Manole CojocaruTitu Maiorescu University, Faculty of Medicine of Bucharest, Romania · Preclinical
Manole Cojocaru
Professor of Allergology and Clinical Immunology, MD, PhD, SciRes I, EuSpLM
About
254
Publications
32,835
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2,220
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Introduction
Allergology and Clinical Immunology, Rheumatology, Human Microbiome, Clinical Sexology
Skills and Expertise
Additional affiliations
January 2009 - February 2015
Publications
Publications (254)
Identification of Isoform p53 protein in Chronic Lymphocytic Leukemia by ELISA Method
Aurelian Udristioiu¹, Manole Cojocaru², Delia Nica-Badea³
¹Titu Maiorescu University of Bucharest, Faculty of General Nursing, Targu Jiu, ²Titu Maiorescu University of Bucharest, Faculty of Medicine, ³Constantin Brancusi University, Faculty of Medical Science an...
NATURAL MODULATION OF THE MICROBIOTA
IN PATIENTS WITH ATOPIC DERMATITIS
DENIPLANT NUTRACEUTICALS –
A SUPPORTIVE THERAPY AND ADJUVANT
FOR THE FEMALE REPRODUCTIVE SYSTEM DYSBIOSIS
MICROBIOTA PIELII ȘI INTERACȚIUNEA CU
VINDECAREA PLĂGILOR ȘI ARSURILOR:
IMPACTUL BIOREGENERATORULUI EPITELIAL
A LINK BETWEEN GUT MICROBIOTA AND ALZHEIMER'S DISEASE: IMPACT OF POLENOPLASMIN
GRAPHOLOGICAL ANALYSIS: A POTENTIAL PSYCHODIAGNOSTIC INVESTIGATIVE METHOD FOR NEUROTOXICITY DETECTION OF CHEMOTHERAPY IN CANCER PATIENTS
MODULAREA MICROBIOMULUI
CU AJUTORUL NUTRACEUTICELOR ÎN
BOLI AUTOIMUNE, METABOLICE
ȘI NEUROLOGICE
THE ASSOCIATION BETWEEN
THE CUTANEOUS MICROBIOME
AND HIDRADENITIS SUPPURATIVA
NUTRACEUTICALS DENIPLANT IN THE NEUROPATHIC PAIN IN DOG WITH SPINAL CORD INJURY
DENIPLANT NUTRACEUTICALS MAY HELP FOR ENDOMETRIOSIS PAIN
IMUNIPLANT CAN INFLUENCE DISFUNCTIONAL IMMUNE RESPONSES IN ELDERLY
DENIPLANT NUTRACEUTICALS FOR LONG COVID-19 SYNDROME
Gut Microbiome and Metabolites in Systemic Lupus Erythematosus:
Link, Mechanisms and Deniplant Intervention
INTERACȚIUNI ÎNTRE MICROBIOTA INTESTINALA ȘI MELATONINĂ
THE DOUBLE ROLE OF NUTRIENTS IN IMMUNITY
Deniplant impact on microbiote and metabolites in Parkinson's disease
SEXUAL DYSFUNCTION AND HEPATITIS C VIRUS INFECTION
NATURAL MODULATION GUT MICROBIOTA
IN PSYCHOLOGICAL STRESS:
IMPACT OF DENIPLANT NUTRACEUTICALS
THE LINK BETWEEN THE ALTERED GUT MICROBIOTA
AND CHRONIC SPONTANEOUS URTICARIA:
IMPACT OF ALERGIPLANT
CLINICAL BENEFITS OF DENIPLANT NUTRITIONAL INTERVENTIONS
FOR THE MANAGEMENT OF PSORIASIS
NEUROPEPTIDES AND THE MICROBIOTA-GUT-BRAIN AXIS IN AUTISM
ASSOCIATIONS BETWEEN ALTERED MICROBIOME AND SYSTEMIC SCLEROSIS:
IMPACT OF DENIPLANT NUTRACEUTICALS
NEUROPOLEN FOR RECOVERY AFTER A STROKE
NUTRACEUTICALS DENIPLANT
IN THE NEUROPATHIC PAIN
IN DOG WITH SPINAL CORD INJURY
THE GUT-BRAIN-SKIN AXIS IN ACNE:
IMPACT OF POLENODERM
Conference Istanbul Turkey 23 dec 2021 1
1Major Gheorghe Giurgiu, 2Prof. dr. Manole Cojocaru
1 Deniplant-Aide Sante Medical Center, Biomedicine,
Bucharest, Romania, deniplant@gmail.com
2 Titu Maiorescu University, Faculty of Medicine,
Bucharest, Romania, cojocaru.manole@gmail.com
A PRACTICAL APPROACH TO THE MANAGEMENT
OF PSORIATIC DISEASE IN CHILDHOOD
THE THERAPEUTIC EFFECTS
OF DENIPLANT NUTRACEUTICALS
ON THE GUT MICROBIOME IN PATIENTS WITH PSORIASIS
DENIPLANT NUTRACEUTICALS
MAY HELP FOR ENDOMETRIOSIS PAIN
Background The impact of testosterone on autism symptoms is still being studied, and the precise mechanisms are not yet fully understood. Objectives Numerous studies have been conducted to investigate the relationship between autism and testosterone levels. The biochemical analysis of testosterone is important to perform for boys, especially for th...
