Manas Kumar Biswas

• PhD in Chemistry
• Professor (Assistant) at Asutosh College, University of Calcutta

Induction of undesired toxicity and emergence of multidrug resistance (MDR) are the major obstacles for cancer treatment. Moreover, aggressive cancers are less sensitive towards existing chemotherapeutics. Therefore, selective targeting of cancers without inducing undesired side effects and designing proper strategies to overcome MDR has utmost imp...

Multidrug resistance (MDR) in cancer represents a variety of strategies employed by tumor cells to evade the beneficial cytotoxic effects of structurally different anticancer drugs and thus confers impediments to the successful treatment of cancers. Efflux of drugs by multi-drug resistant protein-1 (MRP1), functional P-glycoprotein (P-gp) and eleva...

Three types of fluorescent coordination complexes of an unsymmetrical diimine ligand (LNNOH) with conjugated 14π electrons (14πe) are reported [LNNOH = (E)-2-((phenyl(pyridin-2-yl)methylene) amino)phenol]. The complexes are: [M(LNNO−)X] [M = Zn, X = Cl, 1; M = Zn, X = Br, 2; M = Cd, X = Cl, 3], [Co(LNNO−)2]Cl, [4]Cl and [Ni2(LNNOH)2(LNNO−)2]Cl2, [5...

Multidrug resistance (MDR) is a major problem in cancer treatment. Cu complexes possess the ability to overcome MDR in cancer. Therefore, the search for new Cu complexes is of great clinical significance and we address the anticancer effects of a previously synthesized novel 9-phenyldibenzo[a,c]phenazin-9-ium cation [1(+)] as [1] [CuCl2] and as [1]...

Reactions of o-phenylenediamine derivatives (L3H2) incorporating a (Ph)(Py)(H)C-N(H)- function with the oxidovanadium(iv) and oxidomolybdenum(vi) ions afford amide complexes of types [VIVO(L32-)] (3), [VIVO(L3t-Bu 2-)] (4) and cis-[MoVIO2(L32-)] (5) (L3H2 = ((E)-2-(((2-((phenyl(pyridin-2-yl)methyl)amino)phenyl)imino)methyl)phenol); L3t-BuH = ((E)-2...

The Ru(ii)-H and water promoted asymmetric cleavage of 2,2'-pyridil to pyridine-2-carbaldehyde and unprecedented picolinic acid anion radical (PyCOOH(-)˙) complexes, which in solution produce H2 gas and diamagnetic picolinate complexes of ruthenium(ii) in moderate yields, is reported.

Reactions of 9,10-phenanthrenequinone (PQ) in toluene with [MII(PPh3)3X2] at 298 K afford green complexes, trans-[M(PQ)(PPh3)2X2] (M = Ru, X = Cl, ; M = Os, X = Br, ) in moderate yields. Reaction of anhydrous RhCl3 with PQ and PPh3 in boiling ethanol affords the dark brown paramagnetic complex, cis-[Rh(PQ)(PPh3)2Cl2] () in good yields. Diffusion of...

The reaction of phenanthrene-9,10-dione with N-phenylbenzene-1,2-diamine in methanol in the presence of anhydrous CuCl2 and HCl affords a 9-phenyldibenzo[a,c]phenazin-9-ium cation, [1]+, as in [1][CuCl2], in good yields. The reaction of [1][CuCl2] in methanol with excess iodide salt affords [1][I]. The formations of [1][CuCl2] and [1][I] have been...

The reaction of 9,10-phenanthrenequinone (PQ) with [M(II)(H)(CO)(X)(PPh(3))(3)] in boiling toluene leads to the homolytic cleavage of the M(II)-H bond, affording the paramagnetic trans-[M(PQ)(PPh(3))(2)(CO)X] (M = Ru, X = Cl, 1; M = Os, X = Br, 3) and cis-[M(PQ)(PPh(3))(2)(CO)X] (M = Ru, X = Cl, 2; M = Os, X = Br, 4) complexes. Single-crystal X-ray...

One electron paramagnetic parent osazone complex of rhodium of type trans-Rh(L(NHPh)H(2))(PPh(3))(2)Cl(2) (1), defined as an osazone anion radical complex of rhodium(III), trans-Rh(III)(L(NHPh)H(2)(•-))(PPh(3))(2)Cl(2), 1((t-RhL•)), with a minor contribution (∼2%) of rhodium(II) electromer, trans-Rh(II)(L(NHPh)H(2))(PPh(3))(2)Cl(2), 1((t-Rh•L)), an...

Two bis(unsymmetrical diimine) complexes of (L(NO(2))(ϕ1))(L(NO(2))(ϕ2))M(II)Cl(2) family with M = Fe and Mn, are reported (L(NO(2))(ϕ) = (E)-3-nitro-N-(pyridine-2-ylmethylene)aniline; ϕ = dihedral angle between the diimine unit including pyridine ring and the phenyl ring planes). Pure tcc-(L(NO2)(33.6))(L(NO2)(79.3))Fe(II)Cl(2)·0.5H(2)O (1) and tc...

Stereoselective coordination affording a luminescent tcc-isomer of dihalobis(diimine)Co(II) family in which two photoactive diimine ligands (LNO2ϕ) are unsymmetrical and non-equivalent is reported (LNO2ϕ = (E)-3-nitro-N-(pyridine-2-ylmethylene)aniline; ϕ = dihedral angle between the diimine unit including pyridine ring and the phenyl ring planes; t...