Mamuna Mukhtar- PhD (Industrial Biotechnology)
- PhD Student at National University of Sciences and Technology
Mamuna Mukhtar
- PhD (Industrial Biotechnology)
- PhD Student at National University of Sciences and Technology
Working in Virology Lab on Therapeutics and Vaccines Development.
About
14
Publications
5,636
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35
Citations
Introduction
Currently I am working with "Therapeutics and Vaccine Development Group" and my PhD project aims “Combating Dengue viral infections in Pakistan”. I am using prophylactic and therapeutic approaches against prevalent dengue virus serotypes.
Current institution
Additional affiliations
October 2023 - April 2024
October 2016 - August 2018
September 2018 - October 2019
University of Kotli
Position
- Visiting Lecturer
Education
September 2019 - March 2025
Publications
Publications (14)
In Salmonella Typhimurium, efflux pump proteins, such as AcrD actively expel drugs and hazardous chemicals from bacterial cells, resulting in treatment failure and the emergence of antibiotic-resistant variants. Focusing on AcrD may lead to the development of novel antimicrobials against multidrug-resistant bacteria. However, challenges persist in...
Dengue fever is a significant health issue in Pakistan, demanding a vaccine effective against all the viral strains. This study employs reverse vaccinology to develop potential dengue vaccine candidates (DVAX I–III). The study thoroughly examined conserved areas of dengue virus serotypes 1–4's structural and non-structural proteins. Key viral prote...
Staphylococcus aureus is a common bacterium that causes a variety of infections in humans. This microorganism produces several virulence factors, including hemolysins, which contribute to its disease-causing ability. The treatment of S. aureus infections typically involves the use of antibiotics. However, the emergence of antibiotic-resistant strai...
Staphylococcus aureus is a common bacterium that causes a variety of infections in humans. This microorganism produces several virulence factors, including hemolysins, which contribute to its disease-causing ability. The treatment of S. aureus infections typically involves the use of antibiotics. However, the emergence of antibiotic-resistant strai...
Viral infections and associated illnesses account for approximately 3.5 million global fatalities and public health problems. Medicinal plants, with their wide therapeutic range and minimal side effects, have gained limelight particularly in response to growing concerns about drug resistance and sluggish development of antiviral drugs. This study c...
Malaria remains a worldwide health concern, requiring novel ways in medication development to counteract the parasite Plasmodium's developing resistance. In this work, we investigated the herb Zanthoxylum armatum's potential as a malaria treatment. This plant is well-known for its abundance of phytoconstituents. Through molecular docking experiment...
Objectives
The current study was conducted to evaluate the antibacterial potential of leaf and fruit extracts of Zanthoxylum armatum against two pathogenic bacterial isolates, Staphylococcus aureus and Staphylococcus epidermidis.
Methods
Twelve commercially available antibiotics were tested S. aureus and S. epidermidis by antimicrobial susceptibil...
Coputational designing of a tetravalent mRNA Vaccine against Dengue Virsus serotypes prevalent in Pakistan.
Haemophilus influenzae is a Gram-negative bacterium characterized as a small, nonmotile, facultative anaerobic coccobacillus. It is a common cause of a variety of invasive and non-invasive infections. Among six serotypes (a–f), H. influenzae type b (Hib) is the most familiar and predominant mostly in children and immunocompromised individuals. Foll...
Members of the genus Sclerotinia are notorious plant pathogens with a diverse host range that includes many important crops. A huge number of mycoviruses have been identified in this genus; some of these viruses are reported to have a hypovirulent effect on the fitness of their fungal hosts. These mycoviruses are important to researchers from a bio...
Dengue fever, a highly infectious and rapidly spreading vector borne illness, is classified as a Neglected Tropical Disease (NTD) by WHO because they generally afflict the world's poor and historically have not received as much attention as other diseases. DENV NS2B/NS3 protease and NS5 polymerase are regarded as significant prospective therapeutic...
Dengue virus belonging to the family Flaviviridae and its four serotypes are responsible for dengue infections, which extend over 60 countries in tropical and subtropical areas of the world including Pakistan. During the ongoing dengue outbreak in Pakistan (2022), over 30,000 cases have been reported, and over 70 lives have been lost. The only comm...
Questions
Questions (13)
- DOPE: Dioleoylphosphatidylethanolamine
- DOTAP: 1,2-Dioleoyl-3-trimethylammonium-propane Chloride
While performing docking analysis the protein structure is taken after removing the previously bound ligand from the active site. How do we use the original ligand as a positive control for evaluating the accuracy of the predicted binding affinity and molecular dynamics simulations?
I came across a lot of suggestions to use AlphaFold for 3-D structure prediction of my proteins but I have experienced that I always get better results with trRosetta than AlphaFold and the PROCHECK confirms this.
As we know that 1 ug/ul of RNA would yeild 1 ug/ul of cDNA. I have to perform in vitro transcription of cDNA into mRNA and how much amount of cDNA will result up to 50ug (0.05mg) of mRNA?
For carrying out MD simulations, online tool iMODs is gaining attention, is it at par with GROMACs and NAMD or performing simulations by later is recommended?
I have a 30 days (No License) free trial for PyMol for visualization of my Docking results, can I document it in my research paper?
