Manju Sharma

Manju Sharma
Jamia Hamdard · Department of Pharmacology

Doctor of Pharmacy

About

140
Publications
31,663
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1,837
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Publications

Publications (140)
Article
Objectives Animal models are widely used to develop newer drugs for treatment of diabetes and its complications. We conducted a systematic review to find various animal models to induce diabetes and also the suitable methods in various diabetic complications. With an emphasis on the animal models of diabetes induction, this review provides a basic...
Article
Antibiotics and immunotherapies possess unavoidable adverse effects that hinder sepsis management. Herbal drugs have demonstrated potential immunomodulatory properties vital for sepsis treatment. We hypothesized in the present study that the use of Carica papaya leaves extract had the potential to improve survival and modulate immune cytokine relea...
Article
Full-text available
Background: Sida cordifolia and Sida rhombifolia are regarded as useful herbs as they have been shown to be effective, inexpensive and harmless in the prevention of diabetes, and are recognized as valuable therapeutic substances. Objectives: The purpose of this study was to assess the effect of S. cordifolia and S. rhombifolia in the treatment o...
Article
Purpose: In this study, we investigate renal function and anaemia during imatinib treatment in patients with chronic myeloid leukaemia. Methods: The patients with chronic myeloid leukaemia with chronic phase who had been treated with only imatinib for 12 months at Rajiv Gandhi Cancer Institute and Research Centre (New Delhi, India) were enrolled...
Article
Full-text available
Sepsis is a serious health concern globally, which necessitates understanding the root cause of infection for the prevention of proliferation inside the host’s body. Phytochemicals present in plants exhibit antibacterial and anti-proliferative properties stipulated for sepsis treatment. The aim of the study was to determine the potential role of Ca...
Article
Full-text available
Objectives: CB1 antagonism arbitrates a dormant shape to the endocannabinoid system that alleviates diverse pathological incidents of diabesity. The present study pursued the synthesis and evaluation of thiazolidine derivative (BAC) having pleiotropic action on CB1R, with or without AM251 (selective antagonist of the CB1 receptor) against high-fat...
Article
Full-text available
Imatinib is a signal transduction inhibitor useful in the management of chronic myeloid leukemia (CML). There is a dearth of evidence available concerning Imatinib and its associated outcomes in Indian CML patients. So, this study is aimed to assess the patient-associated outcome in CML. This observational study was conducted at Rajiv Gandhi Cancer...
Article
Full-text available
Purpose We carried out a meta-analytic synthesis to evaluate the association between diabetes mellitus (DM) and related clinical outcomes, co-morbidities, their risk factors and resource utilization in patients with COVID-19. Methods The MEDLINE and Web of Science databases were reviewed for identification of eligible studies. Meta-analysis was ca...
Article
Objective Tuberculosis (TB) is a deadly infectious ailment causing mortality and morbidity globally. The study objectives were to investigate the effect and possible mechanisms of metformin as adjuvant therapy in the management of tuberculosis. Methods TB patients attending HAHC hospital, New Delhi (India) and had T2DM (Type-2 diabetes mellitus) c...
Article
Full-text available
Background Colchicine is well known drug for the treatment of acute gout. Recently, it has also been used in the management of COVID-19 patients. Aim The aim of current study is to find out the role of colchicine in COVID-19 patients. Material & methods The relevant studies were searched in PubMed/Medline, Google scholar and clinical trail.gov.co...
Article
Background Persistent hyperglycemia in diabetes mellitus (DM) is considered as the leading cause of morbidity and mortality associated with both microvascular and macrovascular complications and has a greater economic impact. This study aimed to assess the impact of socioeconomic status, prescribing patterns, and patient compliance in type 2 diabet...
Article
Backgrounds Imatinib is one of the tyrosine kinase inhibitors used for the treatment of chronic myeloid leukaemia (CML) patients. The exact association of imatinib with anaemia in CML patients is still unclear. Aim The current study aimed to find the prevalence of anaemia in chronic myeloid leukaemia patients treated with imatinib. Methods The re...
Article
Background Recently, multiple epidemiological studies have linked imatinib with the alteration of kidney function in chronic myeloid leukemia (CML) patients. This meta-analysis aimed to summarize the impact of Imatinib use on renal function in CML patients. Methods A systematic search was conducted on MEDLINE and Embase to identify articles assess...
Article
Full-text available
The growing number of deaths related to sepsis has become a major concern for past few years. Sepsis is a complex pathological reactions that is explained by series of host response to microbial insult. The resulted systemic reactions are manifested by early appearance of proinflammatory cytokines leading to hyperinflammatory phase which is followe...
