Manas Bajpai

• M.D.S
• Professor and HOD at Pravara Institute of Medical Sciences

A 28-year-old pregnant woman (in her second trimester) reported to Rural Dental College Loni (In-dia) with a chief complaint of red painful growth on her left, lower back region of the jaw since 1 month. She also complained that the growth bleeds on tooth brushing. A careful intra-oral examination revealed a red to pinkish white growth of 2 ×3 cm i...

This is an Open Access Journal / article distributed under the terms of the Creative Commons Attribution License (CC BY-NC-ND 3.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. All rights reserved. The purpose of this study is to determine the risk factors associated with...

Schwannomas are considered benign soft tissue tumors that originate from Schwann cells. Oral Schwannomas are rare and account for only 1% of all Schwannomas. Cellularschwannoma (CS) is a rare histological variant of schwannoma, characterized by high cellularity and cellular atypia. We present a case of localized growth of palatal mucosa that imitat...

Salivary gland neoplasms account for 3% of all head and neck tumours. Pleomorphic adenoma (PA) is the most common salivary gland tumour that mainly occurs in the parotid gland, followed by minor salivary glands of the oral cavity, however, the occurrence of PA inside the jaw bones is exceedingly rare and very few cases have been reported in the lit...

Paragangliomas are neuroendocrine tumors similar to pheochromocytomas but arising from extra adrenal site. It is a very rare tumor in an intraoral site, we found a single case of intraoral paraganglioma in a literature, and hence as per our best knowledge this is only the second case of paraganglioma presented in an intraoral location. We present h...

Objectives The objectives of this study were as follows: (1) to provide an overview of the feasibility, utility, merits, and demerits of virtual microscopy (VM) in pathological diagnostics and (2) to evaluate its advantages in dental and medical teaching over conventional microscopes. Materials and Methods A literature survey was carried out in Au...

Internal resorption is an asymptomatic condition in teeth seen with past history of injury. In the crown it has a clinical observation of pink mark. It is diagnosed by chance on an x-ray examination. Primal detection and resorption treatment improves prognosis of the condition. Resorption can be broadly classified into normal physiological or patho...

Spindle Cell Carcinoma (SpCC) is a biphasic tumor. They are proven to be monoclonal dedifferentiated forms of conventional squamous carcinomas. It is a rare tumor which is infrequently observed in head, neck and in the aerodigestive tract. The tumor is aggressive and shows high frequency of recurrence and metastasis. It is an aggressive variant of...

Dentinogenic ghost cell tumor (DGCT) is a very rare entity with controversies in its terminology and classification. It is the neoplastic solid counterpart of the calcifying odontogenic cyst (COC), which was first reported by Gorlin et al. in 1962. There are around 31 cases reported in the literature. The mean age of occurrence is 40.27 years, alth...

Basaloid squamous cell carcinoma (BSCC) is a distinctive variant of squamous cell carcinoma (SCC) characterised by nests of basaloid cells. BSCC is an aggressive and rare tumor of head and neck region; and is relatively rare in oral cavity in comparison to SCC. Although, infrequent, but primary intra-osseous SCC (PIOSCC) has been reported in the ja...

We report a case of Langerhans cell histiocytosis (LCH), earlier known as histiocytosis X. It is a group of idiopathic disorders which is characterised by increase in number of Langerhans cells derived from bone marrow and mature eosinophils. The clinical features of LCH resemble those of oral findings, which are common such as gingival ulcers, enl...

Epitheloid hemangioendothelioma (EHE) is a rare vascular neoplasm of intermediate malignant potential. EHE commonly involves lungs, liver soft tissue, and bone. EHE is extremely rare in tongue and up to our best knowledge only nine cases of EHE of tongue reported in the literature. Clinicallyو EHE usually presents as an asymptomatic mass. Microscop...

Spindle cell lipoma (SCL), also called as pleomorphic adenoma, is a rare variant of lipoma histopathologically characterized by an admixture of mature fat cells with spindle cells and occasionally mast cells with myxoid connective tissue stroma and thick bends of birefringent collagen. Although buccal mucosa is the most common location for oral lip...

Osteosarcoma (OS) is a rare but highly malignant bone tumour. Based on the extracellular matrix produced by tumor cells, conventional OS can be subdivided in fibroblastic, osteoblastic and chondroblastic types.1 Chondroblastic OS is defined as any osteoid and/or bone, produced by uncommitted mesenchymal cells without first passing through a cartila...

Haemangioma is a benign neoplasm of vascular phenotype. 65% of haemangiomas have been noted to occur in the head and neck and mainly salivary glands are affected. The parotid gland is the most common site with hemangiomas comprising of 0.4-0.6% of parotid gland tumors. Salivary gland haemagniomas in adults are of the cavernous type while infantile...

Adenoid cystic carcinoma (ACC) is a malignant tumor of salivary glands characterized histopathologically by biphasic epithelial tumor comprised of myoepithelial and ductal cells. There is a paucity of the literature regarding the immunohistochemical labelling of ACC arising in minor salivary glands. This paper reports an additional case of palatal...

