
Manfred HeroldInnsbruck Medical University · Department of Internal Medicine II
Manfred Herold
MD PhD Ass.-Prof.
About
458
Publications
103,548
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
13,658
Citations
Introduction
Additional affiliations
January 2010 - September 2021
Education
October 1967 - February 1981
Publications
Publications (458)
br> Aim: Antinuclear antibodies (ANA) are important for the diagnosis of various autoimmune diseases. ANA are usually detected by indirect immunofluorescence assay (IFA) using HEp-2 cells (HEp-2 IFA). There are many variables influencing HEp-2 IFA results, such as subjective visual reading, serum screening dilution, substrate manufacturing, microsc...
Objectives
Machine learning models can support an individualized approach in the choice of bDMARDs. We developed prediction models for 5 different bDMARDs using machine learning methods based on patient data derived from the Austrian Biologics Registry (BioReg).
Methods
Data from 1397 patients and 19 variables with at least 100 treat-to-target (t2...
Despite significant therapeutic advances in recent years, treatment of metastatic prostate cancer (PCa) remains palliative, owing to the inevitable occurrence of drug resistance. There is increasing evidence that epithelial glucocorticoid receptor (GR) signaling and changes in the tumor-microenvironment (TME) play important roles in this process. S...
Background
The continuous development of biological disease modifying antirheumatic drugs (bDMARDs) in recent years has significantly improved the treatment options for patients suffering from rheumatoid arthritis. Selecting the most effective biologic remains a challenge, since therapy-response is highly individual depending on the patient history...
Objectives:
Antinuclear antibodies (ANA) are important for the diagnosis of various autoimmune diseases. ANA are usually detected by indirect immunofluorescence assay (IFA) using HEp-2 cells (HEp-2 IFA). There are many variables influencing HEp-2 IFA results, such as subjective visual reading, serum screening dilution, substrate manufacturing, mic...
Zusammenfassung
Sowohl nach COVID-Infektion als auch nach ein oder mehreren COVID-Impfungen können rheumatische Beschwerden beginnen. In beiden Fällen scheint der Mechanismus ähnlich zu sein und mit dem Coronavirus oder seinen spezifischen Folgen zusammenzuhängen. Zumeist wird von einer reaktiven Arthritis gesprochen, wenngleich die Bezeichnung COV...
Objectives
No reference data are available on repositories to measure precision of autoantibody assays. The scope of this study was to document inter- and intra-run variations of quantitative autoantibody assays based on a real-world large international data set.
Methods
Members of the European Autoimmunity Standardisation Initiative (EASI) group...
About importance of recognizing AC-4a and AC-4b subpatterns on HEp-2 cells.
The establishment of the International Consensus on ANA Patterns (ICAP) in 2014-2015 was welcomed by members of the medical community as a significant improvement in guiding harmonization of ANA test interpretation and reporting. In the subsequent years, several itinerant meetings and continuous interaction with the community contributed to dissemi...
Results of the anti-nuclear antibodies-indirect immunofluorescence assay (anti-cell antibodies test) on HEp-2 cell substrates should be communicated to clinicians in a standardized way, adding value to laboratory findings and helping with critical clinical decisions. This paper proposes a test report based on the practices informed by 118 laborator...
Vasculitis affecting the nervous system is a rare disease that can not only present with nonspecific initial symptoms, but also run a severe course without accurate treatment. Although improvements have been achieved, diagnosis of vasculitis remains challenging, because many classification criteria are unspecific or inconclusive with regard to cent...
Introduction
The first wave of COVID-19 pandemic has disrupted almost all areas of the health care services to some extent throughout the world. Although the negative impact of COVID-19 on patients with autoimmune diseases has also been recognized, available data in this regard are limited. In the current study of the European Autoimmunity Standard...
Background: Whether the safety and efficacy of Januskinase Inhibitors (JAKis) in daily routine treatment of
Background
Gender differences in prevalence and disease course are known in various rheumatic diseases; however, investigations of gender difference concerning therapeutical response have yielded variable results.
