Mairim Serafini

• Professor
• Professor (Full) at Federal University of Sergipe

Small fiber neuropathies (SFN) are a group of diseases that affect finely myelinated fibers and unmyelinated C fibers and can result in pain, temperature sensitivity and altered sensations, as well as have an impact on sweating due to its effect on the nerves responsible for regulating of sweat glands. Its evaluation requires the use of auxiliary t...

The COVID-19 pandemic exposed the fragility of today's marketed treatments for respiratory infections. As a primary site of infection, the upper airways may represent a key access route for the control and treatment for these conditions. The present study aims to explore and identify, through a patent review, the novelty of therapies for COVID-19 t...

Antimicrobial resistance (AMR) is a critical public health concern that arises when microorganisms evolve mechanisms to evade the effects of antibiotics, thereby rendering conventional treatments ineffective. This growing challenge underscores the urgent need for novel therapeutic approaches. Nanotechnology, particularly when combined with environm...

Passiflora ligularis (P. ligularis) is a species of the genus Passiflora distributed from Mexico to Bolivia, particularly along the Andes, found at altitudes between 1500 and 2500 m above sea level. This plant is of significant economic importance due to the commercialization of its fruits as food, and it has also been widely used in folk medicine....

Flavonoids such as silibinin, hesperetin, and phloretin exhibit well-documented biological activities, including anti-inflammatory, cytoprotective, anticarcinogenic, and antioxidant effects. However, their clinical application remains limited due to challenges such as poor aqueous solubility, low bioavailability, and restricted intestinal absorptio...

Aim: Trans-chalcone has emerged as a promising candidate for new therapeutic alternatives, owing to its pharmacological properties and potential in various medical areas. This study aimed to conduct a systematic review of articles, patents and clinical trials on trans-chalcone's applications and biological activities.Areas covered: The review propo...

UV radiation causes long- and short-term skin damage, such as erythema and skin cancer. Therefore, the use of sunscreens is extremely important. However, concerns about UV filter safety have prompted exploration into alternative solutions, with nanotechnology emerging as a promising avenue. This systematic review identified 23 experimental studies...

Tuberculosis (TB) is an ancient global public health problem. Several strategies have been applied to develop new and more effective vaccines against TB, from attenuated or inactivated mycobacteria to recombinant subunit or genetic vaccines, including viral vectors. This review aimed to evaluate patents filed between 2010 and 2023 for TB vaccine ca...

Synthetic sunscreen offers protection against excessive exposure to ultraviolet (UV) radiation from the sun, and protects the skin from possible damage. However, they have low efficacy against the formation of reactive oxygen species (ROS), which are highly reactive molecules that can be generated in the skin when it is exposed to UV radiation, and...

Developing effective and targeted drug delivery systems is crucial in searching for improved pain management strategies. Here, it is shown the preparation of a nanocarrier using chitosan hydrogel, and polymeric nanocapsules loaded with linalool for enhancing transdermal permeation and targeted delivery of this antinociceptive monoterpene for the pa...

Nanoparticle characterization is crucial for developing and optimizing nanocarriers, as it is necessary to have a comprehensive understanding of their characteristics to achieve optimal stability and efficiency. This chapter presents key nanocarrier characterization methods and explores additional techniques related to supramolecular structure, mor...

Nanocarriers have crucial applications in medicine, mainly in drug delivery. The choice of administration route assumes significance during the drug development phase, as it influences the effectiveness and safety of the formulation. Different routes of administration offer specific advantages, disadvantages, and precautions for the development of...

Introduction: Osteoarthritis is a musculoskeletal disease that can lead to the loss and inability of those affected to perform normal daily functions, which leads to a decrease in quality of life. The main symptoms of osteoarthritis are tenderness, joint pain, stiffness, crepitus, limited movement, and local inflammation. Areas covered: The sele...

Aim: The study aimed to review experimental models using cyclodextrins to improve antibacterial drugs' physicochemical characteristics and biological activities. Methods: The following terms and their combinations were used: cyclodextrins and antibacterial agents in title or abstract, and the total study search was conducted over a period up to Oct...

