Manfred F Maitz

Manfred F Maitz
Leibniz Institute of Polymer Research Dresden | ipfdd · Max Bergmann Center for Biomaterials

Dr. med.

About

180
Publications
37,964
Reads
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5,775
Citations
Introduction
Manfred Maitz currently works at the Max Bergmann Center for Biomaterials, Leibniz Institute of Polymer Research Dresden. He is Guest Professor at Southwest Jiaotong University, Chengdu, China. Manfred does research in Biotechnology, Bioengineering and Materials Engineering for hemocompatible materials. His focus is on feedback controlled materials that interact with blood clotting and inflammation.
Additional affiliations
January 2006 - present
Max Bergmann Center of Biomaterials (MBC)
Max Bergmann Center of Biomaterials (MBC)
January 2006 - present
Leibniz Institute of Polymer Research Dresden
Position
  • Representative of the topic
November 2004 - November 2005
Southwest Jiaotong University
Description
  • I have ongoing projects and publications with this group
Education
November 1990 - November 1994
University of Wuerzburg
Field of study
  • Medizin
November 1988 - October 1990
Universität Regensburg
Field of study
  • Medizin

Publications

Publications (180)
Article
Full-text available
Bio-responsive polymer architectures can empower medical therapies by engaging molecular feedback-response mechanisms resembling the homeostatic adaptation of living tissues to varying environmental constraints. Here we show that a blood coagulation-responsive hydrogel system can deliver heparin in amounts triggered by the environmental levels of t...
Article
Feedback-controlled anticoagulant hydrogels were formed by crosslinking the anticoagulant heparin with star-shaped poly(ethylene glycol) using peptide linkers, which are selectively cleaved by different activated blood coagulation factors acting as proteolytic enzymes. Various cleavable peptide units, differing either in their thrombin turnover rat...
Article
Endothelial cell activation as result of biomaterial contact or in response to biomaterial-induced blood activation may in turn affect hemostasis and inflammatory processes in blood. Current in vitro hemocompatibility assays typically ignore these modulating effects of the endothelium. This study sets up a co-incubation system of human whole blood,...
Article
Full-text available
Cardiovascular diseases have been the leading cause of death in modern society. Using vascular stents to treat these coronary and peripheral artery diseases has been one of the most effective and rapidly adopted medical interventions. During the twenty-five years’ development of vascular stents, revolutionary cardiovascular stents like drug eluting...
Article
Over the past 30 years, silk has been proposed for numerous biomedical applications that go beyond its traditional use as a suture material. Silk sutures are well tolerated in humans, but the use of silk for vascular engineering applications still requires extensive biocompatibility testing. Some studies have indicated a need to modify silk to yiel...
Article
Full-text available
So far, cloaking materials with platelet membranes have been widely studied, mainly focused on covering nanosized materials but rarely forwarded to dressing large-scale materials. Herein, a platelet-membrane coating (PMC) constructed on the surface of a macroscopic device is reported, driven by the spontaneous fusion of platelet-membrane vesicles (...
Article
Full-text available
The number of patients in intensive care units has increased over the past years. Critically ill patients are treated with a real time support of the instruments that offer monitoring of relevant blood parameters. These parameters include blood gases, lactate, and glucose, as well as pH and temperature. Considering the COVID-19 pandemic, continuous...
Article
Interrelated coagulation and inflammation are impediments to endothelialization, a prerequisite for the long-term function of cardiovascular materials. Here, we proposed a self-regulating anticoagulant coating strategy combined with anti-inflammatory capacity, which consisted of thrombin-responsive nanogels with anticoagulant and anti-inflammatory...
Article
Full-text available
Atherosclerosis, the principle cause of cardiovascular disease (CVD) worldwide, is mainly characterized by the pathological accumulation of diseased vascular cells and apoptotic cellular debris. Atherogenesis is associated with the upregulation of CD47, a key antiphagocytic molecule that is known to render malignant cells resistant to programmed ce...
Article
Poor corrosion resistance and osseointegration of titanium/hydroxyapatite (Ti/HA) composites or coatings limit their application of long-term implants. In this study, spark plasma sintering was employed to fabricate Ti/HA nanocrystalline composites, in which HA was proposed to improve osseointegration of Ti alloys and surface-functionalized nanocar...
Article
Full-text available
Mimicking the nitric oxide (NO)-release and glycocalyx functions of native vascular endothelium on cardiovascular stent surfaces has been demonstrated to reduce in-stent restenosis (ISR) effectively. However, the practical performance of such an endothelium-mimicking surfaces is strictly limited by the durability of both NO release and bioactivity...
Conference Paper
Background/Introduction Bovine pericardium is the main natural source for patches or valve substitutes in cardiac surgery, but still, long-term durability is limited. An alternative, glutaraldehyde (GA)-free preparation combining decellularization, riboflavin/UVA crosslinking, and low-energy electron irradiation (SULEEI) procedure was established t...
