Majid Mohammadhosseini

Islamic Azad University of Shahrood · Chemistry Department, Faculty of Basic Sciences

Since the anticancer drugs exhibited a variety of inhibitory mechanisms in cancer cells, the use of two or more anticancer drugs may have excellent therapeutic effects, particularly in drug-resistant tumors. In this study, the efficient entrapment of two clinically used single-agent drugs, Cisplatin (CDDP) and Methotrexate (MTX) is reported against...

The aim of the present study was to magnetize Plantago ovata Forssk. hydrogel and produce a nanosphere system to carrier mefenamic acid as the drug model. For this propose, P. ovata seeds hydrogel (POSH) was extracted and magnetized by Fe3O4 being functionalized using tetraethyl orthosilicate and trimethoxyvinysilane. Thereafter, mefenamic acid (MF...

The aim of this review article is to present, for the first time, an appraisal of the phytochemical, ethnobotanical and pharmacological data on Bunium species. The literature search was conducted using the Scopus, Google Scholar and PubMed databases. The genus Bunium has been found to produce both essential oil (EO) , mainly comprising monoterpenes...

Ruta L. is a typical genus of the citrus family, Rutaceae Juss. and comprises ca. 40 different species, mainly distributed in the Mediterranean region. Ruta species have long been used in traditional medicines as an abortifacient and emmenagogue and for the treatment of lung diseases and microbial infections. The genus Ruta is rich in essential oil...

Herein, a comprehensive review is given focusing on the chemical profiles of the essential oils (EOs), non-volatile compounds, ethnobotany, and biological activities of different Haplophyllum (Rutaceae family) species. To gather the relevant data, all the scientific databases, including Scopus, ISI-WOS (Institute of Scientific Information-Web of Sc...

Herein, the chemical profiles of the essential oils and volatiles obtained from the aerial parts of Mentha pulegium L. (Lamiaceae) are reported respectively using microwave-assisted hydrodistillation (MAHD) and headspace solid phase microextraction (HS-SPME) approaches associated to gas chromatography-mass spectrometric (GC-MS) quantification. Usin...

A novel quantitative structure–activity relationship study was established on a set of ethyl-2-amino-6-(3.5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3 carboxylate (CXL017) derivatives to predict their half-maximal inhibitory concentration (IC50) values. A principal component analysis pattern was first used to divide the whole data set i...

Tanacetum fisherae Aitch. & Hemsl. is an endemic plant growing wild in some brackish regions of Iran. Since there are not enough reports concerning the quantitative and qualitative analyses of its essential oil, it was decided to characterise the respective water-distilled oils obtained from the flowers and leaves of this medicinal plant. Character...

Undoubtedly, identification of the chemical composition of organic extracts or secondary metabolites of plant materials and evaluation of their potential bioactivity are among the main objectives of natural products-based investigations. In the present study, we report the chemical composition and antidiabetic activity of Sophora pachycarpa (Family...

Aloysia Paláu is an important herbal genus from the Verbenaceae family and possesses numerous remedial properties in the folk medicine of Asian, European, and, in particular, South American countries. Only a few reports have discussed some phytochemical characteristics associated with Aloysia species. Right the lack of an exhaustive report prompted...

In this study, nickel nanoparticles (NiONPs) have been successfully synthesized in an aqueous medium using the aqueous extract from the leaves of Calendula officinalis. The synthesized NiONPs were characterized using different techniques. According to the XRD analysis, the mean crystal size for NiONPs was found to be 33.17 nm. In addition, SEM imag...

Background The poly(ADP-ribose) polymerases (PARP) is a nuclear enzyme super family present in eukaryotes. Methods: In the present report, some efficient linear and non-linear methods including multiple linear regression (MLR), support vector machine (SVM) and artificial neural networks (ANN) were successfully used to develop and establish quantita...

Perovskia Kar. is a small genus from the Lamiaceae family which includes a variety of promising medicinal and phytochemical properties. This review paper was undertaken to integrate all the data published about the ethnobotany, phytochemistry and biological activities of species belonging to the genus Perovskia during the past decades. A literature...