The expected outcome after a scaffold augmented hernia repair is the regeneration of a tissue composition strong enough to sustain biomechanical function over long periods. It is hypothesised that melt electrowriting (MEW) medical-grade polycaprolactone (mPCL) scaffolds loaded with platelet-rich plasma (PRP) will enhance soft tissue regeneration in...

Large-volume bone defect regeneration is complex and demands time to complete. Several regeneration phases with unique characteristics, including immune responses, follow, overlap, and interdepend on each other and, if successful, lead to the regeneration of the organ bone’s form and function. However, during traumatic, infectious, or neoplastic cl...

Osteoarthritis is considered a degenerative joint disease that is characterised by inflammation, chronic pain, and functional limitation. The increasing development of nanotechnology in drug delivery systems has provided new ideas and methods for osteoarthritis therapy. This review aimed to evaluate patents that have developed innovations, therapeu...

Large volume bone defect regeneration is complex and demands time to complete. Several regeneration phases with unique characteristics including immune responses follow, overlap, and interdepend on each other and, if successful, lead to the regeneration of the organ bone's form and function. However, during traumatic, infectious, or neoplastic clin...

Background: Acne is a highly prevalent disease that mainly affects the pilosebaceous units associated with sebaceous glands, causing inflammatory skin lesions and affecting the self-esteem, mental health, and quality of life of those who suffer from this disease. Different treatments exist today to prevent, reduce, and improve symptoms; however, o...

O infarto do miocárdio (IM) é um estado urgente causado por necrose em uma parte do músculo cardíaco devido ao fluxo sanguíneo insuficiente o que resulta em altas taxas de disfunção cardíaca. A reperfusão do fluxo sanguíneo coronário é essencial para minimizar o tamanho do IM, no entanto, esse processo também causa dano adicional e acentua a disfun...

Pain is one of the most prevalent and difficult to manage symptoms in cancer patients, and conventional drugs present a range of adverse reactions. The development of β-cyclodextrins (β-CD) complexes has been used to avoid physicochemical and pharmacological limitations due to the lipophilicity of compounds such as p-Cymene (PC), a monoterpene with...

Antibiotics have become a widely used drug classes worldwide. Its indiscriminate use in the clini-cal-hospital environment ended up causing antibiotic-resistance genes. Pharmaceutical technology is an essential ally for new formulation development in the antibacterial field. Cyclodextrins (CDs) are ap-proaches that can potentially improve the effec...

Background: Cannabis use for tumor treatment has been explored in several areas, and its potential for tumor remission is currently being studied after the discovery of the endogenous cannabinoid. Objective: The study aimed to conduct a critical patent review to identify and explore the latest advances and therapeutic strategies using cannabis t...

Tyrosine is an enzyme responsible for melanin production. Its abnormal accumulation in different parts of the body is known as hyperpigmentation. Tyrosinase inhibitors have been used as one of the main approaches to treat these kinds of cosmetic and medical issues. This review aimed to discuss the advances in patents for this class of inhibitors, f...

Introduction: Bacterial antibiotic resistance occurs when bacteria mutate and escape the effect of antibiotics, which makes the antibiotics no longer effective in treating infections. New solutions for bacterial infections are a persistent need including the identification of drugs with better pharmacological profiles, more potent, and safer. Cycl...

Candida auris is responsible for hospital outbreaks worldwide. Some C. auris isolates may show concomitant resistance to azoles, echinocandins, and polyenes, thereby possibly leaving clinicians with few therapeutic options. In addition, this multi-drug-resistant yeast is difficult to identify with conventional methods and has the ability to persist...

Fibromyalgia is a debilitating and chronic pain processing disorder, in which the proportion of patients who achieve good results with pharmacotherapy is small. However, choosing the best available evidence on pharmacotherapy can optimize patient clinical outcomes. Objective: This overview aimed to identify in systematic reviews the effects of phar...

The COVID-19 pandemic has been declared since March 11, 2020. Until December 2020, the absence of specific treatments or vaccines for COVID-19 implied the need to use non-pharmacological strategies to reduce infection rates. This study aimed to track and compare the policy responses of countries with the highest number of COVID-19 deaths in the wor...

Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most prevalent and difficult-to-treat symptoms in cancer patients. For this reason, the explore for unused helpful choices able of filling these impediments is essential. Natural products from plants stand out as a valuable source of therapeutic agents, being options for the treatment...

UV radiation can cause damages, such as erythema, skin photoaging, and carcinogenesis. The adoption of protective measures against sun exposure is essential to prevent these damages, and the interest in using natural substances as an alternative for photoprotection is growing. Thus, hesperetin with antioxidant, anti-inflammatory, and anticancer pro...

Background The worldwide pandemic fought by COVID-19 could emerge another type of pandemic, the increase in bacterial resistance against antibiotics. Emergency treatment based on antibioticsis a major influence in increasing this resistance. Bacteria, such as Klebsiella pneumoniae, are most affected by the indiscriminate use of antibiotics since th...

A dengue é uma doença infecciosa causada por um vírus transmitido pelo mosquito Aedes aegypti e tem um grande potencial geográfico, principalmente em regiões tropicais e subtropicais. O presente estudo constitui-se de um protocolo de revisão de escopo e tem como objetivo identificar e caracterizar as substâncias fitoquímicas com maior potencial lar...

Natural products from plants have gained prominence in the search for therapeutic alternatives. Monoterpenes, such as carvone, are suggested as candidates for the treatment of several diseases. Therefore, the objective of this study is to review the pharmacological activities of carvone in experimental models in vitro and in vivo. For this, the...

Although chemotherapy-induced peripheral neuropathy is one of the main medical complaints of cancer patients, there are currently no specific drugs for the effective treatment. In this respect, α-terpineol (TP) seems to be a potential candidate for this purpose, since it has several pharmacological properties that can be improved by nanosytems. The...

Epilepsy, a neurologic condition associated with recurring seizures, affects around 70 million people worldwide and it is responsible for health costs. The current drug therapies used for treating epilepsy have low efficacy and many adverse side effects. In addition, drug resistance can also be found. The association of these factors considerably c...

Recently, many consumers have been adding plant-based beverages to their diets, due to different reasons. The addition of plant proteins to enrich these products in order to make them more nutritionally balanced has become a trend, mainly because of their lower prices and reduced environmental damage. Thus, the aims of the present patent review are...

A systematic review was performed searching data published in PubMed and Google Scholar databases, using subject headings or keywords related to point of care and rapid test diagnostic for SARS-CoV-2 and COVID-19. Results: The first survey identified 403 articles, but only 23 met the defined criteria for the systematic analysis. The sensitivity an...

Background: It is estimated that one in five people worldwide faces a diagnosis of a malignant neoplasm during their lifetime. Carvacrol and its isomer, thymol, are natural compounds that act against several diseases, including cancer. Thus, this systematic review aimed to examine and synthesize the knowledge on the antitumor effects of carvacrol a...

Introduction Nonsteroidal anti-inflammatory drugs (NSAIDs) are a class of drugs widely used due to their pharmacological potential, demonstrating anti-inflammatory, analgesic, or antipyretic activity. However, prolonged use of these medications can lead to the development of gastric ulcers in patients. This review aimed to find patents for drugs wi...

Purpose: The last two decades have seen the emergence of several viral outbreaks. Some of them are the severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and severe acute respiratory syndrome 2 (SARS-CoV2) - the cause of the coronavirus disease 2019 (COVID-19). Ever, vaccines for emergency use have been authorized f...

A doença renal crônica (DRC) é uma grande preocupação de saúde pública em todo o mundo, pois está associada a um risco significativamente elevado de múltiplos resultados adversos à saúde. Nesse sentido, este artigo teve como objetivo realizar o mapeamento e análise de patentes relacionadas à DRC produzidas e depositadas nos últimos 20 anos. Para ta...

Farnesol (FAR) is a sesquiterpene alcohol with a range of reported biological effects including cardioprotective, antioxidant and antiarrhythmic properties. However, due to its volatility, the use of drug incorporation systems, such as cyclodextrins, have been proposed to improve its pharmacological properties. Thus, the aim of this study was to ev...