Article
Full-text available
Newly developed materials for blood-contacting devices need to undergo hemocompatibility testing to prove compliance with clinical requirements. However, many current in vitro models disregard the influence of flow conditions and blood exchange as it occurs in vivo. Here, we present a flow model which allows testing of blood-surface interactions un...
Article
Silk has a long track record of use in humans, and recent advances in silk fibroin processing have opened up new material formats. However, these new formats and their applications have subsequently created a need to ascertain their biocompatibility. Therefore, the present aim was to quantify the haemocompatibility and inflammatory response of silk...
Article
Full-text available
Poly(ethylene glycol) (PEG)‐glycosaminoglycan (GAG) hydrogel networks are established as very versatile biomaterials. Herein, the synthetic gel component of the biohybrid materials is systematically varied by combining different poly(2‐alkyl‐2‐oxazolines) (POx) with heparin applying a Michael‐type addition crosslinking scheme: POx of gradated hydro...
Article
Full-text available
Today’s smallest energy storage devices for in-vivo applications are larger than 3 mm ³ and lack the ability to continuously drive the complex functions of smart dust electronic and microrobotic systems. Here, we create a tubular biosupercapacitor occupying a mere volume of 1/1000 mm ³ (=1 nanoliter), yet delivering up to 1.6 V in blood. The tubula...
Article
Hydrogel coatings can improve the biocompatibility of medical devices. However, stable surface bonding and homogeneity of hydrogel coatings are often challenging. This study exploits the benefits of biohybrid hydrogels of crosslinked four-armed poly(ethylene glycol) and heparin to enhance the hemocompatibility of cobalt-chromium (CoCr) vascular ste...
Article
The in-situ formation of silver nanoparticles (AgNPs) via dopamine-reduction of Ag⁺ has been widely utilized for titanium implants to introduce antibacterial properties. In previous studies, the preparation of AgNPs has focused on controlling the feeding concentrations, while the pH of the reaction solution was ignored. Herein, we systematically de...
Article
Full-text available
The real-time monitoring of physiological parameters is essential for point-of-care testing. While nowadays routine tests are done through ex vivo analysis on frequently extracted blood, placing implantable sensors monitoring key blood parameters such as lactate, glucose, ions, and oxygen would mean a giant step forward in the care of critically il...
Article
Full-text available
Thrombosis and infections are the main causes of implant failures (e.g., extracorporeal circuits and indwelling medical devices), which induce significant morbidity and mortality. In this work, an endothelium‐mimicking surface is engineered, which combines the nitric oxide (NO)‐generating property and anti‐fouling function of a healthy endothelium....
Article
Full-text available
Coronary atherosclerotic lesions exhibit a low-pH chronic inflammatory response. Due to insufficient drug release control, drug-eluting stent intervention can lead to delayed endothelialization, advanced thrombosis, and unprecise treatment. In this study, hyaluronic acid and chitosan were used to prepare pH-responsive self-assembling films. The hyd...
Article
Full-text available
Titanium dioxide (TiO2) has a long history of application in blood contact materials, but it often suffers from insufficient anticoagulant properties. Recently, we have revealed the photocatalytic effect of TiO2 also induces anticoagulant properties. However, for long-term vascular implant devices such as vascular stents, besides anticoagulation, a...
Article
Antithrombogenicity, anti-inflammation, and rapid re-endothelialization are central requirements for the long-term success of cardiovascular stents. In this work, a plant-inspired phenolic-amine chemistry strategy was developed to combine the biological functions of a plant polyphenol, tannic acid (TA), and the thrombin inhibitor bivalirudin (BVLD)...
Article
Blood-contacting devices have emerged in the 21st century as the go-to clinical treatment for severe cardiovascular diseases. Due to their poor hemocompatibility, many coatings have been developed to improve their biocompatibility with limited success due to the lack of robustness in biomolecule conjugation. In this paper, we propose a new self-pro...
Article
Controlled corrosion and proper biological response are key demands for biodegradable Mg-alloy based vascular stents. To achieve those properties, herein, a chemical conversion coating was fabricated through layer-by-layer (LBL) assembly via the sequential assembly of poly (dimethyl-diallyl ammonium chloride) (PDDA), epigallocatechin gallate (EGCG)...
Article
In-stent restenosis after stenting is generally characterized by an inflammatory response, excessive proliferation of smooth muscle cells, and delayed healing of the endothelium layer. In this study, inspired by catechol/gallol surface chemistry, a sandwich-like layer-by-layer (LBL) coating was developed using chitosan and heparin as polyelectrolyt...
Article
Bio-sourced nanoparticles have a range of desirable properties for therapeutic applications, including biodegradability and low immunogenicity. Glycogen, a natural polysaccharide nanoparticle, has garnered much interest as a component of advanced therapeutic materials. However, functionalizing glycogen for use as a therapeutic material typically in...
