Manfred Beutel

• Doctor of Medicine
• Universitätsmedizin der Johannes Gutenberg-Universität Mainz

Objective Psychological distress is associated with a higher risk of cardiovascular disease (CVD) and mortality, whereas psychological resilience may confer a protective effect. However, evidence on these relationships remains limited. This study aimed to examine the associations between psychological resilience, CVD, and all-cause mortality within...

The present study investigated if there are differences in the neural activity of the healthy human brain during the imagination of activities from the real world in comparison to the imagination of activities from the online world. Using functional MRI, healthy subjects were scanned during a monetary incentive delay task (functional localizer of r...

Objective Impairment in personality functioning (PF) has been linked to a number of mental disorders, including eating disorders (EDs). However, the precise relationship between PF and symptom severity, as well as the potential impact on outcome, remains unclear. The study aimed to analyse the association of PF and its change with severity of ED sy...

Background In view of demographic change, rising retirement age, and a growing shortage of skilled workers, it is increasingly important to prevent widespread diseases such as type 2 diabetes or its risk factor metabolic syndrome. Since the workplace is an important setting for preventive measures and little is known about incident cases in the wor...

Zusammenfassung Die Onlinesexsucht gewinnt in der digitalen Welt zunehmend an Relevanz, da einfacher Zugang zu sexuellen Inhalten die Befriedigung sexueller Bedürfnisse jederzeit ermöglicht und dies oft mit sozialer Isolation und realweltlichen Intimitätsproblemen einhergeht. Ziel der vorliegenden Studie ist es, den Zusammenhang zwischen traumatisc...

Background: Understanding the trajectories of health-related quality of life (HRQoL) across different age cohorts and sociodemographic factors is crucial for pro moting healthy aging. This study aims to examine the course of physical and mental HRQoL over a 16-year period in a nationwide sample of the German population. Methods: Data from the Germa...

Background Childhood maltreatment (CM) significantly increases the risk of developing post-traumatic stress disorder (PTSD) for which the prevalence in Europe is higher than initially assumed. While the high economic burden of PTSD is well-documented, little is known about the health care cost differences between individuals with PTSD-CM and those...

Increased risk of suicide attempts among descendants of displaced persons – An epidemiological contribution to the study of transgenerational consequences of flight experiences Objectives: The far-reaching consequences of flight and displacement are well documented. Such traumatic experiences may affect the next generation. However, mental health...

Abstract Im Poster wird ein Pat. mit Onlinesexsucht vorgestellt. Nach jahrelangem, exzessivem Pornokonsum stellt sich der Pat. in der Spielsuchtambulanz in Mainz vor. Diagnose gemäß ICD10: F65.0G. Der Patient beschreibt eine stark belastende Kindheit mit einer emotional nicht eichbaren jungen Mutter und einem weitgehend abwesenden Vater. Die konze...

Zusammenfassung Gewalterfahrungen in der Kindheit erhöhen das Risiko für psychische Probleme im Erwachsenenalter. Wie die frühe institutionelle Betreuung in der DDR mit Gewalterfahrungen assoziiert ist und Angst und Depression im Erwachsenenalter beeinflussen, ist wenig erforscht. Die Stichprobe umfasst N=1743 Personen, geboren in der DDR (1949–198...

Background: Results from recent studies suggest that altered implicit and explicit cognitions in individuals with substance dependencies are involved in the development of the respective disorders. Based on the I-PACE (Interaction of Person-Affect-Cognition-Execution) model (Brand et al., 2019), research project RP7 of FOR2974 investigates whether...

Randomized controlled trials are routinely used to assess the efficacy of psychotherapy. To date, our knowledge about how patients experience participation in such a trial is scant. Therefore, the present analysis aims at an in-depth exploration of patients’ perspectives on how a trial environment affects them. This study was conducted within the f...

The strong migration of former East German residents to the western part of Germany opens a unique way to study the impact of migration modifying gender-related attitudes towards division of labor. While in West Germany more traditional gender attitudes have been prevailing for decades, the East pursued more progressive attitudes regarding the home...

Es wird ein älterer männlicher Patient vorgestellt, der nach jahrelang exzessivem Pornografiekonsum eine mehrjährige, heimliche Affäre mit seiner Schwiegermutter begann, die seine Ehe gefährdet. Geplagt von unerträglichen Schuldgefühlen gestand er dies seiner Frau. Neben einer psychodynamischen Therapie nehmen beide an einer Paartherapie teil, da s...

Background: Job-Exposure Matrices (JEMs) are a common method used in occupational epidemiology to assess exposure when individual data is lacking. In 2022, experts from Denmark, the Netherlands and the United Kingdom systematically ranked the expected exposures and workplace characteristics for each job and country to construct three country-specif...