The skin microbiota is intimately coupled with cutaneous health and disease. Interactions between commensal microbiota and the multiple cell types involved in cutaneous wound healing regulate the immune response and promote barrier restoration. This dialog between host cells and the microbiome is dysregulated in chronic wounds and burns. To investi...
The presence of multiple unknowns and uncertainty factors in medical research has made it extremely challenging to distinguish the preclinical phase of a chronic disease, such as the metabolic syndrome (MS), from the initial condition of health. MS is a complex and multifactorial medical condition characterized by the presence of at least three of...
Background A diet rich in red meat, and poor in fruits and vegetables, can hinder the body's ability to detoxify, therefore, an alternative vegetarian diet maintained over a certain period, determines the elimination of excess toxins and accumulated residues, helping the body to regenerate and recharge energy. Following this simple rule, there are...
Background The brain possesses an extraordinary ability to heal itself after a stroke. This ability is known as neuroplasticity. The relationship between the gut microbiota and stroke is recent, with early studies dating from 2013. Recent studies support that gut microbiota is associated with ischemic stroke through the gut-brain axis, thereby modu...
"Background Conditions such as cancers, metabolic disorders, psoriasis, and degenerative disorders have been found to be related to epigenetic alterations. Diet is one of the more easily studied, and therefore better understood, environmental factors in epigenetic change. Thus, an enhanced understanding of how epigenetic mechanisms modulate gene ex...
"Background Nutrients are the substances found in food which drive biological activity, and are essential for the human body. Dietary nutrients may be converted into metabolites by intestinal microbes that serve as biologically active molecules affecting regulatory functions in the host. Objectives To demonstrate role of nutrients as functional foo...
When studying the role of the microbiota in pregnancy, it is crucial to consider the stage at which the essential interaction between the host and its microbes begins. The gut microbiota changes dramatically during pregnancy. The gut microbiota during pregnancy is influenced not only by internal cues, but also by environmental factors, primarily by...
Context:
Magnesium plays a key role in regulating many cellular functions and enzymes, including ion channels, metabolic cycles, and signaling pathways.
Objective:
The objective of the study was to evaluate the correlation between the serum levels of lactate dehydrogenase (LDH) and magnesium (Mg) in patients diagnosed with hematological malignan...
As known, vaginal microbiota is crucial for women's health. Host–microbiome interaction is critical for numerous essential host functions. The composition of the vaginal microbiota changes throughout a woman's lifetime from birth, through puberty, reproductive age and menopause. The vagina contains a number of immune-related cells and receptors to...
The microbiome of semen is a field of increasing scientific interest. Compared to other body sites, the seminal microbiota has been minimally investigated.
