Małgorzata Kujawska

Małgorzata Kujawska
Uniwersytet Medyczny im.Karola Marcinkowskiego w Poznaniu · Department of Toxicology

Ph. D.

About

61
Publications
9,294
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Introduction
My research work has been focused on seeking natural origin substances exhibiting the potential to optimize health status and reduce the risk of civilization's diseases. I have been involved in projects investigating the protective effects of plant preparations, bioactive compounds, and their metabolites against cancer and neurodegenerative diseases. My ongoing research interest is the implication of the Brain-Gut Axis in in neurodegeneration and neuroprotection.
Additional affiliations
March 2019 - present
Poznan University of Medical Sciences
Position
  • Professor (Associate)
November 2012 - December 2012
NASA Ames Research Center
Position
  • RISK AND SAFETY ASSESSMENT FOR FOOD PRODUCED IN SPACE
Description
  • Intern
January 2003 - February 2019
Poznan University of Medical Sciences
Position
  • Professor (Assistant)
Education
June 2018 - January 2019
Poznan University of Medical Sciences
Field of study
  • Pharmacy/Toxicology
October 2012 - December 2012
Stanford University, USA, Stanford CA
Field of study
  • Science Management and Commercialization
October 2010 - June 2011
Adam Mickiewicz University
Field of study
  • Research Project Manager

Publications

Publications (61)
Article
Full-text available
COVID-19 is a global pandemic triggered by the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 entry point involves the interaction with angiotensin-converting enzyme 2 (ACE2) receptor, CD147, and erythrocyte Band3 protein. Hemolytic anemia has been linked to COVID-19 through induction of autoimmune hemolytic anemia (AI...
Article
Modafinil (MOD, 2‐diphenyl‐methyl‐sulphinil‐2‐acetamide) is stimulant-like medicine used for the treatment of narcolepsy. Off-label uses include improving cognitive ability in the course of other diseases. This review aims to discuss findings demonstrating the memory and learning enhancing activity of MOD in experimental and clinical studies. We in...
Article
Full-text available
Kale ( Brassica oleracea L. var. acephala DC) is a leafy green vegetable which belongs to the Brassicaceae family, one of the most commonly cultivated and consumed edible plants. The aim of this study was to investigate the potential adverse effects and antioxidant properties of freeze-dried kale leaves in 90-day dietary experiment on Wistar rats....
Article
Full-text available
Parkinson’s disease (PD) and other chronic and debilitating neurodegenerative diseases (NDs) impose a substantial medical, emotional, and financial burden on individuals and society. The origin of PD is unknown due to a complex combination of hereditary and environmental risk factors. However, over the last several decades, a significant amount of...
Poster
Full-text available
Ziemniaki (Solanum tuberosum L.), spożywane codziennie przez miliony ludzi na całym świecie, są jedną z najważniejszych roślin spożywczych. Sok ziemniaczany (PJ) jest produktem ubocznym procesu produkcji skrobi i zawiera wszystkie składniki bulw ziemniaka z wyjątkiem skrobi i błonnika. Podczas kampanii skrobiowej co roku wytwarzana jest duża ilość...
Article
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is linked with inflammatory disorders and the development of oxidative stress in extreme cases. Therefore, anti-inflammatory and antioxidant drugs may alleviate these complications. Ginkgo biloba L. folium extract (EGb) is a herbal medicine containing various active constitu...
Article
Coronavirus disease 2019 (Covid-19) is a primary respiratory disease with an alarming impact on citizens worldwide. Triggered by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), Covid-19 may present with a variety of neurological symptoms, including headache, changes in consciousness and seizure/convulsion. SARS-CoV-2 has neuroinv...
Article
Full-text available
Rich in polyphenols, cranberry juice (CJ) with high antioxidant activity is believed to contribute to various health benefits. However, our knowledge of the neuroprotective potential of cranberries is limited. Previously, we have demonstrated that CJ treatment controls oxidative stress in several organs, with the most evident effect in the brain. I...
Article
Potatoes (Solanum tuberosum L.), consumed daily by millions of people around the world, are one of the most important food crops. Potato juice (PJ) is a by-product of the starch production process and contains all the constituents of potato tubers except starch and fiber. A large volume of PJ is produced annually during the starch campaign. Current...
Article
Calcium dobesilate (CaD) is used for the treatment of diabetic retinopathy and nephropathy. This agent exerts antioxidant effects. In the present study, we evaluated the protective effects of oral administration of CaD against hepatorenal damages in a mice model of aging induced by D‐galactose (D‐gal). We used twenty‐eight male albino mice, which e...
