Majid Asadi-Samani

• PhD (Biomedical Sciences-Medical Immunology)
• PhD at Shahrekord University of Medical Sciences

Background: Background: Curcumin possesses numerous properties, including anti-influenza effects. Various natural analogs and metabolites of curcumin have been identified. Objective Objective: To better understand the mechanism of curcumin's anti-influenza effect, the inhibitory effect of natural analogs and secondary metabolites of curcumin on 11...

Background Despite the availability of chemotherapy drugs such as 5-fluorouracil (5-FU), the treatment of some cancers such as gastric cancer remains challenging due to drug resistance and side effects. This study aimed to investigate the effect of celastrol in combination with the chemotherapy drug 5-FU on proliferation and induction of apoptosis...

Background and aims: Herpes simplex type 1 (HSV-1) is one of the most common and contagious viruses in humans. Curcumin is a natural polyphenol that produces antiviral effects against various viruses, such as HSVs. Despite curcumin’s numerous effects and benefits, its insolubility has reduced its clinical effectiveness. During recent decades, signi...

Influenza neuraminidase (NA) plays a main role in the viral replication of the influenza virus. It has been considered one of the targets for anti-influenza drugs. Anti-influenza drugs such as zanamivir, oseltamivir, and peramivir can fight the virus via the inhibition of NA. However, due to adverse reactions, the resistance of the viral strains an...

Introduction: Due to the high prevalence and drug resistance reported for the influenza virus in recent years, much research is being conducted on the discovery and introduction of more effective drugs against the virus. In this regard, the present bioinformatics study examined the inhibitory effects of berberine, a plant-based alkaloid, on influen...

Corticosteroids improve the complications of Covid-19 but may cause some side effects such as hyperglycemia. Royal jelly is one of the bee products that exert anti-inflammatory, insulin-like, and hypoglycemic activities. The present study was conducted to investigate the effect of royal jelly capsules on blood sugar and the clinical course of Covid...

Background: Estimation of seroprevalence of COVID-19 antibodies can be used to predict the epidemic more accurately and estimate the vulnerability of the community, gain information on disease progression, and manage disease treatment. Aims: The present study was designed to evaluate the seroprevalence of IgG antibodies against the COVID-19 virus i...

Background and aims: Due to the different levels of exposure of different people to the coronavirus and different levels of immune response among them, this study was designed to investigate the humoral immune responses against the coronavirus disease 2019 (COVID-19) in healthcare staff in hospitals and medical centers admitting COVID-19 patients....

Background This study aimed to investigate the effects of the miR-221 inhibition on the human B-chronic lymphocytic leukemia (B-CLL) cell viability and the p27 gene expression, to introduce a new treatment approach for this type of cancer. In this context, the cyclin-dependent kinase (Cdk) inhibitor 1B (p27 Kip1 ) is considered as an enzyme inhibit...

Introduction: Despite large studies on the COVID-19 pandemic, little evidence is available on immune response in recovered patients. Objectives: The aim of this study was to investigate the humoral immune responses (IgM and IgG antibodies) in recovered COVID-19 patients and the role of risk factors and symptoms with respect to the immune responses....

Objective: To compare the effects of intravenous dexamethasone and methylprednisolone on the treatment of inpatients with COVID-19. Methods: In this randomized clinical trial, 143 patients under 80 years of age with moderate to severe COVID-19 were enrolled and randomly assigned to two groups: dexamethasone (8 mg/day) and methylprednisolone (60...

Background Several diagnostic methods have been proposed and evaluated for the COVID-19 disease. However, the published studies have reported different diagnostic values for these methods. Aims The present study aimed to evaluate the diagnostic performance and accuracy of CT in the novel corona virus disease (COVID-19) and to develop and present a...

Background The miRNAs have been shown to be involved in breast cancer. The aim of the present research was to evaluate the impacts of extract from Euphorbia szovitsii Fisch & C.A. Mey on the expression level of microRNAs in triple-negative breast cancer (MDA-MB-231) cell line. Methods and Result The alterations in the expression level of miRNAs in...

