Man Li

Man Li
Tongji University · Shanghai No.10 People's Hospital

Doctor of Philosophy

About

22
Publications
1,565
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296
Citations
Introduction
Skills and Expertise

Publications

Publications (22)
Article
Full-text available
Disrupted gastrointestinal (GI) motility is highly prevalent in patients with inflammatory bowel disease (IBD), but its potential causative role remains unknown. Herein, the role and the mechanism of impaired GI motility in colitis pathogenesis are investigated. Increased colonic mucosal inflammation is found in patients with chronic constipation (...
Article
Full-text available
Fusobacterium nucleatum (F. nucleatum) promotes intestinal tumor growth and its relative abundance varies greatly among patients with CRC, suggesting the presence of unknown, individual-specific effectors in F. nucleatum-dependent carcinogenesis. Here, we identify that F. nucleatum is enriched preferentially in KRAS p.G12D mutant CRC tumor tissues...
Article
Full-text available
Background One reason patients with cancer cannot benefit from immunotherapy is the lack of immune cell infiltration in tumor tissues. Cancer-associated fibroblasts (CAFs) are emerging as central players in immune regulation that shapes tumor microenvironment (TME). Earlier we reported that integrin α5 was enriched in CAFs in colorectal cancer (CRC...
Article
Full-text available
Mast cells (MCs) are abundantly distributed in the human intestinal mucosa and submucosa. However, their roles and mechanisms in the development of colorectal cancer (CRC) are still unclear. In the present research, we found that the infiltration density of MCs in CRC tissues was positively correlated with improved patients’ prognoses. Moreover, MC...
Article
Full-text available
Given that only a subset of patients with colorectal cancer (CRC) benefit from immune checkpoint therapy, efforts are ongoing to identify markers that predict immunotherapeutic response. Increasing evidence suggests that microbes influence the efficacy of cancer therapies. Fusobacterium nucleatum induces different immune responses in CRC with diffe...
Article
p>Immune cell infiltration is important for predicting the clinical outcomes of colorectal cancer (CRC). Integrin β7 (ITGB7), which is expressed on the surface of leukocytes, plays an essential role in the homing of immune cells to gut-associated lymphoid tissue and facilitating the retention of lymphocytes in gut epithelium; however, its role in C...
Article
Full-text available
Due to its unique structure and superior performance, carbon nanotubes are proposed to have great potential applications in many fields. Recently, more and more concerns have been focused on the application of carbon nanotubes in space technology. It is believed that carbon nanotubes can have a broad impact on space missions in future with benefits...
Article
Full-text available
To investigate the characteristic of carbon nanotube (CNT) arrays with high resistance to the hazardous conditions of atomic oxygen in space environment, the erosion effects of atomic oxygen on CNT arrays with different density have been studied by atomic oxygen simulation equipment. To characterizing the change of the surface morphologies of CNT a...
Article
Full-text available
In this paper, an initiative Martian dust fluid simulating research based on the energy dissipation method was developed to simulate the deposition process of Martian dust fluid which was caused by surface adhesion between particles and Martian rovers. Firstly, an energy dissipation model of particles based on the Discrete Element Method (DEM) was...
Article
Due to the tiny size of dust particles and the low atmospheric pressure, the Martian aeolian activity between Martian dust particles and Martian airflow should be considered as a rarefied two-phase flow. In this paper, a simulation approach for the rarefied characteristic of Martian dust storm has been studied based on discrete element method (DEM)...
Article
Full-text available
Due to their unique properties, carbon nanotubes will have great potential applications in many fields, particularly in space applications. But in development of carbon nano-materials intended for operation in aerospace, one of the most important problems is assurance of their resistance against the impact of the AO which is one of the predominant...
Article
Full-text available
A new type of space crawling robot was proposed for spacecraft maintenance missions and a nanoscale microarray structure was designed as the robot foot structure. In this study, a carbon nanotube array structure was adopted as the adhered nanoscale microarray structure of the robot foot. A theoretical model of the carbon nanotube structure was esta...
Article
According to the on-orbit maintenance mission requirements of a proposed space cooperative spacecraft, a new type of space crawling robot, which can be mounted on a grasping manipulator, is proposed. After the active spacecraft and the faulty target form a connection, the crawling robot can move to the spot on the faulty target that requires mainte...
Article
Full-text available
Mars atmospheric composition probing is one of critical tasks of mars exploration. The mars atmosphere may have the existence of water, methane, organic matter, conducting mars atmospheric composition probing is very critical to studying whether the mars has, or once had the existence of living matter, analyzing the forming, evolution of mars atmos...
Article
Full-text available
The erosion effects of atomic oxygen (AO) in different incidence direction on carbon nanotube (CNT) arrays have been studied by ground‐based AO simulation facility. The surface morphologies and the molecular structures of CNT arrays before and after AO experiments have been characterized by scanning electron microscopy and Raman spectroscopy. It is...
Chapter
Lunar dust plays an important part in Lunar Exploration Program. It could influence normal operation of thermal control materials, optical cameras, optical sensors and other aircraft components and even seriously damage the solar arrays electrical generation by reducing their working efficiency. In this paper, a review of the lunar dust environment...
Chapter
Using Lunar Dust Environment Simulator, the effects of friction and abrasion of lunar dust simulants in vacuum were investigated at the Beijing Institute of Spacecraft environment Engineering (BISEE). The abrasion characteristics of lunar dust on materials were studied, focusing on the CE-3 rover wheel axles. The sample coupons included aluminum al...
Article
Indium (In) nanowires were synthesized on self-ordered hexagonal porous anodic aluminum oxide (AAO) template by electrodepositing In2(SO4)3 in the pores of AAO template. In nanowires obtained are very straight and have uniform-diameter about 45 nm. The ion emission properties of In nanowires were investigated. The onset field of ion emission is obs...

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