In this review, the species from the genus Eremostachys Bunge are described and explored from different standpoints. In particular, the main attention is focused on phyto-chemistry also with reference to the biogenesis of the most important class of chemotaxonomic marker, the iridoids, and their co-occurrence with volatile terpene components of ess...

This study aims to provide a comprehensive overview of the medicinal, folkloric and traditional culinary uses of Ferula species, related products and extracts in different countries together with the description of recently isolated new components and the related bioactivities. The phytochemical composition of the essential oils (EOs), oleo-gum-res...

In this work, we found that 1-nitroso-2-naphtol (NN) can be used as a sensing material for the fabrication of a new highly selective neodymium(III) ion-selective membrane sensor. The best characteristics was obtained for the proposed Nd 3+ sensor having a composition of PVC: nitrobenzene (NB): sodium tetraphenyl borate (NaTPB): NN in the ratio of 3...

Chemical profiles of the essential oils and volatile compounds from the aerial parts of Sclerorhachis platyrachis (Boiss.) Podlech ex Rech.f. obtained through hydrodistillation (HD), solvent-free microwave extraction (SFME), microwave assisted hydrodistillation (MAHD) and headspace solid-phase microextraction (HS-SPME) methods were subsequently inv...

In this study, essential oils were extracted from the roots of Berberis integerrima Bunge using hydrodistillation (HD) and modified microwave-assisted hydrodistillation (MAHD) techniques for the first time. In the first step, amine- and phenyl-functionalized magnetic nanoparticles were synthesized through the silanization method. Afterwards, their...

The present paper describes the fabrication of a new polyvinylchloride (PVC) membrane electrode for the determination of Nd(III) ion based on 4-hydroxypyrrolidine-2-carboxylic acid (LHP) as an active material along with sodium tetraphenyl borate (NaTPB) as an anionic additive and acetophenone (AP) as solvent mediator. The optimum composition (%, w/...

This paper introduces the development of an original Lu 3+-PVC membrane electrode based on 2,2'-[propane-1,3-diylbis(thio)]dianiline (PDTD) as a sensing carrier. The electrode presents a Nernstian slope of 19.8±0.4 mV decade-1 for the in the Lu 3+ ions across a broad working concentration range from 1.0×10-6 to 1.0×10-2 mol L-1 with a lower detecti...

This review was undertaken because of the lack of a comprehensive review on the compositions of secondary metabolites, extracts and volatiles of Ziziphora species and of the biological activities of these materials. The Lamiaceae or Labiatae family comprises a large number of flowering plants of widespread distribution, which have been classified i...

The essential oils isolated from the aerial parts of two samples of Platycladus orientalis (L.) Franco, cultivated in national oil company (NOC) of Shahrood by hydrodistillation (HD) technique, were analyzed by means of GC and GC-MS methods. The impacts of soil composition and general profiles of the common heavy metals were also investigated. Acco...

In the present work, volatile constituents from the dried stems, leaves and fruits of Artemisia tschernieviana obtained by hydrodistillation (HD), solvent-free microwave extraction (SFME) and headspace solid-phase microextraction (HS-SPME) techniques, were subsequently analyzed by means of GC and GC- MS instruments. It was concluded that approximat...

The essential oils of Tanacetum parthenium (L.) Schultz. Bip. and Tanacetum punctatum (Desr.) Grierson. leaves were obtained by hydrodistillation and analysed by GC and GC-MS. The oil yields (v/w) on moisture free basis of T. parthenium and T. punctatum leaves were 0.8 % and 0.2 %, respectively. The essential oil of T. parthenium and T. punctatum w...

The essential oils and volatiles from the aerial parts of Salvia leriifolia obtained by hydrodistillation (HD), solvent-free microwave extraction (SFME) and headspace solid-phase microextraction (HS-SPME) approaches were analyzed using the GC and GC-MS instrumentations. Using the HD, SFME and HS-SPME methods, we were able to recognize thirty five,...

n the present work, the essential oils and volatiles from flowers, leaves, and stems of Salvia limbata obtained using microwave-assisted hydrodistillation, solvent-free microwave extraction, headspace-assisted analysis, and headspace-solid phase microextraction have been characterized for the first time. The results have been also compared with tho...

