Manfredi Greco

Manfredi Greco
Universita' degli Studi "Magna Græcia" di Catanzaro | Università Magna Græcia di Catanzaro · Department of Experimental and Clinical Medicine "Gaetano Salvatore"

MD

About

53
Publications
13,635
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504
Citations
Citations since 2017
10 Research Items
295 Citations
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20172018201920202021202220230204060
20172018201920202021202220230204060

Publications

Publications (53)
Article
IntroductionNipple-sparing mastectomy (NSM) is a surgical procedure increasingly performed for breast cancer or risk reduction surgeries. The site of skin incision seems to affect not only cosmesis but also technical ease in operating and vascular viability of the nipple. We present a series of patients who underwent a modified vertical surgical ap...
Article
Full-text available
Prosthesis-based techniques are the predominant form of breast reconstruction worldwide. The most performed surgical technique involves the placement of the expander in a partial submuscular plane. The coverage of the implant remains a difficult management problem that can lead to complications and poor outcomes. The use of the serratus fascia flap...
Article
Background: Implant-based reconstruction is the most performed breast reconstruction, and both subpectoral and prepectoral approaches can lead to excellent results. Choosing the best procedure requires a thorough understanding of every single technique, and proper patient selection is critical to achieve surgical success, in particular when dealin...
Article
Full-text available
Background The use of conservative mastectomies has risen significantly during the last few years. The reconstructive choice of direct-to-implant reconstruction has become more practicable with modern mastectomy techniques. The initial trend in Italian centers was to use dual-plane hybrid reconstruction. However, a high level of complications has b...
Article
Full-text available
Objective: Current trends show a rise of attention given to breast cancer patients' quality of life and the surgical reconstructive result. Along with this trend, surgical training quality and efficacy are gaining importance and innovative training methods such as online videos shared on social media portals, are becoming main updating tools. In ha...
Article
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Deep sternal wound infections are a serious complication following sternotomy for cardiothoracic surgery. “Conventional” treatment provides debridement and secondary closure or closed catheter irrigation. The combination of the Negative Pressure Therapy with flap coverages is an accepted technique and one or both Pectoralis Major muscles could be c...
Article
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HMGA1 (high mobility group A1) is a nonhistone architectural chromosomal protein that functions mainly as a dynamic regulator of chromatin structure and gene transcription. As such, HMGA1 is involved in a variety of fundamental cellular processes, including gene expression, epigenetic regulation, cell differentiation and proliferation, as well as D...
Article
Background/aim: The High-Mobility Group A1 (HMGA1) protein has been implicated in human malignancies, playing an important role in cancer proliferation, angiogenesis and metastasis. Increased HMGA1 expression has been found in skin mouse tumors, whereas Hmga1-null mice were protected against skin carcinogenesis. Here, we examined the expression of...
Article
Full-text available
Reconstruction of the eyelids after skin cancer excision can be challenging. Surgical treatment options are multiple; deep anatomy knowledge of lamellar components is mandatory to choose the most adequate surgical planning. Eyelids’ role in vision and social relationship is critical; both function and aesthetics are tough to restore. Using a flap p...
Article
Background: The lips are a common site prone to squamous cell carcinomas, which arise in the facial region. There are different techniques to reconstruct the excised lip region, according to dimensions, area, and position of the tumor. The authors describe a new technique of lip reconstruction born from a combination between a nasolabial flap and...
Chapter
The extensive loss of tissue, especially if located in certain parts of the body, often provokes serious problems for their reconstruction. The use of skin expanders where the skin is less elastic, such as at the level of the scalp or limbs, allows the use of quantities of similar skin sufficient enough to reconstruct the defect.
Chapter
Since ancient times taking care of the body has always been a common practice to get both a state of exterior body well-being and also able to make oneself more self-confident.
Article
Post-mastectomy radiotherapy (PMRT) is well known in the plastic surgery community for having a negative impact on expander-implant based immediate breast reconstruction (IBBR), although recently some technical improvements allow better results. Very recent papers would suggest that there is no difference in postoperative complications in patients...