Danio rerio (zebrafish) is a suitable animal model that has been used to model a wide range of diseases such as aquaculture-relevant infectious agents and inflammatory processes. This study reviewed methods employed to study inflammation in zebrafish to reveal its usefulness in modeling inflammation. PubMed, Scopus, Web of Science, and Lilacs datab...

Monoterpenes are non-polar secondary metabolites widely used by industry due to their excellent therapeutic, food-ingredient and cosmetic properties. However, their low solubility in water limits their use. In this sense, cyclodextrins (CDs) have been widely used to solve these technological challenges. Thus, this study aims to use (–)-borneol as a...

Fungal biofilms, such as Candida albicans biofilms, are capable of surviving in hostile environments owing to their remarkable ability to adhere to surfaces and their tolerance to chemical interventions. Currently, therapeutic treatment options are few, making these biofilm-based infections problematic particularly due to their great tolerance to c...

Nursing education and training based on content and technicality has undergone a process over the years mainly with the proposal of national curriculum guidelines to implement changes in the curriculum and the insertion of new teaching methodologies by educational institutions. Thus, realistic simulation is born with the proposal to actively teach...

Since January 2020, the World Health Organization announces COVID-19 outbreak a case of public health emergency of international interest, and declaring it a pandemic on March. Due to the high transmission of this disease, rate precautions have been implemented, such as the use of masks by the population, personal protective equipment (PPE), and sa...

Background. In recent years, the use of digital serious games in the education of healthcare students and professionals has been frequent. However, there are no high-level evidence studies focused on the effect of this tool in the development of patient care-related competencies in pharmacy education. Aim. To assess the effect of digital serious ga...

Este estudo objetivou evidenciar as contribuições dos intercâmbios internacionais na formação e atuação do enfermeiro através do âmbito acadêmico, profissional e de pós-graduação. Trata-se de uma revisão integrativa realizada no período de julho a setembro de 2020 nas bases de dados PubMed, LILACS, Cochrane e Scielo. A seleção dos estudos por títul...

Prestar um cuidado integral é importante para que o paciente tenha suas necessidades atendidas em diferentes ângulos. Este estudo objetivou analisar a percepção dos acadêmicos sobre a integralidade do cuidado e trabalho em equipe no processo de sua formação profissional. Trata-se de um estudo exploratório, descritivo, com abordagem quantitativa de...

In recent years, allergies are on the rise. The growth of allergies cases has changed the immune system's response to new pathogens. The therapy used to treat these diseases is based on allergen avoidance, pharmacotherapy and allergen-specific immunotherapy. The last one has received a lot of interest in the research field, due to the possibility o...

Self-emulsifying drug delivery systems (SEDDS) are lipid-based isotropic mixtures that enhance the bioavailability of poorly water-soluble drugs and reduce the possible side effects, offering a wide variety of treatments for several pathologies. The aim of this review is to discuss the state of the art of patents for this drug delivery system by st...

Coronavirus disease 2019 (COVID-19), the infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an aggressive disease that attacks the respiratory tract and has a higher fatality rate than seasonal influenza. The COVID‐19 pandemic is a global health crisis, and no specific therapy or drug has been formally...

Background: Epilepsy affects more than 65 million people worldwide. Treatment for epileptic seizures is ineffective and has many adverse effects. For this reason, the search for new therapeutic options capable of filling these limitations is necessary. Hypothesis/Purpose: In this sense, natural products, such as monoterpenes, have been indicated as...

The emergence of a new coronavirus (SARS-CoV-2) outbreak represents a challenge for the diagnostic laboratories responsible for developing test kits to identify those infected with SARS-CoV-2. Methods with rapid and accurate detection are essential to control the sources of infection, to prevent the spread of the disease and to assist decision-maki...

Background: Cancer is a complex, multifactorial disease, and a major public health problem, as it is a leading cause of morbidity and mortality worldwide. Although treatments have significantly improved, there is a still a search for more effective drugs. One source for these are natural products (NPs). One NP that has shown anticancer activity is...

Background Cancer is a major public health problem, and it is one of the leading causes of death globally. Treatment can be surgical removal, chemotherapy or hormonal therapy, radiation therapy, or a combination of them. Many treatments are ineffective or have serious side effects. In view of this, there is a search for new more effective alternati...