Background The Brief Resilience Coping Scale (BRCS) is a brief instrument suitable for epidemiological studies. The aims of this paper were to analyze changes in BRCS depending on time, sex, age group, relationship status, as well as risk of poverty, to test the psychometric properties including test-retest reliability and measurement invariance, a...

Background Self-rated physical health (SRPH) is known as an important predictor of mortality. Previous studies mostly used baseline values of self-rated health to predict long-term mortality. The effect of change in self-rated physical health on mortality during the course of aging has rarely been researched. The present study aimed to determine SR...

Background Childhood trauma is a major risk factor for chronic depression. It has been suggested that adults with chronic depression who have experienced childhood trauma may require long-term treatment owing to a breakdown of basic trust and related difficulties in developing a productive therapeutic relationship. Aims As empirical studies have b...

Research indicates that patients with a lifetime history of suicide attempts are particularly burdened. However, investigations of their characteristics and comparisons with other patients are scarce. This study aimed to fill this research gap, using routine clinical data and guided by theoretical models. Data of N = 706 patients (54.4% women) was...

Background The transition from school to university is often accompanied by a change in students’ lifestyles. So far little is known whether convenience behavior is an essential factor affecting students’ health and social interaction. In a heterogeneous population regard to sociodemographic and anthropometric characteristics the Convenience Behavi...

Objective The purpose of the present study was to develop and validate a brief screening instrument (F-SozU K-3) for the measurement of perceived social support in large scale surveys by shortening a well-established German questionnaire (F-SozU K-6). Method First, a brief three-item version of the F-SozU was developed based on a representative sa...

Das Lehrbuch stellt die zentralen Inhalte des reformierten Masterstudiengangs Klinische Psychologie und Psychotherapie dar. Eingegangen wird dabei auf alle psychotherapeutischen Richtlinienverfahren, also die Kognitive Verhaltenstherapie, die Systemische Therapie, die Tiefenpsychologisch fundierte Therapie und die Analytische Psychotherapie, sowie...

There are considerable interindividual differences in adjustment processes in satisfaction with life (SWL) following critical life events. We focused on a collective life event, the German reunification in 1989/90, which prompted fundamental changes in the political, social, and economic conditions to investigate the heterogeneity of short- and lon...

Einsicht gilt als zentraler Wirkmechanismus von Psychotherapie, wurde jedoch bisher kaum empirisch in der Behandlung Posttraumatischer Belastungsstörungen (PTBS) untersucht. Zunächst wird ein objektbeziehungstheoretisches Modell der PTBS skizziert, welches deren Aufrechterhaltung unter anderem auf maladaptive interpersonelle Muster zurückführt. Anh...

Background The pathophysiology of tinnitus is not yet fully understood. Although there is a large amount of evidence associating traffic noise exposure with non-auditory health outcomes, there is no evidence regarding the impact of noise annoyance on auditory disorders such as tinnitus. Objective Thus, we aimed to investigate the association betwe...

Background Peripheral hypertrophic subepithelial corneal opacification (PHSCO) is a corneal disease that may severely affect vision. The major goal of this study was to test the hypothesis that tear secretion, medication and systemic diseases are associated with PHSCO. Methods This is a retrospective, case–control study conducted at the Department...

Hintergrund: Die Antwort auf die Frage, ob eine externe frühkindliche Betreuung zu psychischen Belastungssymptomen im Erwachsenenalter führen kann, ist in Deutschland umstritten. Insbesondere in der ehemaligen DDR wurden Kinder bereits früh außerfamiliär untergebracht. Methode: Um den Zusammenhang zwischen frühkindlicher außerfamiliärer Betreuung...

Background: Preterm birth is a risk factor for a variety of detrimental health outcomes. Previous studies have identified recalled (or remembered) parental rearing behaviour as a potential modifier of preterm individuals’ mental health in adulthood. However, no investigations to date have contrasted the parents’ and children’s views, explored wheth...

Even 30 years after the reunification of the two German states, skepticism often occurs in public discussions about the formation of a common democratic culture in Germany. The success of the right-wing populist party Alternative for Germany (AfD) in East Germany and an East–West gap in terms of right-wing violence seem to support these opinions. T...

Background Social relations are crucial for maintaining physical and mental health across the life span. As social roles, networks and needs change with age a valid assessment of social support in older adults and age-specific norms are necessary. The present work aims to [1) assess the level of social support in individuals > 60 years of the gener...

Structural changes in chronically depressed patients in psychoanalyses compared to cognitive-behavioral longterm psychotherapy

Background Symptoms of depersonalization (DP) and derealization (DR) are a risk factor for more severe impairment, non-response to various treatments, and a chronic course. In this study, we investigated the effects of DP/DR symptoms in patients with clinically significant depressive symptoms on clinical characteristics and various outcomes in a re...

