Manos Vlasiou

Manos Vlasiou
University of Nicosia · Department of Life & Health Sciences

PhD in Chemistry
Computer Aided Drug Discovery, Medicinal Inorganic Chemistry, Structural Dynamics on Drug-Proteins/DNA Interactions

About

44
Publications
6,315
Reads
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186
Citations
Citations since 2017
37 Research Items
162 Citations
201720182019202020212022202301020304050
201720182019202020212022202301020304050
201720182019202020212022202301020304050
201720182019202020212022202301020304050
Additional affiliations
September 2019 - present
University of Nicosia
Position
  • Faculty Member
August 2012 - May 2018
University of Cyprus
Position
  • Research Collaborator
March 2012 - March 2014
University of Cyprus
Position
  • Research Assistant
Education
August 2011 - May 2016
University of Cyprus
Field of study
  • Bioinorganic Chemistry

Publications

Publications (44)
Article
Full-text available
The first appearance of SARS-CoV-2 is dated back to 2019. This new member of the coronavirus family has caused more than 5 million deaths worldwide up until the end of January 2022. At the moment, and after intensive vaccination programmes throughout the world, the pandemic is still active, whilst new mutations constantly appear. Researchers are wo...
Article
Full-text available
Herein, we propose two chalcone molecules, (E)-1-(4-methoxyphenyl)-3-(p-tolyl) prop-2-en-1-one and (E)-3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl) prop-2-en-1-one, based on the anticancer bioactive molecule Xanthohumol, which are suitable for further in vitro and in vivo studies. Their ability to create stable complexes with the antiapoptotic X-...
Article
Since the discovery of the anticancer properties of cis-platin the road for the development of less toxic and more specific metal ion based anticancer drugs has opened. Based on the low toxicity of VIV/V, MoVI and ZnII metal ions, their binuclear hydroquinonate complexes have been synthesized and their biological activity towards their anticancer p...
Preprint
Herein, we are proposing two chalcone molecules, (E)-1-(4-methoxyphenyl)-3-(p-tolyl) prop-2-en-1-one and (E)-3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl) prop-2-en-1-one, based on the anticancer bioactive molecule Xanthohumol, which are suitable for further in vitro and in vivo studies. Their ability to create stable complexes with the antiapopto...
Article
Four novel mononuclear complexes of Zn2+ and V5+ ions were synthesized by the chelation of tridentate ligands of hydroquinone derivatives in 1:1 M ratios. The synthesis of the two novel ligands and their metal complexes were identified and characterized by NMR, IR, UV-Vis, cyclic voltammetry, and conductivity measurements. Structural information wa...
Article
Full-text available
Fibrillar structures derived from plant or animal origin have long been a source of inspiration for the design of new biomaterials. The Asn-Gly-Ile-Trp-Tyr-NH2 (NGIWY-amide) pentapeptide, isolated from the sea cucumber Apostichopus japonicus, which spontaneously self-assembles in water to form hydrogel, pertains to this category. In this study, we...
Article
Full-text available
The binding patterns of the metal cations Cu 2+ and Zn 2+ with the symmetric ligands (Z)-2-((3,5-dimethyl-2H-pyrrol-2-yl) methylene)-3,5-dimethyl-2H-pyrrole (L1) and (Z)-2-(1-(3,5-dimethyl-2H-pyrrol-2-yl)ethylidene)-3,5-dimethyl-2H-pyrrole (L2), have been investigated at B3LYP and MM2 level of theories in the gas phase and a solution respectively....
Presentation
Full-text available
Herein, we are proposing the synthesis of hydroquinone [2-((bis(2-hydroxyethyl)amino)methyl)-5-(tert-butyl)benzene-1,4-diol (L1) and 2-((bis(2-hydroxyethyl)amino)methyl)-5-methylbenzene-1,4-diol (L2)] chelate derivatives with their and V V complexes C 1 =[V V OL 1 ], C 2 =[V V OL 2 ]). The complex molecules have been characterized, and their antiba...
Article
Eugenol emulsions based on a palmitate surfactant were prepared. The palmitate surfactant was synthesized via a simple esterification reaction of poly(ethylene glycol) (Mn 10,000 g mol⁻¹) and palmitic acid. Subsequently, the surfactant was combined with poly(acrylic acid) (PAA) to give intermolecular complexes that served as the emulsions' stabilis...
Article
A newly synthesized chalcone derivative was used as a ligand to form a stable cobalt (II/III) complex. The cytotoxic activity of the complex was evaluated against breast cancer cells MDA-MB-231. The prooxidant and DNA binding activity of the complex was also evaluated. The complex showed prooxidant activity and potent binding tendency with the base...
Poster
Full-text available
The dramatic increase in antimicrobial resistance has led to active research for new treatments. Antimicrobial peptides (AMPs) are small 7 to 100 amino acids [1, 2]. One discovered mode of action of AMPs is membrane disruptive activity, associated with the interaction with membrane phospholipids [3]. Another way of action of AMPs is intracellular t...
