Manoj Kumbhare

Manoj Kumbhare
smbt college of pharmacy dhamangaon t-igatpuri d-nasik-m.s. india 422403 · pharm chem

M.Pharm. Ph.D.

About

35
Publications
10,071
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189
Citations
Education
March 2014 - July 2021
in S.M.B.T. College of Pharmacy, Dhamangaon Tal- Igatpuri Dist. Nashik (M.S.). India
Field of study

Publications

Publications (35)
Article
The present study is aimed to evaluate in vitro thrombolytic activity and antioxidant activity of Hibiscus tiliaceus L. Chemical characterization of bioactive extract was determined by using GC-MS analysis. The thrombolytic potential was performed by the clot lysis method. Antioxidant activity was evaluated by an in vitro assay involving DPPH radic...
Article
Abstract: Title: Benzothiazole analogues and their biological aspects: A Review Authors : Popli, Jyoti V; Kumbhare, Manoj R; Surana, Ajay R; Bhalerao, Mrunal R; Agrawal, Pranay A : Heterocyclic compounds analogues have attracted strong interest in medicinal chemistry due to their pharmacological properties. Benzothiazole belongs to the heterocyclic...
Article
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Background Herbs are an important source of pharmaceuticals. Herbs are traditionally used by millions of peoples for medicine, food and drink in developed and developing nations considering that they are safe. But, interaction of herbs with other medicines may cause serious adverse effects or reduces their efficacy. The demand for “alternative” med...
Article
Full-text available
Plant products serve as an alternative to synthetic products because of local accessibility, eco-friendly nature and lower cost compared to synthetic drugs. In recent years, there has been an exceptional increase in the awareness of scientific community to investigate the pharmacological actions or to verify the authenticity of claims made with ref...
Article
Full-text available
Nipah virus (NiV) is a pathogenic paramyxovirus that has been responsible for sporadic outbreaks of respiratory and encephalitic disease in tropical countries. Elevated case mortality rate has also been connected with recent outbreaks in India (Kerala), Malaysia and Bangladesh. The virus generally infects animals like pigs and bats, but they do not...
Article
Full-text available
Leptospirosis occurs all over the globe but is maximum in the tropics. Leptospirosis, a spirochaetal zoonotic infection, has been documented as a significant rising infectious disease in the last several years. This review deals with the concerns in the epidemiology, diagnosis and clinical management which tackle community health responses, and...
Article
Full-text available
Background and Objective: Free radicals accumulation in the body causes many oxidative stress related diseases like arthritis, diabetes, inflammation, cancer and genotoxicity. The objectives of present study were to assess total phenolic and flavonoid content and to evaluate in vitro antioxidant activity of extracts of Hamelia patens stems. Methodo...
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Full-text available
In this study, new compounds of pyrazolone heterocyclic derivatives were synthesized by reaction of 5-methyl pyrazol-3-one with appropriate substituted aromatic aldehydes to obtain various substituted 4-benzylidene-5-methyl-2,4-dihydro-3H-pyrazol-3-one (2a–j), which on treatment with benzyl chloride afforded the compound (3a–j). The synthesized com...
Article
The present study reported the synthesis and biologic evaluation of new pyrazolone derivatives for COX-2 inhibitory activities and investigated in vivo for their anti-inflammatory activities using carrageenan-induced rat paw edema model as well as in vitro using HRBC membrane stabilization and protein denaturation method. Eight derivatives showed p...
Article
Novel dihydropyrimidine derivatives were synthesized and evaluated for their calcium channel blocker activity. Synthesis involves the modification of dihydropyrimidine (DHPM) pharmacophore with thiosemicarbazide, semicarbazide and hydrazide functions. The calcium channel blocker effect was tested on rat ileum by taking cumulative responses of the t...
Article
Full-text available
The present study reports the synthesis and biological evaluation of new pyrazolone derivatives for COX-2 inhibitory activities, and investigated in vivo for their anti-inflammatory activities using carrageenan-induced rat paw edema model as well as in vitro using HRBC membrane stabilization & protein denaturation method. Eight derivatives showed p...
Article
