Manickam Rajkumar- Doctor of Philosophy
- PDF at Sri Sivasubramaniya Nadar College of Engineering
Manickam Rajkumar
- Doctor of Philosophy
- PDF at Sri Sivasubramaniya Nadar College of Engineering
Development of nanomaterials to target for Neurodegenerative disease and biomedical applications
About
21
Publications
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Introduction
I am working on polymer-based biomaterials, Nanotechnology, Plant phyto medicine, Behaviour analysis, Neurochemistry, Animal Science and neuro disease, Biomaterials, Cell Culture Biocompatibility, Polymeric Biomaterials, 3D Culture Biomaterial Functionalization, and Biomaterials.
Current institution
Education
April 2019 - December 2023
June 2017 - May 2018
June 2015 - May 2017
Publications
Publications (21)
Non-healing wounds are a serious complication of bacterial infections, and finding effective treatments is crucial. The novelty of the current study is the synthesis and characterization of gelatin-loaded magnesium hydroxide nanocomposite using an extract from Coleus amboinicus leaves. Investigations presented that the Ge/Mg(OH)2NCs exhibited highe...
Nanotechnology is a crucial field that is being widely researched in various fields. This innovative study investigates the synthesis of cerium oxide nanoparticles (CeO2NPs) using an extract from the plant Alternanthera sessilis and its various biological applications. Several methods, such as UV–Vis spectroscopy, FTIR, XRD, FESEM, HR-TEM, and DLS...
Green synthesis of nanoparticles has gained significant attention as an eco-friendly and sustainable alternative to conventional chemical and physical methods, leveraging biological resources such as plants, bacteria, fungi and algae. This approach minimizes the use of hazardous chemicals, reduces energy consumption and improves the biocompatibilit...
Nanotechnology has witnessed remarkable advancements in recent years, capturing considerable attention in diverse biomedical applications. Using the green precipitation method, this study aims to synthesize and characterize chitosan/polyvinyl alcohol-copper oxide nanocomposites (CS/PVA/CuONCs) using Anacardium occidentale plant fruit extract. The C...
Nanotechnology has experienced significant advancements, attracting considerable attention in various biomedical applications. This innovative study synthesizes and characterizes Ge/PLA/AuNCs (gelatin/PLA/gold nanocomposites) using Syzygium cumini extract to evaluate their various biomedical applications. The UV–Visible spectroscopy results in an a...
Laggera alata plants have emerged as a valuable resource in biomedicine. In this study, we present an environmentally friendly method for synthesizing zinc oxide nanoparticles (ZnONPs). The properties of the synthesized nanoparticles were analyzed using various techniques, including UV–Vis, FTIR, XRD, SEM-EDAX, and Zeta potential analysis. UV–Vis a...
The synthesis of magnesium hydroxide nanoparticles (Mg(OH)2 NPs) using plant extracts are known to be a practical, economical, and an environmentally friendly approach. In this work, Mg(OH)2 NPs were synthesized using aqueous leaf extract of Tinospora cordifolia, a medicinal plant commonly found in India. The synthesized Mg(OH)2 NPs were characteri...
The growing demand for stricter environmental regulations surrounding waste disposal has sparked the development of advanced waste treatment techniques. This is crucial because the consumption of contaminated water can lead to the transmission of life-threatening diseases, resulting in millions of deaths worldwide each year. One promising approach...
Green bioremediation is an innovative and rapidly expanding technique that holds great promise for tackling the issue of toxic waste in polluted environments. Our planet is burdened with a wide array of contaminants, ranging from heavy metals and polychlorinated biphenyls to plastics and agrochemicals. These pollutants persist in the environment du...
The compound 2-(3-(5-(4-chlorophenyl)furan-2-yl)acryloyl)-3,4-dihydro-2H-naphthalen-1-one (CHFADN) was synthesized using the Claisen-Schmidt condensation method, reacting aromatic aldehydes with methyl ketones. Characterization was performed using NMR, FTIR, and UV-visible spectroscopy. A theoretical model was developed with Gaussian 09 software, u...
This present study deals with the synthesis of gelatin-loaded zinc oxide nanocomposites (GN/ZnONCs) using Coccinia indica seed extract using the green preparative method. Synthesized GN/ZnONCs were confirmed by using various characterization techniques for chemical and physical properties. The results of the UV–Vis spectral absorption peak showed 2...
This present study deals with the synthesis of gelatin-loaded zinc oxide nanocomposites (GN/ZnONCs) using Coccinia indica seed extract using the green preparative method. Synthesized GN/ZnONCs were confirmed by using various characterization techniques for chemical and physical properties. The results of the UV-Vis spectral absorption peak showed 1...
Strobilanthes cordifolia has emerged as a promising material in traditional medicine. In this study, we have made an attempt to synthesize zinc oxide nanoparticles derived from S. cordifolia leaf. The team employed a wide range of techniques including UV, FT‐IR, XRD, FE‐SEM with EDAX, HR‐TEM with SAED, DLS, Zeta potential, BET and PZC analysis to t...
Alzheimer's disease (AD) is a neurodegenerative disease characterized by amyloid-beta (Aβ) aggregation, neuroinflammation, oxidative stress, and dysfunction in the mitochondria and cholinergic system. In this study, the synthesis of chitosan-polylactic acid-loaded magnesium oxide nanocomposite (CH/PLA/MgONCs) was examined using the green precipitat...
Alzheimer’s disease (AD) is an age-dependent neurodegenerative disease hallmarked by Amyloid-β (Aβ) aggregation, cognitive impairment, and neuronal and synaptic loss. In this study, AD was induced in male Wistar rats (n = 6) by the administration of intracerebroventricular-streptozotocin (ICV-STZ-3 mg/kg/day), and Voglibose (Vog) was administered a...
Amyloid-β (Aβ) plaque formation, neuronal cell death, mitochondrial and cholinergic dysfunction are key indicators of Alzheimer's disease (AD). In this study, gelatin and polyvinyl alcohol (PVA) were tethered with magnesium hydroxide (Mg(OH)2) to synthesize nanocomposite (Ge/PVA/Mg(OH)2) through alkali co-precipitation. The characterization studies...
Amyloid-β (Aβ) plaque formation, neuronal cell death, and cognitive impairment are the unique symptoms of Alzheimer's disease (AD). No single step remedy is available to treat AD, so the present study aimed to improve the drugability and minimize the abnormal behavioral and biochemical activities in streptozotocin (STZ) induced AD experimental Wist...
Chitosan (CS) is one of the most abundant biopolymers present on the wings of arthropod members like insects, prawns, etc. It has potential biomedical value in developing drugs and drug delivery systems. Such a biomedically valuable polymer was combined with mesoporous silica nanoparticles (MSNs) to form chitosan-poly (acrylic acid) coated mesoporo...
