Mahmoud F. Farhat

• PhD 1976 ,University of Salford U.K,
• Professor (Full) at University of Tripoli Tripoli, Libya

Silver nanoparticles (AgNPs) possess unusual optical, electrical, and catalytic properties. Hence, they are promising candidates in biomedical applications due to their shape and high surface area. Therefore, in present study, AgNPs were functionalized by using chalcone derivative as reducing and capping agent. The synthesized chalcone derivative w...

N-[(5-Azido-1,3-diphenyl-1H-pyrazole-4-yl)methylene]-N-arylamines (4a-c) and N-[(5-Substituted-1,3-diphenyl-1H-pyrazole-4-yl)methylene]hydrazides (5a-e) were prepared from 5-azido-1,3-diphenyl-1H-pyrazole-4-carbaldehyde (3) and 5-chloro-1,3-diphenyl-1H-pyrazole-4-carbaldehyde (2), respectively. Thermolysis of (4a-c) and (5d-e) afforded 5-arylamino-...

N-[(5-Azido-1,3-diphenyl-1H-pyrazole-4-yl)methylene]-N-arylamines (4a-c) and N-[(5-Substituted-1,3-diphenyl-1H-pyrazole-4-yl)methylene]hydrazides (5a-e) were prepared from 5-azido-1,3-diphenyl-1H-pyrazole-4-carbaldehyde (3) and 5-chloro-1,3-diphenyl-1H-pyrazole-4-carbaldehyde (2), respectively. Thermolysis of (4a-c) and (5d-e) afforded 5-arylamino-...

Comments Citations References (18) Related research (10+) Share Save Abstract and figures 3-Amino-2-thiophenecarboxamides (3a-e) were synthesized from 2-(4-oxo-3-phenyl- thiazolidin-2-ylidene)malononitrile(1) and employed in the synthesis of a variety of thiophene derivatives. These 3-Amino-2-thiophenecarboxamides (3a-c) which when treated wit...

3-Amino-2-thiophenecarboxamides (3a-e) were synthesized from 2-(4-oxo-3-phenyl- thiazolidin-2-ylidene)malononitrile(1) and employed in the synthesis of a variety of thiophene derivatives. These 3-Amino-2-thiophenecarboxamides (3a-c) which when treated with aromatic aldehydes under relatively mild conditions produced the 3-arylideneamines (6a-d)....

3-Amino-2-thiophenecarboxamides (3a, d-g) were synthesized from 2-(4-oxo-3-phenyl-thiazolidin-2-ylidene)malononitrile (2) and employed in the synthesis of a variety of thiophene and thienopyrimidinone derivatives. 3-Amino-2-thiophenecarboxamides (3a, d, e) on refluxing in acetic acid gave the tetrahydrothienopyrimidinones (6a-m). On the other hand,...

3-Amino-2-thiophenecarboxamides (3a, d-g) were synthesized from 2-(4-oxo-3-phenyl-thiazolidin-2-ylidene)malononitrile (2) and employed in the synthesis of a variety of thiophene and thienopyrimidinone derivatives. 3-Amino-2-thiophenecarboxamides (3a, d, e) on refluxing in acetic acid gave the tetrahydrothienopyrimidinones (6a-m). On the other hand,...

3-Amino-2-thiophenecarboxamides (3a, d-g) were synthesized from 2-(4-oxo-3-phenyl-thiazolidin-2-ylidene)malononitrile (2) and employed in the synthesis of a variety of thiophene and thienopyrimidinone derivatives. 3-Amino-2-thiophenecarboxamides (3a, d, e) on refluxing in acetic acid gave the tetrahydrothienopyrimidinones (6a-m). On the other hand,...

Alkyl 3-aminothiophene carboxylates derivatives (3a-d) were prepared via reaction of (4-oxo-3-phenyl-1,3-thiazolidin-2-ylidene)malononitrile (2) with alcohols. Compound 3a was allowed to react with acetic anhydride, chloroacetyl chloride and nitrous acid to afford N,N,N-triacetylthiophene, 3-chloro-acetamidothiophene and 3-diazothiophene derivative...

6-(Benzo[d][1,3]dioxol-5-yl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile has been utilized for synthesis of the fused heterocyclic compounds namely thiazolopyrimidines, tetrazolopyrimidine, pyrimidoquinazoline, pyrimidothiazolopyrimidine, pyrimidothiazolotriazine and pyrrolothiazolopyrimidine derivatives. The newly synthesized compou...

2-Ylidene and 2,5-diylidene-4-thiazolidinones 2a–d were synthesized and converted into pyrazole derivatives 4a–d by reaction with hydrazine hydrate. A mechanism of this novel conversion is suggested.

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Reactions of 3-amino-2-(4-bromobenzoyl)-4-cyano-5-phenylaminothiophene(3a)or 2-acetyl-3-amino-4-cyano- 5-phenylaminothiophene(3b) with a variety of active methylene compounds,such as ethyl cyanoacetate, ethyl acetoacetate,ethyl benzoylacetate and diethyl malonate ,yielded the corresponding thieno[3,2-f]pyridine-one derivatives 4(a,b-7a,b). Also the...

Ketene N,S-acetal potassium salts (2a–g), prepared via reaction of active methylenes (1a–g) with phenyl isothiocyanate in the presence of potassium hydroxide, were allowed to react with ethyl chloroacetate or chloroacetamide to afford the corresponding 2-ylidene-4-thiazolidinones (3a–g) in good yields. Compounds (3a–g) reacted with a variety of aro...

Bis[thieno(3,2-b)-1,4-diazepine] (4) and bis[imidazo(1′,2′)thieno(3,2-b)-1,4-diazepine (7) derivatives were prepared starting with thieno(2,3-b)thiophenes (1) and (2), respectively. Also, benzodiazepine derivatives (11a–f) were prepared via a reaction of cyclohexenone carboxylates (8a–f) with cyclohexylamine and chloroacetyl chloride followed by cy...

The aldehyde group of 2,4-dichlorothiazole-5-carbaldehyde was protected and the chlorine atom at position 2 was replaced by hydrogen and a methylthio group, via Cl → Li exchange, to give 4-chloro-thiazole-5-carbaldehyde and its 2-methylthio derivative, respectively. Ethyl 2-mercaptoacetate reacted with 4-chlorothiazole-5-carbaldehydes to give thien...

Durch Umsetzung der (aus entsprechenden Phenylendiaminen zugänglichen) IsobenzimidazoI- Spiroverbindungen (I) mit entsprechenden Nucleophilen (II), (V), (VII), (IX), (XI) unter den angegebenen Bedingungen lassen sich mono- bzw. disubstituierte Derivate wie (III), (VI), (VIII), (X) bzw. (XII) gewinnen [Folgereaktionen entsprechender (III) mit (IIb),...

Isobenzimidazole-2-spirocyclohexane(1)can be made to react with nitrogen, oxygen, sulphur, and carbon nucleophiles to give mono-and di-substitied derivatives. On reductive ring-opening the correspondingly substituted o-phenylenediamine is obtained. The scope of this synthetic principle has been studied and the reaction used to prepare various heter...