Doença renal crônica (DRC) é a condição na qual os rins perdem a capacidade de efetuar a manutenção da homeostase do corpo humano, implicando no comprometimento de todos os outros órgãos. A DRC tem sido considerada um problema de saúde pública, uma vez que o número de casos aumenta exponencialmente em todo o mundo. Nesta perspectiva, este artigo te...

Myrtenol has gained wide interest because of its pharmacological profiles, mainly for treatment of chronic diseases. To improve the solubility of myrtenol, the formation of inclusion complexes with β-cyclodextrin was performed by physical mixture, kneading process or slurry complexation (SC) methods and characterized using thermal analysis, XRD, SE...

Objective: To estimate the prevalence of SARS-CoV-2 antibodies in an asymptomatic population in the state of Sergipe, Brazil. Methods: This cross-sectional study with stratified sampling (sex and age) includeD serological immunofluorescent tests for IgM and IgG on samples from 3 046 asymptomatic individuals. Sample collection was performed in wet-m...

Fibromyalgia (FM) is a chronic disease that has as main characteristic generalized musculoskeletal pain, which can cause physical and emotional problems to patients. However, pharmacological therapies show side effects that hamper the adhesion to treatment. Given this, (−)-linalool (LIN), a monoterpene with several therapeutic properties already re...

Introduction Leishmaniasis is a neglected tropical disease caused by protozoa of the genus Leishmania. Worldwide, approximately 1.5 million to 2 million new cases of leishmaniasis and 20,000-30,000 deaths occurs each year. Effective treatment for all forms of leishmaniasis have numerous adverse effects contributing to poor adherence and/or treatmen...

Worldwide, the lack of resolution of the current pharmaceutical arsenal to heal some diseases, including chronic kidney disease, opens space for further research in the field of health. Technological horizons monitoring actions are highlighted in the tracking of relevant technologies to solve certain health issues that are still considered incurabl...

Introduction: Coronavirus has been responsible for several virus outbreaks since 2003, caused by SARS-CoV-1, MERS-CoV, and currently SARS-CoV-2 (COVID-19), the causative agent of coronavirus disease in 2019. COVID-19 has become a global public health emergency because of its high virulence and mortality capacity. This patent review aims to provide...

Described as a projection (prolapse) of tissue through a fascial defect in the abdominal wall, hernias are associated with significant rates of complications, recurrence and reoperations. This literature review is aimed at providing an overview of the prosthetic surgical meshes used for the repairing of hernia defects. The review was carried out us...

Introduction: The most conventional drug delivery systems exist with limitations such as drug degradation, toxicity and low bioavailability. Also, hypodermic injections can cause pain, compromising patient compliance. Due to this, transdermal drug delivery systems (TDDS) can minimize several problems associated with conventional drug delivery. The...

Twenty-four phenolic compounds including daidzein, epicatechin and artepillin C were identified in Passiflora leschenaultii DC. fruit by UHPLC-QqQ-MS/MS analysis. The aroma profile has been studied using the HS–SPME/GC–MS which revealed 67 volatile compounds including 13 terpenes, 18 alcoholics, 15 esters, ketones and phenolic acids. Further, the p...

Background Conventional treatments of arthritis use toxic and poorly tolerated drugs; Therefore, natural products are an alternative because they are important sources of bioactive substances with therapeutic potential. Objective To perform synthesis of patent applications associated with the use of natural products in the technological developmen...

Oral infections are associated with the appearance of systemic diseases. Among the natural products, commercially used in dental formulations is thymol (TM). However, this compound presents low stability. In order to overcome these limitations, the membranes were prepared using the solvent evaporation method and TM/β-cyclodextrin using the liofiliz...

Eplingiella fruticosa (Lamiaceae), formally known as Hyptis fruticosa, is an important aromatic medicinal herb used in folk medicine in northeastern Brazil. We aimed to evaluate the anti-hyperalgesic effect of essential oil obtained from E. fruticosa (HypEO) complexed with βCD (HypEO-βCD) in a chronic widespread non-inflammatory muscle pain animal...