Article
Objective Thelimited information available concerning the role of periostin associated with cardiovascular risk in patients with type 2 diabetes mellitus (T2DM). Therefore, this study aimed to find out the association between periostin level and inflammatory markers in patients with T2DM as well as in the acute coronary syndrome (ACS) patients. Me...
Article
Background: Non-adherence to anti-diabetic medication is an important cause of uncontrolled blood glucose that leads to complications of diabetes. However, there is lack of evidence on the burden of and factors associated with non-adherence to anti-diabetic medication among individuals living with diabetes in low-and middle-income countries (LMICs...
Chapter
Apart from the accessibility of antitubercular therapy (ATT), tuberculosis (TB) emerged to be a chief cause of mortality around the world. The present ATT had a disadvantage of lengthy period that creates a problem of noncompliance in patients and growth of resistance. The greater price and delayed temperament of TB medication development coupled w...
Article
Objective Periostin may be playing a central role in the pathogenesis of heart failure and myocardial infraction among patients with diabetes, and therapies targeting the periostin pathway may represent a novel treatment strategy. The unmet need of early detection and diagnosis of cardiovascular (CV) risk in patients with type 2 diabetes mellitus (...
Preprint
Full-text available
Aims: We carried out a systematic literature review and meta-analytic synthesis to find out association between DM and related outcomes in patients with COVID-19 infection. Methods: We systematically searched MEDLINE, and Web of Science to identify studies investigating comorbidities, clinical manifestations and resource utilization of diabetic pat...
Poster
Full-text available
Aim: To evaluate the effects of Curcumin on total cholesterol, LDL cholesterol, HDL cholesterol, and Triglyceride in acute hyperlipidemia. Introduction: Dyslipidemias, (Including hyperlipidemia and low HDL cholesterol levels) is a major cause of atherosclerosis and atherosclerosis-induced coronary heart disease (CHD), and accounts for about one thi...
Article
‘Diabesity’ refers to a rising epidemic indicated by the intricate relationship between obesity and diabetes. The global prevalence of these coexisting, insidious diseases increases social and economic health burdens at a rapid pace. Numerous reports delineate the involvement of the underlying endocannabinoid (EC) signaling system through the canna...
Preprint
Objective: There is lack of evidence on the burden of and factors associated with non-adherence to anti-diabetic medication among individuals living with diabetes in low-and middle-income countries (LMICs). Therefore, we carried out a systematic literature review and meta-analytic synthesis to estimate non-adherence to anti-diabetic medication repo...
Article
Full-text available
First-line antituberculosis (anti-TB) compounds have been considered as proven components of the Directly Observed Treatment-Short course (DOTS). Drug therapy against tuberculosis has been categorized as I, II, or III following the Revised National Tuberculosis Control Program guidelines. Anti-TB are drugs are quite common and show limited adverse...
Article
Cardiovascular complications associated with diabetes mellitus remains a leading cause of morbidity and mortality across the world. Diabetic cardiomyopathy is a descriptive pathology that in absence of co-morbidities such as hypertension, dyslipidemia initially characterized by cardiac stiffness, myocardial fibrosis, ventricular hypertrophy, and re...
Article
The aim of the present study was to investigate the effects of Cichorium intybus on lipid peroxidation activities of both enzymatic and non-enzymatic antioxidants, inflammatory mediators, myocardial enzymes and histopathology of cardiac tissues in experimental diabetic cardiomyopathy (DCM). DCM was induced by single intraperitoneal injection of str...
Article
Full-text available
Before the emergence of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) in 2003, only 12 other animal or human coronaviruses were known. The discovery of this virus was soon followed by the discovery of the civet and bat SARS-CoV and the human coronaviruses NL63 and HKU1. Surveillance of coronaviruses in many animal species has incr...
Article
Objective To assess the impact of metformin use on health‐related quality of life (HRQoL) in tuberculosis (TB) patients who are presented with type 2 diabetes mellitus (T2DM). Methodology In this community‐based prospective study, TB patients attending Hakeem Abdul Hameed Centenary Hospital, New Delhi (India) and had comorbidity of T2DM between Ap...
Article
Cardiovascular complications associated with diabetes mellitus remains a leading cause of morbidity and mortality across the world. Diabetic cardiomyopathy is a descriptive pathology that in absence of co-morbidities such as hypertension, dyslipidemia initially characterized by cardiac stiffness, myocardial fibrosis, ventricular hypertrophy, and re...
Article
Full-text available
This paper systematically and critically reviewed all published economic evaluations of drugs for the treatment postmenopausal osteoporosis. A systematic search was conducted using relevant databases for economic evaluations to include all relevant English articles published between January 2008 to January 2020. After extracting the key study chara...
Article
Objective The objective of this study is to measure the relationship between sleep quality and health-related quality of life (HRQOL), in Indian population with type 2 diabetes mellitus (T2DM). Methods A cross-sectional study, included a total of 300 patients with T2DM. All participants were responding to the Pittsburgh Sleep Quality Index (PSQI)...