Article
Full-text available
Diethanolamine is a tridentate symmetric ligand that is used for organic synthesis to increase metal chelation or alter the molecular polarities. Prenylated flavonoids are well known for their anticancer properties even in colon cancer. Colorectal cancer is a major threat to society causing death through metastasis to several patients with stage IV...
Article
Xanthohumol is a prenylated chalcone derived from hops and very well known for its biological activity as an anticancer agent. We have previously reported a complete computational evaluation of two novel chalcone derivatives, substituted with diethanolamine on the second ring with increased biological activity. Herein, using density functional theo...
Article
The present study aims to investigate an odd–even effect of the number of ethylene imine units in the side‐groups of totally abiotic synthetic polymers on their efficiency in DNA transfection. A library of fifteen polymers was fabricated. Two star homopolymers and one linear homopolymer based on glycidyl methacrylate were synthesized and used as pr...
Preprint
Full-text available
Colorectal cancer is a major threat to the society causing the death through metastasis to several patients with stage IV. Computational tools provide a relatively quick procedure in order to evaluate several molecules for their drug activity. Prenylated flavonoids are well known for their anticancer properties even in colon cancer. Here, we provid...
Article
Three chalcone derivatives (L1, L2, L3) were synthesized using Claisen-Schmidt condensation reaction. Their molecular structures and spectroscopic properties (IR, UV-vis, ¹HNMR), were calculated at B3LYP level. Electrostatic interactions and HOMO-LUMO properties were calculated using TD-DFT method. Molecular docking was used to compare the HSA (hum...
Article
Full-text available
After the Covid-19 pandemic and the aggressively infection control measures taken by the governments in the whole world, the need for a rapid pharmaceutical solution was more that necessary. The computer aided chemistry and molecular docking is a rapid tool to drug screening and investigation. Moreover, more metal-based drugs are tested daily by re...
Poster
Full-text available
Scorpions during their long evolutionary existence on the planet, more than 400 million years, managed to develop series of venom peptides that display diverse biological activities and pharmacological functions. Scorpion venom peptides are generally classified into two main groups: the disulfide bridged peptides (DBPs) which usually target membran...
Preprint
Full-text available
Three chalcone derivatives ( L 1 , L 2 , L 3 ) were synthesized using Claisen-Schmidt condensation reaction. Their molecular structures and spectroscopic properties (IR, UV-vis, ¹ HNMR), were calculated at B3LYP level. Electrostatic interactions and HOMO-LUMO properties were calculated using TD-DFT method. Molecular docking was used to compare the...
Article
Background: Every year we encounter more projects indicating the promising anticancer activity of vanadium molecules against different types of cancer cells. The new generation of metal-based drugs are targeting the energy supplies of the cell through ROS generation leading them to cell arrest and apoptosis. The relatively low toxicity of vanadium...
Article
Background: Remdesivir, a drug in use for Ebola it is already tested in clinical trials phase III Objective: To evaluate any other possible related structures with similar properties that could be used in clinical trials for Covid-19. Methods: Molecular docking studies, DFT studies, ADMET studies Result: Saquinavir is a chemical structure with s...
Poster
Full-text available
In silico molecular docking took place in order to evaluate already FDA approved drugs for several diseases, as inhibitors for SARS-Cov-2 RNA- dependent polymerase. The best candidates with the highest binding affinities, evaluated for their energy determined by their electron density. Remdesivir and Saquinavir seemed to be good candidates for clin...
Preprint
Full-text available
In silico molecular docking took place in order to evaluate already FDA approved drugs for several diseases, as inhibitors for SARSCov-2 RNA-dependent polymerase. The best candidates with the highest binding a nities, evaluated for their energy determined by their electron density. Remdesivir and Saquinavir seemed to be good candidates for clinical...
Poster
Full-text available
Using UV-Vis, FT-IR, fluorescence spectroscopy and protein ligand docking, the interactions between the zinc complexes with drug analogues and bovine serum albumin were investigated. In addition, considering the ubiquitous presence of zinc ions in the human system, we studied the interactions bbetween this ion with hymecromone, dihydropyridine anal...
Article
Full-text available