Recent studies indicate that presence of bacteria in semen is relatively frequent, including in fertile individuals with normal sperm parameters. Semen has a unique microbiome.
The seminal micro...
Background: Nowadays, regulation of the immune system through gut microbiota is supposed to affect the chronic spontaneous urticaria. Unfortunately, the whole intestinal microbiome in chronic spontaneous urticaria patients is rarely being clarified. Lactobacillus in the prevention and treatment of the allergic and inflammatory diseases was reported...
"The microbiota plays a fundamental role in the induction, education, and function of the host immune system. The gut microbiota has such profound effects on both the innate and adaptive immune system. Both environmental factors as well as host genetics influence the composition and homeostasis of gastrointestinal tract microbiome. Objectives Under...
Relationship between LDH and Mg in Monitoring of Hematological and Non-Hematological Malignant Disease
Aurelian Udristioiu,
Titu Maiorescu University of Bucharest, Faculty of Medicine, Department of Molecular Biology
ABSTRACT
Background
Magnesium, which is the second most abundant into-cellular cation after potassium, plays a key role in regulating...
Background
In general, the role of vitamin D, [25 (OH)D], is to regulate calcium and phosphate metabolism by bone remodeling but the studies, in the recent decades, shown that low exposure at the sun and vitamin D deficiency are associated with the increased risk of many other extra-skeletal disorders, such as cancer diseases.
Content
Several orig...
Some diagnosed cases of chronic lymphocytic leukemia (CLL) with possible mutations of the p-53 gene in the human B lymphocyte genome were investigated in this study.
Method
Using the ELISA technique, the frequency of p-53 protein expression in 20 patients diagnosed with CLL were analyzed, including the relationship of this protein to the disease s...
Gynecological cancers have been associated with microbiome formation. Cervical cancer (CC) in frequency is the fourth most common cancer in women worldwide. The human microbiota represents the constellation of microorganisms that inhabit our bodies.
The microbiome is able to modulate immune responses, alter the physiology of the human organism and...
The role of skin microbiota in acne remains to be fully elucidated. The emotions of stress (e.g., depression and anxiety), for instance, have been hypothesized to aggravate acne by altering the gut microbiota and increasing intestinal permeability, potentially contributing to skin inflammation. It is increasingly believed that the interaction betwe...
Recent research suggests that the intestinal microbiota influences the development and function of the immune system, may also play a role in the pathogenesis of autoimmune diseases. Systemic sclerosis, also known as scleroderma (SD), is a rare disease. Scleroderma is an immune-mediated systemic autoimmune disease, of unknown etiology, with high mo...
Introduction
It was discovered in the last few years that the production of some percentage of mutant p-53 proteins, with the increased stability in type B lymphocytes, leads to the carcinogenesis process. This discovery led to the identification and quantification of the p-53 protein by different methods such as immuno-histochemistry (IHC), polyme...
It is known that, among chronic liver diseases, the most common cause of morbidity and/or mortality is hepatocellular carcinoma. Due to the fact that most patients are diagnosed with advanced disease, surgical resection is no longer possible. These patients constitute the ideal group for transarterial chemoembolization, which consists of the local...
Dysbiosis of the nasopharyngeal microbiome attracts dysbiosis of the intestinal microbiome and activation of the intestinal microbiome-brain axis. If the first sign of the disease is quickly intervened with the modulation of the activity of the microbiome, implicitly of the immune system (neuroimmunomodulation), the appearance of the disease is eli...
In order to be able to move, animals like man need the nervous and muscular system to function optimally. The brain, spine, nerves and muscles must work together. If there is a disturbance, the messages will not reach the destination and the animal will not be able to move. Depending on the location and extent of the neurological lesions, the dog m...
ABSTRACT
Autophagy is a cellular process that maintains the homeostasis of the normal cell, but autophagic dysfunction is associated with human diseases, such as cancer. In cancer, autophagy can be neutral, tumor-suppressive, or tumor-promoting in different contexts. Genomic analysis of human cancers indicates that the loss or mutation of core auto...