Article
Full-text available
Biomedical researchers have subsequently been inspired the development of new approaches for precisely changing an organism's genomic DNA in order to investigate customized diagnostics and therapeutics utilizing genetic engineering techniques. Clustered Regulatory Interspaced Short Palindromic Repeats (CRISPR) is one such technique that has emerged...
Article
Background Despite increasing worldwide incidence of Parkinson’s disease, the therapy is still suboptimal due to the diversified clinical manifestations, lack of sufficient treatment, the poor patient’s adherence in advanced patients, and varied response. Proper intake of medications regarding food and managing drug-food interactions may optimize P...
Article
Full-text available
Parkinson’s disease (PD) is a neurodegenerative disease in which the neurotransmitter dopamine (DA) depletes due to the progressive loss of nigrostriatal neurons. Therefore, DA measurement might be a useful diagnostic tool for targeting the early stages of PD, as well as helping to optimize DA replacement therapy. Moreover, DA sensing appears to be...
Article
Full-text available
Pomegranate juice (PJ) is a rich source of ellagitannins (ETs), precursors of colonic metabolite urolithin A, which are believed to contribute to pomegranate’s neuroprotective effect. While many experimental studies involving PJ’s role in Alzheimer’s disease and hypoxic-ischemic brain injury have been conducted, our knowledge of pomegranate’s effec...
Poster
Full-text available
Urolithin A (UA) is a metabolic compound generated by intestinal bacteria from ellagitannins (ETs). Due to its antioxidative, anti-inflammatory, and autophagy-inducing activities [1], UA also demonstrates neuroprotective potential. Previously, we reported that the treatment with pomegranate juice, rich in ETs, provided neuroprotection in a rotenone...
Poster
Full-text available
Cranberry juice (CJ) is a rich source of polyphenols with strong antioxidant activity believed to contribute to this fruit's wide range of health benefits. However, to date, our knowledge of cranberry neuroprotective potential is very scarce and limited to only a few in vitro studies. Recently, we have reported that treatment of rats with CJ contro...
Article
Background & objective Neurological diseases are becoming a significant problem worldwide, with the elderly at a higher risk of being affected. Several researchers have investigated the neuroprotective effects of Carvacrol (CAR) (5-isopropyl-2-methyl phenol). This review systematically surveys the existing literature on the impact of CAR when used...
Article
Full-text available
The long-term treatment of mice with D-galactose (D-gal) induces the overproduction of reactive oxygen species (ROS) and is a well-accepted experimental model of oxidative stress-linked cognitive disorders in physiological aging. Calcium dobesilate (CaD, Doxium®) is an established vasoactive and angioprotective drug commonly used for the clinical t...
Article
Full-text available
The high polyphenols content of cranberry accounts for its strong antioxidant activity underlying the beneficial health effects of this fruit. Rotenone (ROT) is a specific inhibitor of mitochondrial complex I in the brain which leads to the generation of oxidative stress. To date, there are few data indicating that toxicity of ROT is not limited to...
Article
Full-text available
Urolithin A (UA) is a metabolic compound generated during the biotransformation of ellagitannins by the intestinal bacteria. The physiologically relevant micromolar concentrations of UA, achieved in the plasma and gastrointestinal tract (GI) after consumption of its dietary precursors, have been revealed to offer GI protection. The health benefit h...
Article
Full-text available
Many phytochemicals demonstrate nonmonotonic dose/concentration-response termed biphasic dose-response and are considered to be hormetic compounds, i.e., they induce biologically opposite effects at different doses. In numerous articles the hormetic nature of phytochemicals is declared, however, no experimental evidence is provided. Our aim was to...
Article
Full-text available
Pomegranate juice is a rich source of ellagitannins (ETs) believed to contribute to a wide range of pomegranate’s health benefits. While a lot of experimental studies have been devoted to Alzheimer disease and hypoxic-ischemic brain injury, our knowledge of pomegranate’s effects against Parkinson’s disease (PD) is very limited. It is suggested that...
Article
Full-text available
Parkinson’s disease (PD) is a neurodegenerative disorder resulting from degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). PD is characterized by motor dysfunctions as well as gastrointestinal symptoms and mental impairment. The pathological hallmark of PD is an accumulation of misfolded α-synuclein aggregates within...