Article
Full-text available
Blood-contacting medical devices play an important role within healthcare and are required to be biocompatible, hemocompatible and resistant to microbial colonization. Here we describe a high throughput screen for copolymers with these specific properties. A series of weakly amphiphilic monomers were combinatorially polymerized with acrylate glycol...
Article
Full-text available
In this work, we present a versatile surface engineering strategy by the combination of mussel adhesive peptide mimicking and bioorthogonal click chemistry. The main idea reflected in this work derived from a novel mussel-inspired peptide mimic with a bioclickable azide group (i.e., DOPA 4 -azide). Similar to the adhesion mechanism of the mussel fo...
Article
Full-text available
Stenting is currently the major therapeutic treatment for cardiovascular diseases. However, the nonbiogenic metal stents are inclined to trigger a cascade of cellular and molecular events including inflammatory response, thrombogenic reactions, smooth muscle cell hyperproliferation accompanied by the delayed arterial healing, and poor reendothelial...
Article
Micromotors are recognized as promising candidates for untethered micromanipulation and targeted cargo-delivery in complex biological environments. However, their feasibility in the circulatory system has been limited due to the low thrust force exhibited by many of the reported synthetic micromotors, being not sufficient to overcome the high flows...
Article
While absorbable magnesium (Mg) based vascular stents show promise, more progress is needed to fulfil suitable durability, fast endothelialization, anti‐restenosis, and anti‐inflammation. To design a multifunctional stent, the authors screen a common oral atorvastatin calcium (ATVC) loaded into a surface‐eroding poly(1,3‐trimethylene carbonate) (PT...
Article
The total synthesis of a new dabigatran derivative featuring a tosyl protecting group at the amidine group of dabigatran was explored. During the course of this work, different new synthetic pathways towards dabigatran intermediates are investigated and known concepts revisited. In this context, it was found that, in our hands, a published synthesi...
Article
Environmentally responsive polymer films have received much attention, but the stability of such films and the sensitivity of the response still have to be improved. The preparation of responsive films for low pH changes still faces challenges. In this study, catechol groups were used to functionalize chitosan and hyaluronic acid for mussel-inspire...
Article
Performance and safety of materials in contact with living matter are determined by sequential and competitive protein adsorption. However, cause and consequences of these processes remain hard to be generalized and predicted. In a new attempt to address that challenge, the authors compared and analyzed the protein adsorption and displacement on va...
Article
Following protein adsorption/activation which is the first step after the contact of material surfaces and whole blood (part 2), fibrinogen is converted to fibrin and platelets become activated and assembled in the form of a thrombus. This thrombus formation is the key feature that needs to be minimized in the creation of materials with low thrombo...
Article
Biomedical devices in the blood flow disturb the fine-tuned balance of pro- and anti-coagulant factors in blood and vessel wall. Numerous technologies have been suggested to reduce coagulant and inflammatory responses of the body towards the device material, ranging from camouflage effects to permanent activity and further to a responsive interacti...
Article
Despite over 50 years of study, there are no materials that are truly nonthrombogenic. Some materials minimize protein adsorption or cell adhesion while others such as heparin-coated surfaces, actively inhibit thrombin generation. Nonetheless, despite these advances, the problem of biomaterial-associated thrombogenicity persists. While once an acti...
Article
Co-immobilization of two or more molecules with different and complementary functions to prevent thrombosis, suppress smooth muscle cell (SMC) proliferation, and support endothelial cell (EC) growth is generally considered to be promising for the re-endothelialization on cardiovascular stents. However, integration of molecules with distinct therape...
Article
Despite >50 years of study, there are no materials that are considered truly nonthrombogenic. Some materials minimize protein adsorption or cell adhesion while others actively inhibit thrombin generation through heparinization. Nonetheless the problem of biomaterial associated thrombogenicity remains. While once an active area of research, the prob...
Article
Full-text available
Thrombosis and infections of extracorporeal circuits and indwelling medical devices are the two major life-threatening complications faced in clinical practice. Herein, we report a novel and facile metal-phenolic-amine surface modification strategy to engineer a multifunctional coating on these devices to combat thrombosis and infection. This strat...
Article
The development of a facile and versatile strategy to endow surfaces with synergistically anti-inflammatory, antimicrobial and anticoagulant functions is of particular significance for blood-contacting biomaterials and medical devices. In this work, we report a simple and environmentally friendly “one-pot” method inspired by byssal cuticle chemistr...
Article
Advanced blood contacting biomaterials are designed to combine antiseptic and anticoagulant functionalities. Here, we present a new in vitro methodology for the analysis of bacterial adhesion and growth after the preceding human whole blood incubation of the tested materials. Poly(styrene) surfaces as well as thrombin-responsive and non-responsive...