Article
Scalp reconstruction has always been a challenging task, in particular after oncological demolition and this article gives an overview on the state of the art in scalp reconstruction strategies. We elaborated a systematic algorithm for scalp reconstruction based on location and size defects, presence or absence of periosteum, bone involvement, the...
Article
Liraglutide is a glucagon-like peptide-1 receptor analog recently approved for the treatment of type 2 diabetes mellitus (T2DM). We aimed to assess the efficacy and safety of liraglutide versus glimepiride, as adjunct treatments to metformin, in achieving glycemic control in Italian patients with T2DM uncontrolled by metformin alone. One hundred se...
Article
Desmoid tumors are rare soft tissue tumors derived from musculoaponeurotic structures of the abdominal wall musculature. Although they are considered benign tumors because they don't metastasize to other parts of the body, they are clinically considered as malignant for their high tendency on infiltrative growth with local invasion and trend to rec...
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ACTA PHLEBOLOGICA 129 common type of leg ulcers, accounting for approxi-mately 70% of cases: 3-15 arterial ulcers account for another 5% to 10% of leg ulcers; 16, 17 the majority of diabetic ulcers are neuropathic but almost the 60% have an ischemic component, and 10% have only an ischemic disturbance; 18, 19 mixed venous and ar-terial ulcers accou...
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The High-Mobility Group AT-Hook 1 (HMGA1) protein is an architectural transcription factor that binds to AT-rich sequences in the promoter region of DNA and functions as a specific cofactor for gene activation. Previously, we demonstrated that HMGA1 is a key regulator of the insulin receptor (INSR) gene and an important downstream target of the INS...
Article
Muscular flaps are considered by many surgeons as a treatment of choice for pressure sores. Nevertheless fasciocutaneous and adipofascial flaps are less sensitive to ischemia, more resistant to pressure and have higher mechanical resistance. The aim of this study is to evaluate the results of our integrated rehabilitative and surgical protocol in p...
Article
Ink spot lentigo, also known as reticulated black solar lentigo, is a melanotic macula commonly described in fair-skinned individuals on sun-exposed areas of the body. Clinically it is a darkly pigmented type of solar lentigo; herein the term ink spot lentigo. In contrast to common solar lentigines, ink spot lentigo is reported as a unique lesion....
Article
The lipoma is the most common tumor of the body and can be found in virtually every tissue or organ. However, a parosteal lipoma is a rare benign fatty neoplasm having an intimate relationship to the periosteum. The incidence of this tumor is 0.3% of all lipomas. Over 150 cases of parosteal lipoma have previously been described in the literature. O...
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The metabolic syndrome (MetS) is a common disorder, where systemic insulin-resistance is associated with increased risk for type 2 diabetes (T2D) and cardiovascular disease. Identifying genetic traits influencing risk and progression of MetS is important. We and others previously reported a functional HMGA1 gene variant, rs146052672, predisposing t...
Article
Full-text available
The metabolic syndrome (MetS) is a common disorder, where systemic insulin-resistance is associated with increased risk for type 2 diabetes (T2D) and cardiovascular disease. Identifying genetic traits influencing risk and progression of MetS is important. We and others previously reported a functional HMGA1 gene variant, rs146052672, predisposing t...
Article
Full-text available
We previously showed that loss of the high mobility group A1 (HMGA1) protein expression, induced in mice by disrupting the Hmga1 gene, considerably decreased insulin receptor expression in the major target tissues of insulin action, causing a type 2-like diabetic phenotype, in which, however, glucose intolerance was paradoxically associated with in...
Article
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Spider bites are not very common, especially in the Mediterranean area, and those affecting the ocular-palpebral region involving reconstructive surgery are particularly rare. In May 2010, the case of a Caucasian 24-year-old female patient was brought to the attention of the Dermatology Department, University of Cagliari, Italy. The patient reporte...
Article
Venous leg ulcers are responsible for more than half of lower extremity ulcerations, with an overall prevalence ranging from 0.06 to 2% in the general population. A total number of 120 patients with chronic venous leg ulcers (CEAP C6), secondary to primary chronic venous insufficiency, were recruited (81 F, 39 M, age range: 50-79, mean age: 64.6)....
Article
Blepharoplasty of the upper eyelids is one of the most commonly performed procedures in aesthetic plastic surgery. The orbicularis muscle flap technique provides good results for patients with atonic skin and an atonic orbicularis muscle when there is excessive fullness in the lateral aspect of the upper lid. This flap also can be used to contain a...
