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Publications (19)
The short wavelength, i.e., blue light, is crucial for non-image forming effects such as entrainment of the circadian system in humans. Moreover, many studies showed that blue light enhances alertness and performance in cognitive tasks. However, most scientific reports in this topic are based on experiments using short exposure to blue or blue-enri...
Sleep parameters, daytime sleepiness, melatonin & cortisol levels in 19 subjects wearing amber contact lenses (blue-light blockade) during four weeks.
The effects of four-week blockade of blue-light on hedonic tone (and other affective variables), melatonin and cortisol in healthy young individuals.
Cannabis has been cultivated by man since Neolithic times. It was used, among others for fiber and rope production, recreational purposes and as an excellent therapeutic agent. The isolation and characterization of the structure of one of the main active ingredients of cannabis - Δ9 - tetrahydrocannabinol as well the discovery of its cannabinoid bi...
Melanoma is the most aggressive of all skin cancers and is exceptionally resistant to therapies. During melanoma progression, cancer cells reprogram their proliferation and survival pathways and achieve resistance to treatment-induced apoptosis. Galectin-3 (gal-3) is a member of the lectin family and is involved in such biological processes as cell...
Streszczenie Konopie siewne (Cannabis sativa) były wykorzystywane przez człowieka od czasów neolitycznych. Stosowano je m.in. do produkcji włókien i lin, jako substancje rekreacyjne oraz jako doskonały środek leczniczy. Wyizolowanie i opisanie struktury jednej z głównych substancji czynnych ko-nopi – Δ 9-tetrahydrokannabinolu oraz odkrycie receptor...
N-glycosylation of integrins plays an important role in cancer progression. Increased αvβ3 integrin expression during melanoma progression is well-documented but the role of its glycans in tumorigenesis is still poorly understood. In the present study we used the WM793 primary melanoma cell line and its highly metastatic variant, WM1205Lu, to exami...
The number of overweight and obese people is increasing at an alarming rate, especially in the
developed and developing countries. Obesity is a major risk factor for diabetes, cardiovascular disease, and cancer, and in consequence for premature death. The development of obesity results from
the interplay of both genetic and environmental factors,...
The number of overweight and obese people is increasing at an alarming rate, especially in the developed and developing countries. Obesity is a major risk factor for diabetes, cardiovascular disease, and cancer, and in consequence for premature death. The development of obesity results from the interplay of both genetic and environmental factors, w...
Streszczenie: Czerniak należy do najbardziej złośliwych nowotworów człowieka, a liczba zachorowań na ten typ nowotworu wzrasta na świecie w zastraszającym tempie. Komórki czerniaka charakteryzują się wyjątkową opornością na stosowane obecnie metody leczenia. Badania z ostatnich lat przyczyniły się do lepszego poznania i zrozumienia biologii nowotwo...
Melanoma is one of the most aggressive human cancers. Its cells are inevitably resistant to conventional therapies. In recent years, better understanding of melanoma biology, has led to the development of a number of new potential therapeutic agents. Many of these compounds are being tested in early phase of clinical trials, some have already reach...
The metastatic transformation of melanocytes is associated with altered expression of adhesion molecules, including alpha(v)beta(3) and alpha(3)beta(1) integrins. Integrin as alpha(v)beta(3) is a primary vitronectin (VN) receptor, while both integrin types take part in adhesion to VN when they are in complex with uPAR. Although their role in melano...
Streszczenie: alektyna-3 (gal-3) należy do rodziny wiążących b-galaktozydy lektyn zwierzęcych i jest jedynym przedstawicielem galektyn typu chimerowego. Zbudowana jest z dwóch strukturalnych domen: domeny N-końcowej zawierającej miejsce fosforylacji i szereg powtórzeń 9-aminokwasowego łańcucha bogatego w Pro, Gly, Tyr i Glu, oraz domeny C-końcowej,...
Streszczenie: Galektyna-3 (gal-3) nale¿y do rodziny wi¹¿¹cych b-galaktozydy lektyn zwierzêcych i jest jedynym przedstawicielem galektyn typu chimerowego. Zbudowana jest z dwóch strukturalnych do-men: domeny N-koñcowej zawieraj¹cej miejsce fosforylacji i szereg powtórzeñ 9-aminokwasowego ³añ-cucha bogatego w Pro, Gly, Tyr i Glu, oraz domeny C-koñcow...
Galectin-3 is a member of a family of beta-galactoside-binding animal lectins and is the only chimera type galectin. Galectin-3 consists of two structural domains: a N-terminal domain that contains a phosphorylation site and a repeated 9 amino acids sequence rich in Pro, Gly, Tyr and Glu; and a C-terminal domain that contains a carbohydrate recogni...
Gal-3 shares several significant structural properties with Bcl-2 family. Both proteins contain anti-death motif, critical for their anti-apoptotic function but the mechanism by which gal-3 exhibits antiapoptotic activity cannot be explained solely on it. Depending on the type, state and condition of the cell as well as depending on the type of sti...
The metastatic transformation of melanocytes is associated with altered expression of adhesion molecules, including alpha(v)beta(3) and alpha(3)beta(1) integrins. Integrin alpha(v)beta(3) is a primary vitronectin (VN) receptor, while both integrin types take part in adhesion to VN when they are in complex with uPAR. Although their role in melanoma...
