Manfred Eggersdorfer

Manfred Eggersdorfer
University of Groningen | RUG · Department of Internal Medicine

Professor

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152
Publications
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Publications

Publications (152)
Article
Objectives To assess if baseline iron deficiency, with or without anemia, is associated with incident infections over 3 years among community-dwelling older adults.DesignProspective secondary analysis of DO-HEALTH, a 3-year randomized, double-blind controlled trial.Setting And Participants2157 community-dwelling adults age 70+ from 5 European count...
Article
Die Empfehlungen für die Aufnahme von Vitamin E über die Nahrung variieren von Land zu Land und von Organisation zu Organisation erheblich – auch in Europa. Hier liegen die Referenzwerte für Erwachsene bei 3–15 mg/Tag. Nur etwa 50% der deutschen Bevölkerung erreichen die Zufuhrempfehlung für Vitamin E durch die Ernährung. Angesichts der Bedeutung v...
Article
Neue Ansätze zur Rolle von Vitamin E in verschiedenen Bereichen der menschlichen Gesundheit werden in verschiedenen Arbeitsgruppen untersucht und versprechen neue Anwendungen in der gesundheitlichen Unterstützung von Risikogruppen. Nach 100 Jahren Forschung zu und über Vitamin E eröffnen neue Technologien und Studien auch für die Zukunft vielverspr...
Article
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The immune system is weakened by advancing age, often referred to as immunosenescence, increasing the vulnerability to, and frequently the severity of, infectious diseases in older people. This has become very apparent in the current coronavirus disease 2019 (COVID-19) pandemic for which older people are at higher risk of severe outcomes, even thos...
Article
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The world has entered the third year of the coronavirus disease 2019 (COVID-19) pandemic. Vaccination is the primary public health strategy to protect against infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in addition to other measures, such as mask wearing and social distancing. Vaccination has reduced COVID-19 severi...
Article
Zusammenfassung Betrachtet man die Ernährungssituation der allgemeinen Bevölkerung in Deutschland, so zeigt sich, dass die Menschen zwar gut mit Nahrungsmitteln versorgt sind, aber keinen „guten“ Lebensstil bezüglich Bewegung, Körpergewicht und der Zufuhr von essenziellen Mikronährstoffen haben. Dasselbe gilt auch für bestimmte Risikogruppen wie Äl...
Article
Life expectancy as a measure of population health does not reflect years of healthy life. The average life expectancy in the Asia-Pacific region has more than doubled since 1900 and is now above 70 years. In the Asia-Pacific region, the proportion of aged people in the population is expected to double between 2017 and 2050. Increased life expectanc...
Article
Objectives Vitamin E deficiency (VED) appears to be common in rural areas of South Asia, with prevalence of ≥ 50% reported among women of reproductive age. Long term deficiency may impart neurological damage, but little information exists about persistence of VED. We provide initial estimates of chronic VED (CVED) in women of reproductive age livin...
Article
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The US Dietary Guidelines for Americans (DGA) provide dietary recommendations to meet nu-trient needs, promote health, and prevent disease. Despite 40 years of DGA, the prevalence of under-consumed nutrients continues in the US and globally, although dietary supplement use can help to fill shortfalls. Nutrient recommendations are based on Dietary R...
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Background The enormous health impact of the COVID-19 pandemic has refocused attention on measures to optimize immune function and vaccine response. Dietary deficiencies of micronutrients can weaken adaptive immunity. The aim of this review was to examine links between micronutrients, immune function and COVID-19 infection, with a focus on nutritio...
Article
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Background Methylmalonic acid (MMA) is best known for its use as a functional marker of vitamin B12 deficiency. However, MMA concentrations not only depend on adequate vitamin B12 status, but also relate to renal function and endogenous production of propionic acid. Hence, we aimed to investigate to what extent variation in MMA levels is explained...
Article
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Background: a large number of studies have linked vitamin B6 to inflammation and cardiovascular disease in the general population. However, it remains uncertain whether vitamin B6 is associated with cardiovascular outcome independent of inflammation. Methods: we measured plasma pyridoxal 5'-phosphate (PLP), as an indicator of vitamin B6 status,...
Article
Background Socioeconomic status (SES) patterned health disparities have been related to differences in dietary intake, especially in the elderly. Still, it is not known to what extent these differences culminate in vitamin deficiencies, as most studies have assessed nutrient intake, instead of measuring nutritional biomarkers. Hence, we aimed to ob...