Objectives
The aim of this retrospective study was to investigate, whether a gender difference in response rate to biological disease-m...
The diagnosis of COVID-19 relies on the direct detection of SARS-CoV-2 RNA in respiratory specimens by RT-PCR. The pandemic spread of the disease caused an imbalance between demand and supply of materials and reagents needed for diagnostic purposes including swab sets. In a comparative effectiveness study, we conducted serial follow-up swabs in hos...
Background
The International Consensus on Antinuclear Antibody (ANA) Patterns (ICAP) has recently proposed nomenclature in order to harmonize ANA indirect immunofluorescence (IIF) pattern reporting. ICAP distinguishes competent-level from expert-level patterns. A survey was organized to evaluate reporting, familiarity, and considered clinical value...
Special conditions associated with laboratory autoimmune testing are not well compatible with recent developments in regulatory frameworks such as EN/ISO 15189 accreditation or in vitro diagnostic medical device regulation (IVD-R). In addition, international recommendations, guidelines and disease criteria are poorly defined with respect to require...
Background
The International Consensus on Antinuclear Antibody (ANA) Patterns (ICAP) has recently proposed nomenclature in order to harmonize ANA indirect immunofluorescence (IIF) pattern reporting. ICAP distinguishes competent-levelfrom expert-level patterns. A survey was organized to evaluate reporting, familiarity, and considered clinical value...
Background
The International Consensus on Antinuclear Antibody (ANA) Patterns (ICAP) has recently proposed nomenclature in order to harmonize ANA indirect immunofluorescence (IIF) pattern reporting. ICAP distinguishes competent-level from expert-level patterns. A survey was organized to evaluate reporting, familiarity, and considered clinical value...
The diagnosis of COVID-19 relies on the direct detection of SARS-CoV-2 RNA in respiratory specimens by RT-PCR. The pandemic spread of the disease caused an imbalance between demand and supply of materials and reagents needed for diagnostic purposes including swab sets. In a comparative effectiveness study, we conducted serial follow-up swabs in hos...
Background and objectives:
Laser hair removal is the most common laser therapy and the third most commonly performed procedure with more than one million treatments in United States in 2016. This retrospective study was conducted to assess long-term efficacy and safety of the 755 nm laser for hair removal.
Study design/materials and methods:
Nea...
Abstract
Background: As data on the efficacy of biologics in
patients with mild/moderate rheumatoid arthritis are limited,
this study was performed to assess the efficacy and
safety of tocilizumab plus methotrexate versus tocilizumab
monotherapy on disease activity.
Methods: Seventy-seven patients with mild/moderate
rheumatoid arthritis and an inad...
The indirect immunofluorescence assay (IIFA) on HEp-2 cells is widely used for detection of antinuclear antibodies (ANA). The dichotomous outcome, negative or positive, is integrated in diagnostic and classification criteria for several systemic autoimmune diseases. However, the HEp-2 IIFA test has much more to offer: besides the titre or fluoresce...
Zusammenfassung
In Österreich wurde vergleichsweise spät im Jahre 2009, das „Biologikaregister für entzündlich rheumatische Erkrankungen e. V.“, kurz BioReg, gegründet, mit den auch in anderen Ländern verfolgten Zielen, jene PatientInnen, die mit Biologika behandelt werden, hinsichtlich Tolerabilität und Effektivität zu dokumentieren. Aus dem Verei...
Background
The goal for the treatment of rheumatoid arthritis (RA) should be remission or at last low disease activity. Using data of the Austrian biologic registry we evaluated disease activity in patients with RA and treated with biologics for more than six years.
Objectives
The aim of this evaluation was to elucidate long term disease activity...