Article in Romanian journal of internal medicine = Revue roumaine de médecine interne · January 2010 CITATIONS 16 READS 122 7 authors, including: Some of the authors of this publication are also working on these related projects: The correlation between the cellular energy expressed in ATP and levels of mutant p53 protein in CLL. View project
Article in Romanian journal of internal medicine = Revue roumaine de médecine interne · January 2010 CITATIONS 16 READS 122 7 authors, including: Some of the authors of this publication are also working on these related projects: The correlation between the cellular energy expressed in ATP and levels of mutant p53 protein in CLL. View project
Background
Histological activity is important in the choice of drug treatment and the patients with residual microscopic acute inflammation are more likely to relapse. The aim of this study was to see if there is any correlation between the macroscopic aspect of the colon and the degree of histological activity in patients with ulcerative colitis....
Sepsis is currently defined as the presence of organ dysfunction occurring as the result of a disturbed host response to a serious infection. Sepsis is one of the most common diseases, which cause mortality and a considerable absorber of healthcare resources. Despite progress in technology and improving knowledge of pathophysiology, the disease mec...
PURPOSE
Aim of this current review is to emphasis a possible links between alterations of P-53 gene together with its protein in pathological features of breast cancer.
DESIGN
The study examines the gene-expression patterns of breast cancer suggested that at least four major molecular classes of breast cancer exist: luminal-like, basal-like, normal...
Background: Prevalence of upper GI involvement in CD has been reported to be low. This can be due to difficulties encountered in establishing a clear diagnosis. The aim of the study was to evaluate the rate of upper GI involvement in CD patients based on the data coming from a regional, population-based romanian registry, and to identify their chra...
Table of contents
A1 The outcome of patients with recurrent versus non-recurrent pneumococcal meningitis in a tertiary health-care hospital in Bucharest
Cristian-Mihail Niculae, Eliza Manea, Raluca Jipa, Simona Merisor, Ruxandra Moroti, Serban Benea, Adriana Hristea
A2 Influence of bacteriophages on sessile Gram-positive and Gram-negative bacteria...
Aims. In the present study, we aimed to assess the concentrations of IL-13 and IL-17 in serum of patients with early rheumatoid arthritis (eRA), the investigation of correlation between the concentrations of these cytokines and disease activity score, and the concentration of some autoantibodies and the evaluation of the utility of IL-13 and -17 co...
Antisynthetase syndrome (ASS) is a rare chronic autoimmune disorder (2-3 times more common in women than in men), associated with interstitial lung disease (the most important feature), dermatomyositis (DM), and polymyositis (PM). The cause of ASS is unknown. Recent developments in immunology have improved our knowledge and it is now possible to cl...
Abstract
Serum of healthy individuals contains antibodies that react with self and non-self antigens, generated in absence of external antigen stimulation. These antibodies, called natural antibodies, are particularly IgM isotype, are considered natural autoantibodies (NAA), displaying a moderate affinity for self-antigens. Although incidence of N...
Vasculitis in rheumatoid arthritis (rheumatoid vasculitis, RV) has a heterogeneous clinical presentation that includes skin disorders, neuropathy, eye symptoms and systemic inflammation. Rheumatoid vasculitis is an unusual complication of longstanding, severe rheumatoid arthritis (RA).
While RA affects the body’s joints, vasculitis is a condition i...
Candida (C.) albicans is the most frequent cause of fungal infections. Conventional identification tests of pathogenic yeasts are laborious, time-consuming and sometimes ambiguous because of strains variability. The aim of this study was to evaluate the use of one molecular typing method such as PCR (polymerase chain reaction) followed by RFLP (res...
Rezumat Bolile cardiovasculare reprezintă principala cauză a mortalităţii în Europa de Vest şi ele sunt asociate cu o creştere a valorii colesterolului sanguin. Organismul uman nu are echipamentul enzimatic necesar pentru degradarea totală a compuşilor steroizi. Speciile de bacterii lactice Lactobacillus şi Bifidobacterium au capacitatea de a metab...