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Socioeconomic health inequalities are an important global public health problem. However, it is not well known to what extent socioeconomic inequalities culminate in impaired vitamin status and whether this is mediated by diet. We, therefore, aimed to assess vitamin status in a population already at increased risk of micronutrient deficiency, i.e.,...
Article
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Life expectancy is increasing and so is the prevalence of age-related non-communicable diseases (NCDs). Consequently, older people and patients present with multi-morbidities and more complex needs, putting significant pressure on healthcare systems. Effective nutrition interventions could be an important tool to address patient needs, improve clin...
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Vitamin C is an essential nutrient which humans cańt produce. Vitamin C has many important functions in the body, such as immune-system stimulation, growth and repair of tissue, sustain cardiovascular and bone health and protecting cells from oxidative stress by neutralizing harmful free radicals. To ensure adequate vitamin C levels intake recommen...
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Objectives Vitamin E deficiency (VED), common in areas of rural South Asia, can affect neuromuscular health. This study determined the extent of VED and its association with neuromuscular function, indicated by hand grip strength, in Nepalese school aged children. Methods This cross-sectional study was conducted in a birth cohort of 6–8 year old c...
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Public health practices including handwashing and vaccinations help reduce the spread and impact of infections. Nevertheless, the global burden of infection is high, and additional measures are necessary. Acute respiratory tract infections, for example, were responsible for approximately 2.38 million deaths worldwide in 2016. The role nutrition pla...
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Whether the affinity of serum vitamin E with total lipids hampers the appropriate assessment of its association with age-related risk factors has not been investigated in epidemiological studies. We aimed to compare linear regression-derived coefficients of the association of non-indexed and total lipids-indexed vitamin E isoforms with clinical and...
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Background: Many countries have established Food-Based Dietary Guidelines (FBDG). For some foods, such as cheese, there is no consensus on whether or not to include them in these guidelines. Cheese may, however, be an excellent source of vitamin K2, which is a macronutrient with demonstrated positive results on cardiovascular-related outcomes. Aim:...
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Redox imbalance is an adverse on-going phenomenon in renal transplant recipients (RTR). Vitamin E has important antioxidant properties that counterbalance its deleterious effects. However, plasma vitamin E affinity with lipids challenges interpretation of its levels. To test the hypothesis that erythrocyte membranes represent a lipids-independent s...
Article
Zusammenfassung Die Versorgung mit essenziellen Mikronährstoffen, also Vitaminen und Mineralstoffen, ist für ein gesundes Leben und Altern von großer Bedeutung. Der Nutzen eines optimalen Nährstoffstatus für ein gesundes Leben und Altern zeigt sich bei der Mobilität im Alter aufgrund von guter Muskelstärke und Knochendichte, der Augengesundheit dur...
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Thanks to advances in modern medicine over the past century, the world’s population has experienced a marked increase in longevity. However, disparities exist that lead to groups with both shorter lifespan and significantly diminished health, especially in the aged. Unequal access to proper nutrition, healthcare services, and information to make in...
Poster
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INTRODUCTION: Oxidative stress is an adverse long-term ongoing phenomenon in renal transplant recipients (RTR) and vitamin E has important antioxidant properties that substantially counterbalance it. However, plasma vitamin E affinity with circulating lipids challenges its levels interpretation. We aimed to test the hypothesis that plasma vitamin E...
Article
Vitamin E is a lipid soluble antioxidant which mainly circulates as α-tocopherol in the human plasma. Its deficiency is associated with ataxia, neuropathy, anaemia and several other health conditions. Although substantial data on vitamin E status has been published worldwide, there is paucity of data on the extent of deficiency from most Asian coun...
Book
This comprehensive volume examines the role of vitamin E as an essential micronutrient in human health and its extensive clinical benefits. Sections cover a wide breadth of topics, including vitamin E intake and recommended daily allowance, understanding the biological activities of Vitamin E and observed physiological effects, benefits of vitamin...
Chapter
This chapter highlights the achievements in vitamin E research of the last decades including the adventurous early years of the discovery of this fat-soluble vitamin almost 100 years ago.
Chapter
According to data from various surveys, mean vitamin E intakes in Europe were between 7.8 and 16.0 mg α-tocopherol per day (EFSA Panel on Dietetic Products N, and Allergies. EFSA J 13(7):4149, 2015). About 50% of all German men and women had a daily intake of vitamin E below the recommended value (II. NV. Max-Rubner-Institut, Karlsruhe, http://www....