Article
Full-text available
The year 2019 ended with the discovery of a supposedly mutated strain of the coronavirus family. COVID-19; previously known as 2019-nCoV, outbreak originated from Wuhan a Hubei province in China, at the end of 2019 was declared a public health emergency of international concern on Jan 30, 2020, by the WHO. With more than millions of confirmed cases...
Article
Full-text available
Before the emergence of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) in 2003, only 12 other animal or human coronaviruses were known. The discovery of this virus was soon followed by the discovery of the civet and bat SARS-CoV and the human coronaviruses NL63 and HKU1. Surveillance of coronaviruses in many animal species has incr...
Article
Full-text available
Isoniazid is the most commonly used drug for treatment of tuberculosis, and is administered individually or in combination with other drugs as standard first line therapy. Offsetting its efficacy, severe adverse effects, especially peripheral neuropathy and hepatotoxicity, are associated with isoniazid therapy, limiting its use in tuberculosis. Iso...
Article
Full-text available
Purpose: Understanding the appearance of anti-tubercular drug-related adverse drug reactions (ADRs) in patients receiving tuberculosis (TB) treatment is important, and may be related to morbidity and mortality if not recognized early. Here, we aimed to characterize the mechanisms underlying adverse drug reactions due to combination anti-tuberculos...
Article
Aim Excessive and insufficient sleep disrupts glycaemic control in patients with type 2 diabetes mellitus (T2DM). However, the evidence underlining the association between sleep duration, sleep quality and glycaemic control in Asian diabetic population remains unclear. We aimed to perform a systematic literature review and meta-analysis of observat...
Article
Full-text available
Aim: To evaluate the effects of Curcumin on total cholesterol, LDL cholesterol, HDL cholesterol, and Triglyceride in acute hyperlipidemia.
Article
Breast cancer is considered a major health problem causing death in women around the world and is ranked second most common carcinoma. Millions of women are diagnosed with breast cancer every year, and more than a half-million women die annually due to this disease. So this work was designed to detect the effect of diosgenin on breast cancer. The p...
Article
Full-text available
Background Periostin is a matricellular protein, expressed in various normal adult and fetal tissues. Recently, elevated periostin levels have been reported in heart failure, coronary artery disease, and stroke. However, there is lack of clinical studies to clarify the prognostic significance of systemic periostin levels in cardiovascular diseases...
Article
Full-text available
Aim: To evaluate the effects of Curcumin on total cholesterol, LDL cholesterol, HDL cholesterol, and Triglyceride in acute hyperlipidemia.
Article
Full-text available
The aim of the present study was to investigate the effects of Cichorium intybus on lipid peroxidation activities of both enzymatic and non-enzymatic antioxidants, inflammatory mediators, myocardial enzymes and histopathology of cardiac tissues in experimental diabetic cardiomyopathy (DCM). DCM was induced by single intraperitoneal injection of str...
Article
This study was intended to develop and optimize agomelatine loaded lipid-based transdermal vesicles (AGLTVs) for the treatment of depression. For the optimization purpose, central composite design was used and the selected independent variables were phospholipid and ethanol. The individual and joined impacts of independent variables were assessed o...
Research
Full-text available
Drug utilization (DU) is systematic regulatory approach designed to identify diversity of drugs use and to evaluate the ratio nal use of medicines in population. Anticoagulants are drugs used to avoid thrombus extension and embolic consequences with associated risks related to their administration. Objectives: The objectives of the present study we...
Article
Full-text available
The present research was carried out to study the effect of 2β-hydroxybetulinic acid 3β-oleiate (HBAO), a novel compound isolated from the seeds of Euryale ferox salisb. on glycemic control, antioxidant status and histopathological morphological alterations in the liver, pancreas, kidney and heart in streptozotocin induced type-2 diabetes in rats....
Research
Aim To perform a systematic literature review and network meta-analysis (NMA) of randomized controlled trials (RCTs) to estimate effect of SGLT2 inhibitors on fracture risk in patients with T2DM. Methods A systematic search was performed on PubMed/Medline and ClinicalTrials.gov from inception to May, 2018 to identify RCTs reporting fracture events...
Article
Aim To perform a systematic literature review and network meta-analysis (NMA) of randomized controlled trials (RCTs) to estimate effect of SGLT2 inhibitors on fracture risk in patients with T2DM. Methods A systematic search was performed on PubMed/Medline and ClinicalTrials.gov from inception to May, 2018 to identify RCTs reporting fracture events...
Article
Full-text available
Introduction: The signalling function of 2-arachidonoylglycerol (2-AG) in endocannabinoid system is delineated by Monoacylglycerol lipase (MAGL). MAGL readdresses the lipid stores in the direction of pro-tumorigenic signalling lipids in cancer cells. Selective as well as potent MAGL inhibitors are limited in number hence their continuous developmen...
