Mainak Chakraborty

• Doctor of Pharmacy
• Academic Researcher at ADAMAS University

Keratitis left untreated can lead to blindness. Various factors contribute to ocular keratitis, primarily viral infections such as VZV and HSV. Ganciclovir is effective in treating viral keratitis by inhibiting viral DNA polymerase replication, thereby suppressing viral reproduction and delaying the progression of the disease, which ultimately redu...

An antioxidant-rich mushroom noodles (gluten-free) rich in L-tryptophan-serotonin-melatonin (TSM) was developed under minimal processing condition(s) without perturbing the natural antioxidant synergy. In vitro release kinetics studies in a standard dissolution apparatus confirmed substantial releases of the target biomolecules from the designer no...

Background New nanoparticles (NPs) and biomaterials are utilized more frequently in biological research for vaccinations, diagnostic procedures, and drug administration. Nanomaterials are materials with d50 value from 1 to 100nm. They are also found in various consumer goods, the environment, and work. Thus, it has become crucial for the appropriat...

Background Research on the use of silver nanoparticles in the context of diabetes mellitus has gained attention due to the unique properties of these nanoparticles, such as their antimicrobial, anti-inflammatory, and antioxidant characteristics. While the field is still in its early stages, several studies have explored the potential applications a...

Aim of the Study: The primary objective of this study was to investigate the impact of yogic practices on selected physiological variables among middle-aged hypertensive women. The study aimed to explore whether there were significant differences in specific physiological parameters, namely Systolic Blood Pressure (SBP) and Body Mass Index (BMI), a...

Background: The 21 st century has marked an increase in global health challenges due to lifestyle transformations associated with globalization and modernization. Diseases such as mental stress, diabetes, hypertension, and cardiovascular ailments have become prominent, emphasizing the need for effective interventions. Objective: The objective of th...

Anti-diabetic activity of Phyllanthus Reticulatus fruit extract was carried out against streptozotocin induced diabetic model in wistar rats. Soxhlet extraction using methanol was carried out on Phyllanthus Reticulatus fruit to obtain the extract. Acute Oral Toxicity– Acute Toxic Class Method 423 was performed to obtain the low and high doses respe...

Background Ophthalmic in situ gel is a novel preparation. It can be instilled into the eye as a liquid but gels upon contact with the ocular surface, generating a sustained-release depot of the drug. The main body of the abstract Among drug delivery modalities, ocular drug administration requires careful study and parameter assessment. This is bec...

Abstract: Background: Developmental toxicology deals with the effects of compounds on fertility and with birth defects that could occur at any stage of the reproductive cycle. In this study, we evaluated the teratogenic effects of Lablab purpureus (L.) Sweet beans on zebrafish embryo. Objectives: The developmental toxicity study was carried out to...

The purpose of the current experiment was to determine the anti-convulsant activity of methanolic extract of Plumbago indica L. In a 50 ml beaker 200 mg of the methanolic extract of Plumbago indica L. was dissolved in water containing the experimental zebrafish. After about 20 minutes the fish was administered with pentylenetetrazole (PTZ) (30 mg i...

Diabetes is becoming more common across the world at an alarming rate. Its position has evolved dramatically over the last three decades; formerly, it was seen as a benign condition affecting the elderly. It is now a leading source of illness and mortality among the young and middle-aged. According to the International Diabetes Federation’s Diabete...

Molecular pharmacology is basically a division of pharmacodynamics which plays a crucial role in drug discovery and therapeutics. The action of drugs in biological systems can only be understood by the study of molecular pathways. Systems biology is in an exponential development stage in recent years and has been widely utilized in the field of bio...

Background : Breast adenocarcinoma is one of the leading causes of death among women regardless of development in the field of diagnosis, treatment and prevention. Synergistic approaches are emerging as a strategy to overcome monotherapy resistance in cancer treatment. Purpose : Evaluation of the combinatory activity of β-carotene (BC) and lupeol...

The present study was aimed to investigate the phytochemical Characterization, in vitro antioxidant and antidiabetic activity of Aerva sanguinolenta (L.) Blume. This is an herb belonging to the family Amaranthaceae. Traditionally the plant is rich sources of the constituents like tannins, flavonoids, terpenoids, sphingolipids, polyphenolic compound...

Regulatory Affairs in pharmaceutical industries is a one of the most critical job. Regulatory Affairs is mainly concerned about the lifecycle of healthcare product and it gives tactical, strategic and operation advice to work within regulation to develop safe and effective healthcare product around the World. The work of Regulatory Affairs to nurtu...

Objective: The research was design to conduct anti-diabetic activity of methanol extract of Aeschynanthus sikkimensis (Clarke) Stapf. in streptozotocin induce hyperglycemic rats. Material and method: Streptozotocin 35mg/kg body weight was injected intraperitoneal to produce hyperglycemia rats which were pretreated with a high fat diet.72 hours afte...