Background & objectives: Cyclin-dependent kinase 2 (CDK-2) is a serine/threonine protein kinase with regulatory activity in the cell cycle. Inhibitors of this protein are the treatment of choice for a variety of cancers by stopping the cell cycle. In this in silico study, the effects of docking and molecular dynamics of Abemaciclib, Hymenialdisine,...

Background A large number of Euphorbia species have been evaluated for anticancer effects; however, their anticancer mechanisms have not been established up to now. Objective The present study aimed to evaluate the effects of Euphorbia microsciadia (E. microsciadia) Boiss on the modulation of micro (mi) RNAs in MDA-MB-231 cell line. Methods As th...

Background As one of the most commonly diagnosed cancers among men and women, colorectal cancer (CRC) leads to high rates of morbidity and mortality across the globe. Recent anti-CRC therapies are now targeting specific signaling pathways involved in colorectal carcinogenesis. Ubiquitin proteasome system (UPS) and autophagy are two main protein qua...

Background: Cyclin-Dependent Kinases-6 (CDK-6) is a serine/threonine protein kinase with regular activity in the cell cycle. Some inhibitors, such as abemaciclib, hymenialdisine, and indirubin, cause cell arrest by decreasing its activity. Objectives: The purpose of this study was to evaluate the Molecular Dynamic (MD) effects of abemaciclib, hy...

Background: Plants have long served as a rich source of drugs. Given some microorganisms’ acquisition of resistance to the current antibiotics, there is a need for discovering new drugs. Objectives: The aim of the present study was to investigate the phytochemical properties and antibacterial effects of Salvia multicaulis Vahl., Euphorbia microscia...

Resumen Context: Breast cancer is one of the most prevalent cancers that causes substantial numbers of deaths among women, worldwide. Medicinal plants can be used for discovering new anti-breast cancer drugs. Aims: To investigate the antioxidant effects of twenty Iranian herbs and their anticancer effects against breast cancer cell lines (i.e. MDA-...

The study of phytochemical compounds of plants grown in different regions can reveal their biological potentials for the identification and discovery of effective drugs. This study was conducted to investigate the total phenolic and flavonoid content of twenty Iranian medicinal plants. The plants were gathered from Chaharmahal va Bakhtyari and thei...

Some medicinal herbs and compounds are known to target cancer cells, but the success of them as anticancer compounds depends to a large extent on their ability to activate pathways that kill cancer cells by arresting cell cycle and inducing apoptosis. The aim of the present study was to determine the anticancer effects of Euphorbia szovitsii Fisch....

This Book is in Persian and around using some useful medicinal plants which effect on cancer therapy.I ll appreciate my Parents who support and supported me ever.I thank my nice friend Mr Majid Asadi-Samani for being as nice pal.I ll invite all to read and prepare it

The article dealt more on the relaxant properties of three plants

Background: In traditional medicine, Euphorbia was used to treat inflammations, tumors, gout, back pain, sciatica, arthritis, pneumonia, intestinal parasites, gonorrhea, and skin diseases. The species of this genus that distribute in most regions worldwide studied to discover and produce effective medicines because they contain valuable active comp...

Background: Prostate cancer has been known as one of the most common malignancy in the men and it is therefore very important to prevent and treat this cancer. In this study, the anticancer effects of 20 species of medicinal plants in Iran, especially those grown in Chaharmahal and Bakhtiari province, were investigated on prostate cancer cell line...

Background: Since drug resistance has become one of the predominant problems of health worldwide, it is necessary to use new methods to combat drug-resistant bacteria. In this regard, medicinal plants are considered one of the richest sources to produce antibiotics. The aim of this study was to investigate the antibacterial effects as well as total...