Central Giant Cell Granuloma (CGCG) is a benign tumor of jaw. As compared to males, females are more commonly affected. Mandible is the common site of occurrence. Aneurysmal bone cysts (ABCs) are cystic lesions which are expansile osteolytic blood-filled lesions. These are commonly seen in the mandible, and they also show gender-predilection toward...

Angiolipomas, histopathological variant of lipoma are benign mesenchymal tumor characterized by proliferation of mature adipocytes and interspersed with angiomatous proliferation composed of several congested blood vessels. Although they are the most common tumor of trunk and extremities but they are exceedingly rare in oral cavity according to the...

Dear Editor, Cystic lymphangiomas (CL) are benign tumors of lymphatic system usually centered in the posterior triangle or the sub-mandibular space. Most of the lymphangiomas appear before the age of 2 years 1. Very few cases of CL occurring in parotid gland of adults has been reported 2. A 51 year old male presented to the department of oral medic...

Dear Editor-in-Chief Myxoid tumors of oral cavity encompass a broad spectrum of lesions, primarily neoplastic.(1) The significant variations in the biological behaviour; ranging from completely harmless to malignant neoplasm they require an accurate histopathological diagnosis to ensure a proper treatment. (2) Because of the considerable overlappin...

Background: Lipomas are benign mesenchymal tumors of soft tissue that can be found anywhere in the body: However their presence in oral cavity is very rare (4.4%). Histopathologically lipomas are classified as simple lipomas and different variants. The present study describes the prevalence of oral lipomas with relation to patient's age, their site...

Background: Lipomas are benign mesenchymal tumors of soft tissue that can be found anywhere in the body. However their presence in oral cavity is very rare (4.4%). Histopathologically lipomas are classified as simple lipomas and different variants. The present study describes the prevalence of oral lipmas with relation to patient's age, their site...

The Mucoepidermodi Carcinoma is a tumor of salivary gland. It comprises <3% of all head and neck tumors. As suggested by its name, MEC comprises of mucus-producing, squamous and intermediate type cells. Majority of these arise in the parotid gland, rest arise within the minor salivary glands. In minor salivary glands, MEC is seen on palate followed...

Neurofibroms are benign peripheral nerve sheath tumor comprising of an admixture of fibroblasts, Schwan cells, and perineurial cells. Clinically, neurofibromas may present either as solitary lesion or as a part of the generalized syndrome of neurofibromatosis. Oral neurofibromas are unusual and occurrence of these on gingiva is even more rare. Neur...

Introduction: malignant disorders. Incidence of cancer has been reported to be more in patients with reduced cholesterol levels. Patients with oral cancer with reduced cholesterol a mortality. We carried out a hospital based case control prospective study to assess the relationship between lipid profile and oral squamous cell carcinoma and potentia...

Basal cell tumors (BCT) are tumors usually derived from pluripotential stem cell compartments of the basal layer of epidermis and/or oral epithelium. BCTs are infrequent entities in the oral cavity and are not discussed separately in general and oral pathology. A literature review did not reveal any classification of tumors with basaloid morphology...

Minor salivary glands are relatively rare location for these tumors. Microscopically, they are composed of isomorphic cells, similar to basaloid cells with palisading arrangement and distinctive basement membrane like material. Herein, we report a case of BCA presenting as a soft tissue growth of left hard palate involving maxillary alveolus of a 4...

Osteosarcoma is a rare primary malignant bone tumor with considerable variations not only in clinical and histologic appearance, but also in the course and prognosis of the disease. It mainly occurs in the metaphyseal region of long bones. Jaw osteosarcomas are relatively rare as compared to those occurring in long bones and share similar histopath...

in 1981 by Wright, due to its different histology and relatively low recurrence rate. Parakeratinized odontogenic cyst is now considered as keratocystic odontogenic tumor (KCOT) owing to its neoplastic nature. Although rare, calcification in the form of dystrophic calcification, dentinoid and cartilage has been reported in KCOT, but calcification i...

Dear editor, Pigmented lesions are relatively rare in the oral cavity. They represent a variety of entities ranging from racial pigmentation to manifestation of systemic illness (Addison’s disease), to benign (hemangioma, lymphangioma, melanotic nevi) and malignant neoplasms (Kaposi’s sarcoma, malignant melanoma, pigmented basal cell carcinoma).1...

Objective: To assess the prognostic potential for N-cadherin in oral squamous cell carcinoma and oral epithelial dysplasia. Study Design: A cross-sectional study, analytical study. Place and Duration of Study: Maharishi Markandeshwar College of Dental Science Research (MMCDSR), Ambala, India, from 2011 to 2014. Methodology: Immunohistochemistry was...

Orthokeratinized odontogenic keratocyst (OOC) was first identified as orthokeratinized variant of odontogenic keratocyst in 1981 by Wright, due to its different histology and relatively low recurrence rate. Parakeratinized odontogenic cyst is now considered as keratocystic odontogenic tumor (KCOT) owing to its neoplastic nature. Although rare, calc...