Pain is a designation for a spectrum of sensations of highly divergent character and intensity ranging from unpleasant to intolerable. The struggle to relieve pain began with the origin of humanality. An analgesic may be defined as a drug bringing about insensibility to pain without loss of consciousness. Analgesic drugs act in various ways on the...
Article
Full-text available
Couroupita guianesis Aubl. (CG) family Lecythidaceae is found extensively all over the Indian subcontinent and Northeastern South Africa. The plant has regional synonyms such as canon ball tree, Shivlingam and kailashpati in English, Kannada and Hindi respectively. The present study was carried out to assess the antioxidant activity of aqueous and...
Article
Full-text available
Pain is a designation for a spectrum of sensations of highly divergent character and intensity ranging from unpleasant to intolerable. The struggle to relieve pain began with the origin of humanality. An analgesic may be defined as a drug bringing about insensibility to pain without loss of consciousness. Analgesic drugs act in various ways on the...
Article
Full-text available
Moringa oleifera (Moringaceae) is a bush of African savannah, commonly known as Drum stick used in folk Medicine for the treatment of rheumatic pain, analgesic activity, antipyretic activity. The aims of present study were Evaluation of Membrane Stabilizing Potential and Antimicrobial Activity stem bark of Moringa oleifera (Moringaceae) against Sel...
Article
In the present research work, the motto was to develop new chemical entities as potential antimicrobial agent. The recent expansion of antimicrobial drug research has occurred because there is a critical need for new antimicrobial agents to treat these life threatening invasive infections. In the present study three series of new substituted pyrazo...
Article
Plant products serve as an alternative to synthetic products because of local accessibility, eco-friendly nature and lower cost compared to synthetic drugs. In recent years, there has been an exceptional increase in the awareness of scientific community to investigate the pharmacological actions or to verify the authenticity of claims made with ref...
Article
Full-text available
Couroupita guianesis Aubl family Lecythidaceae has a wide distribution throughout the Indian subcontinent and Northestearn South Africa. Couroupita guianesis having regional synonyms as cannon ball tree, shivlingam, kailashpati in French, Kannada and Hindi respectively. All the parts of the plant contains phytoconstituents which are used in folklor...
Article
A novel series of 4-(substituted)-5-methyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one (5a-n) were synthesized by reacting various substituted R-NH 2 with 5-methyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one in the presence of formaldehyde. Structures of all new synthesized compounds were characterized on the basis of spectral data (IR, 1 H NMR and 13C NMR). T...
Article
The World Health Organization estimates that a staggering two billion people harbor parasitic worm infections. Helminth infections are the most common health problems in India and in developing countries. Present study evaluates the anthelmintic activity of various extracts of pods of Caesalpinia pulcherrima using Indian earthworms i.e. Pheritima p...
Article
Full-text available
Objective To assess the phytochemical constituents, total phenolic content, cytotoxicity and in-vitro antioxidant activity of stem bark extracts of Moringa oleifera (M. oleifera) (Moringaceae).Methods Brine shrimp lethality (BSL) bioassay was used to investigate the cytotoxic effects. DPPH and nitric oxide radical scavenging activity was used to de...
Article
Full-text available
Caesalpinia pulcherrima L. Swartz (Caesalpiniaceae) is an ornamental plant also used as a common medicinal plant in India, Taiwan and South-East Asian countries. Majority of the diseases/disorders are mainly linked to oxidative stress due to free radicals. The aims of this study were to screen for phytochemical constituents, evaluate cytotoxicity,...
Article
Present study evaluates the Anti-inflammatory and antinociceptive activities of various extracts of pods of Caesalpinia pulcherrima using various experimental models. The analgesic activity pods of Caesalpinia pulcherrima carried out using acetic acid-induced writhing in mice and tail flick test in rats. The anti-inflammatory activity was evaluated...
Article
The present study evaluates the Anti-inflammatory and analgesic activities of various extracts of stem bark of Moringa oleifera using various experimental models. The analgesic activity of stem bark of Moringa oleifera carried out using acetic acid-induced writhing in mice and tail flick test in rats. The anti-inflammatory activity was evaluated us...

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