A major threat to public health worldwide is that the antimicrobial activity of the established drugs is constantly reduced due to the resistance that bacteria develop throughout the years. Some transition metal complexes show higher antibacterial activity against several bacteria compared to those of clinically used antibiotics. Novel classes of m...
Article
ABSTRACT Using UV-Vis, FT-IR, fluorescence spectroscopy and protein-ligand docking, the interactions between the zinc complexes with drug analogues and bovine serum albumin were investigated. In addition, considering the ubiquitous presence of zinc ions in the human system, we studied the interactions between this ion with hymecromone, dihydropyrid...
Poster
Full-text available
The computer aided chemistry and molecular docking is a rapid tool to drug screening and investigation. After the Covid-19 pandemic and the aggressively infection control measures taken by the governments in the whole world, the need for a rapid pharmaceutical solution was more than necessary. Here, we used theoretical studies on previously publish...
Preprint
Full-text available
After the Covid-19 pandemic and the aggressively infection control measures taken by the governments in the whole world, the need for a rapid pharmaceutical solution was more that necessary. The computer aided chemistry and molecular docking is a rapid tool to drug screening and investigation. Moreover, more metal based drugs are tested daily by re...
Article
Novel vitamin E chelate derivatives and their VIV/V complexes have been synthesized and characterized, and their anticancer properties have been evaluated. The new complexes have been designed to exhibit enhanced cytotoxicity by combining high lipophilicity, with the properties of vanadium to induce the formation of reactive oxygen species (ROS). I...
Article
Full-text available
In this paper we are reviewing the potent anticancer activity of xanthohumol (XN) molecule and its analogues. The anticancer activity is explained according to the mechanisms of action of the molecule on tumour cells. We also comparing the isolation techniques and the synthetic routes that have been developed as far as now, indicating the most reas...
Article
Full-text available
The objective of the present work was the geographical discrimination of the most common honeydew honeys produced in Greece, namely pine and fir, on the basis of sugar, free amino acid and organic acid content, determined by nuclear magnetic resonance spectroscopy (¹H NMR) and high-performance liquid chromatography (HPLC), along with moisture conte...
Article
Full-text available
This mini-review is focused to the latest advances of the last five years regarding the synthetic strategies and the evaluation of the biological activity of coordinated cobalt (II)/(III) compounds. The structures are much closed connected with the activity of the molecules related with chelation to metal centre which is also a piece of discussion...
Article
Corrosiveness is one of the main drawbacks of using the iodide/triiodide redox couple in dye-sensitized solar cells (DSSCs). Alternative redox couples including transition metal complexes have been investigated where surprisingly high efficiencies for the conversion of solar to electrical energy have been achieved. In this paper, we examined the de...
Article
Full-text available
A novel method for the speciation and the quantification of the minor OH-molecules in complex matrices in one pot experiment based on 19F NMR spectroscopy is demonstrated. The method exerts high resolution and sensitivity comparable with the conventional ones and gives reliable results when directly applied on the edible oils.
Article
Reaction of hydroxylamine hydrochloride with prop-2-enamide in dichloromethane in the presence of triethylamine resulted in the isolation of the N,N'-disubstituted hydroxylamine-(diamido) ligand, 3,3'-(hydroxyazanediyl)dipropanamide (Hhydia). The ligand Hhydia was characterized by multinuclear NMR, high-resolution electrospray ionization mass spect...
Article
Full-text available
Reaction of an aqueous solution of NaVO3 or a methanol solution of [VO(acac)2] with 2,5-bis((bis(2-hydroxyethyl)amino)methyl)hydroquinone, H6bdeah, results in the formation of two major vanadium species characterized by X-ray crystallography: the [(V(5+)O)2(bdeah)] and the [(V(4.5+)O)2(bdeas)S2] (S = DMSO or MeOH). The vanadium ions in the two spec...

Questions

Questions (2)
Question
Dear colleagues, I have an invitation for Bio interface Research in Applied Chemistry. Does anyone has or had an experience with this journal?
Question
For example journals with a total number of 45 people (editors, associate editors, executive editors and editors in chief) are struggling to publish 2 papers per year, while if those people publish a paper every 2 years in this journal, the journal would be Scopus indexed.

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Projects

Projects (4)
Project
How does zinc interacts with drug molecules on transport proteins
Project
Molecular docking, molecular dynamics, computational chemistry, drug discovery
Project
Anticancer and Antimicrobial Metal Based Drugs