Malgorzata Kolodziej

Malgorzata Kolodziej
Justus-Liebig-Universität Gießen | JLU · Neurosurgery

Doctor of Medicine

About

66
Publications
4,879
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410
Citations
Education
April 1996 - October 2002

Publications

Publications (66)
Article
Objective To evaluate the neurological and neurophysiological outcomes of retractor-endoscopic versus open release in carpal tunnel syndrome (rCTS and oCTS, respectively) and cubital tunnel syndrome (rCbTS and oCbTS, respectively) at 3- and 12-month follow-up. Methods Between 2013 and 2017, 80 patients were prospectively blindly randomized. McGowa...
Article
Fragestellung: In der EF-14-Studie zeigte die Optunetherapie in Kombination mit Temodal (TMZ) eine deutliche Überlegenheit ge- genüber der alleinigen TMZ- Therapie beim neu diagnostizierten Glio- blastom (ndGBM) Das Ziel unserer Studie war es die Sicherheit und Machbarkeit der Optunetherapie nach Protonen-Boost zu untersuchen Methodik: In dieser mo...
Poster
Background: Patients with radiculopathy frequently show sensory symptoms outside of the affected dermatome. We aimed to objectively describe sensory symptoms of the affected and the neighboring dermatome. Methods: We investigated the sensory profiles of 15 patients with a disc herniation affecting only the L5 root (7 women; age 56.9 ± 2.9 years) an...
Article
The present study investigated the expression of epithelial-mesenchymal transition (EMT)-related factors zinc finger E-box-binding homeobox 1 (ZEB1), cadherin-1 (CDH1), cadherin-2 (CDH2) and the cell cycle modulating kinase cyclin-dependent kinase 1 (CDK1) in human glioblastoma (GBM) compared to normal brain tissue, as well as whether the levels of...
Preprint
Introduction : High-mobility group AT-hook protein 2 (HMGA2) is a gene regulatory protein that correlates with malignancy, metastatic potential, and poor prognosis. It has been shown that HMGA2 is overexpressed in various tumors such as esophageal squamous cell cancer, lung cancer and pancreatic cancer. The invasive character and highly aggressive...
Article
Full-text available
Since high grade gliomas are aggressive brain tumors, intensive search for new treatment options is ongoing. For adult patients with newly diagnosed (ndGBM) and recurrent glioblastoma (rGBM), low intensity intermediate frequency alternating electric fields, known as tumor treating fields (TTFields) have been established as a new treatment modality....
Preprint
Full-text available
Paediatric hydrocephalus is a result of cerebrospinal fluid circulatory dysfunction and has diverse pathogeneses. This study investigates the epidemiology of paediatric hydrocephalus and influences of primary aetiology, type of implants, and of complications to develope new therapeutic approaches and strategies. Between 2013-2018 a retrospective an...
Article
OBJECTIVE Combination therapy, a treatment modality that combines two or more therapeutic agents, is a cornerstone of cancer therapy. The optimal combination therapy for Tumor Treating Fields (TTFields) in glioblastoma (GBM) treatment is unknown. The aim of our study was to analyze, the effects of the TERT-inhibitor eribulin in combination with TTF...
Article
Purpose/Objective(s) Treatment options of glioblastoma (GBM) are limited. Therapy options include tumor resection, radiation therapy, chemotherapy, and the treatment with Tumor Treating Fields (TTFields). The aim of the study was to analyze, for the first time, the effects of the TERT-inhibitor eribulin in combination with TTFields on cell death of...
Article
Full-text available
Glioblastoma multiforme (GBM) is the most common malignant brain tumour in adults. The poor prognosis and short median overall survival of patients with GBM is associated with resistance to therapy after surgical and adjuvant treatment. The expression of various acetylcholine receptors (AChR) in GBM has been widely reported. The present study aimed...
Article
Objective Peripheral nerve field stimulation (PNFS) is an effective alternative treatment for patients with chronic low back pain. The treatment of low back pain strongly depends on psychological factors like anxiety, depression, and mental stress. The aim of this study was to evaluate the impact of such factors on outcome measures after lead‐ and...
Article
Nusinersen, an antisense oligonucleotide enhancing the production of the survival motor neuron protein, is approved for the treatment of spinal muscular atrophy (SMA) but requires repetitive lumbar punctures. Application via a subcutaneous port connected to a permanent intrathecal catheter has been proposed as an alternative for patients with sever...
Article
Full-text available
PurposeWe report five rare cases of programmable valve breakage (Codman Hakim-Medos valve) in shunt systems of children with posthemorrhagic hydrocephalus. Only four similar studies have been published in the current literature.Methods Between 2013 and 2018, five children with posthemorrhagic hydrocephalus were admitted to the pediatric department....
Article
Full-text available