Cancer is the second cause of death after cardiovascular diseases. With due attention to rapid progress in the phytochemical study of plants, they are becoming popular because of their anticancer effects. The aim of this study was to investigate the effective medicinal plants in the treatment of cancer and study their mechanism of action. In order...

Hearing loss as one of the most common disabilities approximately over 5% of the world's population - 360 million people - has disabling hearing loss (328 million adults and 32 million children). Recent developments in stem cell technology provide new opportunities for the treatment of deafness. miRNAs are essential factors of an extensively conser...

MicroRNAs consist of 18 to 25 non-coding ribonucleic acids (RNA) that can act as oncogenes or tumor suppressors and in which mutations can lead to cancer. The identification of microRNAs and their target molecules has created a new horizon for studies of causes of cancer. MicroRNAs can be used as potential biological markers in diagnosis, predictio...

Background and Aims: Free-radical-mediated peroxidation of membrane lipids and oxidative damage of DNA and proteins are believed to be associated with a variety of chronic pathological complications such as cancer. The aim of this study was to describe antioxidant and anti-inflammatory of silver nanoparticles (AgNPs) synthesized using medicinal pla...

Background Obesity and physical inactivity are currently on the rise due to industrialization of the communities, which has recently led to increased incidence of different diseases such as diabetes. Epidemiological studies and figures have demonstrated the growing incidence of diabetes. Relevantly, the side effects of chemical drugs have led patie...

Context Kidney is one of the vital organs maintaining homeostasis of body and thus dysfunction of kidney affects quality of life and health severely. Anticancer drugs, particularly chemotherapeutic agents, cause high toxicity leading kidney dysfunction and irreparable kidney injury. Therefore, attention has recently been paid to seeking out alterna...

Searching for new natural drugs that are capable of targeting Th1 and Th17 may lead to development of more effective treatments for inflammatory and autoimmune diseases. Most of the natural drugs can be derived from plants that are used in traditional medicine and folk medicine. The aim of this systematic review is to identify and introduce plants...

Background and purpose: Despite numerous trials, there has not yet been any definite strategy to reduce replicable long-term tinnitus and earache. Complementary and alternative medical approaches have been used to decrease the symptoms of tinnitus and earache. This study was conducted to report medicinal plants that are used to treat ear disorders...

The present study was conducted to compare the effectiveness of assertiveness group training on social anxiety (SAD) between deaf and hearing impaired adolescents. Forty eight (24 deaf and 24 hearing impaired) people participated in this study. First, participants with SAD, i.e. attaining the scores above 40 for Connor's Social Inventory Scale 2000...

Introduction: Tinnitus is one of the common diseases of the ear that is associated with numerous physical and mental disorders. One of the known mechanisms in the tinnitus area with unknown reason is oxidative events. Based on the prevalence and economic costs and physical- psychological side effects caused by tinnitus and the importance of findin...

Objective: To investigate the possible inhibitory action of pure quercetin on secretion and gene expression of leptin in the T47D breast cancer cell line. Methods: In this experimental study, T47D cells were cultured in monolayers in RPMI 1640. IC50 was determined by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay after...

Many of the plants from the Lamiaceae family have been traditionally used as medicine all over the world. Also, some of the secondary metabolites isolated from this family have shown interesting biological function. In this study we have analyzed phytochemicals of some plants from Lamiaceae family frequently used in folk medicine in Aligudarz regio...

Chitosan is a natural polysaccharide that has antioxidant properties. It can consider as an antioxidant agent in food supplements. In this study the effect of extraction methods on the antioxidant activity of chitosan was investigated. Three methods including enzymatic, acid and alkaline methods were applied for isolating the chitosan from shrimp w...

Different parts of Pistasia atlantica have been used in traditional medicine for various purposes in Iran. The aim of this study was to measurement and compare antioxidant activity and polyphenolic compounds of crude ethyl alcohol extract and four fractions of P. atlantica leaf. Crude ethyl alcohol extract of P. atlantica leaf was prepared using ma...