Eichhornia crassipes belonging to the family pontederiaceae, found in almost all over the world. It is proven that it has anti-inflammatory, antifungal, hepatoprotective activity. So this study was done to screen anti-diabetic, diabetic wound healing and anti-seizure activity of shoot and rhizome extract of Eichhornia crassipes.

Manilkara hexandra (Roxb.) Dubard is a large evergreen tree species widely distributed throughout India and other countries and belongs to family Sapotaceae. Conventionally, the entire plant has been used for the treatment of various diseases. The present study has been carried out for identification of its bioactive constituents by high resolution...

BACKGROUND: Aervasanguinolenta (L) (Amaranthaceae), commonly known as Blume in India and its native place. Objective: To evaluate the hypoglycemic activity of methanol extract of A.sanguinolentai.e MEAS leaves in streptozotocin (STZ)-induced diabetic Wistar rats. Materials and Methods: In rats fed with HFD for 4 weeks, hyperglycemia was induced by...

The aim of this research was to conduct phytochemical characterization, in vitro antioxidant and in vitro anti-inflammatory evaluation of methanol extract of Aeschynanthus sikkimensis (Clarke) Stapf. The phytochemical test was held towards glycosides, carbohydrates, steroids, terpenoids, phenols, tannins, flavonoids and saponins. Determination of t...

Objective: On the basis of traditional use and Ethno pharmacological evidences Boerhavia diffusa whole plant and root part of Asparagus racemosus (Shatavari) both are widely used to enhance the immunity. But in combination there is no scientific evidence so current study was designed. Methods: Laboratory based study, namely, carbon clearance, cyclo...

Abstract: Citrus fruit has great importance all around the world. Many citrus species are cultivated in Asian subcontinent. Among them, Sweet lime (Citrus limetta) also known as “mosambi”are harvested in the Indian subcontinent. Herbal drugs are considered to be the oldest remedy for any disease. Use of herbal medicines dates back to 5000 years. An...

Hyperlipidemia is a popular disorder and a state of body where there is elevated level of triglyceride above 200mg/dl, LDL above 160mg/dl, Total cholesterol above 200mg/dl and HDL below40mg/dl. Now it can be found on every other person, when LDL increases it travels through our blood vessels and tends to accumulate in the vessels the accumulation i...

Nature always stands as a golden mark to exemplify the outstanding phenomena of symbiosis. Plant has been used to prevent and treat many types of disease along with the epidemic from thousand of year ago. Some medicinal plant has been used as nutraceuticals. Nature exemplify as an inexhaustible origin of novel chemo types and pharmacophores, a sour...

This study was implement to actuate the chemical components of Aeschynanthus sikkimensis (Clarke) Stapf. whole plant using Gas Chromatography–Mass Spectrometry, our results of GC-MS compounds in the extract was relevant to the National Institute of Standards and Technology (NIST) library. GC-MS analysis of methanol extract of Aeschynanthus sikkimen...

Lipids are mandatory substance readily present in living body. They play a very vital role in maintaining a balance between all the mechanisms of the body. Lipids are almost water insoluble molecules that are transported in a protein capsule, commonly known as lipoprotein. Lipids undergoes a metabolism which is the major energy supplier for a livin...

Objective: On the basis of traditional use and Ethno pharmacological evidences Boerhavia diffusa whole plant and root part of Asparagus racemosus (Shatavari) both are widely used to enhance the immunity. But in combination there is no scientific evidence so current study was designed. Methods: Laboratory based study, namely, carbon clearance, cyclo...

For understanding the pathogenesis of human disease at cellular and molecular level bio medical research depends on the use of animal models. Maximum animal models used in medical research of human disease are basically performed in murine system. Though there are advantages of using these animals, murine’s have long gestational period, sexual matu...

Nosocomial infections (NI) are infections acquired by a patient during hospital stay. They cause a surge in morbidity, mortality, prolonged hospital stay and increased health care costs and also increase antibiotic use, leading to the development of antimicrobial resistance in the hospital. Nosocomial microorganisms are transmitted from person to p...

Objective: The purpose of the study was to evaluate the antitumor and antioxidant status of ethanolic extract of Cyperus kyllingia Endl. on Ehrlich ascites carcinoma (EAC)-treated mice.Methods: The determination of in vivo antitumor activity was performed using EAC cells inoculated mice groups (n=12). The groups were treated for 9 consecutive days...

Background: Campylandra aurantiaca (Asparagaceae), commonly known as Nakima in Sikkimese Tibetan, is a plant grown in South-Central China and Northeast India. Objective: To evaluate the hypoglycemic activity of ethyl acetate fraction of methanol extract from C. aurantiaca rhizome (EFCA) in high-fat diet (HFD) and low-dose streptozotocin (STZ)-induc...

Objective: Methanol extract of Calamus rotang (MECR) root was appraised as a spotlight for the candidate of anticancer activity through the vehicle (Ehrlich Ascites Carcinoma) on Swiss albino mice.Methods: In vitro cytotoxicity assay has been accessed by trypan blue and MTT assay. In vivo anticancer activity was done using EAC cells (2 × 106) where...