Article
Full-text available
Parkinson's disease (PD) is the second most common neurodegenerative disorder. However, therapeutic options treating only its symptoms are very disappointing. Therefore there is an ongoing search for compounds capable of tackling the multi-dimensional features of PD. Recently natural polyphenols have gained great interest as potential therapeutic a...
Poster
Full-text available
Nawracający stan zapalny w obrębie przewodu pokarmowego u pacjentów ze zdiagnozowanymi nieswoistymi stanami zapalnymi jelit prowadzą do znacznego upośledzenia wchłaniania substancji odżywczych. W badaniach in vitro właściwości przeciwzapalnych suszonego soku ziemniaczanego wykorzystano model komórkowy złożony z dojrzałego nabłonka jelitowego Caco-...
Article
Full-text available
Background: Peptic ulcer disease, including its complications and functional dyspepsia, are prevalent gastrointestinal diseases, etiopathogenesis of which is associated with mucosal inflammation. Research into new therapeutics capable of preventing or curing gastrointestinal mucosal damage has been steadily developing over past decades. This study...
Article
Full-text available
Gallotannins are class of hydrolyzable tannins consisting of gallic acid and a sugar moiety. Currently, there is growing interest around a possible neuroprotective effect of this class of phytochemicals, which is suggested to be a result of their active metabolites. Evidence from experimental studies has suggested that tannin-rich plant preparation...
Article
Gallotannins are class of hydrolyzable tannins consisting of gallic acid and a sugar moiety. Currently, there is growing interest around a possible neuroprotective effect of this class of phytochemicals, which is suggested to be a result of their active metabolites. Evidence from experimental studies has suggested that tannin‑rich plant preparation...
Article
Full-text available
Background/aim: The leaves of white mulberry (Morus alba L.) contain various polyphenolic compounds possessing strong antioxidant activity and anticancer potential. This study was designed to investigate the chemopreventive effect of aqueous extract of mulberry leaves against N-nitrosodiethylamine (NDEA)-induced liver carcinogenesis. Materials an...
Article
The aim of the study was to examine whether antioxidant properties of 3,4,4',5-tetramethoxystilbene (DMU-212) contribute to its anticarcinogenic activity and whether DMU-212 affects the expression of apoptosis-related genes. Two-stage model of hepatocarcinogenesis was used; male Wistar rats were challenged withN-nitrosodiethylamine (NDEA), 200 mg/k...
Article
Full-text available
Ferritin-iron is currently considered as one of the most promising iron forms to prevent iron deficiency anaemia. We found that the cultivation of soybean seeds in a solution of ferrous sulfate results in material with extremely high iron content - 560.6 mg Fe/100 g of dry matter, while ferritin iron content was 420.5 mg/100 g dry matter. To assess...
Article
The article presents an evaluation of the safety of yellow tea (Camellia sinensis) extract consumption and its antioxidant activity in an animal model. Wistar rats were exposed through diet to 2, 6, and 10 g yellow tea extract/kg feed for 90 days. No signs of toxicity and no differences in mean body weight gain in the treated and control rats were...
Article
Context Yellow tea containing the same catechins as other types of tea but in different proportions has been suggested to possess potent anticancer activities. Objective This study investigates the chemopreventive effect of yellow tea aqueous extract against N-nitrosodiethylamine (NDEA)-induced liver carcinogenesis in rats by employing histological...
Article
Full-text available
Melissa officinalis ( MO , English: lemon balm, Lamiaceae), one of the oldest and still most popular aromatic medicinal plants, is used in phytomedicine for the prevention and treatment of nervous disturbances. The aim of our study was to assess the effect of subchronic (28-fold) administration of a 50% ethanol extract of MO leaves (200 mg/kg, p.o....
Article
Because humans commonly consume chokeberry, especially as a nutritional supplement, it must be checked to determine whether its excessive ingestion can cause adverse effects, in particular, in the case of simultaneous exposure to some xenobiotics. From this point of view, we examined the impact of long-term cotreatment of rats with chokeberry juice...
Article
Full-text available
Eryngium planum L. (EP) is as a rare medicinal plant with a lot of potentials as pharmaceutical crops. The aim of our study was to assess the effect of subchronic (28-fold) administration of a 70% ethanol extract of EP roots (200mg/kg, p.o.) on behavioral and cognitive responses inWistar rats linked with acetylcholinesterase (AChE), butyrylcholines...
Article
Full-text available
Lycopene is a carotenoid pigment produced by vegetables and fruits, with tomatoes and their processed products being the most abundant sources. A high number of conjugated dienes make lycopene a powerful radical scavenger. Its antioxidant properties are considered to be primarily involved in many beneficial health effects. The present study was des...