Purpose The aim of this study is to investigate the distribution of spherical equivalent and axial length in the general population and to analyze the influence of education on spherical equivalent with a focus on ocular biometric parameters. Methods The Gutenberg Health Study is a population-based cohort study in Mainz, Germany. Participants unde...

Psychological variables substantially shape the risk of suicidal thoughts and behaviours (STBs). However, it is unclear to what extent they are considered in individuals with cancer. We synthesized the quantitative research landscape concerning psychological risk/protective factors of STBs in the (psycho-) oncological context. This pre-registered...

Background Socio-political change often leads to disruptions in employment and social networks, which can exacerbate health issues and increase mortality rates. These consequences are likely observed as an increase in negative life events (NLEs), serving as indicators of the broader social and health impacts. Using the German reunification in 1989/...

Background Depression is associated with an increased risk for type 2 diabetes mellitus. However, depression may take different courses, and it is not fully understood how these affect the development of diabetes. It is further to be determined whether sex modifies the association between depression and type 2 diabetes. Methods We analyzed data fr...

Background Following discharge, it is crucial for patients to transfer intentions and action plans from inpatient rehabilitation into everyday life. This ensures their reintegration into social and working life and prevents economic costs due to sick leave or reduced earning capacity pension. However, most established aftercare programs do not spec...

Objective: This study aimed to determine if there is an increased risk of incident cardiovascular diseases (CVD) resulting from cumulative night shift work in the German population-based Gutenberg Health Study (GHS). Methods: We examined working participants of the GHS at baseline and after five years. Cumulative night shift work in the 10 years...

Background: Depression and fatigue are commonly observed sequelae following viral diseases such as COVID-19. Identifying symptom constellations that differentially classify post-COVID depression and fatigue may be helpful to individualize treatment strategies. Here, we investigated whether self-reported post-COVID depression and post-COVID fatigue...

Purpose The Oldenburg Sentence Test (OLSA) is a German matrix test designed to determine speech recognition thresholds (SRT). It is widely used for hearing-aids and cochlear implant fitting, but an age-adjusted standard is still lacking. In addition, knowing that the ability to concentrate is an important factor in OLSA performance, we hypothesized...

Objective Previous research on psychotherapy treatment response has mainly focused on outpatients or clinical trial data which may have low ecological validity regarding naturalistic inpatient samples. To reduce treatment failures by proactively screening for patients at risk of low treatment response, gain more knowledge about risk factors and to...

1) Background: Cigarette smoking, risky alcohol consumption, and marijuana smoking are the most common behaviors related to legal and illicit drug use worldwide, including among university students. To plan effective evidence-based programs to prevent the risky consumption of these substances among university students, the present study aimed to id...

Background The effort-reward imbalance at work model offers a theoretical and analytical framework to estimate the subjective perception of work-related stress. High demands and low rewards in return can harm mental and physical health, well-being, and life satisfaction. According to the theory, overcommitment partially explains why employees endu...

Abstract Background. The present study aimed to investigate whether prematurity and perinatal stress exert long-term effects on the onset of panic disorder in later life. Methods. From 40,189 adults born in Germany between 1969-2002, a study cohort (n = 427) stratified by gestational age (GA) (extremely preterm: GA < 29 weeks; very preterm: GA 29-3...

Previous studies on self-rated health and mortality have usually not differentiated between physical and mental health, respectively have not considered physical diseases. This study aims to determine self-rated physical and mental health from middle to old age, examine associations with mortality adjusted for objective risk factors and assess effe...

Objectives Vertigo describes symptoms of abnormal movement of the environment or the patient's own body. As such, it affects patients' quality of life, prevents them from following their daily activities, and increases healthcare utilization. The Global Burden of Disease Project aims to quantify morbidity and mortality worldwide. In 2013, a separat...

Introduction Overweight and obesity lead to numerous complications and their treatment. The associated costs represent a health and sociopolitical burden. Therefore, the development of overweight and obesity is of great importance for health policy. Methods The Gutenberg Health Study (GHS), a population-based observational study of individuals aged...

Objectives: The aim of the present study was to investigate (1) the type and frequency of reported life events of the East German population related to the German reunification and (2) their associations with psychosocial health. Methods: Data of 2247 participants of the Study of Health in Pomerania was used.These qualitative responses were analyse...

Objectives: Personality organization or functioning describes biographically acquired characteristics for the regulation of psychological processes. Limitations correlate with symptom load. This study examines whether significant improvement in personality functioning can be achieved in the framework of a multimodal psychodynamic treatment and its...

Objectives: Personality organization or functioning describes biographically acquired characteristics for the regulation of psychological processes. Limitations correlate with symptom load. This study examines whether significant improvement in personality functioning can be achieved in the framework of a multimodal psychodynamic treatment and its...

