Majid Jabir

• PhD in Immunology / University of Glasgow/UK
• University of Technology - Iraq

Photoelectrochemical (PEC) techniques seamlessly combine electrochemical and spectroscopic principles, offering a powerful platform for the detection of biomarkers and biological molecules in clinical and biomedical settings. This review provides a comprehensive overview of microfluidic PEC probes, emphasizing their potential for ultrasensitive det...

The only subtype of breast cancer (BC) without specific therapy is triple-negative breast cancer (TNBC), which represents 15–20% of incidence cases of BC. TNBC encompasses transformed and nonmalignant cells, including cancer-associated fibroblasts (CAF), endothelial vasculature, and tumor-infiltrating cells. These nonmalignant cells, soluble factor...

In this research, Mesoporous silica KIT-6 nanoparticles were synthesized and functionalized through post-grafting method with (3-Aminopropyl) trimethoxysilane to form (KIT6-NH2) as a carrier for LOX loading and release. The synthesized materials were characterized using FTIR, XRD, N2 physisorption, TEM, SEM, and TGA. The adsorption efficiency was s...

The developments that have been made in nanoscience and nanotechnology have made a substantial contribution to the widespread use of nanomaterials that are based on metals across a wide range of scientific fields, institutes, and industries. The eco-friendly production of metal nanomaterials via plant derivatives has become crucial in sustainable m...

Staphylokinase is a virulence factor produced by Staphylococcus aureus that enhances its ability to degrade proteins, contributing to tissue damage and increased bacterial invasiveness. This investigation studied staphylokinase production by S. aureus isolates obtained from wound and burn patients. Optimal conditions for enhancing staphylokinase pr...

Cobalt chromite nanoparticles (CoCr2O4 NPs) have emerged as an engrossing material class because of their wide range of uses spanning catalysis, magnetic recording, biomedical engineering, and environmental remediation. This review has addressed all the available literature and described the synthetic strategies, characteristics, and applications o...

In this study, Borago officinalis flower extract was performed for green synthesis of silver nanoparticles (AgNPs) and Zinc Oxide (ZnONPs). The plant extract played essential roles as a stabilising and reducing agent. The aim of the current study was to evaluate the pharmaceutical applications for green fabricated ZnO NPs and Ag NPs such as antibac...

A label‐free electrochemical immunosensor based on the zeolitic imidazolate framework‐8 (ZIF8)/bismuth ferrite (BFO) nanocomposite was fabricated for the specific and sensitive quantification of prostate‐specific antigen (PSA). The ZIF8‐BFO material not only increases the surface area effectively but also enhances the catalytic capability of the el...

This study investigates the synthesis of gold nanoparticle (Au NP)–doped carbon nanofibers (CNFs) via laser ablation, followed by dispersion in dimethylformamide (DMF), with controlled doping achieved by varying the number of laser pulses. Structural and morphological characterizations were conducted using field emission scanning electron microscop...

Background Ticks are blood-feeding ectoparasites that can transmit different diseases in livestock and humans. Globally, 994 tick species are recognized, belonging to three families, that is, Argasidae (220 species), Ixodidae (773 species) and Nuttalliellidae (one species). The current study investigated the impact of geo-climatic conditions on the...

The EZH2 gene encodes an enzyme that is part of the epigenetic factor Polycomb Repressive Complex 2 (PRC2). In order to control gene expression, PRC2 mainly modifies chromatin structure. In this complex process, EZH2 methylates histone proteins, which in turn suppresses further RNA transcriptions. As a result, EZH2 dysregulations can occasionally i...

Macrophages are key tumor microenvironment (TME) regulators, exhibiting remarkable plasticity that enables them to either suppress or promote cancer progression. Emerging evidence highlights the critical role of macrophage-derived long non-coding RNAs (lncRNAs) in shaping tumor immunity, influencing macrophage polarization, immune evasion, angiogen...

In this manuscript, numerical analysis in graphene-wrapped cylindrical waveguide filled with lithium fluoride (LiF) in terahertz (THz) frequency regime. Transfer matrix technique is used to derive the characteristics curve. The analysis of surface plasmon polaritons (SPPs) at the graphene-LiF interface is examined under various parameters, includin...