Article
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An increasing aging population worldwide accounts for a growing share of noncommunicable diseases (NCDs) of the overall social and economic burden. Dietary and nutritional approaches are of paramount importance in the management of NCDs. As a result, nutrition programs are increasingly integrated into public health policies. At present, programs ai...
Chapter
Vitamin E has important antioxidant properties and is implicated in protection against the development of age-related diseases. An important problem hampering correct interpretation of circulating concentrations of vitamin E is its affinity for circulating lipids, causing a high correlation with total cholesterol and fasting triglycerides. Many stu...
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The global population, including the United States, is experiencing a demographic shift with the proportion of older adults (aged ≥ 65 years) growing faster than any other age group. This demographic group is at higher risk for developing nutrition-related chronic conditions such as heart disease and diabetes as well as infections such as influenza...
Article
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Decreases in global cardiovascular disease (CVD) mortality and morbidity in recent decades can be partly attributed to cholesterol reduction through statin use. n-3 long chain polyunsaturated fatty acids are recommended by some authorities for primary and secondary CVD prevention, and for triglyceride reduction. The residual risk of CVD that remain...
Article
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PurposeTo report the vitamin D status in adults from seven European countries and to identify behavioural correlates. Methods In total, 1075 eligible adult men and women from Ireland, Netherlands, Spain, Greece, UK, Poland and Germany, were included in the study. ResultsVitamin D deficiency and insufficiency, defined as 25-hydroxy vitamin D3 (25-OH...
Article
Carotenoids are naturally occurring pigments found in most fruits and vegetables, plants, algae, and photosynthetic bacteria. Humans cannot synthesize carotenoids and must ingest them in food or via supplementation. Carotenoids have a range of functions in human health. They primarily exert antioxidant effects, but individual carotenoids may also a...
Article
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The 2017 annual symposium organized by the University Medical Center Groningen in The Netherlands focused on the role of the gut microbiome in human health and disease. Experts from academia and industry examined interactions of prebiotics, probiotics, or vitamins with the gut microbiome in health and disease, the development of the microbiome in e...
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A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
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Inorganic sulfate is essential for normal cellular function and its homeostasis is primarily regulated in the kidneys. However, little is known about renal sulfate handling in humans and particularly in populations with impaired kidney function such as renal transplant recipients (RTR). Hence, we aimed to assess sulfate reabsorption in kidney donor...
Article
Micronutrients are essential to health at every life stage and their deficiencies are associated with increased incidence of various pathophysiological states and poor quality of life. Efficient methods are therefore needed to monitor micronutrient status of individuals and to improve evidenced-based recommendations for populations. This review (i)...
Article
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The antioxidant activity of tocopherols in vegetable oils was shown to chiefly depend on the amount and the tocopherol homolog present. However, the most effective ratio of tocopherol homologs with regard to the antioxidant capacity has not been elucidated so far. The present study analyzed the effect of different tocopherol concentrations, homolog...
Article
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Surveys in high-income countries show that inadequacies and deficiencies can be common for some nutrients, particularly in vulnerable subgroups of the population. Inadequate intakes, high requirements for rapid growth and development, or age- or disease-related impairments in nutrient intake, digestion, absorption, or increased nutrient losses can...
Article
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Background: Elevated resting heart rate (HR) has emerged as a new risk factor for all-cause and cardiovascular mortality. The effect of marine-derived omega-3 long-chain polyunsaturated fatty acid (n-3 LCPUFAs) supplementation on HR was investigated as an outcome in many clinical trials. The present study was to provide an updated meta-analysis on...
Article
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Background: The oxidative deterioration of vegetable oils is commonly measured by the peroxide value, thereby not considering the contribution of individual lipid hydroperoxide isomers, which might have different bioactive effects. Thus, the formation of 9- and 13-hydroperoxy octadecadienoic acid (9-HpODE and 13- HpODE), was quantitated after shor...
Article
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Haptoglobin (Hp) is an acute phase protein that has recently been linked to components of the metabolic syndrome (MetS). We aimed to evaluate Hp as marker of MetS, and to assess its association with long-term outcome in renal transplant recipients (RTR). We measured plasma Hp in a prospective cohort of 699 stable RTR and 149 healthy controls. Media...
Article
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Background: Low plasma concentrations of pyridoxal 5'-phosphate (PLP) are common in renal transplant recipients (RTRs) and confer increased risk of long-term mortality. To our knowledge, it is not known whether low plasma PLP concentrations have functional (i.e., intracellular) consequences and, if so, whether such consequences are associated with...