This study aimed to assess the chemical compositions of essential oils (EOs) extracted through microwave-assisted hydrodistillation from aerial parts of 11 Artemisia species growing wild in different regions in Northern, Eastern, Western, and Central parts of Iran. The EOs were subsequently analyzed via GC and GC-MS. The percentage yields of the EO...

Optical fiber was modified with 3-(methacryloxy)propyltrimethoxysilane and copolymerized with the vinyl end groups and methacrylic to graft a thin layer of molecular imprinted polymer on the surface of the fiber without surface controlling. The modified fiber with phenol-imprinted polymer was coupled with gas chromatograph for headspace solid-phase...

Liposome is a new nanostructure for the encapsulation and delivery of bioactive agents. There are a lot of bioactive materials that could be incorporated into liposomes including cosmetics, food ingredients, and pharmaceuticals. Liposomes possess particular properties such as biocompatibility, biodegradability; accompanied by their nanosize they ha...

Ethnopharmacological relevance: The Asteraceae (alt. Compositae) family incorporates a large number of flowering plants, which have been classified under ca. 1600 genera covering more than 23,000 species. The genus Achillea is one of the best-known genera of this family. The Achillea species are important for their uses in the chemical and pharmac...

The present study describes the potential capabilities of an efficient extraction technique, namely headspace solid-phase microextraction (HS-SPME) to isolate the volatile fractions from the flowers, leaves and stems of Marrubium anisodon in combination with the analysis by GC and GC-MS. By means of the HS-SPME method, 24, 16 and 24 components were...

The aim of this research was to investigate chemical compositions, antibacterial properties and in vitro and in vivo antioxidant properties of essential oil and methanol and ethanol extracts of Feoniculum vulgare. Antimicrobial properties of Feoniculum vulgare essential oil and extracts against pathogenic bacteria, fungi, and yeast were determined...

The volatile fractions isolated from the ground aerial parts of Satureja hortensis were trapped using the headspace solid phase microextraction (HS-SPME) strategy and subsequently monitored using gas chromatography in combination with mass spectrometry (GC-MS) instrumentation. Eleven constituents were totally recognized in the analyzed volatile par...

Gold nanoparticles (AuNPs) due to their unique properties and manifold surface functionalities have been applied in bio-nanotechnology. The application of GNPs in recent medical and biological research is very extensive. Especially it involves applications such as detection and photothermalysis of microorganisms and cancer stem cells, biosensors; o...

The present work is mainly focused on relative abilities of three different extraction techniques, namely hydrodistillation (HD), solvent-free microwave extraction (SFME) and headspace solid-phase microextraction (HS-SPME) to separate the essential oils and volatile fractions from stems, leaves and fruits of Artemisia absinthium L., in combination...

In this work, the volatile profile from the aerial parts of S. lavandulifolia using the HSSPME- GC-MS technique along with phytochemical evaluations involving antioxidant and antibacterial activities of its methanolic extract have been screened. Volatile fractions were trapped on an SPME fiber and immediately transferred onto the injection port of...

Cancer is a main public health problem that is known as a malignant tumor and out-of-control cell growth, with the potential to assault or spread to other parts of the body. Recently, remarkable efforts have been devoted to develop nanotechnology to improve the delivery of anticancer drug to tumor tissue as minimizing its distribution and toxicity...

Latest nanotechnological advances propose that nanoparticles have been predictable to be used in different fields. Nanomaterials are used in a extensive diversity of commercial goods for example electronic components, sports equipment, sun creams and biomedical applications. Employing nanoparticles in medicine is ever increasing, and it is signific...

Approximately 35 million people worldwide suffer from Alzheimer’s disease (AD). The cellular uptake and specific transport of drugs and imaging agents to brain are common issues in the diagnosis and therapy of AD. New advances in nanotechnology have supplied favorable solutions to this issue. Various nanocarriers such as polymeric nanoparticles, li...