Article
Full-text available
Malignant tumors occurring in the scalp are not common and when asymptomatic or small in size, may be covered by hair and neglected by the patient, leading to a potential risk of delay in detection and resulting in poorer outcomes. In our Departments in the last five years more than 200 malignant tumors of the scalp have been operated on. In this a...
Article
Full-text available
We present a clinical case of Melkersson-Rosenthal (M-R) syndrome associated with Down syndrome. No evidence of this association is described in the literature. We also present a technique for the macrocheilia treatment of lower lip caused by M-R syndrome in a patient with Down syndrome. This patient during pediatric age had many events of facial n...
Article
The birth of plastic surgery is identified with the history of rhinoplasty, which was practiced in ancient India when nose amputations were a common practice. Nose reconstruction was the most frequent surgical operation required in India at that time, and it was based on the use of a forehead flap and called an Indian method. The revolution of this...
Article
Fournier's gangrene is a rare pathology, whose aetiopathogenesis is very varied and much debated. In most cases, it occurs in debilitated patients with chronic diseases involving tissue ischaemia. Despite substantial progress in scientific research, it carries a high mortality rate because of the rapidity with which it sets in and evolves, presenti...
Article
Eccrine porocarcinomas (EP) are skin appendage tumors originating from the acrosyringium. Pagetoid form is rare and exceptionally it can involve eyelid. We report a 70-year-old patient presenting a lesion sited on the left cheek region involving the internal canthus, the dorsum of nose and the half inferior eyelid in full thickness. A wide surgical...
Article
The authors compared the results of 10 scalp reductions using the "Nordstrom suture" with the earlier published results of scalp reductions without a device to prevent stretch-back and of reductions with extenders. At 1 month postoperatively, the Nordstrom suture eliminated the stretch-back of 8.3 mm seen in earlier studies and, in fact, it shrank...
Article
The authors compared the results of 10 scalp reductions using the "Nordstrom suture" with the earlier published results of scalp reductions without a device to prevent stretch-back and of reductions with extenders. At 1 month postoperatively, the Nordstrom suture eliminated the stretch-back of 8.3 mm seen in earlier studies and, in fact, it shrank...
Article
The senior author has been using micrografts for correction of male pattern baldness since 1978. He has also been using these small grafts for correction of temporal hairline and loss of sideburn due to rhytidectomies, burns, avulsions, irradiation, and alopecia triangularis congenitas circumscripta [1,2]. Technique and results are presented.
Article
The authors present an unusual case of nasal tip deformity of the nose not mentioned in the literature. The nose tip presented hypertrophy of all the components of the crura and the cranial part of the lateral crus was rotated externally and widened. An extra dome was present bilaterally between the medial crus and the medial part of the lateral cr...
Article
Pilomatricoma is a tumour which rarely occurs on the eyelid and may be a source of diagnostic error because of several clinico-morphological similarities with other benign and malignant tumours. On a review of the case histories of the Department of Plastic Surgery of Catania University, collected over the last twenty years (1975-1995), 9 cases of...
Article
Penile tumors, although not frequent, represent a difficult diagnostic and therapeutic challenge. Of the malignant penile neoplasms, the most frequent is penile carcinoma, which includes squamous cell carcinoma and its well-differentiated variant, verrucous carcinoma. Current concepts about classification, epidemiology, pathogenesis, histopathology...
Article
The Authors, after a brief description of the anatomical and functional features of the various foot regions, underline the importance of neurovascular cutaneous flaps to repair small to medium sized losses of tissue. These flaps are specially indicated because they provide tissues similar to those lost but also provide with their own nerve supply...
Article
The authors briefly describe the commonest forms of mitochondrial myopathies particularly those associated with disorders of ocular motility. They report their series of four patients suffering from ptosis of the eyelid caused by mitochondrial myopathies. The ptosis was corrected surgically in all cases by means of Müller's muscle adaptation techni...
Article
The Authors discuss the problems related to male infertility, pointing out their different clinical and therapeutical features. They stress the importance of plastic surgery in the treatment of disorders such as penile chordee, hypospadias as well as nervous and vascular lesions.

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