Sphingosine‑1‑phosphate (S1P) plays a key role in cell survival, growth, migration, and in angiogenesis. In glioma, it triggers the activity of the S1P‑receptor 1 and of the sphingosine kinase 1; thus influencing the survival rate of patients. The aim of the present study was to investigate the anti‑proliferative effect of the S1P analogue FTY720 (...
Article
Objective Peripheral nerve field stimulation (PNFS) is an effective alternative treatment for patients with chronic low back pain. Transcutaneous electrical nerve stimulation (TENS) is frequently used in pain therapy. Aim of this prospective study was to examine the predictive value of TENS for later PNFS treatment. Materials and Methods Between 2...
Article
Background: Open intrauterine MMC repair has been proven to result in a significant improvement of long term milestones like shunt placement rates as well as motor and mental development, when compared to postnatal surgery. A fetoscopic approach offers reduced invasiveness, a lower risk of uterine rupture, and the option of vaginal delivery. Obje...
Article
Objective The aim of this study was to report on the use of laparoscopic implantation of leads on the branches of the sacral plexus for neuromodulation in the treatment of chronic pelvic pain (CPP) in a multidisciplinary setting with the help of electrophysiological neuromonitoring. Materials and Methods Between 2012 and 2019, six female patients...
Article
Full-text available
Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults. We present a case of a 42-year-old male patient presenting with headache and vomiting. Imaging demonstrated obstructive hydrocephalus and a ring-enhancing lesion in the right posterior thalamus. After endoscopic third ventriculostomy and stereotactic biopsy, the his...
Article
Background: Vasospasm, delayed ischemic neurologic deficit (DIND), and ischemic brain lesions after acute subarachnoid hemorrhage (SAH) are associated with increased morbidity and mortality. The purpose of this study was to analyze age cutoffs for vasospasm, DIND, and ischemic brain lesions after SAH. Methods: This study included 292 aneurysmal...
Article
Objective: Cardiopulmonary (CP) complications are well-known phenomena after an isolated traumatic brain injury (iTBI) and they may be associated with an elevated serum troponin I (TnI) value. However, the influence of an elevated TnI level on CP parameters within the first 24 h after an iTBI is still unknown. The current study was conducted to as...
Article
Background and aims Complex regional pain syndrome (CRPS) is a common pain condition which is characterized by pain, functional impairment, and trophic changes. Neurosurgical treatment is not widely offered. In this study the treatment with spinal cord stimulation (SCS) was evaluated over 24 months follow up. Methods A retrospective case analysis...
Article
BACKGROUND The protein Galectin-1 (gal-1) is known to be involved in proliferation and progression of several malignancies. The allosteric gal-1 inhibitor OTX-008 has an antiproliferative effect on various tumors in vitro and in vivo. However, the effect of OTX-008 on patient derived GBM cultures is unknown. The aim of our study was to investigate...
Article
BACKGROUND Proton therapy is able to apply high radiation doses to the tumor while sparing healthy tissues by reducing integral dose. Tumor Treating Fields (TTFields) are low intensity (1–3 V/cm) and intermediate frequency (100–300 kHz) alternating electric fields that demonstrated significantly increased survival rates in combination with adjuvant...
Conference Paper
In this work, fully automatic binary segmentation of GBMs (glioblastoma multiforme) in 2D magnetic resonance images is presented using a convolutional neural network trained exclusively on synthetic data. The precise segmentation of brain tumors is one of the most complex and challenging tasks in clinical practice and is usually done manually by ra...
Conference Paper
Full-text available
Objective: Decompressive craniectomy (DC) is a life-saving procedure in patients with malignant brain infarction (MBI). However, population-based data for outcome after acute care and early neurorehabilitation (ENR) has not been systematically analyzed. Aim of the current study was to evaluate the clinical outcome after DC for MBI based on a prospe...
Article
Patients suffering treatment resistant Parkinson´s disease (PD) are potential candidates for deep brain stimulation (DBS). Commonly most implanted electrodes have a cylindrical shape with quadripolar electrode contacts and generate a symmetrical stimulation field around the lead. To reduce side effects through activation of neighboring fibers a new...
Data
Skull-stripped Contrast-Enhanced MRI Datasets. Please use the following citations if you use them in your work: L. Lindner, M. Kolodziej, J. Egger. Skull-stripped Contrast-Enhanced MRI Datasets. Figshare, 2018. and J. Egger, et al. GBM Volumetry using the 3D Slicer Medical Image Computing Platform. Sci Rep., 3:1364, 2013. Further Information:...
Data