Background Evidence shows that vitamin D affects brain function. Transcription of over 1000 genes is known to be controlled by vitamin D, potentially contributing to the neurotrophic and neuroprotective effects that can influence suicidal behavior. Several investigations with contradicting findings have identified an association between suicidal be...

The green synthesis approach has drawn a lot of interest as an environmentally friendly and sustainable acceptable means of producing a diverse range of nanoparticles (NPs). This piece described a rapid approach for synthesizing selenium nanoparticles (SeNPs) with grape seed extract. A biologically active composition of selenium-chitosan nanopartic...

In this study, the chemometrics method of kinetic regression–based PLS2 (partial least squares) was used for the simultaneous determination of tetracycline (TECY) and phenylephrine (PHRN) in binary mixtures and commercial formulations. The proposed method is based on the use of kinetic-spectrophotometric data coupled with PLS2 multivariate calibrat...

In this study, we explore the plasmonic properties of a cylindrical waveguide filled with lithium fluoride (LiF) layers sandwiched between graphene sheets, analyzing the effective mode index and permittivity variations across different frequencies and chemical potentials. Our results reveal that both the effective mode index and permittivity are hi...

The structural and electronic behavior of thiosemicarbazone (TSC)-based metal complexes of Mn (II), Fe (II), and Ni (II) have been investigated. The synthesized metal complexes were characterized using elemental analysis, magnetic susceptibility, molar conductivity, FTIR, and UV–Vis spectroscopy, the computational path helped with further structura...

RNA interference (RNAi) is a primordial biological process that protects against external intrusion. SiRNA has the potential to selectively silence disease-related genes in a sequence-specific way, thus offering a promising therapeutic approach. The efficacy of siRNA-based therapies in cancer treatment has gained significant recognition due to mult...

Graves disease (GD), an autoimmune disease affects the thyroid gland, results in hyperthyroidisms and goiter. The main cause of GD is not clearly defined; however, stimulating autoantibodies for thyroid stimulating hormone receptor (TSHR) known as thyroid-stimulating immunoglobulins (TSIs) are the primary proposed mechanism. The TSI activation of T...

Background Xanthones are dubbed as putative lead-like molecules for cancer drug design and discovery. This study was aimed at the synthesis, characterization, and in silico target fishing of novel xanthone derivatives. Methods The products of reactions of xanthydrol with urea, thiourea, and thiosemicarbazide reacted with α-haloketones to prepare t...

Green sources are superior to conventional chemical sources because they are less expensive, produce less contamination, and promote natural and human well-being and security. The invasive plant Lantana camara (L. camara) has become a valuable resource for the environmentally benign synthesis of metallic nanoparticles (NPs), emphasizing the concept...

This study has applied the density functional theory (DFT) to calculate the structural, magnetoelectronic, optical, and thermoelectric characteristics of Cs2XMoBr6 (X = Li, Na). The magnetic stability of studied compounds is examined by minimizing their total ground state energies. Also, both compounds exhibit cubic stability by tolerance factor as...

Background Phosphodiesterase-4 is an enzyme that regulates immune responses and contributes to the development of psoriasis. Dipyridamole and roflumilast function as phosphodiesterase-4 inhibitors, reducing pro-inflammatory cytokine expression. The aim was to evaluate the anti-psoriatic effect of the topical administration of dipyridamole and roflu...

It has been established that the Hydrazone derivatives have important pharmacological effects. In the first step, hydrazine (NH2NH2) reacts with a compound containing a carbonyl group (C = O) in the presence of ethanol and heat, leading to the formation of hydrazone compound (H1). The second step is the formation of the Schiff base (H2) by the reac...

Zinc (Zn) and iron (Fe) are necessary for structural and metabolic functions of the body like, immune competence, physical growth, reproductive function, and neurobehavioral development. The deficiency of micronutrients is a severe public health distress in nearly all developing countries which leads to the syndrome of malnutrition mostly in childr...

Silver nanoparticles (AgNPs) were produced using diverse techniques, but each had negative implications. Physical procedures are expensive and inefficient, whereas chemical methods are highly poisonous and unstable. Researchers have discovered a novel way to create AgNPs using fungi, bacteria, actinomycetes, and plants. The process is known as bios...