Background/objectives: Thyroid cancer is the most common endocrine malignancy and accounts for 1% of cancers. In recent years, there has been much interest in the feasibility of using miRNAs or miRNA panels as biomarkers for the diagnosis of thyroid cancer. miRNAs are noncoding RNAs with 21-23 nucleotides that are highly conserved during evolution...

Medicinal plants contribute greatly to increase the therapeutic properties of bee products such as honey, pollen, royal jelly, and propolis. In fact, the pharmaceutical value of honeybee products is associated with the plants that attract honeybees. In this study, pollinating plants used by honeybees were gathered and identified from different regi...

Natural products, mainly isolated from medicinal plants, have considered as valuable sources for herbal anticancer drugs. The present study aimed to determine total phenolic and flavonoid contents, antioxidant activity, and anti proliferative activity of black tea (Camellia sinensis Kuntze) extract in vitro. Crude ethyl alcohol extract of black tea...

Acquiring infectious diseases due to resistant infectious agents leads to serious problems such as taking higher doses of antibiotics, additional treatments, lengthened hospital stay, and imposing additional costs. The aim of the current study is to study antibacterial effects of the hydroalcoholic extracts of four Iranian medicinal plants, occurri...

Recently a lot of studies have been conducted to identify natural compounds for prevention of the development and recurrence of cancers. The present study aimed to determine phytochemical content and anti proliferative activity of Pistacia atlantica extract. Ethanolic extract of Pistacia atlantica was prepared. The antioxidant activity, total pheno...

Cadmium (Cd), highly toxic heavy metal, has been considered as a possible risk factor for diabetes and its complications. However, the underlying mechanisms of Cd-induced diabetes are not clear. The present study was designed to evaluate the effects of Cd on the oxidative system in the diabetic and non-diabetic rats. Rats were divided into the foll...

The liver is a vital organ which plays a major role in the metabolism and excretion of xenobiotics from the body, and liver disease is a worldwide health problem. The currently available synthetic drugs to treat liver disorders cause further damage to the liver and kidney so it is imperative to find new drugs with least side effects. There are a nu...

This systematic review was conducted to evaluate the protective effects and the role of medicinal plants and their derivatives in reducing the cyclophosphamide-induced side effects in the male urinary system. For this systematic review, the search terms cyclophosphamide, urinary system,male reproductive system, toxicity, cancer, chemotherapy, and s...

Tumor cells have deviated pathway that lead to increased constant state levels of free radicals and consequently lead to DNA damage, and then activates signaling pathways that causes unlimited growth, the inability to differentiation, and the malignant phenotype. Some studies have demonstrated that antioxidants can inhibit free radicals generation...

Recent studies on the analgesic effects of Allium jesdianum herb across different types of pain including formalin test biphasic pain, have suggested the probability of effectiveness of the extract of this herb on cyclooxygenase enzymes (COX). In this study we investigated the effects of the essence and extract of A. jesdianum on COX-1 and COX-2 in...

Introduction: Pulsed electromagnetic fields (PEMFs) are usually used to treat non-union fractures. Saffron is a medicinal plant with various pharmacologic effects. In the present study, the synergistic effect of PEMF and saffron aqueous extract on osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) was evaluated Methods: BMSCs...

Allergic rhinitis is a common disease of immune system that negatively affects general health, quality of life, and social relationships. In the recent years, many studies have been conducted to discover novel treatments for this disease particularly using natural products. Here, we review findings of recent studies that harness medicinal plants an...

Objective: BK virus (BKV) infection after kidney transplantation has been a topic of great interest in the recent decade. Prospective screening studies have revealed that BKVN is principally an early complication of renal transplantation occurring within the first post-transplant year in most cases. The aim of the present study was to observe the i...

According to previous publications, cancers seem to be a major public health problem internationally. Consequently prostate cancer (PCa) is a medical common problem of male population. Therefore, the main objective of this investigation was to evaluate patients with prostate disorders for primary recognition of PCa. In this retrospective study, 614...