Skull-stripped MRI GBM Datasets. Please use the following citations if you use them in your work: L. Lindner, D. Wild, M. Weber, M. Kolodziej, G. von Campe, J. Egger. Skull-stripped MRI GBM Datasets. Figshare, 2018. and J. Egger, et al. GBM Volumetry using the 3D Slicer Medical Image Computing Platform. Sci Rep., 3:1364, 2013. Further Informatio...
Article
Objective Transcutaneous electrical nerve stimulation (TENS) and peripheral nerve field stimulation (PNFS) may be proposed to patients with chronic lumbar pain refractory to conventional treatment. Aim of this study was to assess the importance of preoperatively treatment with TENS as a predictive value for later successful PNFS and impact of PNFS...
Conference Paper
Objective: Human glioblastoma multiforme (GBM) has a poor prognosis and several new target drugs were not able to improve survival. Drug resistance through the expression of O6-methylguanine methyltransferase (MGMT) is one mechanism that is associated with temozolomide (TMZ) resistance and poor outcome. For other tumor entities such as melanoma it...
Conference Paper
Full-text available
Objective: Despite several publications on the treatment of chronic subdural hematoma (CSDH), the optimal surgical approach is still controversial, and a standard therapy does not exist. The purpose of this study is to compare three different surgical approaches for the treatment of CSDH. Methods: In this retrospective study the data of 198 patient...
Chapter
Synapse formation is a unique biological phenomenon. The molecular biological perspective of this phenomenon is different from the fractal geometrical one. However, those perspectives are not mutually exclusive and supplement each other. A cornerstone of the first one is a chain of biochemical reactions with the Markov property, that is, a determin...
Conference Paper
Objective: Prolonged length of stay (LOS) of surgically and conservatively treated patients with spontaneous intracerebral hemorrhage (ICH) is an important cost driver during acute care stay. Currently no clear definition of prolonged LOS for surgically and conservatively treated patients with ICH exists. The purpose of this study was to define cha...
Article
Chudley-McCullough syndrome (CMS) is a rare autosomal recessive disorder characterized by sensorineural deafness, agenesis of the corpus callosum, frontal polymicrogyria, interhemispheric cyst, and ventricular enlargement. CMS is caused by mutations in the GPSM2 gene, but until now no more than eight different mutations are on record. We describe t...
Article
Aim: The N-myc down-regulated gene (NDRG) family is a group of genes that have predominantly tumor-suppressive effects. The goal of this study was to investigate the expression of NDRG2 and NDRG4 in surgical specimens of human glioblastoma and in normal brain tissue, and to search for correlations with overall (OS) and progression-free survival (P...
Article
Full-text available
High-mobility group AT-hook protein 2 (HMGA 2) is a transcription factor associated with malignancy and poor prognosis in a variety of human cancers. We correlated HMGA 2 expression with clinical parameters, survival, and O-6-methylguanine-DNA methyltransferase methylation status (MGMT) in glioblastoma patients. HMGA 2 expression was determined by...
Article
Full-text available
. The definition of prolonged length of stay (LOS) during acute care remains unclear among surgically and conservatively treated patients with intracerebral hemorrhage (ICH). Methods . Using a population-based quality assessment registry, we calculated change points in LOS for surgically and conservatively treated patients with ICH. The influence o...
Article
Pre-treatment with antiplatelet agents is described to be a risk factor for mortality after spontaneous intracerebral hemorrhage (ICH). However, the impact of antithrombotic agents on mortality in patients who undergo hematoma evacuation compared to conservatively treated patients with ICH remains controversial. This analysis is based on a prospect...
Article
Objective: Secondary complications (SC) after intracerebral hemorrhage (ICH) can worsen outcome and are associated with early death. The purpose of the present study was to determine in-hospital mortality rates and SC after spontaneous ICH during acute care stay in a population based cohort in central Europe. Methods: A prospective database of t...
Article
Objective Motor cortex stimulation (MCS) is an alternative treatment modality for central neuropathic pain, if conservative treatment failed. Study aim was outcome assessment after MCS. Material and Methods This study is a retrospective case series review of patients who had undergone MCS for central pain (n = 8), deafferentation pain (n = 3) and n...
Article
Full-text available
A wide variety of therapeutic options are available for the treatment of chronic back pain, a very common condition in Western countries with high related social and economic costs. Nevertheless, it is not always possible to achieve adequate long-term pain relief in spite of intensive analgesic therapies. Subcutaneous peripheral nerve field stimula...
Article
