechanism of these factors is unclear. In response to injury, growth factors are secreted by kinds of cutaneous cells. The goal of ‎this proj...
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Exposure to morphine during pregnancy produced long-term effects in offspring behaviors. Recent studies have shown that voluntary exercise decreases the severity of anxiety behaviours in both morphine-dependent and withdrawn rats. Thus, the aims of the present study was to examine whether maternal exercise decreases prenatal dependence -induced anx...
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Parkinson´s disease(PD) is a common and progressive neuropathological disorder due to degeneration of neurodopaminergic system in substantianigra pars compacta. With regard to the role of free radicals and oxidative agents in PD, it seems that aqueous extract of propolis with antioxidant contents can prevent neural degeneration. In this study, neur...
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such as glucose and lipid profiles changes. Propolis is as a bee-collected natural product is very useful and has diverse biological properties. The propose of this study was to test the effects of hydro-alcoholic extracts of Iranian Propolis on serum glucose, lipids profile, BUN and creatinine levels in streptozotocininduced diabetic Rats. Materia...
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Objective(s): The effect of maternal voluntary exercise on hippocampal BDNF level in rat offspring was studied. In addition, the possible role of hippocampal BDNF receptors in maternal exercise induced enhancement of learning in the rat pups was investigated. Materials and Methods: Pregnant rats have been randomly assigned to sedentary control or...
Article
Full-text available
The electromagnetic frequencies that induced normally in human body, comprise from the action potentials of nerves, heart tissue and skeletal muscles, were categorized in the range of extremely low frequencies. With increase in developed devices that produced or induced electromagnetic fields, human anxiety about effects of these fields on normal o...
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Background: Spinal anesthesia is a route for anesthesia. In this route some drugs like Lidocaine, Procaine, Ropivacaine used. For decreasing the side effects and increasing the quality also duration of anesthesia added to the others drugs like Morphine, Sufentanil, Fentanyl and Epinephrine. This study was compared the effect of sufentanil and lidoc...
Article
Postnatal hypoxia is a main cause of neuronal damage in newborn. However, our understanding of the possible preventive or therapeutic methods to reduce the harmful effects of hypoxia is still primary. Pregnant rats were provided with running wheels during their pregnancy. On PND4 (postnatal day 4)to PND8, the rat pups were exposed to postnatal chro...
Article
Chronic exposure to opiates impairs spatial learning and memory. Given the well-known beneficial effects of voluntary exercise on cognitive functions, we investigated whether voluntary exercise would ameliorate the cognitive deficits that are induced by morphine dependence. If an effect of exercise was observed, we aimed to investigate the possible...
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Traditional teaching methods cannot keep up with the new knowledge in medical students anymore. There are several challenges ‎between traditional and new teaching methods in different courses .This study has tried to compare the effects of two teaching ‎approaches on education of osteology( lecture VS work in small groups). Methods: In a quasi expe...
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Stem cell therapy is widely considered as a therapeutic approach for retinal degeneration. Retinal injury results in permanent visual disturbance or blindness. Repair of such damage by stem cells is one of the most feasible types of central nervous system repair. In this review, we consider how stem cells might be optimized for use as donor cells....
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Objective: Transplants of multipotent stem cells have been shown to have a neuropro- tective effect after central nervous system injury. The bulge region of the hair follicle has been reported as a putative source of hair follicle stem cells (HFSC) for many years; however, few studies have documented the properties of bulge derived cells in vitro u...
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The results of several studies have demonstrated that cell differentiation influenced by derivatives of retinoic acid. To determine whether retinoic acid mediate the differentiation of neural stem cells we treated dissociated hippocampal stem cells with different concentrations of all trans or 9-cis retinoic acid and analyzed the effects on cell fa...
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The aim of this study was to study the changes of inducible and constitutive Nitric Oxide Synthase (NOS) after brain injury. In order to brain injury 42 wistar rats were submitted and divided in 7 groups. Nitric oxide synthase activities were assayed at different times after injury. Present results showed that a significant increase of iNOS and cNO...
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The beneficial effects of physical activity and exercise on brain functions such as improvement in learning and memory are well documented. The aim of this study was to examine the possible role of hippocampal angiotensin II receptors in voluntary exercise-induced enhancement of learning and memory in rat. In order to block the hippocampal angioten...
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Introduction: Epithelial is an important tissue in our body. The human epithelium forms a barrierbetween the external and internal environment. Natural process of wound healing e.g. ischemia,necrotic tissues and infection is a concept that has been in practice for a long time. Large full thicknesswounds don’t heal spontaneously and are life treatin...
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The beneficial effects of exercise on learning and memory are well documented but the effects of prenatal exposure to maternal exercise on offspring are not clear yet. Using a two-trial-per-day Morris water maze for five consecutive days, succeeded by a probe trial 2 days later we showed that maternal voluntary exercise (wheel running) by pregnant...
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Although there are many reports about variation of the branches of abdominal aorta, the present report is a very rare case that it has not been reported so far. The coeliac trunk is a wide ventral branch of abdominal aorta with 2.25cm long. The coeliac trunk divided into three branches: left gastric, common hepatic and splenic branch. Normally, the...