Makhala Khammy

Makhala Khammy
University of Melbourne | MSD · Department of Pharmacology & Therapeutics

BBiomedSc, BSc (Hons), PhD

About

11
Publications
375
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59
Citations
Introduction
A researcher intrigued by the complex integrated mechanisms that regulate blood pressure and drive pathophysiological changes in hypertension. She is interested in the function of the neuroeffector junction and perivascular nerves and their role in the regulation of vascular tone. Believes that identifying abnormalities in the function of the neuroeffector junction will facilitate the development of a treatment for hypertension as well as other cardiovascular diseases in which aberrant sympathetic function is a key pathological mechanism.
Additional affiliations
August 2015 - October 2016
University of Copenhagen
Position
  • PostDoc Position

Publications

Publications (11)
Article
Recently, the β2-adrenoceptor agonist terbutaline was shown to have α1-adrenolytic activity in mouse isolated pulmonary arteries in vitro and to lower pulmonary artery pressure in anaesthetised mice. The aim of our study was to determine the α1-adrenoceptor antagonist activity of terbutaline and its structurally close resorcinol, orciprenaline, in...
Article
Full-text available
Objectives The vascular amplifier in hypertension is a result of structural changes in resistance arteries. We estimated the vascular amplifier hypertensive:normotensive (H:N) ratio in the renal bed compared with the total peripheral bed in conscious rabbits during infusion of vasoconstrictor and vasodilator stimuli. Methods Rabbits were subjected...
Article
Aim This study aimed to assess intracellular Ca²⁺ dynamics in nerve cells and Schwann cells in isolated rat resistance arteries and determine how these dynamics modify noradrenaline release from the nerves and consequent force development. Methods Ca²⁺ in nerves was assessed with confocal imaging, noradrenaline release with amperometry, and artery...
Article
Microtubules can regulate GPCR (G protein-coupled receptor) signaling in various cell types. In vascular smooth muscle, activation of the β-adrenoceptor leads to production of cAMP to mediate a vasorelaxation. Little is known about the role of microtubules in smooth muscle, and given the importance of this pathway in vascular smooth muscle cells, w...
Article
Background and purpose: Kv7.4 and Kv7.5 channels are regulators of vascular tone. 4-aminopyridine (4-AP) is considered a broad inhibitor of voltage-gated potassium (KV ) channels, with little inhibitory effect on Kv7 family members at millimolar concentrations. However, the effect of 4-AP on Kv7 channels has not been systematically studied. The ai...
Article
Background and purpose: Phosphodiesterase 1 (PDE1), a subfamily of cyclic nucleotide phosphodiesterases consisting of three isoforms, PDE1A, PDE1B, and PDE1C, has been implicated in regulation of vascular tone. The PDE1 isoform(s) responsible for tone regulation is unknown. This study used isoform-preferring PDE1 inhibitors, Lu AF58027, Lu AF64196...
Article
We investigated the acute effects of glucagon-like peptides-1 (GLP-1), GLP-1(1-36) and GLP-1(7-36) on vascular endothelial growth factor-A (VEGFA)-induced endothelium-dependent signaling and vasodilation. Our hypothesis was that GLP-1 released from intestinal L-cells modulates processes related to PLCγ activation, Src and eNOS signaling, thereby co...
Article
Background: In the kidney, the medullary and cortical regions form two functionally distinct microcirculations. Medullary, cortical and whole renal blood flow have varying degrees of influence over systemic blood pressure so characterisation of their vascular reactivity is important. Methods: Vascular reactivity was assessed in ring segments of int...
Article
Nitric oxide (NO) bioavailability is markedly impaired in diabetes, contributing to endothelial and myocardial dysfunction. Our aim was to determine if endothelial-specific overexpression of Cationic Amino Acid Transporter 1 (CAT-1, to enhance L-arginine uptake and NO generation) prevents diabetes-induced endothelial and cardiac dysfunction in diab...

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