Background: Infertility is one of the world's most common problems that affect both males and females. There are a variety of plants used in traditional medicine to increase fertility and determine the gender of the fetus. Objectives: The purpose of this study was to investigate the effect of celery leaf on delivery rate in female rats, weight and...

Background: Infertility is one of the world's most common problems that affect both males and females. There are a variety of plants used in traditional medicine to increase fertility and determine the gender of the fetus. Objectives: The purpose of this study was to investigate the effect of celery leaf on delivery rate in female rats, weight and...

Background: Diabetic dermopathy is one of the most prevalent skin complications in diabetes patients. Some studies have pointed to association of diabetic dermopathy with retinopathy and nephropathy in patients with type 2 diabetes as microangiopathy presentations, but no rigorous study has been conducted to confirm this association. Objectives:...

Black seed (Nigella sativa) is an annual flowering plant from Ranunculaceae family, native to southwest Asia. This plant has many food and medicinal uses. The use of its seeds and oil is common for treatment of many diseases, including rheumatoid arthritis, asthma, inflammatory diseases, diabetes and digestive diseases. The purpose of this study wa...

Helicobacter pylori (H. pylori) usually colonizes the gastric mucosa of more than 50% of the human population, causing an infection that may appear in early childhood and can persist for life. H. pylori is suggested as the main cause of peptic ulcer and chronic gastritis. It is also associated with gastric cancer. Its severity and symptoms depend o...

Introduction: The study aimed to investigate the anti-fertility effect of fennel ( Foeniculim vulgare Mill) seed extract in male rats. Material and Methods: Forty Wistar rats were divided into five equal groups. The control group received distilled water and the experimental groups were orally administered 1 ml of hydro-alcoholic extract of fennel...

Nowadays, cardiovascular diseases are highly prevalent in human communities. Hypertension is a multifactorial disease which causes a mortality twice higher than general population. Given the fact that medicinal plants have long been used to treat hypertension and are currently being administered for this disease, we sought to report the mostly effe...

Prostate cancer is one of the most dangerous diseases in men worldwide. The apoptotic factors such as BID, BIM and APAF1 have a main role in inducing apoptotic pathways. Some of the compounds can active this apoptotic factors. In this study, this notion was investigated by the use of the comet assay technique and molecular dynamics simulations....

Introduction: Public and occupational exposure to electromagnetic fields due to the growing trend of electronic devices may cause adverse effects on human health. This paper describes the risk of mutation and sexual trauma and infertility in masculine sexual cell by mobile phone radiations. Methods: In this study, we measured the emitted dose fr...

Introduction: Quercetin is an effective compound which is found in many medicinal plants. Quercetin antioxidant properties against cancerous tumors and apoptosis induction have been demonstrated. This study is aimed to investigate the molecular dynamics of quercetin with regard to activating the pre-apoptotic factors such as Bim, Bak, and Bad using...

Increase in cases of various cancers has encouraged the researchers to discover novel, more effective drugs from plant sources. This study is a review of medicinal plants in Iran with already investigated anticancer effects on various cell lines. Thirty-six medicinal plants alongside their products with anticancer effects as well as the most import...

Parasitic diseases are a major public health proble m with negative effects on the lives of hundreds millions of people around the world, especially in tropical dev eloping countries. WHO estimates that three and a h alf billion people worldwide are infected with parasitic diseas es that between four hundred and fifty million people suffer from thi...

Inflammasome activation is mediated by (NOD)-like receptors (NLR) proteins that respond to stimuli. Among NLRs, NACHT-LRR and PYD domains-containing protein 3 (NLRP3) senses the widest array of stimuli. NLRP3 inflammasome has an important role in the development of many inflammation disorders. Regarding the significance of inflammatory diseases, an...

Inflammasome activation is mediated by (NOD)-like receptors (NLR) proteins that respond to stimuli. Among NLRs, NACHT-LRR and PYD domains-containing protein 3 (NLRP3) senses the widest array of stimuli. NLRP3 inflammasome has an important role in the development of many inflammation disorders. Regarding the significance of inflammatory diseases, an...