In the current study, we used an environmentally friendly method called pulsed laser irradiation for the prep- aration of AuNPs and hydroxyapatite NPs alone and as a composite nanomaterials. The optical, morphology, and chemical bonding possessions of prepared AuNPs, hydroxyapatite NPs, and Au-hydroxyapatite composites were studied using different...

In the current study, we used an environmentally friendly method called pulsed laser irradiation for the preparation of AuNPs and hydroxyapatite NPs alone and as a composite nanomaterials. The optical, morphology, and chemical bonding possessions of prepared AuNPs, hydroxyapatite NPs, and Au-hydroxyapatite composites were studied using different te...

This study explores the use of graphene oxide (GO) modified with PyrCO-cyclo@Fe as an efficient and selective catalyst. The modification of GO with PyrCO-cyclo@Fe provides a robust platform for the synthesis of (S)-2-phenylpropanoic acid derivatives 4(a–l), facilitated by the presence of choline chloride ethylene glycol (ChCl/EGC) as the electrolyt...

The use of plant extracts as potent reducing agents for the environmentally friendly production of nanoparticles (NPs) has recently attracted the interest of scientists. NPs have received high attention because of their novel properties. The aim of the present study is to biosynthesize zinc oxide nanoparticles (ZnO NPs) using Raphanus sativus and s...

Nanotechnology is widely regarded as a transformative force in the twenty-first century, revolutionizing various aspects of modern life. Over time, nanotechnology has made significant progress, with one notable area of focus being the eco-friendly fabrication of cadmium oxide nanoparticles (CdO NPs). Green-synthesized CdO NPs find extensive applica...

This work reports the electrochemical fabrication of thin films comprising polyaniline nanofibers (PANI) in conjunction with graphene oxide (GO) and reduced graphene oxide (rGO) on ITO substrate, along with examining the electrochemical properties, with a focus on the influence of the substrate and electrolyte in the electrodeposition methods. The...

Background Single-walled (SWCNTs) and multi-walled carbon nanotubes (MWCNTs) can pose risks in biological systems leading to harmful effects, such as, reactive oxygen species (ROS) formation, DNA damage, mitochondrial dysfunction, and ultimately, the cell death through apoptosis. Objectives The study assessed the nephrotoxicity of the SWCNTs and SW...

This study reports the facile hydrothermal synthesis of pure Bi2WO6 and Bi2WO6\MWCNTs nanocomposite at specific molar ratio 1:2.5 of Bi2WO6:MWCNTs and elucidates their role in modulating the NLRP3 inflammasome pathway via autophagy induction. Comprehensive characterization techniques, including XRD, Raman, UV.Vis PL,FESEM,EDS and TEM, revealed the...

Personalized radiation therapy in Nuclear Medicine aims to tailor treatment regimens to individual patients based on their unique biological characteristics. Recent advancements in radiobiology techniques offer promising avenues for achieving this goal. This review explores key developments in radiobiology, including molecular imaging, radiomics, b...

Laser ablation in liquid (LAL) in recent years has emerged as a promising approach for the synthesis of industrial and functional nanomaterials. In this study, LAL was used to synthesize Au@WO3 core–shell nanoparticles under various preparation conditions without the use of a catalyst. The optical characteristics of the resulting colloid confirmed...

Inflammatory bowel disease (IBD) is an idiopathic disease caused by a dysregulated immune response to host intestinal microflora. A hyperactive inflammatory and immunological response in the gut has been shown to be one of the disease’s long-term causes despite the complexity of the clinical pathology of IBD. The innate immune system activator know...

The phagocytic activities of various immune cells can be enhanced by the use of medicinal preparations that can confer physiological homeostasis through the elimination of both pathogenic material and cells experiencing apoptosis. Nevertheless, studies on the achievement of this kind of reaction by the use of 2-(benzhydrylsulfinyl)-N-sec-butylaceta...

Meticulous electrode design is pivotal in advancing greener and more sustainable electro‐organic synthesis practices. In this research, our team designed and synthesized a copper‐doped electrode on multiwalled carbon nanotubes (MWCNTs) and characterized it using Fourier transform infrared spectroscopy (FT‐IR), scanning electron microscopy (SEM), en...