Article
Biodegradable magnesium (Mg)-based vascular stents have been designed as temporary scaffolds to treat angiostenotic lesions for the maintenance of normal blood flow. Numerous studies have presented in vitro and in vivo tests for the evaluation of the safety and feasibility of Mg-based vascular stents and the related materials. Therein the cytocompa...
Chapter
Reliable hemocompatibility testing of a biomaterial has to be done in consideration of the intended application in the final medical product. The testing conditions should reflect the fact that hemocompatibility is less an independent and immanent characteristic of a material itself but has to be viewed as the interaction of a material with the sur...
Chapter
Despite rapid advances in cardiovascular technology, none of the cardiovascular materials in clinical use can fulfill all the requirements of blood compatibility. To overcome unfavorable material-related biological responses, surface modification strategies enable the combination of material bulk properties with the desired biological attributes of...
Article
Full-text available
The DC-pulsed magnetron sputtering was employed to deposit Ti–Zr–N thin film on AISI 316 substrates. All the plasma parameters were kept to be constant except the plasma-processing power which was varied from 125 to 250 W. The structure, tribological, electrochemical and biocompatibility properties of Ti–Zr–N films have been investigated. X-ray pat...
Article
Contact between biomedical materials and blood often initiates undesirable pro-coagulant and pro-inflammatory processes. On negatively charged materials blood coagulation is known to be triggered through auto-activation of Factor XII, while activation on cationic surfaces follows a distinct and so far enigmatic mechanism. As Factor VII activating p...
Article
Full-text available
Sustained and controllable release characteristics are pivotal factors for novel drug delivery technologies. TiO2 nanotube arrays prepared by self-ordering electrochemical anodization are attractive for the development of biomedical devices for local drug delivery applications. In this work, several layers of polydopamine (PDA) were deposited to fu...
Article
Neutrophil extracellular trap (NET) formation, a reaction of the innate immune system to fight pathogens, was shown to be involved in thrombus formation. In the present study blood-contacting biomaterials with graded surface characteristics were investigated as a potential cause of NET formation on medical devices. Surface properties are known to g...
Article
The regulatory agencies provide recommendations rather than protocols or standard operation procedures for the hemocompatibility evaluation of novel materials e.g. for cardiovascular applications. Thus, there is a lack of specifications with regard to test setups and procedures. As a consequence, laboratories worldwide perform in vitro assays under...
Article
Full-text available
Many nanoparticles are designed for use as potential nanomedicines for parenteral administration. However, emerging evidence suggests that hemocompatibility is important, but is highly particle- and test-bed dependent. Thus, knowledge of bulk material properties does not predict the hemocompatibility of uncharacterized nanoparticles, including silk...
Article
Heparin (Hep) or bivalirudin (BVLD) was immobilized in an organic phytic acid (PA) coating by in-situ chemial method on Mg. Such drug-loaded PA coating was designed to enhance both corrosion control and biocompatibility. It was found that both Hep- and BVLD-loaded PA coatings on Mg exhibited dual effectiveness in corrosion control and bio-functiona...
Article
Statement of significance: Magnesium and its alloys are candidates for a new generation of biodegradable stent materials. However, the in vitro degradation of magnesium stents does not match the clinical degradation rates, corrupting the validity of conventional degradation tests. Here we report an ex vivo vascular bioreactor, which allows simulat...
Article
The corrosion behavior of Zn was compared with those of Fe and Mg in a long-term course of immersing in phosphate buffered saline (PBS) as biodegradable metal for bio-implants application. The comparison focused on corrosion rate, mode, products and surface characteristics along the immersion degradation up to 21 days. For transient assays, the ope...
Article
Efficient immobilization of the antibody to the substrate is of crucial importance in the development of anti-CD34-based endothelial progenitor cells capturing cardiovascular devices. This should go along with precise control of the antibody orientation by appropriate immobilization technology for retaining antibody activity, like in immunosensors....
Article
Mussel-inspired self-polymerization of dopamine in the presence of catechols and amines can be used to form coatings on various substrates. In this work dopamine was co-polymerized with poly (ethylene imine) (PEI) to form coatings on 316 L stainless steel (SS). The coating formation was confirmed by Fourier transform infrared spectra (FTIR) and X-r...
Article
Surface biofunctional modification of cardiovascular stents is a versatile approach to reduce the adverse effects after implantation. In this work, a novel multifunctional coating was fabricated by coimmobilization of the sulfated polysaccharide of brown algae fucoidan and laminin to biomimic the vascular intimal conditions in order to support rapi...
Article
Under physiological conditions, the opening and closing of the leaflets of an implanted artificial heart valve (AHV) affects the blood components and therefore may cause various complications to the patient such as hemolysis or platelet activation. In this paper, a computational fluid model is presented. The regional distribution of flow shear stre...