The indirect immunofluorescence assay (IFA) on HEp-2 cells is the reference method for autoantibody screening. The HEp-2 IFA pattern provides useful information on the possible autoantibodies in the sample. The International Consensus on Antinuclear Antibody Patterns (ICAP) initiative seeks to define and harmonize the nomenclature of HEp-2 IFA patt...
Zusammenfassung
Primäres Ziel von ICAP (internationaler Konsens für antinukleäre Antikörpermuster) ist es, einen Konsens zu finden zur Beschreibung der Fluoreszenzmuster, die mit indirekter Immunfluoreszenztechnik auf HEp-2-Zellen erkannt werden können. 28 Muster (14 Kern-, 9 zytoplasmatische und 5 mitotische Muster) wurden bisher definiert. Neben...
Polymyalgia rheumatica (PMR) typically presents with acute onset of bilateral upper extremity pain (JAMA 315:2442–58, 2016) followed by functional impairment, including difficulties in rising, dressing, lifting, and reaching. Constitutional symptoms such as fatigue, depression, night sweats, weight loss, and low-grade fever are frequent. Elevated e...
Background
Remission or at last low disease activity is the aim of drug therapy in patients with chronic inflammatory rheumatic diseases. We evaluated disease activity in patients treated with biologics and using data of the Austrian biologic registry.
Objectives
The aim of this evaluation was to elucidate disease activity in patients with rheumat...
Results: With respect to demographic characteristics no differences of the five TNF-blockers available in Austria could be found. The older drugs Etanercept (ETA), and Adalimumab (ADA) were the ones most frequently prescribed, while the Infliximab (IFX) prescriptions, only intravenously applicable, were in the same range as Certolizumab Pegol (CZP)...
Background and Aims
The indirect immunofluorescence (IIF) pattern in ANA test provides initial assessment of autoantibody responses in candidate patients at risk of developing SLE. The International Consensus on ANA Patterns (ICAP) Initiative workshop originated in 2014, followed by the 2nd and 3rd workshops in 2015 and 2016. The goal of ICAP is to...
Background
Detection of anti-neutrophil cytoplasmic antibodies (ANCA) is important for the diagnosis of the ANCA-associated vasculitides (AAV). For AAV, especially ANCA directed against myeloperoxidase (MPO) and proteinase 3 (PR3) are most relevant. ANCA with less well-defined specificities may, however, also be detected in other inflammatory and n...
The purpose of the present study was to check the validity of data collected in BIOREG, the Austrian register for biological treatment in rheumatology, and to elucidate eventual differences with respect to disease activity (DA) in patients with rheumatoid arthritis (RA) on established biological DMARDs (bDMARDs) before inclusion into the register (...
Background
The purpose of the present study was to check the validity of data collected in BIOREG, the Austrian register for biological treatment in rheumatology, and to elucidate eventual differences with respect to disease activity (DA) in patients with rheumatoid arthritis (RA) on established biological DMARDs (bDMARDs) before inclusion into the...
The second meeting for the International Consensus on Antinuclear antibody (ANA) Pattern (ICAP) was held on 22 September 2015, one day prior to the opening of the 12th Dresden Symposium on Autoantibodies in Dresden, Germany. The ultimate goal of ICAP is to promote harmonization and understanding of autoantibody nomenclature, and thereby optimizing...
Background
Formation of anti-drug antibodies (ADA) might be responsible for sub-therapeutic serum drug levels resulting in a lack of clinical response. The need to test ADA levels in patients treated with a TNF inhibitor is the subject of discussion (1, 2).
Objectives
ADA levels were measured in patients treated with ADL or ETN or IFX to check imm...
Background
The discordance between patients and physicians in estimation of patients' global health is well known especially from RA patients. We tried to find out whether differences in global health estimation are the same in patients with different diseases using data of the Austrian biologic registry.
Objectives
The aim of this evaluation was...
This dictionary provides a comprehensive list of the terms and definitions commonly used in clinical rheumatology and osteology, and the new edition has been extended to include more than 50 additional entries. The book contains systematic descriptions relating to diseases of the locomotor apparatus, including osteoporosis, and important laboratory...
