Malcolm Nobre

• MSc
• Senior Researcher at Advanced Centre for Treatment, Research and Education in Cancer

We have identified 164 somatic mutations in mitochondrial DNA in gingivobuccal oral cancer by deep sequencing the mitochondrial genome from paired tumor and blood DNA samples from 89 patients. We have found evidence of positive selection of somatic nonsynonymous mutations. Non-synonymous mutations in mitochondrial respiratory genes were found to in...

Background: We have recently reported that cell-free DNA (cfDNA) fragments derived from dying cells that circulate in blood are biologically active molecules and can readily enter into healthy cells to activate DNA damage and apoptotic responses in the recipients. However, DNA is not conventionally known to spontaneously enter into cells or to hav...

Introduction: We have reported that chromatin fragments (Cfs) from dead cancer cells can enter into healthy cells to damage their DNA and induce inflammation and genomic instability. Furthermore, Cfs isolated from cancer patients can induce oncogenic transformation in NIH3T3 cells. It follows that if extracellular Cfs could be prevented from reachi...

Introduction: Radiation-induced bystander effect (RIBE) is a phenomenon associated with ionizing radiation wherein non-targeted cells show evidence of heritable DNA damage and genomic instability. RIBE is thought to be responsible for radiation-related local and systemic toxicity. Damaging substances released from irradiated cells are thought to be...

Researchers have made considerable progress in last few decades in understanding mechanisms underlying pathogenesis of breast cancer, its phenotypes, its molecular and genetic changes, its physiology, and its prognosis. This has allowed us to identify specific targets and design appropriate chemical entities for effective treatment of most breast c...

Mutational landscape of gingivo-buccal oral squamous cell carcinoma reveals new recurrently-mutated genes and molecular subgroups India Project Team of the International Cancer Genome Consortium 1 Gingivo-buccal oral squamous cell carcinoma (OSCC-GB), an anatomical and clinical subtype of head and neck squamous cell carcinoma (HNSCC), is prevalent...

Calotropis procera R.Br. (Asclepiadiaceae) is an important medicinal plant whose leaves and roots have multiple uses. The plant is a rich source of many bioactive compounds which are of medicinal importance. The study was undertaken to investigate the anti HIV-1 and antibacterial activities of the crude leaf extracts of C. procera. Hot water extrac...

Background & Objectives: A nutritionally balanced diet has become a vital part in Human Immunodeficiency Virus care. The breakdown of natural immunity which could occur if the diet is poor can lead to a host of health problems created by viruses and bacteria. Nutritional counseling has been shown to be effective. Therefore in the present study we h...

Aristolochia elegans Mast. (Aristolochiaceae) is an important medicinal plant whose leaves and roots have multiple uses. The present study was undertaken to investigate the Anti HIV-1 and Anti bacterial activities of the crude leaf extracts. Hot water extract was used for evaluating the efficacy against the growth of HIV. Inhibition of p24 antigen'...

The diagnosis of a non-surgical cause of delayed passage of meconium in a neonate may be challenging to the pediatric surgeon. The usefulness of determining trypsin activity (TA) in stool and duodenal aspirate for the diagnosis of cystic fibrosis (CF) and the existence of an entity called transient deficiency of trypsin (TTD) was assessed in 49 neo...