Background: Recent studies have sought to draw attention of biological activity of Campylandra aurantiaca. The aim of the present study was to evaluate the effect of flavonoid enriched fraction of Campylandra aurantiaca (FEFCA) on in vitro and in vivo antioxidant and DNA protective effect in mouse peritoneal macrophages cells. Methods: FEFCA was...

The methanol extract of Curcuma caesia (MECC) rhizome showed antidiabetic activity by lowering blood glucose in in vivo studies and controlled intestinal absorption of monosaccharides by inhibiting alpha amylase and alpha glucosidase. It also enhanced the glucose uptake in yeast cells, proving proper glucose utilization. The IC50 values of MECC wer...

Objective: This work was undertaken to develop colon targeted tablets that can minimize premature release of ibuprofen (IBP) and metronidazole (MNZ) in a lag period of 7h during which the tablets are likely to remain in the upper gastro-intestinal tract, and produce rapid pulse release within 1-5 h after the lag period when the tablets could be loc...

The present study evaluates the antioxidant and cytotoxic activity of Zanthonitrile isolated from Zanthoxylum alatum leaves. The structure of Zanthonitrile [4-[(3-Methyl-2-buten-1-yl) oxy] phenyl acetonitrile] was elucidated form the data obtained from UV, IR, Mass, and NMR. The in vitro antioxidant activity of Zanthonitrile was estimated by standa...

Objective: Anti proliferative Activity of Hymenodictyon excelsum (MEHE) Stem Bark was evaluated using the Ehrlich Ascites Carcinoma (EAC) cells on Swiss albino mice. Material and methods: Twenty four hours after intraperitoneal inoculation of tumor (EAC) cells in mice, MEHE was administered at 100 and 150 mg/kg body weight for nine consecutive days...

Evaluation of Anticancer Activity of Methanol Extract of Monstera deliciosa in EAC Induced Swiss Albino Mice

Cascabela thevetia (L.) Lippold (Apocynaceae) is an ornamental as well as poisonous plant which has antibacterial, antimicrobial, anti-inflammatory properties. The present study investigated the attenuating effects of the methanol extract of Cascabela thevetia fruits (MECT) on developmental toxicity and behavioral safety in zebrafish embryos. Healt...

Objective: Evaluation of anti cancer activity of methanol extracts of Curcuma zedoaria against Ehrlich's ascities carcinoma (EAC) cell line in Swiss albino mice. Method: In vitro cytotoxicity assay has been evaluated by using the trypan blue and MTT assay method. In vivo anti cancer activity was performed by using EAC cells induced mice groups (n=1...

Aim of study: The purpose of the study was to evaluate the antitumor and antioxidant status of methanol extract of Monstera deliciosa (MEMD) on Ehrlich ascites carcinoma (EAC) treated mice. Materials and methods: In vitro cytotoxicity assay has been evaluated by using the trypan blue and MTT assay method. The determination of in vivo antitumor acti...

S Objective: Anticancer activity of methanol extract of Hippophae salicifolia (MEHS) bark was evaluated using the Ehrlich Ascites Carcinoma (EAC) cells on Swiss albino mice. Methods: In vitro cytotoxicity assay has been evaluated by using the trypan blue and MTT assay method. The determination of in vivo anticancer activity was performed using EAC...

Many of the major chemotherapeutic agents are secondary metabolites found in nature. Zanthoxylum alatum Roxb. (Rutaceae) is traditionally used in the treatment of various diseases. The present study evaluates the apoptotic activity of methanol extract of Z. alatum (MEZA) on Ehrlich ascites tumor (EAT) in Swiss albino mice. The presence of flavonoid...

Methanol extracts of Thevetia peruviana (METP) (Apocynaceae) fruit showed antitumor activity against Ehrlich's ascites carcinoma (EAC) cell line in Swiss albino mice. The METP-treated group's tumor volume, tumor weight, and viable cell count were decreased compared to the EAC control group. Tumor volumes were 3.62±0.12 ml, 2.88±0.23 ml, and 1.34±0....

Methanol extracts of Thevetia peruviana (METP) (Apocynaceae) fruit showed antitumor activity against Ehrlich's ascites carcinoma (EAC) cell line in Swiss albino mice. The METP-treated group's tumor volume, tumor weight, and viable cell count were decreased compared to the EAC control group. Tumor volumes were 3.62±0.12 ml, 2.88±0.23 ml, and 1.34±0....

Objectives: The present study evaluates the free radical scavenging activity and total phenolic content of methanol extract of Monstera deliciosa. Methodology: The antioxidant activities of above mentioned extract of Monstera deliciosa were measured by different in vitro standard methods like 1,1-diphenyl-2-picrylhydrazil radical (DPPH), nitric oxi...

Introduction: The present study evaluates the antioxidant effect of methanol extract of Hippophae salicifolia (MEHS) bark with special emphasis on its role on oxidative DNA damage in mouse peritoneal macrophages. Material and methods: In vitro antioxidant activity was estimated by standard antioxidant assays whereas the antioxidant activity conc...