The International Consensus on ANA Patterns (ICAP) was initiated as a workshop aiming to thoroughly discuss and achieve consensus regarding the morphological patterns observed in the indirect immunofluorescence assay on HEp-2 cells. One of the topics discussed at the second ICAP workshop, and addressed in this paper, was the harmonization of report...
Objective:
To measure the views of general practitioners (GPs) and rheumatologists in a nationwide evaluation, so as to optimise their cooperation in managing patients with inflammatory rheumatic diseases.
Methods:
A questionnaire covering aspects of collaboration was sent, both by mail and/or by email, to all GPs and rheumatologists in Austria....
Background:
Addition of the anti-CD20 monoclonal antibody rituximab to chemotherapy improves response rates and survival in patients with B-cell non-Hodgkin lymphoma (NHL). However, rituximab induces a transient B-cell depletion and a dose-dependent T-cell inactivation that could impair T-cell immunosurveillance. The impact of rituximab on second...
Background. Rheumatoid arthritis is a systemic autoimmune disease characterized by joint erosions, progressive focal bone loss, and chronic inflammation. Methods. 20 female patients with moderate-to-severe rheumatoid arthritis were treated with anti-TNF-antibody adalimumab in addition to concomitant antirheumatic therapies. Patients were assessed f...
Background/Purpose:
An Austrian multi-center study of the effect on disease activity and the safety of Tocilizumab (TCZ) in combination with Methotrexate (MTX) versus TCZ Monotherapy in patients with mild to moderate rheumatoid arthritis (RA), with inadequate response to MTX – The OPTIMISE trial (EUDRACT No. 2011-001863-39)
As only limited data...
Background/Purpose:
An Austrian multi-center study of the effect on disease activity and the safety of Tocilizumab (TCZ) in combination with Methotrexate (MTX) versus TCZ Monotherapy in patients with mild to moderate rheumatoid arthritis (RA), with inadequate response to MTX – The OPTIMISE trial (EUDRACT No. 2011-001863-39)
As only limited data...
During the 12th International Workshop on Autoantibodies and Autoimmunity held in Sao Paulo, Brazil, on August 28, 2014, a full day session was devoted to establishing a consensus on the nomenclature of staining patterns observed in the antinuclear antibody (ANA) indirect immunofluorescence test on HEp-2 cells. The current report summarizes the col...
Um das Jahr 2000 wurden in Europa die ersten Biologika vom Typ der TNF-Hemmer zur Therapie der Rheumatoiden Arthritis zugelassen und etwa zeitgleich in mehreren Ländern Biologikaregister etabliert [1, 2], um die Wirksamkeit und Sicherheit der neuen Therapieformen zu dokumentieren. In Österreich wurde 2009 der Verein „Biologicaregister für entzündli...
Seit über 60 Jahren werden im Therapiestollen in Bad Gastein Patienten mit chronischen Leiden behandelt. Die größte Gruppe bilden Patienten mit Schmerzen aufgrund einer rheumatischen Erkrankung. Kurverlaufsbeobachtungen an mehreren Hundert Patienten sowie eine randomisierte kontrollierte Studie im Rahmen eines Rehabilitationsaufenthaltes bestätigen...
Background BIOREG, the Austrian registry for patients (pts.) with chronic rheumatic diseases treated with biologic DMARD's, includes pts with rheumatoid arthritis (RA), spondylarthritis (SPA), psoriatic arthritis (PSA) and other diseases since 2010. Patients on biologic treatment are included irrespective of treatment duration and history. The prim...
Background The Austrian BioReg registry (http://www.bioreg.at) was initiated in 2009. Patients treated with one of the nine biologics (abatacept, adalimumab, anakinra, certolizumab, etanercept, golimumab, infliximab, rituximab, tocilizumab) approved in Austria can be included. Patients with ongoing biologic therapy as well as biologic-naïve patient...