The goal of the study was to evaluate the need for postnatal neurosurgical interventions after fetoscopic patch coverage of spina bifida aperta (SBA). Retro- and partial prospective analysis of a cohort of 71 fetuses who underwent minimally-invasive fetoscopic patch coverage of SBA between 21 + 0 and 29 + 1 weeks + days of gestation. Localization o...
Article
Full-text available
Purine analogue roscovitine, a cyclin-dependent kinase (CDK) inhibitor, has shown strong anti-proliferative and pro-apoptotic effects in solid and hematologic cancers such as non small-cell lung cancer and lymphomas. It targets CDK2, 7 and 9 preferentially, which are also overexpressed in glioblastoma. Τherefore, the biological effects of roscoviti...
Conference Paper
Full-text available
Objective: Cardiopulmonary stress (CPS) in patients with non-traumatic subarachnoid hemorrhage (ntSAH) is a well-known phenomenon. An acute elevation of the initial serum cortisol value (CV) based on a stress situation could imply CPS. The impact of elevated CV on CPS within the first 24 hours after ntSAH is still unknown. Therefore, the present st...
Article
Sphingosine-1-phosphate (S1P), the corresponding kinases SphK1-2, and receptors S1P1-3 and S1P5 are involved in cell survival and growth. Pathway components are overexpressed in many tumors including glioblastoma. Previous studies showed that the expression of SphK1 influenced survival of glioblastoma patients, yet the roles of SphK1-2 and receptor...
Article
Subarachnoid hemorrhage is sometimes difficult to diagnose radiologically. Cerebrospinal fluid (CSF) ferritin has been proposed to be highly specific and sensitive to detect hemorrhagic central nervous system (CNS) disease. We analyzed here the specificity of CSF ferritin in a large series of various CNS diseases and the influence of serum ferritin...
Article
Non-invasive and invasive cortical stimulation allows the modulation of therapy-refractory neuropathic pain. High-frequency repetitive transcranial magnetic stimulation (rTMS) of the contralateral motor cortex yields therapeutic effects at short-term and predicts the benefits of epidural motor cortex stimulation (MCS). The present article summarize...
Article
Full-text available
Die nichtinvasive und invasive Motorkortexstimulation können therapierefraktäre neuropathische Schmerzen verbessern. Mit der hochfrequenten repetitiven transkraniellen Magnetstimulation (rTMS) des kontralateralen Motorkortex können kurzzeitige therapeutische Effekte erzielt und der Effekt einer epiduralen Motorkortexstimulation (MCS) vorhergesagt w...
Article
2 , H. Strik Background: Sphingosine 1-phosphate (S1P), sphingosine kinases (SK) 1 and 2 and the Sphingosine-1-phosphate receptors 1−5 (S1PR1−5) are involved in cell survival, growth, migration and angiogenesis. Pathway components are overexpressed in many solid tumors including glioma. Previous studies have shown that the expression of SK1 influen...
Article
Full-text available
We present a rectangle-based segmentation algorithm that sets up a graph and performs a graph cut to separate an object from the background. However, graph-based algorithms distribute the graph's nodes uniformly and equidistantly on the image. Then, a smoothness term is added to force the cut to prefer a particular shape. This strategy does not all...
Article
The goal of this study was to evaluate the incidence and mechanisms of head injury during soccer games and to describe the results after spontaneous resolution of symptoms or after treatment. In a retrospective study from 2005, records on 451 players from the German Soccer Association who had suffered various injuries were collected. The study used...
Article
Full-text available
Malignant gliomas, the most common malignant primary brain tumors, have a deleterious clinical prognosis of approximately 12 months in unselected series. The resistance against antineoplastic therapy is apparently not only associated with a high proliferative potential, marked antiapoptotic resistance and high migratory capacity. Effective mechanis...
Article
A 54-year-old woman had nausea, vomiting and personality changes since a few weeks. Paresis of the abducens and hypoglossal nerves on the left side, a right sided reduction of the visual field, discrete dysarthri×a and ataxia were diagnosed. Cranial magnetic resonance imaging demonstrated a contrast enhancing circular meningeal lesion of the forame...
Article
Motor cortex stimulation is an alternative treatment modality indicated for the therapy of central pain and neuropathic pain [1-5]. It is a fast, effective and a somewhat invasive method of medical treatment of refractory neuropathic pain. Patients suffering from long-lasting pain have a reduced quality of life and multidimensional impairment [6, 7...
Article
The present study aims to provide preliminary results of the thermal effects on rat brain tissue after argon plasma coagulation (APC). It also presents and discusses the clinical experiences in the treatment of brain tumor using APC. A controlled study of APC in the rat brain was conducted. Twelve rats were randomly divided into 2 experimental grou...

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