Article
Full-text available
Polyphenolics can act as prooxidants leading to the generation of reactive oxygen species and electrophilic metabolites which bind to DNA, protein and glutathione. The aim of the present study was to evaluate potential adverse effects of the long-term dietary administration of freeze-dried chokeberry juice to rats. Groups of 8 males and 8 females...
Article
The aim of the study was to evaluate a protective effect of apple juice on KBrO(3) -induced oxidative stress in rats. Male Wistar rats were administered apple juice per os, 10 ml/kg b.w. for 28 days. On 27 day of the experiment, some rats were given i.p. a single 125 mg/kg b.w. dose of KBrO(3) . Markers of oxidative damage and clinical chemistry pa...
Conference Paper
Because of the lengthening of human life, there is an increased risk of dementia incidence, including Alzheimer disease, which pathogenesis is associated with changes in the cholinergic system of CNS [1]. The search of nonselective inhibitors of acetyl- and butyrylcholinesterases (AChE, BuChE) may be a key way in optimization of pharmacotherapy of...
Article
Male Wistar rats were treated with chokeberry juice per os, 10 mL/kg/day, for 28 days and a single intraperitoneal (i.p.) dose of N-nitrosodiethylamine (NDEA), 150 mg/kg, or carbon tetrachloride (CCl(4)), 2 ml/kg. The level of hepatic microsomal lipid peroxidation, expressed as thiobarbituric acid reactive substances (TBARS), was increased in anima...
Article
Full-text available
Apples abundant in phenolic compounds show a variety of biological activities that may contribute to beneficial effects against some chronic diseases. The aim of our study was to assess the protective effect of cloudy apple juice against chemical-induced oxidative stress in rats. Male Wistar rats were treated with apple juice per os, 10 mL/kg/day f...
Article
The aim of this study was to investigate cytotoxicity, acute and subchronic oral toxicity of an ionic liquid didecyldimethylammonium saccharinate [DDA][Sac] in rat. IC(50) values tested on six human cell lines varied from 1.44 microM to 5.47 microM. The compound tested was classified to the 4th toxicity class with a fixed LD(50) cut-off value 500 m...
Article
Full-text available
The aim of this study was to investigate acute and subacute oral toxicity of an ionic liquid, didecyldimethylammonium acesulfamate [DDA][Ace], in rats. The compound tested was classified to the fourth toxicity class with a fixed LD(50) cut-off value of 500 mg/kg. Organ pathology induced by [DDA][Ace] in acute experiments included exfoliation of the...
Article
The aim of the study was to investigate the potential protective effect of beetroot juice in a model of oxidative stress induced by N-nitrosodiethylamine (NDEA) and carbon tetrachloride (CCl(4)). Male Wistar rats were treated with beetroot juice per os, 8 mL/kg/day for 28 days, and a single i.p. dose of the xenobiotics: 150 mg/kg NDEA or 2 mL/kg CC...
Article
Full-text available
The ethyl ether extract from Aquilegia vulgaris (L.) (Ranunculaceae) contains a lot of phenolic acids. Their hydroxyl groups are capable of donating hydrogen atoms at the initial stage of lipid peroxidation (LPO), which inactivates hydroxyperoxides formed from polyunsaturated fatty acids (PUFAs) and leads to breakdown of the propagation chain. Rats...
Article
Full-text available
The ethyl ether extract of A. vulgaris inhibited in vitro microsomal lipid peroxidation (IC50 58.8 microg/ml) and showed moderate ability to scavenge superoxide radicals and to chelate iron ions. The extract (100 mg/kg body weight, po) decreased uninduced and enzymatic microsomal lipid peroxidation in the liver of male rats pretreated with CCl4 (1...
Article
Retrospective reports suggest that therapeutic doses of paracetamol may increase the risk of liver injury in alcoholic patient. However, this remark is at odds with other clinical studies that showed that acute ethanol ingestion could protect against acetaminophen-induced hepatotoxicity. In the present paper we extended this problem. We described t...