Article
Teil 1 des Beitrags über Folat und Folsäure widmete sich den ernährungswissenschaftlichen Aspekten des Vitamins bzw. der synthetischen Vorstufe sowie seiner zentralen Funktion im Zellstoffwechsel und bei der Synthese der Amino- und Nukleinsäuren. Nun sollen mit Blick auf die aktuelle Studienlage einzelne medizinische Auswirkungen eines Folatmangels...
Chapter
Aging is not a single process, but an accumulation of modifications, affecting different parts of the body to varying degrees. An estimated 2 billion people aged 60 years and older will inhabit the planet in 2050. Advancing age increases the incidence of non-communicable diseases (NCDs). Epidemiologically, there is a direct link between nutritional...
Book
This book is the first of its kind to tackle in detail the nutritional requirements of the industrialized, so-called developed world. It discusses the link between socio-economic status and food security, focusing especially on the relationship between income and food security in different age groups. The authors calculate the actual levels of esse...
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The public health relevance of drug–nutrition interactions is currently highly undervalued and overlooked. This is particularly the case for elderly persons where multi-morbidity and consequently polypharmacy is very common. Vitamins and other micronutrients have central functions in metabolism, and their interactions with drugs may result in clini...
Article
Zusammenfassung Der Name „Folat“ stammt vom lateinischen Begriff „folium“ („Blatt“). Denn diese bioaktiven Verbindungen wurden erstmals aus Spinatblättern isoliert. Oft werden die Bezeichnungen Folat, Vitamin B9 und Folsäure synonym gebraucht. Hierbei handelt es sich um wasserlösliche Verbindungen der Vitamin-B-Gruppe, zu der auch Folsäure und natü...
Article
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Establishing intake recommendations for vitamin C remains a challenge, as no suitable functional parameter has yet been agreed upon. In this report, we review the emerging evidence on neutrophil motility as a possible marker of vitamin C requirements and put the results in perspective with other approaches. A recent in vitro study showed that adequ...
Article
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The field of nutrition has evolved rapidly over the past century. Nutrition scientists and policy makers in the developed world have shifted the focus of their efforts from dealing with diseases of overt nutrient deficiency to a new paradigm aimed at coping with conditions of excess-calories, sedentary lifestyles and stress. Advances in nutrition s...
Article
Background: Previous studies have reported low circulating concentrations of pyridoxal-5-phospate (PLP) in renal transplant recipients (RTRs). It is unknown whether this is because of low intake or altered handling, and it is also unknown whether variation in circulating concentrations of PLP influences long-term outcome. Objective: We compared vit...
Article
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The purpose of this study is to systematically review the published literature reporting vitamin E intake levels and serum concentrations in order to obtain a global overview of α-tocopherol status. Articles published between 2000 and 2012 were considered; 176 articles referring to 132 single studies were included. Applying an RDA (recommended dail...
Article
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Prospective observational studies have shown inconsistent associations of dietary or circulating n-3 long-chain polyunsaturated fatty acids (LCPUFA) with risk of all-cause mortality. A meta-analysis was performed to evaluate the associations. Potentially eligible studies were identified by searching PubMed and EMBASE databases. The summary relative...
Chapter
Multi-stakeholder partnerships are important facilitators of improving nutrition in developing countries to achieve the United Nations' Sustainable Development Goals. Often, the role of industry is challenged and questions are raised as to the ethics of involving for-profit companies in humanitarian projects. The Second International Conference on...
Article
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Astaxanthin is a coloring agent which is used as a feed additive in aquaculture nutrition. Recently, potential health benefits of astaxanthin have been discussed which may be partly related to its free radical scavenging and antioxidant properties. Our electron spin resonance (ESR) and spin trapping data suggest that synthetic astaxanthin is a pote...
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6077 These authors contributed equally to this work. Abstract: Worldwide approximately two billion people have a diet insufficient in micronutrients. Even in the developed world, an increasing number of people consume nutrient-poor food on a regular basis. Recent surveys in Western countries consistently indicate inadequate intake of nutrients such...
Article
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Background and aims: Demographic changes lead to an increased number of elderly , which has a dramatic impact on health care cost. One factor driving up this cost is the widespread malnutrition in elderly, especially in patients, already before entering the health care system. The aim of this paper was to analyze the adequacy of vitamin intakes in...
Article
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Life expectancy is increasing globally however later life years are often connected to ill-health. One of the reasons is that non-communicable diseases (NCDs) are on the rise and societies face challenges in a continuous increase in the global prevalence of overweight and obesity. This is partly due to the sedentary lifestyle and a trend to process...