In this study, microwave assisted hydrodistillation (MAHD) technique was successfully used to separate volatile essential oils from flowers and leaves of Marsdenia erecta. The obtained oils were subsequently analyzed using the gas chromatography combined with the mass spectrometriy (GC-MS) technique. A total of 19 and 15 compounds were identified i...

Volatile constituent components from aerial parts of Ziziphora capitata L. were successfully separated using headspace solid-phase microextraction (HS-SPME) approach, and were subsequently analyzed by means of GC and GC-MS instruments. The major volatile compounds were found to be pulegone (23.8%), p-mentha-3,8-diene (17.0%), α-pinene (11.4%), β-pi...

Diagnosis and treatment of lung cancer have been characterized with a variety of challenges. However, with the advancement in magnetic nanoparticle (MNP) technology, many challenges in the diagnosis and treatment of lung cancer are on the decline. The MNPs have led to many break-through in cancer therapy. This paper seeks to establish the role of M...

The volatile oil obtained by hydro-distillation (HD) from the aerial parts of Satureja mutica Fisch. & C.A. Mey. has been analyzed by means of GC and GC-MS. The major components of the oil were found to be carvacrol (34.1%), thymol (22%), ρ-cymene (16.2%) and γ-terpinene (12.6%). Furthermore, a reliable quantitative structure-retention relationship...

The Lamiaceae family consists of a broad spectrum of medicinal plants involving Marrubium L. genus. Regarding the diverse pharmaceutical uses of the plants belonging to this genus, they can be considered as proper alternatives for chemical drugs having harmful effects. The present work aims to identify and characterize chemical compositions of the...

A robust and reliable quantitative structure-property relationship (QSPR) study was established to forecast the melting points (MPs) of a diverse and long set including 250 drug-like compounds. Based on the calculated descriptors by Dragon software package, to detect homogeneities and to split the whole dataset into training and test sets, a princi...

Chemical profiles of the essential oils and volatile compounds from the aerial parts of Achillea wilhelmsii C. Koch (Compositae) obtained through hydrodistillation (HD), solvent-free microwave extraction (SFME), microwave assisted hydrodistillation (MAHD) and headspace solid-phase microextraction (HS-SPME) methods were subsequently investigated by...

The present work mainly describes the relative abilities of two different extraction techniques, namely hydrodistillation (HD), and microwave assisted hydrodistillation (MAHD) to separate the essential oils from the aerial parts of Artemisia sieberi, in combination with analysis by GC and GC-MS. By means of the HD method, 47 components were identif...

Background & Aim: Nepeta racemosa is an herbal and medicinal plant and this report aims to identify chemical compositions of the essential oils and volatiles of its aerial parts through classical and advanced methods. Experimental: Chemical profiles of the essential oils and volatile compounds from the aerial parts of Nepeta racemosa obtained throu...

The essential oils and volatiles obtained through a variety of techniques involving microwave-assisted hydrodistillation (MAHD), solvent-free microwave extraction (SFME) and headspace solid-phase microextraction (HS-SPME) from flowers, stems and roots of Salvia multicaulis Vahl., a plant growing wild in Semnan Province (Iran), were analyzed by the...

Volatile oils obtained by hyrodistillation (HD) and solvent free microwave extraction (SFME) from the aerial parts of Ferula gummosa (Apiaceae) were analyzed by means of GC and GC-MS. A total of forty two compounds were identified in the hyrodistilled oil accounting for 96.5 % of the oil, of which γ-elemene (14.1 %), germacrene B (11.8 %), (E)-γ-bi...

Microwave assisted hydrodistillation (MAHD) was applied for the extraction of the essential oil from the aerial parts (tops) of Thymus pubescens. The MAHD method has been compared with conventional hydrodistillation (HD) technique, in terms of extraction time, yields and chemical compositions of the essential oils. The obtained results show similar...

The objective of this study was to evaluate the influence of different wall material component in the microencapsulation of kilka oil (clupeonella cultriventris caspia) by freeze drying. In this study, kilka oil as a core material was microencapsulated with Maltodextrin (MD), Sodium Caseinate (SC), whey protein concentrate (WPC) and modified starch...