Introduction: Diabetes is a serious metabolic disorder and plenty of medical plants are used in traditional medicines to treat diabetes. These plants have no side effects and many existing medicines are derived from the plants. The purpose of this systematic review is to study diabetes and to summarize the available treatments for this disease, fo...

In the recent decades, hyperlipidemia has considerably increased with the development of machine life. It has been accompanied by diseases such as hypothyroidism, liver and kidney diseases, diabetes, chronic kidney disease, as well as obesity and can cause complications such as atherosclerosis, hypertension, increased risk of stroke, and fatty live...

Fever is an important very prevalent disease in children. Fever is developed in the body during response to releasing internal pyrogenic agents throughout infections, malignancy, and inflammatory and rheumatic processes as well as external pyrogenic agents including microbes and toxins. In Iran, medicinal plants have long been used to treat disease...

Most people opt to use natural and traditional methods instead of chemical drugs and intrusive methods of modern medicine to treat minor illnesses and disorders of children or newborns. Since gastrointestinal, infectious, and respiratory diseases are the most significant diseases in children, this review article sought to identify and report the na...

Cough is referred to the strong explosive exhalation which causes removal of secretions and foreign bodies from tracheobronchial tract. Given the prevalence of children's and adults' involvement with and acquisition of cough, this review article was aimed to report the plants used to treat and relieve cough in traditional culture and ethnobotany of...

Migraine is a disabling and very common health problem. This review article reported the plants used to treat migraine in traditional culture and ethnobotany of different regions of Iran. The key words such as ethnopharmacology, ethnobotany, ethnomedicine, phytopharmacology, traditional medicine, phytomedicine, and Iran, combined with migraine and...

Wound is referred to the disruption of joined structure of the body caused by physical, chemical, and biological agents. Wound healing is a reconstructive process which takes place after damage to skin and soft tissues. After damage, inflammatory response is developed and subdermal cells begin to increase the production of collagen and then epithel...

Pain and inflammation are the main problems associated with different diseases in human communities. The currently available drugs including opioids and nonsteroidal anti-inflammatory drugs are helpful for all patients because of complications and side effects. Therefore, there is still the need for suitable analgesics and researchers are still stu...

Shigella is a gram-negative intracellular pathogen which causes bacillus diarrhea in humans. Besides clinical and gastrointestinal diseases, shigella causes food poisoning. In Iran, medicinal plants are used to treat infectious diseases. In this review article, the native medicinal plants to Iran that are effective on shigellosis were reported. For...

Constipation is a prevalent gastrointestinal disease in both children and adults. This disease which is associated with the inability to empty rectum completely is diagnosed when defecation is difficult and delayed for two weeks or more and obviously causes discomfort. The culture of Iran traditional medicine is full of the medicinal plants with pu...

Common cold is a very prevalent disease with cough, rhinorrhea, stuffy nose, and sore throat as the most common symptoms. Other symptoms include myalgia, fatigue, headache, and dyspepsia. Nowadays, there is no specific treatment to common cold but some ethnopharmacoligical and ethnobotanical studies have been done to investigate different therapies...

Thymol (C10H14O) is a monoterpene which is considered a phenolic component and is present in many vegetable oils. Thymol is an aromatic essence which is known as disinfectant in traditional medicine. Thymol is found in plants and has properties such as antibacterial, antipyretic, antispasmodic, antifungal, antioxidant, and hepatorotective, anti wor...

Using antioxidant nutrients may be a good diet strategy for the prevention of oxidative stress associated to agerelated disease. We assessed the changes in activities of antioxidant enzymes (superoxide Dismutase-SOD Glutathione-S-Transferase-GST, Catalase-CAT) and the levels of lipid Per-oxidation (Malondialdehyde -MDA) in liver and serum nitric ox...