Adenomyosis and endometriosis are lesions which have aroused the interest for the investigation of antibodies specific to the structures from the composition, but also for the cause behind the appearance of these lesions in completely different structures. The impact they have on fertility is not known entirely, for they are difficult to diagnose....
At the gastrointestinal tract level there is a balance between microbiota and the digestive tract which has as effect differentiation of pathogenic bacteria commensal species. Lately, due to the development of new therapies and use of a wide spectrum antimicrobian compounds we can notice an increase in the number of opportunistic infections caused...
Seronegative antiphospholipid syndrome (seronegative APS) has remained an enigma and the concept is controversial. A small group of APS patients remain persistently negative for routine assays of antiphospholipid (aPL) antibodies. The clinical features are well defined, and include the tendency to both arterial and venous thrombosis, to recurrent m...
In the recent years, statistically significant associations between rheumatoid arthritis (RA) and
periodontal disease have been identified. Emerging as a chronic inflammatory joint disease, RA displays various features and pathogenetic events similar to chronic periodontitis (CP). The purpose of this study was to evaluate the utility of determining...
A 78-year-old Caucasian man was admitted in the Department of Neurology for visual disturbances, started two days before. The next day the patient experienced headache, fever and gait disturbances. He had hypertension, diabetes mellitus, an ischemic stroke 13 years ago, longstanding seronegative rheumatoid arthritis (17 years), polynodular goiter,...
Our understanding of autoimmune diseases has progressed tremendously in the past 20 years. Estimates of the prevalence of autoimmune diseases in the population may be 4% or higher. It is evident that heavy metals present serious risk to human health. Heavy metals are capable of altering the immune response; they have been implicated in influencing...
A 44-year-old right-handed Caucasian male was initialy diagnosed in 2007 with dermatomyositis (DM) and in 2009 with systemic lupus erythematosus (SLE) (overlap syndrome). He was treated with Methylprednisolone and Hydroxychloroquine. He interrupted the treatment in the last three years. The patient presented with fever (39.8 degrees C), left zoster...
The human microbiome is the collection of all of the genes in all of the microbes in and on our bodies. Recently, the more appropriate term is "microbiota". There are numerous and complex relationships between the microbiome and our immune system. It is also becoming clear that if there is a disruption or disorganization in the microbiome community...
Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease which is associated with an increased risk of cardio and cerebrovascular pathology. A 48-year old Caucasian female was admitted for diffuse arthralgias. She was diagnosed eight years before with seropositive RA and she received Methotrexate, Prednisone and anti-inflammatory drugs....
The peripheral nervous system refers to parts of the nervous system outside the brain and spinal cord. Systemic autoimmune diseases can affect both the central and peripheral nervous systems in a myriad of ways and through a heterogeneous number of mechanisms leading to many different clinical manifestations. As a result, neurological complications...
Unlabelled:
Cerebrovascular complications in 9 patients with inflammatory bowel disease (IBD) are presented, 6 with Crohn's disease (CD) and 3 with ulcerative colitis (UC), 7 men and 2 women, mean age 36.5 +/- 3.5 years, 4 of them during acute disease. Cerebrovascular complications were: cerebral venous thrombosis (CVT)--7 cases (5 CD and 2 UC) an...
In the present study the aim was to measure the levels of Thrombospondin-1 (TSP1) and Lipocalin-2/matrix metalloproteinase 9 (MMP9/NGAL) complex in gingival crevicular fluid (GCF) at different time points of orthodontic treatment, to determine the relationship between these values and those of total-matrix metalloproteinase 9 (MMP9) and theirs impl...
Elevation of cardiac troponin T (cTnT) in serum reflects myocardial injury, but it was also observed in other conditions with cardiac injury including acute ischemic stroke. The objective was to identify the relationship between elevated cTnT and stroke severity, location and outcome, cTnT levels were prospectively performed in 385 patients with di...