The quantitative structure activity relationship (QSAR) of the novel 4-aminopyrimidine-5-carbaldehyde oxime derivatives as effective and selective inhibitors of potent VEGFR-2 was studied. A suitable set of the molecular descriptors was calculated and the most impressive descriptors were subsequently selected using genetic algorithm (GA) variable s...

Volatile constituents from minimal amounts of flowers, leaves and stems of Salvia mirzayanii were obtained using a manual headspace solid phase microextraction (HS-SPME) device equipped with four types of commercially available fibers, namely polydimethylsiloxane (PDMS), polydimethylsiloxane-carboxene (PDMS-CAR), polydimethylsiloxane-divinylbenzene...

The quantitative structure activity relationship (QSAR) of the novel 4-aminopyrimidine-5-carbaldehyde oxime derivatives as effective and selective inhibitors of potent VEGFR-2 was studied. A suitable set of the molecular descriptors was calculated and the most impressive descriptors were subsequently selected using genetic algorithm (GA) variable s...

The present study was designed to identify the chemical composition of essential oil and evaluate in-vitro antibacterial activity of methanolic extract of Stachys lavandulifolia Vahl. against some clinical isolates. The essential oil of S. lavandulifolia Vahl. was obtained by headspace solid phase microextraction (HSSPME) method. The HS-SPME couple...

Correction for ‘Chemical composition of the essential oils from the hulls of Pistacia vera L. by using magnetic nanoparticle-assisted microwave (MW) distillation: comparison with routine MW and conventional hydrodistillation’ by Hamid Hashemi-Moghaddam et al., Anal. Methods, 2014, 6, 2572–2579.

This study was mainly designed to investigate and identify the amounts and types of heavy metals in the soils of National Iranian Oil Refining & Distribution Company in Shahrood region and tried to establish a logical relation between the presence of heavy metals and their damage on vegetation. In addition, considering the power of drained soil and...

The present study describes the potential capabilities of four different extraction techniques, namely hydrodistillation (HD), solvent-free microwave extraction (SFME), microwave assisted hydrodistillation (MWHD) and headspace solid-phase microextraction (HS-SPME) to isolate the essential oils and volatile fractions from the aerial parts of Ferula...

Volatile fractions in the essential oils (EOs) obtained from the peels of Citrus sinensis CV. Thomson Navel by head-space solid phase micro-extraction (HS-SPME), single drop micro-extraction (SDME) and cold-press (CP) techniques were analyzed by means of gas chromatography-mass spectrometry (GC-MS). Fifteen, nine and fourteen compounds were identif...

Homogeneous liquid–liquid microextraction via flotation assistance (HLLME-FA) and high-performance liquid chromatography-UV detection was presented for the extraction and determination of abamectin in aquatic samples. Toluene at microliter volume level and acetone were used as extraction and homogeneous solvents, respectively. In this research, a s...

The main goal of this study is to establish robust theoretical models for prediction of pIC values related to arylsulfonylpiperazines. After drawing the molecular structures, a suitable set of molecular descriptors that fulfill the best fitted models were selected using genetic algorithm. Three models were proposed for prediction of experimental re...

A reliable quantitative structure retention relationship (QSRR) study has been evaluated to predict the retention indices (RIs) of a broad spectrum of compounds, namely 118 non-linear, cyclic and heterocyclic terpenoids (both saturated and unsaturated), on an HP-5MS fused silica column. A principal component analysis showed that seven compounds lay...

This study reports a very selective, easy, and precise method for rapid separation of trace amounts of copper in aqueous samples using octadecyl silica-bonded phase membrane disks modified by 2,2'-[ethane-1,2-diylbis(thio)]dianiline (EDTD) combined with flame atomic absorption spectrometric determination. In addition, the synthesis and spectral cha...

In this paper, classical hydrodistillation (HD) and microwave assisted hydrodistillation (MAHD) are used for extraction of Pistachio hull essential oil combined with subsequent gas chromatographic mass spectrometric (GC-MS) determination. The major focus is on synthesis of amine-functionalized magnetite nanoparticles (AFMN) and their effects on ess...