The utilization of plant bioactive composites has concerned substantial attention due to their possible use in the development of novel antibiotics, containing the environmentally sustainable synthesis of nanoparticles. In the current study, a green and eco-friendly process was employed to synthesize silver nanoparticles (Ag-NPs) and to evaluate th...

This work looks at the production, description, and biological assessment of platinum nanoparticles that were created using an ablation pulse laser, an effective physical strategy for creating nanotechnology, especially when solids are ablated in liquid conditions. This process yields highly pure nanoparticles and is far less complicated than chemi...

The novel material halide double perovskites Cs2TlYF6 (Y = Ag, Co) are the potential candidates for thermoelectric and photovoltaic devices. The ground state and temperature dependent electronic transport properties are computed for Cs2TlYF6 (Y = Ag, Co) by utilizing density functional theory as employed within WIEN2k package. The negative energy o...

In this manuscript, a theoretical investigation of SPPs generated at magnetized plasma–graphene interface is presented. To model graphene conductivity, Kubo formula is utilized, and impedance boundary conditions are applied to obtain dispersion relation. In the presence of strong anisotropy of the plasma medium, the behaviors of the lower and upper...

Iron oxide nanoparticles have been extensively used for different biomedical purposes, especially for targeted drug delivery, and gene transfers, owing to their unique features, i.e., small size, low toxicity, magnetism, and the ability to be chemically surface-modified with various biocompatible and biodegradable polymers, as well as other chemica...

A pulsed laser was used to make the Au@Ag@Au core-double shell nanoparticles in a DMF solution. The samples were characterized and inspected to confirm the structure investigated by XRD tests, and the average crystallite size was 51.988, 51.222, and 47.482 nm at laser energy 300, 500, and 700 mJ, respectively. Transmission electron microscopy (TEM)...

In the present study, a simple and low-cost spectrophotometric method was reported for the quantification of selenium. The method was based on the surface manipulation of citrate-capped silver nanoparticles by selenium in ammonia-ammonium nitrate buffer solution (pH = 9). Citric acid on the surface of nanoparticles could reduce selenium ions to Se⁰...

The magnetite nanoparticles Fe3O4 capped with polyethylene glycol PEG were prepared by hydrothermal method. Due to the successful coating of PEG molecules on the surface of Fe3O4, these nanoparticles exhibited excellent dispersibility and dissolvability in physiological condition. The obtained nanoparticles were characterized by transmission electr...

Drug-resistant pathogens are the primary cause of morbidity and mortality, resulting in the deaths of over 15 million people worldwide. Nanoparticles present a possible technique for improving the effectiveness of drugs and creating efficient carriers for drug delivery. In this context, the antibacterial efficacy of the Nystatin (NYS) against both...

Our research involved the synthesis of a double core-shell structure using gold and silver NPs. The core material used was gold. The initial shell had a silver coating, while the subsequent shell was encased in gold. The wavelength of the laser was 1046 nm and was employed, along with 250 pulses at a frequency of 1 Hz, delivering an energy of 500 m...

Graphene-based materials have been the subject of extensive research due to its exceptional ability to kill a diverse array of microorganisms. The benefits of graphene-based materials include ease of fabrication, renewable resources, special catalytic properties, and remarkable physical properties including tensile strength and a large specific sur...

Lateral flow assays (LFAs) offer some attractive features that are utilized as portable devices in food safety control. However, these platforms have faced challenges such as low specificity, poor detection ability, providing only semi-quantitative and qualitative results, limiting their practical uses. These challenges may sometimes produce false...

Conventional cancer therapies can have significant adverse effects as they are not targeted to cancer cells and may damage healthy cells. Single-stranded oligonucleotides assembled in a particular architecture, known as aptamers, enable them to attach selectively to target areas. Usually, they are created by Systematic Evolution of Ligand by Expone...

Presently, the utilization of nanomaterials has evolved as an appealing alternative for ever-changing healthcare obstacles due to their distinctive features and multifunctional applications. This work aimed to fabricate and analyze novel NiO/Ni2O3 nanoparticles (NPs) using Sargassum tentorium extracts and investigate their antioxidant and anticance...

In this manuscript, we have developed a model for a graphene-loaded surface plasmon polariton waveguide surrounded by uniaxial chiral and plasma layers. Electromagnetic wave theory is utilized to solve numerical problems. Graphene conductivity is modeled physically using the Kubo formula, described in the “Methodology” section. The characteristic e...

