Manon Duquenne

Manon Duquenne
University of Montreal Hospital Research Centre | CRCHUM · Cardiometabolic and Neuroscience

PhD

About

7
Publications
1,519
Reads
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61
Citations
Introduction
My research focuses globally on the causes and consequences of miscommunication in neuroendocrine systems and I am trying to determine the glial implication in these processes. Since my thesis, I was working in the regulation of energy metabolism context but I am trying to diversify my profile. As a postdoctoral fellow, I am now working on the role of astrocytic glucocorticoid signalling in the regulation of feeding behaviour and peripheral metabolism in basal and stressed conditions.
Additional affiliations
August 2021 - present
University of Montreal Hospital Research Centre
Position
  • PostDoc Position
January 2020 - June 2021
French Institute of Health and Medical Research
Position
  • PostDoc Position
September 2015 - December 2019
French Institute of Health and Medical Research
Position
  • PhD Student
Education
October 2015 - December 2019
Université de Lille
Field of study
  • Neuroscience
September 2013 - June 2015
Université de Lille
Field of study
  • Metabolism and Neurosciences
September 2010 - July 2013
Université de Lille
Field of study
  • Cellular Biology and Physiology

Publications

Publications (7)
Article
Full-text available
Dopamine signaling is a crucial part of the brain reward system and can affect feeding behavior. Dopamine receptors are also expressed in the hypothalamus, which is known to control energy metabolism in peripheral tissues. Here we show that pharmacological or chemogenetic stimulation of dopamine receptor 2 (D2R) expressing cells in the lateral hypo...
Article
Full-text available
Research on energy homeostasis has focused on neuronal signaling, however the role of glial cells has remained little explored. Glial endozepines exert anorexigenic actions by mechanisms which remain poorly understood. In this context, the present study was designed to decipher the mechanisms underlying the anorexigenic action of endozepines and to...
Article
Full-text available
Metabolic health depends on the brain’s ability to control food intake and nutrient use versus storage, processes that require peripheral signals such as the adipocyte-derived hormone, leptin, to cross brain barriers and mobilize regulatory circuits. We have previously shown that hypothalamic tanycytes shuttle leptin into the brain to reach target...
Chapter
Tanycytes, a specialized type of ependymoglial cell, modulate an interesting cycle of communication between the brain and the periphery for energy homeostasis and reproduction. While most circulating factors do not enter the brain because of the blood–brain barrier (BBB), homeostatic signals from the periphery converge on the hypothalamus—a brain r...
Article
Liraglutide, an anti-diabetic drug and agonist of the glucagon-like peptide one receptor (GLP1R), has recently been approved to treat obesity in individuals with or without type 2 diabetes. Despite its extensive metabolic benefits, the mechanism and site of action of liraglutide remain unclear. Here, we demonstrate that liraglutide is shuttled to t...
Preprint
Full-text available
The control of body weight and glucose homeostasis are the bedrock of type 2 diabetes medication. Therapies based on co-administration of glucagon-like peptide-1 (GLP-1) long-acting analogues and insulin are becoming popular in the treatment of T2D. Both insulin and GLP-1 receptors (InsR and GLP1-R, respectively) are expressed in brain regions crit...

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