Background Rheumatoid arthritis (RA) is a common autoimmune disease, characterized by cartilage and bone destruction, autoantibody production and systemic disorders. (1) One of the most common comorbidities is anemia, caused by chronic inflammation or iron deficiency, with an high impact on quality of life. (2)
Objectives According to older literat...
A survey was conducted to evaluate whether a steady improvement in the quality of life of Rheumatoid Arthritis (RA) patients as frequently reported in clinical studies, does actually occur. The focus of this study laid on the personal perception of RA patients. How do patients who have been treated along accepted guidelines see the state of their h...
Background:
In this multi-centre, randomised, placebo-controlled pilot trial, we investigated the clinical and haemodynamic effects of the endothelin-receptor blocker Bosentan in patients with heart failure, preserved ejection fraction and pulmonary hypertension (PH-HFpEF).
Materials and methods:
Eligible patients received either 12 weeks of Bos...
Zusammenfassung
2014 wurden in Zusammenarbeit von zwei großen internationalen Expertengruppen Empfehlungen zur Bestimmung von Autoantikörpern gegen zelluläre Antigene, herkömmlich als antinukleäre Antikörper bezeichnet, herausgegeben. Die Empfehlungen wurden in einer 25 Punkte umfassenden Tabelle zusammengefasst und in einer weiteren Tabelle jene M...
To evaluate factors influencing injection patterns and patient evaluations of an autoinjector device in biologic-naïve patients beginning golimumab (GLM) treatment.
GO-MORE was an open-label, multinational, prospective study in patients with active rheumatoid arthritis (RA) (28-joint disease activity score based on erythrocyte sedimentation rate [D...
Vasculitis is an inflammation of the blood vessel wall causing damage to the wall followed by a wide variety of signs and symptoms, depending on the type of vessels and organs affected. Inflammation-caused vessel wall injury leads to vascular stenosis, occlusion, aneurysm and bleeding. Thrombosis is not a common symptom but may occur, resulting in...
Sine syndromes (SSs) represent atypical forms of inflammatory rheumatic diseases, the courses of which are often severe. While the diagnosis of rheumatic diseases can be determined according to an established set ofdiagnostic criteria based on clinical characteristics and laboratory parameters, Sine Syndromes do not fulfill thestandard criteria use...
Antiphospholipid antibodies (aPLs) frequently occur in autoimmune and cardiovascular diseases and correlate with a worse clinical outcome. In the present study, we evaluated the association between antiphospholipid antibodies (aPLs), markers of inflammation, disease progression and the presence of an intra-aneurysmal thrombus in abdominal aortic an...
Objectives:
One of the main goals of the European Autoimmunity Standardisation Initiative (EASI) is the harmonisation of test-algorithms for autoantibodies related to systemic autoimmune rheumatic diseases (SARD).
Methods:
A questionnaire was used to gather information on methodology, interpretation, and the algorithm for detection of anti-nucle...
To determine how fast rheumatoid arthritis (RA) was diagnosed in a group of patients in a rural area and whether medical care and patient satisfaction were adequate in a predominantly non-urban settlement.
When visiting their rheumatologist, patients with RA were asked to complete a questionnaire at home after the consultation and then return it to...
Background Self-injection of subcutaneous (SC) golimumab (GLM) using an autoinjector device may be useful for patients with rheumatoid arthritis (RA), especially if they have functional impairment in the joints of the hand and fingers. An autoinjector designed to account for RA patient disability may improve patient satisfaction.
Objectives To meas...
Background During treatment of patients with rheumatic disease like rheumatoid arthritis (RA), spondylarthritis (SpA) and psoriatic arthritis (PsA) with anti TNF-α antibodies (TNF-inhibitors) induction of antinuclear antibodies (ANA) may occur.
Objectives This study is a retrospective examination, to evaluate the number of patients treated with TNF...