Background Evidence-based treatments for internet use disorders (IUDs) are limited, and online therapy approaches are poorly studied. We investigated the efficacy of a manualised therapist-guided online intervention (OMPRIS) to reduce IUD symptoms and improve psychological well-being. Methods In this multicentre, two-arm, single-blinded trial, ind...

Background The CVSS (Cardiac and Vascular Late Sequelae in Long‐Term Survivors of Childhood Cancer) study aimed to investigate the prevalence of different stages of heart failure (HF) in childhood cancer survivors (CCSs) compared with the general population. Methods and Results A total of 1002 CCSs (age range, 23–48 years) diagnosed with neoplasia...

Hintergrund: Zum Zusammenhang zwischen psychosozialen Belastungen und Gesundheit oder Arbeitszufriedenheit existieren eine Vielzahl von Querschnittstudien – Längsschnittstudien zur Prüfung der Kausalität sind aber aufwändig und daher selten. In der großen bevölkerungsrepräsentativen „Gutenberg Health Study“ (N=15.000) wurden die Instrumente COPSOQ...

Background Mental resources such as optimism and social support are important to face different stressors. The aim of this study is to identify groups in the population that are similar in terms of their mental resources. Methods For this purpose, a randomly selected general population community sample was used, representative for the city of Leip...

Background Epidemiological research on the prevalence of traumatic events and PTSD has shown that there are significant differences between countries, due to their different history and socialization processes. In the case of Germany, this is particularly relevant. Germany was divided into two states from 1949 to 1990. This study examines the preva...

Introduction Teachers work in a job with specific demands that can strain individual coping capabilities and can pose a risk for the development of psychological problems. Prior studies showed that teachers – in comparison with other occupational groups – had high risks of job-related psychological exhaustion. In our study we compared teachers and...

Background Due to the SARS-CoV-2 pandemic, healthcare workers (HCWs) are experiencing tremendous levels of emotional and physical stress. Hospitals are trying to help personnel cope with work-related pressure. The aim of this study was to assess HCWs’ awareness and utilization of counseling and support services during the pandemic, HCWs’ unmet coun...

Background Reliable outcome data of psychosomatic inpatient and day hospital treatment with a focus on psychotherapy are important to strengthen ecological validity by assessing the reality of mental health care in the field. This study aims to evaluate the effectiveness of inpatient and day hospital treatment in German university departments of Ps...

Loneliness is an established risk factor for impaired health. However, the evidence of whether increased alcohol consumption is a coping mechanism to alleviate loneliness for both genders remains sparse. The cross-sectional study included 8898 men and 8910 women (mean age of 56.2 ± 11.5 years) from three population-based cohort studies in Germany (...

Introduction: Long-term psychodynamic/psychoanalytic psychotherapy (LTPP) is a prevalent treatment option for complex mental disorders. Yet, little is known about the role of treatment intensity in LTPP. We present a study protocol for a systematic review and individual participant data (IPD) meta-analysis aggregating and analysing individual data...

Background This study aimed to compare the quality of life (QoL) reported by childhood cancer survivors (CCS) drawn from a cohort of the German Childhood Cancer Registry with a representative general population sample and, within CCS, to test associations between QoL and health behavior, health risk factors, and physical illness. Methods CCS ( N =...

Background: Recurrent events occur frequently after venous thromboembolism (VTE), and remain difficult to predict based on established genetic, clinical and proteomic contributors. The role of circulating microRNAs (miRNAs) was not yet explored in detail. Methods: Data of 181 participants of a cohort study of acute VTE, and 302 individuals with...

Due to the division of Germany into the German Democratic Republic and the Federal Republic of Germany following the Second World War, large parts of the population of today's Germany were socialized under different socio-economic, political, and legal conditions, which could possibly lead to different experiences with corporal punishment as a meth...

Associations of preterm birth with later-life mental distress are well-established. A research gap concerns the role of psychosocial factors such as the family context. This study investigated associations of recalled parental rearing behavior with both preterm birth characteristics and psychological symptom burden later in life. Based on birth re...

Keratoconus appears to be a rare corneal disease with a prevalence previously estimated at 1:2000. The aim of our study was to investigate the prevalence of keratoconus in a large German cohort and to evaluate possible associated factors. Method In the population-based, prospective, monocentric cohort study, Gutenberg Health Study, 12,423 subjects...

Purpose: To investigate the association between intraocular pressure (IOP) and climate parameters. Methods: The Gutenberg Health Study (GHS) is a population-based cohort study in Mainz, Germany. Participants underwent two comprehensive ophthalmologic examinations (baseline visit and five-year follow up) including non-contact tonometry, objective...

Objectives: The COVID-19 pandemic and its protective measures have changed the daily lives of families and may have affected quality of life (QoL). The aim of this study was to analyze gender differences in QoL and to examine individuals living in different partnership and family constellations. Methods: Data from the Gutenberg COVID-19 cohort stud...