Article
A mixture of gymnemic acids was precipitated from the water extract of leaves of Gymnema sylvestre (Retz.) R.Br. ex Sm. (Asclepiadaceae) by acidification with mineral acid. The chromatographic separation of gymnemic acids mixture afforded four new arylated gymnemic acids (1–4) along with a gymnemasaponin (5). The compounds were characterized on the...
Article
Despite significant efforts made to control tuberculosis (TB) through DOTS program, the increasing burden of diabetes mellitus (DM) threatens the progress in reducing TB-related mortality, particularly in developing countries. In recent years, TB-DM comorbidity continues to remain high in countries where DM is on rampant. DM increases the risk of T...
Article
Background: The objective of this study was to apply Quality by Design (QbD) principles on process parameter optimization for development of hybrid delivery system (combination of (SLNs) and In-situ gelling system) for hydrophilic drug Moxifloxacin Hydrochloride (MOX) to achieve its controlled delivery, which otherwise may not be possible through...
Article
The aim of the present study was to investigate the effects of Cichorium intybus on lipid peroxidation activities of both enzymatic and non-enzymatic antioxidants, inflammatory mediators, myocardial enzymes and histopathology of cardiac tissues in experimental diabetic cardiomyopathy (DCM). Diabetic cardiomyopathy was induced by single intraperiton...
Article
Full-text available
4-Methyl-2-[(2-methylbenzyl) amino]-1,3-thiazole-5-carboxylic acid (bioactive compound (BAC)), a novel thiazole derivative, is a xanthine oxidase inhibitor and free radical scavenging agent. Effects of BAC on hyperglycemia, insulin sensitivity, oxidative stress, and inflammation mediators were evaluated in streptozotocin (STZ)-induced neonatal mode...
Conference Paper
Background: Fracture risk is higher in older adults with type 2 diabetes mellitus (T2DM). Anti-diabetic drugs have different effects on bone metabolism. We performed a pairwise and network meta-analysis (NMA) including randomized controlled trials (RCTs) to study risk of bone fractures associated with thiazolidinediones (TZDs), compared to placebo...
Article
Objectives: Fracture risk is higher in older adults with type 2 diabetes mellitus (T2DM). Anti-diabetic drugs have different effects on bone metabolism. We performed a pairwise and network meta-analysis (NMA) including randomized controlled trials (RCTs) to study risk of bone fractures associated with thiazolidinediones (TZDs), compared to placebo...
Article
Objectives: Needlestick injuries (NSIs) constitute a serious occupational health hazard because they can expose healthcare workers to infections by bloodborne pathogens, including hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) for the health care workers (HCWs). Methods: MEDLINE was systematically searched...
Article
Objective: To determine the prevalence of diabetes mellitus (DM), assess its influence on health-related quality of life (HRQoL) among TB patients. Methods: In this prospective study, eligible patients at three primary health care centers in urban slum region of South Delhi, India, underwent blood glucose screening at treatment initiation. HRQoL...
Article
Objectives: Patients with type 2 diabetes mellitus (T2DM) have a higher incidence of bladder cancer (BC); however, the evidence underlining the association between pioglitazone use and BC risk remains inconclusive. We conducted a systematic review and meta-analysis of observational studies to investigate the effect of pioglitazone on risk of BC in...
Article
Diabetes mellitus and osteoporosis both are high prevalence disorders, especially in the elderly population. Pioglitazone, a PPAR-γ agonist associated with bone loss and risk of fracture in type 2 diabetes mellitus patients. In this study, ameliorative effect of berberine against pioglitazone-induced bone loss in diabetic rats and possible mechanis...
Article
Diabetes mellitus is associated with abnormal bone health and an increased risk of fracture even though patients have normal or higher BMD. The mechanisms behind diabetes mellitus- induced various skeletal disorders remain unclear. Anti-diabetic drugs may have negative or positive impact on bone metabolism. For instance, thiazolidinediones increase...
Article
Ethnopharmacological relevance Careya arborea Roxb. (Lecythidaceae) is a large tree found throughout India in deciduous forests and grasslands. C. arborea is traditionally used in tumors, inflammation, anthelmintic, bronchitis, epileptic fits, astringents, antidote to snake-venom, skin disease, diarrhea, dysentery with bloody stools, dyspepsia, ulc...
Conference Paper
Introduction: Diabetes is an important global disease, associated with significant morbidity and an increased risk of death due to chronic end-organ complications. Thiazolidinedione (TZD) was approved for treatment of Type 2 diabetes mellitus (T2DM). However, several observational studies suggest an association of TZD with an increased risk of frac...