Background In the last few decades mycoses caused by opportunistic fungi namely Candida species has gained significant attention. Such infections are very common and present high mortality rates, especially in immunocompromised patients. Currently, limited number of antifungal drugs are available for the treatment of these infections and are also o...

Ethnopharmacological relevance: Polyphenolics (flavonoid and phenolic) rich plants are the effective source for the treatment of acute and chronic degenerative diseases including inflammatory bowel disease. Objective: This study was aimed to examine the effects of polyphenolics rich leaf acetone extract of P. subpeltata against the indomethacin...

Skin diseases have a notable impact on the life of the affected and in their health conditions. In order to allow a more effective and economical treatment for such disorders, new therapeutic approaches have been continuously investigated. Due to its high therapeutic and phytochemical potential, Matricaria species emerges as a pleasant alternative,...

A segurança e eficácia de medicamentos produzidos em farmácias magistrais estão relacionadas diretamente com a uniformidade das doses unitárias. O gral e o saco plástico são métodos bastante utilizados para garantir a homogeneização de pós na produção de cápsulas, contudo, não há estudos relacionados a padronização do tempo de homogeneização. Diant...

O chá verde, proveniente da planta Camellia sinensis, é a segunda bebida não alcoólica mais consumida no mundo. Sua utilização está atrelada a melhorias na saúde cardio-metabólica, redução da pressão arterial, diminuição do Índice de Massa Corpórea (IMC) e aumento da termogênese e oxidação da gordura corporal. O presente estudo objetivou buscar ped...

A Coordenação de Inovação e Transferência de Tecnologia da Universidade Federal de Sergipe (CINTTEC/UFS) possui a finalidade de dar suporte aos pesquisadores da Universidade no processo de patenteamento junto ao Instituto Nacional de Propriedade Industrial (INPI) de produtos e processos, e registros de marcas, desenho industrial e softwares, gerado...

Background: Vanillosmopsis arborea Baker has recognized economic value owing to the high content of (-)-α-bisabolol (BISA) in the essential oil of its stem (EOVA). The antinociceptive effect of EVOA has already been demonstrated, and β-cyclodextrin (βCD) is known to improve the analgesic effect of various substances. Purpose: Thus, we aimed to e...

A Hipertensão Arterial Sistêmica (HAS) é uma condição clínica multifatorial caracterizada por níveis elevados e sustentados da pressão arterial. Um dos mecanismos para controle da HAS é por meio do bloqueio dos receptores de angiotensina II (AII). A losartana potássica (LP), exemplo clássico de antagonistas dos receptores do subtipo AT1, é um dos f...

Background: Some researches have been shown that Lippia pedunculosa essential oil (EOLP) has interesting biological activities. However, its low water solubility is the main challenge to achieve its therapeutic potential. In this context, cyclodextrins (CDs) have been widely used in order to overcame this problem due to your capability to improve...

The diabetic key enzymes inhibition, nutritional, antioxidant activity and bioactive compounds identification of Passiflora subpeltata fruit pulp were investigated. Fifteen polyphenolic compounds including protocatechuic acid, ferulic acid, vanillic acid, epicatechin, p-coumaric acid, cinnamic acid, eriodictyol and quercetin-3-glucoside were identi...

In Brazil, support for scientific activities are mostly carried out by public agencies such as Coordination of Personal and Higher Education (CAPES) and the National Council for Scientific and Technological Development (CNPq) through many research grants, among which we highlight the productivity of the grants in research and technological developm...

A propriedade industrial é fruto da criação humana direcionado às atividades industriais, gerando diferenciais competitivos através da inovação. Desta feita, a propriedade industrial se caracteriza como um ativo intangível, por isso a preocupação com a sua proteção é crescente, proporcionando as condições para uma maior conscientização no âmbito na...

Segundo a Organização Mundial de Saúde (OMS), as plantas medicinais contribuem para a promoção da saúde, prevenção de doenças reabilitação e cura. Neste contexto, o presente estudo buscou realizar a caracterização físico – químico e fitoquímico das plantas medicinais mais comercializadas na feira – livre de Lagarto, munícipio do estado de Sergipe....