Hemangiopericytoma (HPC) is a tumor of pericytes and acounts for 1% of all vascular tumors. World Health Organization (WHO) in 2013 abandoned the term hemangiopericytoma. Currently, the term HPC is used to describe a specific morphological pattern seen in different entities. We report a case of 27-year male reported to NIMS Dental College, Jaipur,...

Schwannomas are benign tumors of peripheral nerve sheath origin, composed of proliferation of Schwann cells in a characteristic pattern. Ancient schwannomas are long-standing lesions exhibit degenerative changes and atypia due to which they could be mistaken for malignancy. The mean age of occurrence of AS in oral cavity is 43 years and no case of...

Mucous membrane pemphigoid (MMP) is an autoimmune blistering disorder of mucosa, characterized by subepithellial bullae. The involvement of skin is only seen in one quarter of the patients with MMP. We report a case of 37 years old male presented with painful erosions involving gingiva, tongue and palatal mucosa without any skin involvement. Hisopa...

Centrally occurring salivary gland tumors are rare. Because of a considerable overlap between the clinical and histopathological features, this group of tumors often produces a diagnostic difficulty to the clinicians and oral pathologists. Acinic cell carcinoma (ACC) is an unusual, low-grade, malignant salivary gland tumor that represents approxima...

Angiomyxolipoma is a rare histological variant of lipoma, characterized by proliferation of adipose tissue associated with a variable amount of myxoid stroma with numerous thick- and thin-walled blood vessels. An exhaustive literature review could reveal only 12 cases of angiomyxolipoma affecting subcutaneous tissue, subungual area and spermatic co...

Pilomatrixoma is a benign tumor of hair follicle first described as calcifying epithelium. It accounts for 1% of all the benign skin tumors. It is a slow-growing, firm, dermal or subcutaneous neoplasm, usually measuring fewer than 3 cm in diameter. Pilomatricomas are considered benign; rarely recur after surgical excision. However, cases of pilomat...

Oral schwannomas (OSs) are rare benign tumors of oral cavity derived from peripheral nerve sheath, composed of proliferation of schwann cells in a characteristic pattern. AS are long-standing lesions which exhibit degenerative changes and atypia due to which they could be mistaken for malignancy. The mean age of occurrence of AS in oral cavity is 4...

Osteosarcoma (OS) is a malignant neoplasm characterised by the formation of osteoid matrix by neoplastic cells. It is the most common primary malignant bone tumor accounting for 20% of all sarcomas, although its occurrence in the jaw is rare. It shows typical clinical behaviour but varied radiological and histopathological features. It presents var...

The glandular odontogenic cyst (GOC), though rare, has now become a well known entity. The frequency of GOC ranges from 0.012% to 1.3% of all jaw cysts and its worldwide prevalence is 0.17%. The GOC's microscopic features have been well documented, and are also included in the list of World Health Organization. We report a case of GOC presenting as...

Odontogenic myxomas are rare odontogenic tumors of jaw characterised by accumulation of mucoid ground substance with little collagen. Peripheral odontogenic myxoma (POM) is extra-osseous variant of odontogenic myxomas, occurring solely in the soft tissue covering the tooth bearing portion of jaws. POM is exceedingly rare, less than 10 cases have be...

Sir, The term unicystic ameloblastoma (UA) was first used in 1977 by Robinson and Martinez to describe cystic lesions with clinico-radiographic features resembling an odontogenic cyst, but histologically showing the presence of ameloblastomatous epithelium lining part of the cyst cavity. 1 UA accounts for 10-15 % of all intra-osseous ameloblastomas...

Cells having distinctive capacity for self renewal and potency are called as stem cells. With proper biochemical signals, these cells can be converted to desirable cell types. This article provides a brief review of stem cells, discussing their types, properties and advantages. Emphasis has been given to what role these stem cells have in oral and...

A 51-year-old male presented to the Department of Oral and Maxillofacial Pathology, NIMS Dental College Jaipur (India) with a painless pigmented patch extending from left side of the palate to the gingiva from 9 months. The patient had noticed the growth 7 months ago; it was a small patch of 1 cm initially, which gradually increased to attain the p...

Juvenile ossifying fibroma (JOF) is a rare fibro-osseous neoplasm that develops among the craniofacial bones at an early age; and in majority of patients, it is diagnosed in the first or second decade of life. We present a case in 41-year male patient having it in the left anterior mandibular region. Peripheral eosinophilic areas resembling psammom...

Introduction: Central tumors of the jaws can manifest in various ways ranging from benign tumors to life-threatening malignancies. Although jaw tumors have been described in the general population, there is a paucity of information available regarding prevalence, distribution, and biological behavior of central jaw tumors in elderly population. Aim...

Bitemark analysis can be used for comparison of a known person's dentition to a patterned injury which appears consisistent with a bitemark. This type of comparison is used to confirm or eliminate the identity of a suspect in relation to the bitemark. Because of the definite subjectivity in bite mark analysis it is considered as one of the most con...

A 13-year-old boy presented with a yellowish-brown thick crusts on both lips for two and half months. His chief complaints were itching, desquamation and dryness of both upper and lower labial mucosa. The past medical history of the patient was irrelevant to the present symptoms. Clinical examination of the lesion revealed multiple yellowish brown...