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Projects (4)
Project
Join our introductory session for Neuroscientists on possible routes to tackle Neuroscience challenges using Quantum technologies on Wednesday at 10 February at 6 pm CET. About this Event 𝐐𝐮𝐚𝐧𝐭𝐮𝐦 𝐭𝐞𝐜𝐡 𝐟𝐨𝐫 𝐇𝐞𝐚𝐥𝐭𝐡𝐜𝐚𝐫𝐞 (𝐐𝐓𝟒𝐇𝐂) 𝐢𝐬 𝐩𝐫𝐨𝐮𝐝 𝐭𝐨 𝐩𝐫𝐞𝐬𝐞𝐧𝐭 𝐭𝐡𝐞 𝐟𝐢𝐫𝐬𝐭 𝐩𝐮𝐛𝐥𝐢𝐜 𝐝𝐢𝐬𝐜𝐮𝐬𝐬𝐢𝐨𝐧 𝐨𝐧 𝐭𝐡𝐞 𝐫𝐨𝐥𝐞 𝐨𝐟 𝐐𝐮𝐚𝐧𝐭𝐮𝐦 𝐜𝐨𝐦𝐩𝐮𝐭𝐢𝐧𝐠 𝐜𝐨𝐮𝐥𝐝 𝐩𝐨𝐭𝐞𝐧𝐭𝐢𝐚𝐥𝐥𝐲 𝐚𝐬𝐬𝐢𝐬𝐭 𝐢𝐧 𝐭𝐚𝐜𝐤𝐥𝐢𝐧𝐠 𝐭𝐨𝐝𝐚𝐲𝐬' 𝐜𝐡𝐚𝐥𝐥𝐞𝐧𝐠𝐞𝐬 𝐢𝐧 𝐍𝐞𝐮𝐫𝐨𝐬𝐢𝐞𝐧𝐜𝐞. Our expert team -𝐃𝐫. 𝐉𝐨𝐬𝐞𝐩𝐡 𝐆𝐞𝐫𝐚𝐜𝐢, CEO and co-Founder at NetraMark Corp | Data Scientist, Mathematician, Medical Scientist, Quantum ML Entrepreneur - 𝐄𝐫𝐢𝐤 𝐕𝐢𝐢𝐫𝐫𝐞 𝐌𝐃, 𝐏𝐡𝐃, Director at Arthur C Clarke Center For Human Imagination | Adjunct Professor of Neurosciences at UC San Diego - 𝐃𝐞𝐧𝐢𝐬𝐞 𝐑𝐮𝐟𝐟𝐧𝐞𝐫, VP of Business Developement of IonQ Inc. | Neurobiologist - 𝐃𝐫. 𝐌𝐚ł𝐠𝐨𝐫𝐳𝐚𝐭𝐚 𝐊𝐮𝐣𝐚𝐰𝐬𝐤𝐚, Associate Professor at the Poznan University of Medical Sciences | R&D Expert | Top 500 Innovator - 𝐍𝐢𝐤𝐡𝐢𝐥 𝐒𝐞𝐡𝐠𝐚𝐥, CEO and Co-Founder at Vastmindz Register on https://www.eventbrite.co.uk/e/qt4hc-quantum-technologies-intro-for-neuroscience-registration-139011375767
Project
Dear Colleagues, As the Guest Editor of the Special Issue in the International Journal of Environmental Research and Public Health" (Impact Factor 2.849), I would like to invite you to contribute a paper focuses on the variety and relevance of recent advances in the field of application of graphene-based nanomaterials in brain theranostics. Please access the detailed Special Issue information at: https://www.mdpi.com/journal/ijerph/special_issues/engineered_graphene-based_materials_brain_theranostics As the Guest Editor of the Special Issue in the International Journal of Environmental Research and Public Health" (Impact Factor 2.849), I would like to invite you to contribute a paper focuses on the variety and relevance of recent advances in the field of application of graphene-based nanomaterials in brain theranostics. Please access the detailed Special Issue information at: https://www.mdpi.com/journal/ijerph/special_issues/engineered_graphene-based_materials_brain_theranostics We look forward to receiving your valuable submission. Guest Editors: Prof. Dr. Marek Osinski Dr. Małgorzata Kujawska Prof. Tor Flå Dr. Grzegorz Kreiner
Project
Dear Colleagues, In collaboration with the journal "Frontiers in Cellular Neuroscience" (Impact Factor 3.900) we are bringing together a selected group of international experts to contribute to an open-access article collection on: "Common Pathways Linking Neurodegenerative Diseases – The Role of Inflammation". We look forward to receiving your valuable submission. Guest Editors: Dr. Grzegorz Kreiner, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland Dr. Andrii Domanskyi, University of Helsinki, Helsinki, Finland Dr. Małgorzata Kujawska, Poznan University of Medical Sciences, Poznań, Poland The submission deadline is 10 December 2020. Please visit the collection homepage for the full description of the project: https://www.frontiersin.org/research-topics/12670