Zinc oxide nanoparticles (ZnONPs) are widely used nanoparticles due to their remarkable antibacterial properties. In this study, we present a novel approach for synthesizing ZnONPs using chemical precipitation techniques and incorporating polyethylene glycol-300 (PEG-300) as an intermediate compound, facilitating the nystatin (NYS) and ZnONP linkag...

In this manuscript, characteristics of photon–plasmon coupling in uniaxial chiral-filled slab waveguide bounded by graphene layers are analyzed. We have explored some novel features of surface plasmon polaritons (SPPs) owing to the interaction between uniaxial chiral and graphene layers. The influence of graphene’s features and chirality on the SPP...

Macroautophagy/autophagy is an essential degradation process that removes abnormal cellular components, maintains homeostasis within cells, and provides nutrition during starvation. Activated autophagy enhances cell survival during stressful conditions, although overactivation of autophagy triggers induction of autophagic cell death. Therefore, ear...

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of motor neurons characterized by muscle weakness, muscle twitching, and muscle wasting. ALS is regarded as the third-most frequent neurodegenerative disease, subsequent to Alzheimer's disease (AD) and Parkinson's disease (PD). The World Health Organization (WHO) in 2007...

New 3-furan-1-thiophene-based chalcones were synthesized, characterized and pharmacologically evaluated as antibacterial and anticancer agents against two bacterial species; Gram-positive (Streptococcus pyogenes) and Gram-negative (Pseudomonas aeruginosa). All tested final compounds were active against the two bacterial species; S. pyogenes and P....

Abstract Objectives This study investigates the impact of injected fish-scale-derived hydroxyapatite nanoparticles (FsHA-NPs) on orthodontic tooth movement (OTM) and the width of the periodontal ligament (PDL) space. Materials and Methods Twenty-six Wistar rats underwent mesial orthodontic traction with a force of 50 g for 21 days. Following the a...

This study investigates the molecular prevalence and phylogenetic characteristics of two prominent blood-borne pathogens, Toxoplasma gondii (T. gondii) and Plasmodium spp., in common quails (Coturnix coturnix) sampled from both wild (N = 236) and farmed (N = 197) populations across four districts (Layyah, Dera Ghazi Khan, Lahore, and Multan) in Pun...

Depression is a mood disorder that may increase risk for the development of insulin resistance (IR) and type 2 diabetes (T2D), and vice versa. However, the mechanistic pathway linking depression and T2D is not fully elucidated. The aim of this narrative review, therefore, was to discuss the possible link between depression and T2D. The coexistence...

In this study, our primary objective was to synthesize and characterize a copper nanoparticle-modified oxidized graphite carbon nitride (ox-g-C3N4). This modified ox-g-C3N4 material was utilized as a reusable catalyst for the environmentally friendly production of benzofuran 4(a-j) derivatives through C–H activation using an electrochemical oxidati...

Designing efficient, non-fused ring-based organic solar cells (OSCs) with high open circuit voltage is a significant challenge. The present research proposes seven novel moieties generated from an existing 4T2CSi-4F (R) asymmetric molecule to increase efficiency. The density functional theory (DFT) was used to examine several essential characterist...

In the present work, we used a pulsed laser deposition technique to embed TiO2 nanostructure on porous silicon substrates using a pulsed laser deposition process. Nanocrystalline porous silicon was synthesized using the photo-assisted electrochemical method. The study analyzed the optoelectronic characteristics of double junctions of TiO2/PS/n-Si s...

In this manuscript, numerical investigations at the chiroplasma-metal planar interface have been performed to explore some features of surface plasmon polaritons (SPPs). Based on the electromagnetic wave theory, we derive a dispersion relation. The effect of tensorial permittivity parameters on effective mode index and propagation loss is analyzed...

An essential research area for scientists is the development of high-performing, inexpensive, non-toxic antibacterial materials that prevent the transfer of bacteria. In this study, pure Bi2WO6 and Bi2WO6/MWCNTs nanocomposite were prepared by hydrothermal method. A series of characterization results by using XRD FTIR, Raman, FESEM, TEM, and EDS ana...